Found 304 hits of ki data for polymerid = 49000274,49000277 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Type-2 angiotensin II receptor
(RAT) | BDBM82431
(L-162,193 | L-162193 | N-[[4-[[[6-[4-(Cyclopropylc...)Show SMILES [#6]-[#6]-[#6]-[#6]-[#8]-[#6](=O)-[#7][S;v6](=O)(=O)c1ccccc1-c1ccc(-[#6]-n2c(-[#6]-[#6]-[#6]-[#6])nc3ccc(cc3c2=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-2-[#6]-[#6]-2)cc1 Show InChI InChI=1S/C38H45N5O6S/c1-3-5-11-35-39-33-19-18-30(41-20-22-42(23-21-41)36(44)29-16-17-29)25-32(33)37(45)43(35)26-27-12-14-28(15-13-27)31-9-7-8-10-34(31)50(47,48)40-38(46)49-24-6-4-2/h7-10,12-15,18-19,25,29H,3-6,11,16-17,20-24,26H2,1-2H3,(H,40,46) | PDB
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| PC cid
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| 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 272: 612-8 (1995)
BindingDB Entry DOI: 10.7270/Q2FB51GP |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50030815
(CHEMBL404594)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(O)=O |wU:8.7,25.27,wD:41.44,4.4,15.16,29.31,45.48,2.2,62.65,(8.44,-18.06,;9.36,-17.24,;9.05,-15.73,;7.88,-15.34,;10.19,-14.7,;9.88,-13.19,;11.03,-12.16,;12.2,-12.55,;10.71,-10.66,;11.74,-9.51,;10.97,-8.18,;9.46,-8.5,;9.33,-10.02,;7.99,-10.79,;7.99,-12.02,;6.66,-10.02,;5.32,-10.79,;5.32,-12.33,;4.07,-13.22,;4.55,-14.68,;6.09,-14.68,;6.56,-13.21,;6.66,-8.48,;5.33,-7.71,;4.43,-8.22,;5.33,-6.17,;3.99,-5.39,;4,-3.85,;5.06,-3.24,;2.66,-3.08,;1.33,-3.85,;-.01,-3.08,;-1.34,-3.84,;-2.67,-3.07,;-2.67,-1.53,;-3.73,-.91,;-1.33,-.76,;,-1.54,;2.67,-1.54,;4,-.77,;5.07,-1.39,;4.01,.77,;5.35,1.53,;5.36,3.07,;4.29,3.69,;6.69,3.84,;6.7,5.37,;8.04,6.14,;8.04,7.68,;9.38,8.44,;9.39,9.99,;10.45,10.6,;8.32,10.61,;8.03,3.06,;8.02,1.52,;6.94,.91,;9.35,.74,;9.34,-.8,;10.22,-1.32,;2.68,1.54,;1.61,.93,;2.69,2.78,;6.66,-5.4,;7.73,-6.01,;6.66,-3.86,;7.73,-3.24,;11.66,-15.17,;11.91,-16.38,;12.58,-14.35,)| Show InChI InChI=1S/C46H73N13O10/c1-8-26(5)37(43(66)55-33(21-29-22-50-24-52-29)44(67)59-19-11-13-34(59)41(64)58-38(45(68)69)27(6)9-2)57-40(63)32(20-28-14-16-30(60)17-15-28)54-42(65)36(25(3)4)56-39(62)31(53-35(61)23-49-7)12-10-18-51-46(47)48/h14-17,22,24-27,31-34,36-38,49,60H,8-13,18-21,23H2,1-7H3,(H,50,52)(H,53,61)(H,54,65)(H,55,66)(H,56,62)(H,57,63)(H,58,64)(H,68,69)(H4,47,48,51)/t26-,27-,31-,32-,33-,34-,36-,37-,38-/m0/s1 | PDB
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| Article
PubMed
| 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Binding affinity to AT2 receptor (unknown origin) |
ACS Med Chem Lett 5: 1129-32 (2014)
Article DOI: 10.1021/ml500278g
BindingDB Entry DOI: 10.7270/Q2BV7J7R |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50030815
(CHEMBL404594)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(O)=O |wU:8.7,25.27,wD:41.44,4.4,15.16,29.31,45.48,2.2,62.65,(8.44,-18.06,;9.36,-17.24,;9.05,-15.73,;7.88,-15.34,;10.19,-14.7,;9.88,-13.19,;11.03,-12.16,;12.2,-12.55,;10.71,-10.66,;11.74,-9.51,;10.97,-8.18,;9.46,-8.5,;9.33,-10.02,;7.99,-10.79,;7.99,-12.02,;6.66,-10.02,;5.32,-10.79,;5.32,-12.33,;4.07,-13.22,;4.55,-14.68,;6.09,-14.68,;6.56,-13.21,;6.66,-8.48,;5.33,-7.71,;4.43,-8.22,;5.33,-6.17,;3.99,-5.39,;4,-3.85,;5.06,-3.24,;2.66,-3.08,;1.33,-3.85,;-.01,-3.08,;-1.34,-3.84,;-2.67,-3.07,;-2.67,-1.53,;-3.73,-.91,;-1.33,-.76,;,-1.54,;2.67,-1.54,;4,-.77,;5.07,-1.39,;4.01,.77,;5.35,1.53,;5.36,3.07,;4.29,3.69,;6.69,3.84,;6.7,5.37,;8.04,6.14,;8.04,7.68,;9.38,8.44,;9.39,9.99,;10.45,10.6,;8.32,10.61,;8.03,3.06,;8.02,1.52,;6.94,.91,;9.35,.74,;9.34,-.8,;10.22,-1.32,;2.68,1.54,;1.61,.93,;2.69,2.78,;6.66,-5.4,;7.73,-6.01,;6.66,-3.86,;7.73,-3.24,;11.66,-15.17,;11.91,-16.38,;12.58,-14.35,)| Show InChI InChI=1S/C46H73N13O10/c1-8-26(5)37(43(66)55-33(21-29-22-50-24-52-29)44(67)59-19-11-13-34(59)41(64)58-38(45(68)69)27(6)9-2)57-40(63)32(20-28-14-16-30(60)17-15-28)54-42(65)36(25(3)4)56-39(62)31(53-35(61)23-49-7)12-10-18-51-46(47)48/h14-17,22,24-27,31-34,36-38,49,60H,8-13,18-21,23H2,1-7H3,(H,50,52)(H,53,61)(H,54,65)(H,55,66)(H,56,62)(H,57,63)(H,58,64)(H,68,69)(H4,47,48,51)/t26-,27-,31-,32-,33-,34-,36-,37-,38-/m0/s1 | PDB
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PubMed
| 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Binding affinity to type-2 angiotensin-2 receptor (unknown origin) |
Bioorg Med Chem Lett 26: 1355-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.10.084
BindingDB Entry DOI: 10.7270/Q2SN0BT6 |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50370684
(CHEMBL1791349)Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O Show InChI InChI=1S/C49H71N13O10/c1-6-29(4)41(46(69)58-36(24-32-25-53-27-55-32)47(70)62-21-11-15-38(62)44(67)59-37(48(71)72)23-30-12-8-7-9-13-30)61-43(66)35(22-31-16-18-33(63)19-17-31)57-45(68)40(28(2)3)60-42(65)34(56-39(64)26-52-5)14-10-20-54-49(50)51/h7-9,12-13,16-19,25,27-29,34-38,40-41,52,63H,6,10-11,14-15,20-24,26H2,1-5H3,(H,53,55)(H,56,64)(H,57,68)(H,58,69)(H,59,67)(H,60,65)(H,61,66)(H,71,72)(H4,50,51,54)/t29-,34+,35+,36+,37+,38+,40+,41+/m1/s1 | PDB
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| 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 h... |
J Med Chem 48: 6620-31 (2005)
Article DOI: 10.1021/jm050280z
BindingDB Entry DOI: 10.7270/Q2HX1DG6 |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50236697
(5-L-isoleucineangiotensin II | 5-isoleucine-angiot...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O |wU:4.4,47.47,60.63,35.36,20.21,wD:2.2,24.32,8.17,64.66,(24.13,1.24,;24.1,-.31,;25.42,-1.09,;26.77,-.35,;25.4,-2.63,;24.05,-3.38,;22.73,-2.59,;22.75,-1.05,;21.38,-3.34,;21.36,-4.88,;22.68,-5.66,;24.01,-4.93,;25.33,-5.71,;25.32,-7.24,;26.64,-8.05,;23.97,-8.01,;22.65,-7.22,;20.06,-2.55,;18.71,-3.29,;18.68,-4.83,;17.38,-2.5,;16.04,-3.25,;14.72,-2.46,;14.74,-.92,;13.37,-3.2,;13.34,-4.74,;14.66,-5.53,;14.64,-7.08,;15.96,-7.87,;15.93,-9.4,;14.59,-10.16,;17.25,-10.21,;12.05,-2.42,;10.69,-3.15,;10.67,-4.69,;9.37,-2.36,;8.03,-3.1,;9.4,-.82,;10.75,-.07,;12.07,-.88,;10.78,1.47,;17.41,-.96,;18.76,-.21,;16.1,-.17,;26.72,-3.43,;26.69,-4.97,;28.07,-2.68,;29.38,-3.48,;30.73,-2.73,;30.75,-1.19,;29.53,-.27,;30.03,1.18,;31.57,1.17,;32.02,-.31,;29.35,-5.02,;28.01,-5.76,;30.54,-5.79,;31.99,-5.25,;32.95,-6.46,;32.1,-7.74,;30.62,-7.33,;29.33,-8.36,;27.89,-7.82,;29.58,-9.88,;28.39,-10.86,;26.95,-10.32,;25.76,-11.3,;26.02,-12.81,;24.84,-13.79,;23.4,-13.26,;23.14,-11.74,;24.32,-10.75,;28.64,-12.38,;27.45,-13.36,;30.08,-12.92,)| Show InChI InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1 | PDB
