Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM59100 (Bi-ligand, 3) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 202 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Triad Therapeutics, Inc | Assay Description All reactions were monitored spectrophotometrically at 340 nm by using initial rates from the first 5% of reaction. | Chem Biol 11: 185-94 (2004) Article DOI: 10.1016/j.chembiol.2004.02.012 BindingDB Entry DOI: 10.7270/Q2K9360M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152418 ((1E,1E)-O,O-(Ethane-1,2-diyl)bis[2,4,5...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152420 ((E)-2,4,5-Trihydroxybenzaldehyde oxime (7)) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152421 ((E)-2,4,5-Trihydroxybenzaldehyde O-methyl oxime (8...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM50044976 (CHEMBL2316879) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 7.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Strasbourg/CNRS Curated by ChEMBL | Assay Description Uncompetitive inhibition of His-tagged Escherichia coli DXR at 1 to 8 uM pre-incubated for 2 mins before reaction initiation in presence of 160 uM NA... | Bioorg Med Chem 22: 3713-9 (2014) Article DOI: 10.1016/j.bmc.2014.05.004 BindingDB Entry DOI: 10.7270/Q2057HKT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM59101 (Bi-ligand, 4) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Triad Therapeutics, Inc | Assay Description All reactions were monitored spectrophotometrically at 340 nm by using initial rates from the first 5% of reaction. | Chem Biol 11: 185-94 (2004) Article DOI: 10.1016/j.chembiol.2004.02.012 BindingDB Entry DOI: 10.7270/Q2K9360M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152422 ((E)-2,4,5-Trihydroxybenzaldehyde O-benzyl oxime (9...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 9.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM59099 (Bi-ligand, 2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Triad Therapeutics, Inc | Assay Description All reactions were monitored spectrophotometrically at 340 nm by using initial rates from the first 5% of reaction. | Chem Biol 11: 185-94 (2004) Article DOI: 10.1016/j.chembiol.2004.02.012 BindingDB Entry DOI: 10.7270/Q2K9360M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152434 ((E)-2-Fluoro-4,5-dihydroxybenzaldehyde O-methyl ox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152417 (Sodium (1E,7E)-1-(2,4,5-trihydroxyphenyl)-3,6-diox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152429 ((E)-3,4,5-Trihydroxybenzaldehyde O-methyl oxime (1...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152433 ((E)-2-Hydroxy-3-nitrobenzaldehyde O-methyl oxime (...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 4.78E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM59098 (Bi-ligand, 1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Triad Therapeutics, Inc | Assay Description All reactions were monitored spectrophotometrically at 340 nm by using initial rates from the first 5% of reaction. | Chem Biol 11: 185-94 (2004) Article DOI: 10.1016/j.chembiol.2004.02.012 BindingDB Entry DOI: 10.7270/Q2K9360M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152419 (2,4,5-trihydroxybenzaldehyde (6)) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | >7.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152424 ((E)-5-[(2-Methylhydrazono)methyl]benzene-1,2,4-tri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | >7.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152423 (5-[(Methoxyamino)methyl]benzene-1,2,4-triol hydroc...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | >7.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152425 ((E,Z)-2,4,5-Trimethoxybenzaldehyde O-methyl oxime ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM50153710 (3S-hydroxypentan-2-one 5-phosphate) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Oregon State University Curated by ChEMBL | Assay Description Inhibitory activity against Escherichia coli deoxyxylulose 5-phosphate reductoisomerase | Bioorg Med Chem Lett 14: 5309-12 (2004) Article DOI: 10.1016/j.bmcl.2004.08.023 BindingDB Entry DOI: 10.7270/Q25T3M75 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM50149225 (3,4-Dihydroxy-benzaldehyde O-methyl-oxime | CHEMBL...