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| Purchase
CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Inhibition of CDK1/Cyclin B (unknown origin) expressed in baculoviral infected insect Sf9 cells using histone H1 as substrate in presence of [gamma-3... |
Bioorg Med Chem Lett 26: 1355-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.10.084
BindingDB Entry DOI: 10.7270/Q2SN0BT6 |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | BDBM82435
(1-[2,4,6-Trichlorophenyl]-3-butyl-4-[[2'-(1H-t...)Show SMILES CCCCc1nn(c(C(O)=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)-c1c(Cl)cc(Cl)cc1Cl |(13.29,.94,;11.96,.17,;10.62,.94,;9.29,.17,;7.95,.94,;7.79,2.47,;6.29,2.79,;5.52,1.46,;3.99,1.29,;3.36,-.11,;3.08,2.54,;6.55,.31,;6.23,-1.2,;7.37,-2.23,;7.05,-3.73,;8.2,-4.76,;9.66,-4.29,;9.98,-2.78,;8.84,-1.75,;10.8,-5.32,;12.27,-4.84,;13.41,-5.87,;13.09,-7.38,;11.63,-7.85,;10.48,-6.82,;9.02,-7.3,;7.77,-6.39,;6.53,-7.3,;7,-8.76,;8.54,-8.76,;5.91,4.28,;7.02,5.35,;8.5,4.93,;6.64,6.85,;5.16,7.27,;4.79,8.76,;4.06,6.2,;4.43,4.7,;3.32,3.63,)| Show InChI InChI=1S/C28H23Cl3N6O2/c1-2-3-8-24-21(25(28(38)39)37(34-24)26-22(30)14-18(29)15-23(26)31)13-16-9-11-17(12-10-16)19-6-4-5-7-20(19)27-32-35-36-33-27/h4-7,9-12,14-15H,2-3,8,13H2,1H3,(H,38,39)(H,32,33,35,36) | PDB
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| PC cid
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| 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 272: 612-8 (1995)
BindingDB Entry DOI: 10.7270/Q2FB51GP |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50370575
(CHEMBL1791308)Show SMILES CC[C@@H](C)[C@H](N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O |wU:68.73,15.15,55.57,41.42,30.30,2.2,wD:4.4,19.26,72.76,(20.86,-11.16,;20.86,-9.62,;19.5,-8.85,;18.13,-9.62,;19.5,-7.31,;18.13,-6.53,;17.29,-7.83,;15.7,-8,;15.29,-9.47,;13.78,-9.86,;12.67,-8.77,;13.1,-7.3,;11.74,-6.61,;10.41,-7.27,;10.41,-8.62,;9.06,-6.59,;7.72,-7.27,;6.37,-6.59,;6.4,-5.24,;5.03,-7.24,;5.03,-8.61,;6.22,-9.28,;6.2,-10.63,;7.41,-11.31,;7.4,-12.65,;6.2,-13.32,;8.58,-13.35,;3.69,-6.58,;2.35,-7.24,;2.35,-8.58,;.99,-6.58,;-.35,-7.21,;1.02,-5.24,;-.33,-4.54,;-1.69,-5.21,;-.32,-3.2,;9.07,-5.22,;10.45,-4.54,;7.71,-4.51,;14.61,-6.9,;14.8,-5.36,;16.14,-4.57,;15.99,-3.04,;16.77,-1.69,;15.97,-.38,;16.74,.97,;18.32,.97,;19.09,2.32,;19.13,-.34,;18.35,-1.69,;17.63,-5.09,;18.76,-3.99,;20.86,-6.53,;20.86,-5,;22.25,-7.3,;23.67,-6.69,;23.73,-5.14,;24.52,-3.79,;26.07,-3.63,;26.4,-2.11,;25.03,-1.35,;23.84,-2.38,;25,-7.41,;24.92,-8.77,;26.39,-6.67,;25.88,-5.19,;27.18,-4.28,;28.45,-5.19,;27.97,-6.67,;29.35,-7.43,;29.34,-8.98,;30.71,-6.67,;32.02,-7.41,;31.94,-8.77,;33.27,-9.48,;34.67,-8.88,;35.98,-9.63,;35.9,-10.95,;34.48,-11.61,;33.19,-10.87,;33.44,-6.8,;34.77,-7.53,;33.52,-5.43,)| Show InChI InChI=1S/C57H76N14O12/c1-5-32(4)48(53(79)67-42(26-36-28-61-30-63-36)54(80)70-23-11-17-44(70)51(77)68-43(56(82)83)25-33-12-7-6-8-13-33)71-29-35-14-9-15-39(47(35)64-41(55(71)81)24-34-18-20-37(72)21-19-34)65-52(78)46(31(2)3)69-50(76)40(16-10-22-62-57(59)60)66-49(75)38(58)27-45(73)74/h6-9,12-15,18-21,28,30-32,38,40-44,46,48,64,72H,5,10-11,16-17,22-27,29,58H2,1-4H3,(H,61,63)(H,65,78)(H,66,75)(H,67,79)(H,68,77)(H,69,76)(H,73,74)(H,82,83)(H4,59,60,62)/t32-,38+,40+,41+,42+,43+,44+,46+,48+/m1/s1 | PDB
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PC cid
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| Article
PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium |
J Med Chem 48: 4009-24 (2005)
Article DOI: 10.1021/jm0491492
BindingDB Entry DOI: 10.7270/Q2BR8SZD |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50370575
(CHEMBL1791308)Show SMILES CC[C@@H](C)[C@H](N1Cc2cccc(NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)c2N[C@@H](Cc2ccc(O)cc2)C1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O |wU:68.73,15.15,55.57,41.42,30.30,2.2,wD:4.4,19.26,72.76,(20.86,-11.16,;20.86,-9.62,;19.5,-8.85,;18.13,-9.62,;19.5,-7.31,;18.13,-6.53,;17.29,-7.83,;15.7,-8,;15.29,-9.47,;13.78,-9.86,;12.67,-8.77,;13.1,-7.3,;11.74,-6.61,;10.41,-7.27,;10.41,-8.62,;9.06,-6.59,;7.72,-7.27,;6.37,-6.59,;6.4,-5.24,;5.03,-7.24,;5.03,-8.61,;6.22,-9.28,;6.2,-10.63,;7.41,-11.31,;7.4,-12.65,;6.2,-13.32,;8.58,-13.35,;3.69,-6.58,;2.35,-7.24,;2.35,-8.58,;.99,-6.58,;-.35,-7.21,;1.02,-5.24,;-.33,-4.54,;-1.69,-5.21,;-.32,-3.2,;9.07,-5.22,;10.45,-4.54,;7.71,-4.51,;14.61,-6.9,;14.8,-5.36,;16.14,-4.57,;15.99,-3.04,;16.77,-1.69,;15.97,-.38,;16.74,.97,;18.32,.97,;19.09,2.32,;19.13,-.34,;18.35,-1.69,;17.63,-5.09,;18.76,-3.99,;20.86,-6.53,;20.86,-5,;22.25,-7.3,;23.67,-6.69,;23.73,-5.14,;24.52,-3.79,;26.07,-3.63,;26.4,-2.11,;25.03,-1.35,;23.84,-2.38,;25,-7.41,;24.92,-8.77,;26.39,-6.67,;25.88,-5.19,;27.18,-4.28,;28.45,-5.19,;27.97,-6.67,;29.35,-7.43,;29.34,-8.98,;30.71,-6.67,;32.02,-7.41,;31.94,-8.77,;33.27,-9.48,;34.67,-8.88,;35.98,-9.63,;35.9,-10.95,;34.48,-11.61,;33.19,-10.87,;33.44,-6.8,;34.77,-7.53,;33.52,-5.43,)| Show InChI InChI=1S/C57H76N14O12/c1-5-32(4)48(53(79)67-42(26-36-28-61-30-63-36)54(80)70-23-11-17-44(70)51(77)68-43(56(82)83)25-33-12-7-6-8-13-33)71-29-35-14-9-15-39(47(35)64-41(55(71)81)24-34-18-20-37(72)21-19-34)65-52(78)46(31(2)3)69-50(76)40(16-10-22-62-57(59)60)66-49(75)38(58)27-45(73)74/h6-9,12-15,18-21,28,30-32,38,40-44,46,48,64,72H,5,10-11,16-17,22-27,29,58H2,1-4H3,(H,61,63)(H,65,78)(H,66,75)(H,67,79)(H,68,77)(H,69,76)(H,73,74)(H,82,83)(H4,59,60,62)/t32-,38+,40+,41+,42+,43+,44+,46+,48+/m1/s1 | PDB
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| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium |
J Med Chem 48: 4009-24 (2005)
Article DOI: 10.1021/jm0491492
BindingDB Entry DOI: 10.7270/Q2BR8SZD |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | BDBM82077
(Angiotensin II | CAS_11128-99-7 | NSC_439662)Show SMILES CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CCCN=C(N)N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(C)=O |(1.13,.52,;1.58,1.99,;.53,3.12,;-.97,2.77,;.98,4.59,;2.48,4.94,;3.54,3.81,;3.08,2.34,;5.04,4.16,;5.49,5.63,;4.44,6.76,;2.93,6.41,;1.88,7.54,;2.33,9.01,;1.28,10.14,;3.84,9.36,;4.89,8.23,;6.09,3.03,;7.59,3.38,;8.04,4.85,;8.64,2.25,;10.14,2.6,;11.19,1.47,;10.74,-0,;12.69,1.82,;13.74,.69,;13.29,-.78,;14.34,-1.91,;13.89,-3.38,;12.39,-3.73,;11.94,-5.2,;11.34,-2.6,;13.14,3.29,;14.64,3.64,;15.69,2.51,;15.09,5.11,;14.04,6.24,;16.59,5.46,;17.04,6.93,;15.99,8.06,;18.54,7.28,;8.19,.78,;9.24,-.35,;6.69,.43,;-.07,5.72,;.38,7.19,;-1.57,5.37,;-2.62,6.5,;-2.17,7.97,;-3.22,9.1,;-2.92,10.61,;-4.27,11.35,;-5.4,10.3,;-4.75,8.91,;-4.12,6.15,;-4.57,4.68,;-5.17,7.28,;-6.67,6.93,;-6.64,5.39,;-7.96,4.6,;-9.38,5.2,;-10.39,4.04,;-9.6,2.72,;-8.1,3.06,;-7.72,8.06,;-7.27,9.53,;-9.22,7.71,;-10.38,8.72,;-11.7,7.93,;-11.36,6.43,;-9.82,6.29,;-10.42,4.87,;-10.87,3.4,;-11.95,4.69,;-12.55,3.27,;-14.08,3.08,;-14.68,1.66,;-13.76,.43,;-14.36,-.98,;-15.89,-1.17,;-16.81,.06,;-16.21,1.48,;-11.63,2.04,;-10.1,2.23,;-12.23,.62,)| Show InChI InChI=1S/C57H80N16O12/c1-6-32(4)48(72-52(81)42(23-35-16-18-38(75)19-17-35)68-54(83)47(31(2)3)71-50(79)40(14-10-20-63-57(59)60)66-49(78)39(58)26-46(76)77)55(84)69-43(24-36-27-61-29-64-36)51(80)70-44(25-37-28-62-30-65-37)56(85)73-21-11-15-45(73)53(82)67-41(33(5)74)22-34-12-8-7-9-13-34/h7-9,12-13,16-19,27-32,39-45,47-48,75H,6,10-11,14-15,20-26,58H2,1-5H3,(H,61,64)(H,62,65)(H,66,78)(H,67,82)(H,68,83)(H,69,84)(H,70,80)(H,71,79)(H,72,81)(H,76,77)(H4,59,60,63) | PDB
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| 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shinshu University
Curated by PDSP Ki Database
| |
Fundam Clin Pharmacol 16: 317-23 (2002)
Article DOI: 10.1046/j.1472-8206.2002.00076.x
BindingDB Entry DOI: 10.7270/Q2697259 |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | BDBM82259
(CAS_123856 | L-158,809 | NSC_123856)Show SMILES CCc1nc2c(C)cc(C)nc2n1-c1ccc(cc1)-c1ccccc1-c1nnn[nH]1 Show InChI InChI=1S/C23H21N7/c1-4-20-25-21-14(2)13-15(3)24-23(21)30(20)17-11-9-16(10-12-17)18-7-5-6-8-19(18)22-26-28-29-27-22/h5-13H,4H2,1-3H3,(H,26,27,28,29) | PDB
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| 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 272: 612-8 (1995)
BindingDB Entry DOI: 10.7270/Q2FB51GP |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | BDBM50030727
(4''-[3-Butyl-5-oxo-1-(2-trifluoromethyl-phenyl)-1,...)Show SMILES CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1 Show InChI InChI=1S/C33H29F3N4O4S/c1-2-3-17-30-37-40(28-15-9-8-14-27(28)33(34,35)36)32(42)39(30)22-23-18-20-24(21-19-23)26-13-7-10-16-29(26)45(43,44)38-31(41)25-11-5-4-6-12-25/h4-16,18-21H,2-3,17,22H2,1H3,(H,38,41) | PDB
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| 0.320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 272: 612-8 (1995)
BindingDB Entry DOI: 10.7270/Q2FB51GP |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | BDBM86060
(CAS_123794 | CGP 42112 | NSC_123794)Show SMILES CCC(C)C(NC(=O)C1CCCN1C(=O)C(Cc1cnc[nH]1)NC(=O)C(CCCCNC(=O)C(CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)c1cccnc1)C(O)=O |(27.48,-27.05,;26.03,-27.58,;24.85,-26.6,;25.11,-25.08,;23.4,-27.13,;22.22,-26.15,;20.78,-26.68,;20.51,-28.19,;19.59,-25.69,;19.69,-24.16,;18.26,-23.58,;17.28,-24.77,;18.1,-26.07,;17.53,-27.5,;18.48,-28.71,;16,-27.72,;15.43,-29.15,;16.39,-30.36,;15.97,-31.84,;17.25,-32.7,;18.46,-31.75,;17.92,-30.3,;15.05,-26.51,;13.53,-26.73,;12.96,-28.16,;12.57,-25.52,;11.05,-25.74,;10.1,-24.53,;8.57,-24.75,;7.62,-23.54,;6.1,-23.76,;5.14,-22.55,;5.72,-21.12,;3.62,-22.77,;3.05,-24.2,;4,-25.41,;3.43,-26.84,;4.38,-28.05,;5.91,-27.83,;6.86,-29.04,;6.48,-26.4,;2.67,-21.56,;1.14,-21.78,;.57,-23.21,;.19,-20.57,;-1.33,-20.79,;-2.29,-19.58,;-3.81,-19.8,;-4.76,-18.59,;-4.19,-17.16,;-2.67,-16.94,;-1.71,-18.15,;13.15,-24.09,;14.67,-23.87,;15.62,-25.08,;15.24,-22.44,;14.29,-21.23,;12.77,-21.45,;12.19,-22.88,;10.67,-23.1,;9.72,-21.89,;8.19,-22.11,;10.29,-20.46,;11.81,-20.24,;16.77,-22.22,;17.34,-20.79,;16.39,-19.58,;18.86,-20.57,;19.81,-21.78,;21.34,-21.56,;21.91,-20.13,;20.96,-18.92,;19.43,-19.14,;23.14,-28.65,;24.33,-29.63,;21.7,-29.18,)| Show InChI InChI=1S/C52H69N13O11/c1-3-32(2)43(50(73)74)64-48(71)42-17-11-25-65(42)49(72)41(27-36-29-56-31-59-36)62-46(69)39(60-47(70)40(26-33-18-20-37(66)21-19-33)61-44(67)35-14-9-22-55-28-35)15-7-8-23-57-45(68)38(16-10-24-58-51(53)54)63-52(75)76-30-34-12-5-4-6-13-34/h4-6,9,12-14,18-22,28-29,31-32,38-43,66H,3,7-8,10-11,15-17,23-27,30H2,1-2H3,(H,56,59)(H,57,68)(H,60,70)(H,61,67)(H,62,69)(H,63,75)(H,64,71)(H,73,74)(H4,53,54,58) | PDB
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| 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shinshu University
Curated by PDSP Ki Database
| |
Fundam Clin Pharmacol 16: 317-23 (2002)
Article DOI: 10.1046/j.1472-8206.2002.00076.x
BindingDB Entry DOI: 10.7270/Q2697259 |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50009338