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152426 ((E)-2-Hydroxybenzaldehyde O-methyl oxime (14)) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152436 ((E)-2-Fluoro-4,5-dimethoxybenzaldehyde O-methyl ox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152435 ((E)-4,5-Difluoro-2-hydroxybenzaldehyde O-methyl ox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152432 ((E)-4-Hydroxy-3-nitrobenzaldehyde O-methyl oxime (...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152431 ((E)-Uracil-6-carbaldehyde O-methyl oxime (19)) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152430 ((E)-3,4-Dihydroxy-5-methoxybenzaldehyde O-methyl o...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152427 ((E)-2,5-Dihydroxybenzaldehyde O-methyl oxime (15)) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM152428 ((E)-2,4-Dihydroxybenzaldehyde O-methyl oxime (16)) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | 8.0 | n/a |
The Johns Hopkins University School of Medicine | Assay Description DXP synthase reaction mixtures containing HEPES (100 mM, pH 8.0), MgCl2 (2 mM), NaCl (5 mM), ThDP (1 mM), BSA (1 mg/mL), pyruvate (12.5-250 然), D-GA... | Chembiochem 16: 1771-81 (2015) Article DOI: 10.1002/cbic.201500119 BindingDB Entry DOI: 10.7270/Q29Z93MS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM84559 (Phosphate analogue, (s)-14) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 7.50E+5 | -18.6 | n/a | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Bristol | Assay Description The assay was monitored spectrophotometrically through the consumption of beta-NADPH. The inhibitor assays contained inhibitor at concentrations of ... | Chembiochem 6: 1866-74 (2005) Article DOI: 10.1002/cbic.200500061 BindingDB Entry DOI: 10.7270/Q26D5RHB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM50153714 (4S-hydroxypentan-2-one 5-phosphate) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 8.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Oregon State University Curated by ChEMBL | Assay Description Inhibitory activity against Escherichia coli deoxyxylulose 5-phosphate reductoisomerase | Bioorg Med Chem Lett 14: 5309-12 (2004) Article DOI: 10.1016/j.bmcl.2004.08.023 BindingDB Entry DOI: 10.7270/Q25T3M75 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM50032981 ((3-Amino-propyl)-phosphonic acid | CHEMBL286077 | ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 4.00E+6 | -14.2 | n/a | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Bristol | Assay Description The assay was monitored spectrophotometrically through the consumption of beta-NADPH. The inhibitor assays contained inhibitor at concentrations of ... | Chembiochem 6: 1866-74 (2005) Article DOI: 10.1002/cbic.200500061 BindingDB Entry DOI: 10.7270/Q26D5RHB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM84560 (Phosphate analogue, (S)-21) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 4.10E+6 | -14.2 | n/a | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Bristol | Assay Description The assay was monitored spectrophotometrically through the consumption of beta-NADPH. The inhibitor assays contained inhibitor at concentrations of ... | Chembiochem 6: 1866-74 (2005) Article DOI: 10.1002/cbic.200500061 BindingDB Entry DOI: 10.7270/Q26D5RHB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM84558 (Phosphate analogue, 9) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 6.50E+6 | -13.0 | n/a | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Bristol | Assay Description The assay was monitored spectrophotometrically through the consumption of beta-NADPH. The inhibitor assays contained inhibitor at concentrations of ... | Chembiochem 6: 1866-74 (2005) Article DOI: 10.1002/cbic.200500061 BindingDB Entry DOI: 10.7270/Q26D5RHB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1-deoxy-D-xylulose 5-phosphate reductoisomerase (Escherichia coli) | BDBM84557 (Phosphate analogue, 6) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents | Article PubMed | 1.80E+7 | -10.4 | n/a | n/a | n/a | n/a | n/a | 8.0 | 37 |
University of Bristol | Assay Description The assay was monitored spectrophotometrically through the consumption of beta-NADPH. The inhibitor assays contained inhibitor at concentrations of ... | Chembiochem 6: 1866-74 (2005) Article DOI: 10.1002/cbic.200500061 BindingDB Entry DOI: 10.7270/Q26D5RHB | |||||||||||
More data for this Ligand-Target Pair |