((S)-2-((S)-1-((S)-2-((S)-2-((S)-2-((S)-2-((S)-5-(d...)Show SMILES CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O |r,wU:60.63,wD:24.23,36.36,43.43,56.59,17.16,6.5,(6.84,-31.4,;5.3,-31.4,;4.53,-30.07,;2.99,-30.07,;2.22,-31.4,;2.22,-28.73,;2.99,-27.4,;4.53,-27.4,;5.3,-26.07,;4.53,-24.73,;5.3,-23.4,;6.84,-23.4,;7.61,-24.73,;7.61,-22.07,;2.22,-26.07,;2.99,-24.73,;.68,-26.07,;-.09,-24.73,;.68,-23.4,;2.22,-23.4,;-.09,-22.07,;-1.63,-24.73,;-2.4,-23.4,;-2.4,-26.07,;-3.94,-26.07,;-4.71,-24.73,;-6.25,-24.73,;-7.02,-23.4,;-8.56,-23.4,;-9.33,-24.73,;-10.87,-24.73,;-8.56,-26.07,;-7.02,-26.07,;-4.71,-27.4,;-6.25,-27.4,;-3.94,-28.73,;-4.71,-30.07,;-6.25,-30.07,;-7.02,-28.73,;-7.02,-31.4,;-3.94,-31.4,;-2.4,-31.4,;-4.71,-32.73,;-3.94,-34.07,;-4.71,-35.4,;-6.25,-35.4,;-7.15,-34.16,;-8.62,-34.63,;-8.62,-36.17,;-7.15,-36.65,;-2.4,-34.07,;-1.63,-32.73,;-1.63,-35.4,;-2.26,-36.81,;-1.12,-37.84,;.22,-37.07,;-.1,-35.56,;.93,-34.42,;.45,-32.95,;2.42,-34.82,;3.5,-33.73,;3.11,-32.24,;5,-34.13,;6.09,-33.04,;5.39,-35.61,)| Show InChI InChI=1S/C42H65N13O10/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39(62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41(64)65/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,43,44,47)/t24-,28-,29-,30-,31-,33-,34-/m0/s1 | PDB
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| 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Binding affinity to AT2 receptor (unknown origin) |
ACS Med Chem Lett 5: 1129-32 (2014)
Article DOI: 10.1021/ml500278g
BindingDB Entry DOI: 10.7270/Q2BV7J7R |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50009338
((S)-2-((S)-1-((S)-2-((S)-2-((S)-2-((S)-2-((S)-5-(d...)Show SMILES CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O |r,wU:60.63,wD:24.23,36.36,43.43,56.59,17.16,6.5,(6.84,-31.4,;5.3,-31.4,;4.53,-30.07,;2.99,-30.07,;2.22,-31.4,;2.22,-28.73,;2.99,-27.4,;4.53,-27.4,;5.3,-26.07,;4.53,-24.73,;5.3,-23.4,;6.84,-23.4,;7.61,-24.73,;7.61,-22.07,;2.22,-26.07,;2.99,-24.73,;.68,-26.07,;-.09,-24.73,;.68,-23.4,;2.22,-23.4,;-.09,-22.07,;-1.63,-24.73,;-2.4,-23.4,;-2.4,-26.07,;-3.94,-26.07,;-4.71,-24.73,;-6.25,-24.73,;-7.02,-23.4,;-8.56,-23.4,;-9.33,-24.73,;-10.87,-24.73,;-8.56,-26.07,;-7.02,-26.07,;-4.71,-27.4,;-6.25,-27.4,;-3.94,-28.73,;-4.71,-30.07,;-6.25,-30.07,;-7.02,-28.73,;-7.02,-31.4,;-3.94,-31.4,;-2.4,-31.4,;-4.71,-32.73,;-3.94,-34.07,;-4.71,-35.4,;-6.25,-35.4,;-7.15,-34.16,;-8.62,-34.63,;-8.62,-36.17,;-7.15,-36.65,;-2.4,-34.07,;-1.63,-32.73,;-1.63,-35.4,;-2.26,-36.81,;-1.12,-37.84,;.22,-37.07,;-.1,-35.56,;.93,-34.42,;.45,-32.95,;2.42,-34.82,;3.5,-33.73,;3.11,-32.24,;5,-34.13,;6.09,-33.04,;5.39,-35.61,)| Show InChI InChI=1S/C42H65N13O10/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39(62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41(64)65/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,43,44,47)/t24-,28-,29-,30-,31-,33-,34-/m0/s1 | PDB
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| 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Binding affinity to type-2 angiotensin-2 receptor (unknown origin) |
Bioorg Med Chem Lett 26: 1355-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.10.084
BindingDB Entry DOI: 10.7270/Q2SN0BT6 |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50156173
((1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-...)Show SMILES CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 Show InChI InChI=1S/C23H29N3O4S2/c1-4-5-12-30-23(27)25-32(28,29)22-21(14-20(31-22)13-17(2)3)19-8-6-18(7-9-19)15-26-11-10-24-16-26/h6-11,14,16-17H,4-5,12-13,15H2,1-3H3,(H,25,27) | PDB
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| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Binding affinity to AT2 receptor (unknown origin) |
ACS Med Chem Lett 5: 1129-32 (2014)
Article DOI: 10.1021/ml500278g
BindingDB Entry DOI: 10.7270/Q2BV7J7R |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50156173
((1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-...)Show SMILES CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 Show InChI InChI=1S/C23H29N3O4S2/c1-4-5-12-30-23(27)25-32(28,29)22-21(14-20(31-22)13-17(2)3)19-8-6-18(7-9-19)15-26-11-10-24-16-26/h6-11,14,16-17H,4-5,12-13,15H2,1-3H3,(H,25,27) | PDB
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| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Binding affinity to type-2 angiotensin-2 receptor (unknown origin) |
Bioorg Med Chem Lett 26: 1355-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.10.084
BindingDB Entry DOI: 10.7270/Q2SN0BT6 |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50156173
((1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-...)Show SMILES CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 Show InChI InChI=1S/C23H29N3O4S2/c1-4-5-12-30-23(27)25-32(28,29)22-21(14-20(31-22)13-17(2)3)19-8-6-18(7-9-19)15-26-11-10-24-16-26/h6-11,14,16-17H,4-5,12-13,15H2,1-3H3,(H,25,27) | PDB
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| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Binding affinity to AT2 receptor |
Bioorg Med Chem 18: 4570-90 (2010)
Article DOI: 10.1016/j.bmc.2010.03.064
BindingDB Entry DOI: 10.7270/Q2VD70F0 |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50156173
((1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-...)Show SMILES CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 Show InChI InChI=1S/C23H29N3O4S2/c1-4-5-12-30-23(27)25-32(28,29)22-21(14-20(31-22)13-17(2)3)19-8-6-18(7-9-19)15-26-11-10-24-16-26/h6-11,14,16-17H,4-5,12-13,15H2,1-3H3,(H,25,27) | PDB
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| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor |
J Med Chem 47: 5995-6008 (2004)
Article DOI: 10.1021/jm049715t
BindingDB Entry DOI: 10.7270/Q29Z95PH |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50156173
((1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-...)Show SMILES CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 Show InChI InChI=1S/C23H29N3O4S2/c1-4-5-12-30-23(27)25-32(28,29)22-21(14-20(31-22)13-17(2)3)19-8-6-18(7-9-19)15-26-11-10-24-16-26/h6-11,14,16-17H,4-5,12-13,15H2,1-3H3,(H,25,27) | PDB
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| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
| Assay Description
Binding affinity to AT2 receptor (unknown origin) |
J Med Chem 61: 9811-9840 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00294
BindingDB Entry DOI: 10.7270/Q2XK8J7N |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50199311
(CHEMBL215160 | N-butyloxycarbonyl-2-(4-imidazol-1-...)Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccc(OCCCC)cc1-c1ccc(Cn2ccnc2)cc1 Show InChI InChI=1S/C25H31N3O5S/c1-3-5-15-32-22-11-12-24(34(30,31)27-25(29)33-16-6-4-2)23(17-22)21-9-7-20(8-10-21)18-28-14-13-26-19-28/h7-14,17,19H,3-6,15-16,18H2,1-2H3,(H,27,29) | PDB
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| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membrane |
J Med Chem 49: 7160-8 (2006)
Article DOI: 10.1021/jm0606185
BindingDB Entry DOI: 10.7270/Q21C1WHK |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50156167
(CHEMBL361927 | butyl (5-isobutylthien-2-yl)sulfony...)Show SMILES CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2C)cc1 Show InChI InChI=1S/C24H31N3O4S2/c1-5-6-13-31-24(28)26-33(29,30)23-22(15-21(32-23)14-17(2)3)20-9-7-19(8-10-20)16-27-12-11-25-18(27)4/h7-12,15,17H,5-6,13-14,16H2,1-4H3,(H,26,28) | PDB
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| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor |
J Med Chem 47: 5995-6008 (2004)
Article DOI: 10.1021/jm049715t
BindingDB Entry DOI: 10.7270/Q29Z95PH |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50199326
(CHEMBL217673 | N-butyloxycarbonyl-2-(4-imidazol-1-...)Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 Show InChI InChI=1S/C25H31N3O4S/c1-4-5-14-32-25(29)27-33(30,31)24-11-8-21(15-19(2)3)16-23(24)22-9-6-20(7-10-22)17-28-13-12-26-18-28/h6-13,16,18-19H,4-5,14-15,17H2,1-3H3,(H,27,29) | PDB
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| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membrane |
J Med Chem 49: 7160-8 (2006)
Article DOI: 10.1021/jm0606185
BindingDB Entry DOI: 10.7270/Q21C1WHK |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50139783
(Angiotensin II analogue | CHEMBL404996)Show SMILES CCSC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O Show InChI InChI=1S/C47H65N13O12S2/c1-2-74-24-36(43(68)56-33(20-28-22-51-25-53-28)45(70)60-17-7-11-37(60)44(69)57-34(46(71)72)19-26-8-4-3-5-9-26)59-41(66)32(18-27-12-14-29(61)15-13-27)55-42(67)35(23-73)58-40(65)31(10-6-16-52-47(49)50)54-39(64)30(48)21-38(62)63/h3-5,8-9,12-15,22,25,30-37,61,73H,2,6-7,10-11,16-21,23-24,48H2,1H3,(H,51,53)(H,54,64)(H,55,67)(H,56,68)(H,57,69)(H,58,65)(H,59,66)(H,62,63)(H,71,72)(H4,49,50,52)/t30-,31-,32-,33-,34-,35-,36-,37-/m0/s1 | PDB
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| 0.620 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Binding affinity for Angiotensin II receptor type 2 using [125I]- Ang II in pig uterus myometrium |
J Med Chem 47: 859-70 (2004)
Article DOI: 10.1021/jm030921v
BindingDB Entry DOI: 10.7270/Q2736RNQ |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50199326
(CHEMBL217673 | N-butyloxycarbonyl-2-(4-imidazol-1-...)Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 Show InChI InChI=1S/C25H31N3O4S/c1-4-5-14-32-25(29)27-33(30,31)24-11-8-21(15-19(2)3)16-23(24)22-9-6-20(7-10-22)17-28-13-12-26-18-28/h6-13,16,18-19H,4-5,14-15,17H2,1-3H3,(H,27,29) | PDB
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| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Binding affinity to type-2 angiotensin-2 receptor (unknown origin) |
Bioorg Med Chem Lett 26: 1355-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.10.084
BindingDB Entry DOI: 10.7270/Q2SN0BT6 |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50199326
(CHEMBL217673 | N-butyloxycarbonyl-2-(4-imidazol-1-...)Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 Show InChI InChI=1S/C25H31N3O4S/c1-4-5-14-32-25(29)27-33(30,31)24-11-8-21(15-19(2)3)16-23(24)22-9-6-20(7-10-22)17-28-13-12-26-18-28/h6-13,16,18-19H,4-5,14-15,17H2,1-3H3,(H,27,29) | PDB
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| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by ChEMBL
| Assay Description
Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins... |
J Med Chem 59: 810-40 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00982
BindingDB Entry DOI: 10.7270/Q2XS5X8K |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50370686
(CHEMBL1791350)Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](N)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O Show InChI InChI=1S/C46H68N12O11/c1-5-26(4)36(56-43(66)37(48)57-41(64)35(25(2)3)55-39(62)30(18-12-20-51-46(49)50)52-38(61)29(47)24-34(59)60)42(65)53-31(22-27-14-8-6-9-15-27)44(67)58-21-13-19-33(58)40(63)54-32(45(68)69)23-28-16-10-7-11-17-28/h6-11,14-17,25-26,29-33,35-37H,5,12-13,18-24,47-48H2,1-4H3,(H,52,61)(H,53,65)(H,54,63)(H,55,62)(H,56,66)(H,57,64)(H,59,60)(H,68,69)(H4,49,50,51)/t26-,29+,30+,31+,32+,33+,35+,36+,37-/m1/s1 | PDB
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| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Binding affinity for angiotensin II receptor, type 2 in pig uterus myometrium using [125I]-Ang II as radioligand, in pH 7.4 Tris-HCl buffer for 1.5 h... |
J Med Chem 48: 6620-31 (2005)
Article DOI: 10.1021/jm050280z
BindingDB Entry DOI: 10.7270/Q2HX1DG6 |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50370375
(CHEMBL268815)Show SMILES [#6]-[#6]-[#6@@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6](-[#8])=O)-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#7])cc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#8])=O Show InChI InChI=1S/C53H74N12O12/c1-5-30(4)44(50(74)61-39(26-32-15-19-34(54)20-16-32)51(75)65-24-10-14-41(65)48(72)62-40(52(76)77)27-31-11-7-6-8-12-31)64-47(71)38(25-33-17-21-35(66)22-18-33)60-49(73)43(29(2)3)63-46(70)37(13-9-23-58-53(56)57)59-45(69)36(55)28-42(67)68/h6-8,11-12,15-22,29-30,36-41,43-44,66H,5,9-10,13-14,23-28,54-55H2,1-4H3,(H,59,69)(H,60,73)(H,61,74)(H,62,72)(H,63,70)(H,64,71)(H,67,68)(H,76,77)(H4,56,57,58)/t30-,36+,37+,38+,39+,40+,41+,43+,44+/m1/s1 | PDB
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| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrium |
J Med Chem 49: 6133-7 (2006)
Article DOI: 10.1021/jm051222g
BindingDB Entry DOI: 10.7270/Q28P619Q |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | BDBM82436
(1-(2,6-Dichlorophenyl)-4-[[2'-(1H-tetrazol-5-y...)Show SMILES CCCc1nn(c(C(O)=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)-c1c(Cl)cccc1Cl |(11.96,.91,;10.62,1.68,;9.29,.91,;7.95,1.68,;7.79,3.22,;6.29,3.54,;5.52,2.2,;3.99,2.04,;3.36,.63,;3.08,3.29,;6.55,1.06,;6.23,-.45,;7.37,-1.48,;7.05,-2.98,;8.2,-4.02,;9.66,-3.54,;9.98,-2.03,;8.84,-1,;10.8,-4.57,;12.27,-4.09,;13.41,-5.12,;13.09,-6.63,;11.63,-7.11,;10.48,-6.08,;9.02,-6.55,;7.77,-5.65,;6.53,-6.55,;7,-8.02,;8.54,-8.02,;5.91,5.03,;7.02,6.1,;8.5,5.68,;6.64,7.59,;5.16,8.02,;4.06,6.95,;4.43,5.45,;3.32,4.38,)| Show InChI InChI=1S/C27H22Cl2N6O2/c1-2-6-23-20(24(27(36)37)35(32-23)25-21(28)9-5-10-22(25)29)15-16-11-13-17(14-12-16)18-7-3-4-8-19(18)26-30-33-34-31-26/h3-5,7-14H,2,6,15H2,1H3,(H,36,37)(H,30,31,33,34) | PDB
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| 0.720 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 272: 612-8 (1995)
BindingDB Entry DOI: 10.7270/Q2FB51GP |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50168428
((3S)-3-amino-3-{[(1S)-1-{[(1S)-1-{[(2S)-4-({[(2S)-...)Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(=O)Nc1cccc2CN(CC(=O)N[C@@H](Cc3cnc[nH]3)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc3ccccc3)C(O)=O)C(=O)[C@H](Cc3ccc(O)cc3)Nc12 Show InChI InChI=1S/C53H68N14O12/c1-29(2)44(65-47(73)37(13-7-19-58-53(55)56)63-46(72)35(54)24-43(70)71)49(75)62-36-12-6-11-32-26-66(50(76)38(61-45(32)36)21-31-15-17-34(68)18-16-31)27-42(69)60-39(23-33-25-57-28-59-33)51(77)67-20-8-14-41(67)48(74)64-40(52(78)79)22-30-9-4-3-5-10-30/h3-6,9-12,15-18,25,28-29,35,37-41,44,61,68H,7-8,13-14,19-24,26-27,54H2,1-2H3,(H,57,59)(H,60,69)(H,62,75)(H,63,72)(H,64,74)(H,65,73)(H,70,71)(H,78,79)(H4,55,56,58)/t35-,37-,38-,39-,40-,41-,44-/m0/s1 | PDB
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| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium |
J Med Chem 48: 4009-24 (2005)
Article DOI: 10.1021/jm0491492
BindingDB Entry DOI: 10.7270/Q2BR8SZD |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | BDBM50042746
(CHEMBL122212 | L-159,882 | [4-(2-Ethyl-5,7-dimethy...)Show SMILES CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc23)cc(CCC)c1OC(C(O)=O)c1ccccc1 Show InChI InChI=1S/C31H37N3O3/c1-6-12-24-17-22(19-34-26(8-3)33-27-20(4)16-21(5)32-30(27)34)18-25(13-7-2)28(24)37-29(31(35)36)23-14-10-9-11-15-23/h9-11,14-18,29H,6-8,12-13,19H2,1-5H3,(H,35,36) | PDB
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Merck Research Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 272: 612-8 (1995)
BindingDB Entry DOI: 10.7270/Q2FB51GP |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | BDBM82433
(CHEMBL302102 | L-159,689 | L-159689 | N-Pentyl-N-[...)Show SMILES CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c(=O)c2c1 Show InChI InChI=1S/C37H37N7O2/c1-3-5-11-23-43(36(45)28-13-7-6-8-14-28)29-21-22-33-32(24-29)37(46)44(34(38-33)12-4-2)25-26-17-19-27(20-18-26)30-15-9-10-16-31(30)35-39-41-42-40-35/h6-10,13-22,24H,3-5,11-12,23,25H2,1-2H3,(H,39,40,41,42) | PDB
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| 0.840 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 272: 612-8 (1995)
BindingDB Entry DOI: 10.7270/Q2FB51GP |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | BDBM50006909
(2-Butyl-5-chloro-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)Show SMILES CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 Show InChI InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28) | PDB
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Merck Research Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 272: 612-8 (1995)
BindingDB Entry DOI: 10.7270/Q2FB51GP |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50236697
(5-L-isoleucineangiotensin II | 5-isoleucine-angiot...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O |wU:4.4,47.47,60.63,35.36,20.21,wD:2.2,24.32,8.17,64.66,(24.13,1.24,;24.1,-.31,;25.42,-1.09,;26.77,-.35,;25.4,-2.63,;24.05,-3.38,;22.73,-2.59,;22.75,-1.05,;21.38,-3.34,;21.36,-4.88,;22.68,-5.66,;24.01,-4.93,;25.33,-5.71,;25.32,-7.24,;26.64,-8.05,;23.97,-8.01,;22.65,-7.22,;20.06,-2.55,;18.71,-3.29,;18.68,-4.83,;17.38,-2.5,;16.04,-3.25,;14.72,-2.46,;14.74,-.92,;13.37,-3.2,;13.34,-4.74,;14.66,-5.53,;14.64,-7.08,;15.96,-7.87,;15.93,-9.4,;14.59,-10.16,;17.25,-10.21,;12.05,-2.42,;10.69,-3.15,;10.67,-4.69,;9.37,-2.36,;8.03,-3.1,;9.4,-.82,;10.75,-.07,;12.07,-.88,;10.78,1.47,;17.41,-.96,;18.76,-.21,;16.1,-.17,;26.72,-3.43,;26.69,-4.97,;28.07,-2.68,;29.38,-3.48,;30.73,-2.73,;30.75,-1.19,;29.53,-.27,;30.03,1.18,;31.57,1.17,;32.02,-.31,;29.35,-5.02,;28.01,-5.76,;30.54,-5.79,;31.99,-5.25,;32.95,-6.46,;32.1,-7.74,;30.62,-7.33,;29.33,-8.36,;27.89,-7.82,;29.58,-9.88,;28.39,-10.86,;26.95,-10.32,;25.76,-11.3,;26.02,-12.81,;24.84,-13.79,;23.4,-13.26,;23.14,-11.74,;24.32,-10.75,;28.64,-12.38,;27.45,-13.36,;30.08,-12.92,)| Show InChI InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1 | PDB
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| 0.898 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs. ... |
US Patent US9624243 (2017)
BindingDB Entry DOI: 10.7270/Q2J67K0B |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM410295
(US10370388, Compound Angiotensin)Show SMILES CC(C)C(NC(=O)C(CCCN=C(N)N)NC(=O)C(N)CC(N)=O)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(C(C)C)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(Cc1ccccc1)C(O)=O |(19.82,-14.34,;18.81,-13.18,;17.3,-13.47,;19.31,-11.72,;20.83,-11.43,;21.83,-12.6,;21.33,-14.05,;23.35,-12.31,;24.35,-13.47,;25.87,-13.18,;26.87,-14.34,;28.39,-14.05,;29.4,-15.22,;30.91,-14.93,;28.89,-16.67,;23.85,-10.85,;25.36,-10.56,;26.37,-11.72,;25.87,-9.11,;24.86,-7.94,;27.38,-8.81,;27.88,-7.36,;26.87,-6.2,;29.4,-7.07,;18.31,-10.56,;18.81,-9.11,;16.79,-10.85,;15.79,-9.69,;16.29,-8.23,;15.28,-7.07,;13.77,-7.36,;12.76,-6.2,;13.26,-4.74,;12.26,-3.58,;14.78,-4.45,;15.79,-5.61,;14.27,-9.98,;13.77,-11.43,;13.26,-8.81,;11.75,-9.11,;11.25,-10.56,;9.74,-10.85,;12.26,-11.72,;10.74,-7.94,;11.25,-6.49,;9.23,-8.23,;8.22,-7.07,;8.73,-5.61,;7.72,-4.45,;6.19,-4.58,;5.59,-3.16,;6.75,-2.15,;8.07,-2.95,;6.71,-7.36,;5.7,-6.2,;6.21,-8.81,;7.09,-10.08,;6.16,-11.31,;4.7,-10.8,;4.73,-9.26,;3.51,-8.33,;3.7,-6.8,;2.09,-8.93,;.86,-8,;-.56,-8.6,;-1.79,-7.67,;-3.21,-8.27,;-4.43,-7.34,;-4.24,-5.81,;-2.83,-5.22,;-1.6,-6.14,;1.05,-6.47,;2.47,-5.88,;-.18,-5.55,)| | PDB
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| US Patent
| 0.898 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NOVARTIS AG
US Patent
| Assay Description
120 μL membrane (5 mg protein/well) was incubated with 15 μL of [125I]-CGP42112A and 15 μL of compound at RT for 1.5 hrs. ... |
US Patent US10370388 (2019)
BindingDB Entry DOI: 10.7270/Q2K35X1F |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50370375
(CHEMBL268815)Show SMILES [#6]-[#6]-[#6@@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6](-[#8])=O)-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#7])cc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#8])=O Show InChI InChI=1S/C53H74N12O12/c1-5-30(4)44(50(74)61-39(26-32-15-19-34(54)20-16-32)51(75)65-24-10-14-41(65)48(72)62-40(52(76)77)27-31-11-7-6-8-12-31)64-47(71)38(25-33-17-21-35(66)22-18-33)60-49(73)43(29(2)3)63-46(70)37(13-9-23-58-53(56)57)59-45(69)36(55)28-42(67)68/h6-8,11-12,15-22,29-30,36-41,43-44,66H,5,9-10,13-14,23-28,54-55H2,1-4H3,(H,59,69)(H,60,73)(H,61,74)(H,62,72)(H,63,70)(H,64,71)(H,67,68)(H,76,77)(H4,56,57,58)/t30-,36+,37+,38+,39+,40+,41+,43+,44+/m1/s1 | PDB
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Uppsala University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ang II from angiotensin II receptor type 2 in pig uterus myometrium |
J Med Chem 48: 4009-24 (2005)
Article DOI: 10.1021/jm0491492
BindingDB Entry DOI: 10.7270/Q2BR8SZD |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50208102
(CHEMBL424755 | [4-NH2-Phe6] Ang II)Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(N)cc1)C(O)=O |wU:8.17,24.32,60.63,47.47,2.2,wD:4.4,20.21,64.66,35.36,(17.7,-20.36,;17.7,-18.82,;16.36,-18.05,;15.03,-18.83,;16.36,-16.51,;15.03,-15.75,;13.7,-16.52,;13.7,-18.06,;12.37,-15.76,;12.36,-14.22,;13.7,-13.44,;15.03,-14.21,;16.36,-13.44,;16.35,-11.9,;17.69,-11.13,;15.01,-11.13,;13.68,-11.91,;11.04,-16.53,;9.71,-15.77,;9.7,-14.23,;8.38,-16.54,;7.05,-15.77,;5.72,-16.54,;5.72,-18.08,;4.39,-15.78,;4.38,-14.24,;3.05,-13.47,;3.04,-11.93,;1.71,-11.17,;1.71,-9.63,;.37,-8.86,;3.04,-8.85,;3.06,-16.55,;1.73,-15.79,;1.72,-14.25,;.4,-16.56,;-.94,-15.79,;.4,-18.1,;-.93,-18.87,;-.93,-20.41,;-2.27,-18.1,;8.38,-18.08,;7.05,-18.85,;9.72,-18.84,;17.69,-15.74,;17.68,-14.2,;19.02,-16.5,;20.35,-15.73,;20.34,-14.19,;21.39,-13.06,;21.08,-11.55,;22.42,-10.8,;23.55,-11.84,;22.91,-13.24,;21.68,-16.5,;21.68,-18.04,;23.01,-15.72,;23.17,-14.19,;24.67,-13.86,;25.44,-15.19,;24.42,-16.34,;24.88,-17.81,;23.84,-18.94,;26.38,-18.15,;26.84,-19.62,;25.51,-20.4,;25.53,-21.94,;24.2,-22.71,;24.22,-24.25,;25.56,-25.01,;25.57,-26.55,;26.89,-24.22,;26.87,-22.68,;28.34,-19.95,;28.81,-21.42,;29.39,-18.82,)| Show InChI InChI=1S/C50H72N14O12/c1-5-27(4)41(47(73)60-36(22-31-24-55-25-57-31)48(74)64-19-7-9-38(64)45(71)61-37(49(75)76)21-28-10-14-30(51)15-11-28)63-44(70)35(20-29-12-16-32(65)17-13-29)59-46(72)40(26(2)3)62-43(69)34(8-6-18-56-50(53)54)58-42(68)33(52)23-39(66)67/h10-17,24-27,33-38,40-41,65H,5-9,18-23,51-52H2,1-4H3,(H,55,57)(H,58,68)(H,59,72)(H,60,73)(H,61,71)(H,62,69)(H,63,70)(H,66,67)(H,75,76)(H4,53,54,56)/t27-,33+,34+,35+,36+,37+,38+,40+,41+/m1/s1 | PDB
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| 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ang2 from AT2 receptor in pig uterus myometrial membrane |
J Med Chem 50: 1711-5 (2007)
Article DOI: 10.1021/jm0613469
BindingDB Entry DOI: 10.7270/Q2NK3FTN |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | BDBM82434
(2-Butyl-6-(dimethylamino)-3-[[2-(cyclopropylcarbon...)Show SMILES [#6]-[#6]-[#6]-[#6]-c1nc2ccc(cc2c(=O)n1-[#6]-c1ccc(cc1)-c1ccccc1[S;v6](=O)(=O)[#6]-[#6](=O)-[#6]-1-[#6]-[#6]-1)-[#7](-[#6])-[#6] Show InChI InChI=1S/C32H35N3O4S/c1-4-5-10-31-33-28-18-17-25(34(2)3)19-27(28)32(37)35(31)20-22-11-13-23(14-12-22)26-8-6-7-9-30(26)40(38,39)21-29(36)24-15-16-24/h6-9,11-14,17-19,24H,4-5,10,15-16,20-21H2,1-3H3 | PDB
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| 0.910 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 272: 612-8 (1995)
BindingDB Entry DOI: 10.7270/Q2FB51GP |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | CHEMBL5286105
Show InChI InChI=1S/C11H10I2N4O/c12-7-2-5(3-8(13)9(7)18)1-6-4-16-11(15)17-10(6)14/h2-4,18H,1H2,(H4,14,15,16,17) | PDB
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TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50199331
(CHEMBL216250 | N-(1-butyloxy-methylcarbonyl)-3-(4-...)Show SMILES CCCCOCC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 Show InChI InChI=1S/C24H31N3O4S2/c1-4-5-12-31-16-23(28)26-33(29,30)24-22(14-21(32-24)13-18(2)3)20-8-6-19(7-9-20)15-27-11-10-25-17-27/h6-11,14,17-18H,4-5,12-13,15-16H2,1-3H3,(H,26,28) | PDB
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Uppsala University
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ang2 from AT2 receptor in pig uterus membrane |
J Med Chem 49: 7160-8 (2006)
Article DOI: 10.1021/jm0606185
BindingDB Entry DOI: 10.7270/Q21C1WHK |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50156176
((2S,5R,7aR)-6-[2-((S)-Acetylamino)-3-methyl-butyry...)Show SMILES CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CS[C@H]2C[C@@](Cc3ccc(O)cc3)(NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N12 Show InChI InChI=1S/C28H37N7O6S/c1-15(2)23(32-16(3)36)26(40)34-28(10-17-5-7-19(37)8-6-17)11-22-35(27(28)41)21(13-42-22)25(39)33-20(24(38)29-4)9-18-12-30-14-31-18/h5-8,12,14-15,20-23,37H,9-11,13H2,1-4H3,(H,29,38)(H,30,31)(H,32,36)(H,33,39)(H,34,40)/t20-,21-,22-,23-,28+/m0/s1 | PDB
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Uppsala University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor |
J Med Chem 47: 6009-19 (2004)
Article DOI: 10.1021/jm049651m
BindingDB Entry DOI: 10.7270/Q2668DZ3 |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | BDBM82430
(2-Propyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-y...)Show SMILES CCCc1nc2ccc(Nc3ccccc3)cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 Show InChI InChI=1S/C31H27N7O/c1-2-8-29-33-28-18-17-24(32-23-9-4-3-5-10-23)19-27(28)31(39)38(29)20-21-13-15-22(16-14-21)25-11-6-7-12-26(25)30-34-36-37-35-30/h3-7,9-19,32H,2,8,20H2,1H3,(H,34,35,36,37) | PDB
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| 1.04 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 272: 612-8 (1995)
BindingDB Entry DOI: 10.7270/Q2FB51GP |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | CHEMBL5274111
Show InChI InChI=1S/C17H25N5/c1-4-10(3)14-8-11(6-12(5-2)15(14)18)7-13-9-21-17(20)22-16(13)19/h6,8-10H,4-5,7,18H2,1-3H3,(H4,19,20,21,22) | PDB
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TBA
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More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50594171
(CHEMBL5186237)Show SMILES CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2ccnc2)cc1 | PDB
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Citation and Details
Article DOI: 10.1016/j.bmc.2022.116790
BindingDB Entry DOI: 10.7270/Q2ZW1QXF |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | BDBM82260
(U-97018)Show SMILES [H]C12CCC([H])(CC1)N1N2Cc2nc(CCCC)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2C1=O |TLB:38:8:2.3:7.6,THB:10:9:2.3:7.6,(17.17,4.69,;16.48,6.31,;19.3,5.14,;18.9,3.65,;16.08,4.82,;17.54,5.9,;14.57,7.62,;15.91,8.39,;13.41,3.28,;12.64,4.62,;11.04,4.64,;10.22,3.26,;8.67,2.92,;8.5,1.34,;7.17,.57,;5.83,1.34,;4.5,.57,;3.17,1.34,;9.96,.69,;10.27,-.82,;9.13,-1.85,;7.66,-1.37,;6.52,-2.4,;6.84,-3.91,;8.3,-4.38,;9.45,-3.36,;5.69,-4.93,;4.23,-4.46,;3.08,-5.48,;3.4,-6.99,;4.86,-7.47,;6.01,-6.44,;7.47,-6.92,;7.94,-8.38,;9.48,-8.39,;9.96,-6.92,;8.72,-6.02,;11.03,1.87,;12.63,1.88,;13.42,.56,)| Show InChI InChI=1S/C29H32N8O/c1-2-3-8-26-30-25-18-36-21-13-15-22(16-14-21)37(36)29(38)27(25)35(26)17-19-9-11-20(12-10-19)23-6-4-5-7-24(23)28-31-33-34-32-28/h4-7,9-12,21-22H,2-3,8,13-18H2,1H3,(H,31,32,33,34) | PDB
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| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Pharmaceuticals Limited
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 274: 1042-53 (1995)
BindingDB Entry DOI: 10.7270/Q20G3HN9 |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | BDBM82259
(CAS_123856 | L-158,809 | NSC_123856)Show SMILES CCc1nc2c(C)cc(C)nc2n1-c1ccc(cc1)-c1ccccc1-c1nnn[nH]1 Show InChI InChI=1S/C23H21N7/c1-4-20-25-21-14(2)13-15(3)24-23(21)30(20)17-11-9-16(10-12-17)18-7-5-6-8-19(18)22-26-28-29-27-22/h5-13H,4H2,1-3H3,(H,26,27,28,29) | PDB
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Upjohn Pharmaceuticals Limited
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 274: 1042-53 (1995)
BindingDB Entry DOI: 10.7270/Q20G3HN9 |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50370375
(CHEMBL268815)Show SMILES [#6]-[#6]-[#6@@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6](-[#8])=O)-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#7])cc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#8])=O Show InChI InChI=1S/C53H74N12O12/c1-5-30(4)44(50(74)61-39(26-32-15-19-34(54)20-16-32)51(75)65-24-10-14-41(65)48(72)62-40(52(76)77)27-31-11-7-6-8-12-31)64-47(71)38(25-33-17-21-35(66)22-18-33)60-49(73)43(29(2)3)63-46(70)37(13-9-23-58-53(56)57)59-45(69)36(55)28-42(67)68/h6-8,11-12,15-22,29-30,36-41,43-44,66H,5,9-10,13-14,23-28,54-55H2,1-4H3,(H,59,69)(H,60,73)(H,61,74)(H,62,72)(H,63,70)(H,64,71)(H,67,68)(H,76,77)(H4,56,57,58)/t30-,36+,37+,38+,39+,40+,41+,43+,44+/m1/s1 | PDB
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Uppsala University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ang II from pig uterus myometrium angiotensin II type 2 (AT2) receptor |
J Med Chem 47: 6009-19 (2004)
Article DOI: 10.1021/jm049651m
BindingDB Entry DOI: 10.7270/Q2668DZ3 |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50594186
(CHEMBL5174659)Show SMILES CCCc1nc(c(s1)S(=O)(=O)NC(=O)OC)-c1ccc(Cn2ccnc2-c2nccs2)cc1 | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2022.116790
BindingDB Entry DOI: 10.7270/Q2ZW1QXF |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(Homo sapiens (Human)) | BDBM50049195
(3-[(2'-(butylsulfonylcarbamate)-3'-propyl-1,1'-bip...)Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc23)cc1 Show InChI InChI=1S/C31H38N4O4S/c1-6-9-17-39-31(36)34-40(37,38)27-16-13-23(10-7-2)19-26(27)25-14-11-24(12-15-25)20-35-28(8-3)33-29-21(4)18-22(5)32-30(29)35/h11-16,18-19H,6-10,17,20H2,1-5H3,(H,34,36) | PDB
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| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by ChEMBL
| Assay Description
Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins... |
J Med Chem 59: 810-40 (2016)
Article DOI: 10.1021/acs.jmedchem.5b00982
BindingDB Entry DOI: 10.7270/Q2XS5X8K |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | BDBM50009338
((S)-2-((S)-1-((S)-2-((S)-2-((S)-2-((S)-2-((S)-5-(d...)Show SMILES CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O |r,wU:60.63,wD:24.23,36.36,43.43,56.59,17.16,6.5,(6.84,-31.4,;5.3,-31.4,;4.53,-30.07,;2.99,-30.07,;2.22,-31.4,;2.22,-28.73,;2.99,-27.4,;4.53,-27.4,;5.3,-26.07,;4.53,-24.73,;5.3,-23.4,;6.84,-23.4,;7.61,-24.73,;7.61,-22.07,;2.22,-26.07,;2.99,-24.73,;.68,-26.07,;-.09,-24.73,;.68,-23.4,;2.22,-23.4,;-.09,-22.07,;-1.63,-24.73,;-2.4,-23.4,;-2.4,-26.07,;-3.94,-26.07,;-4.71,-24.73,;-6.25,-24.73,;-7.02,-23.4,;-8.56,-23.4,;-9.33,-24.73,;-10.87,-24.73,;-8.56,-26.07,;-7.02,-26.07,;-4.71,-27.4,;-6.25,-27.4,;-3.94,-28.73,;-4.71,-30.07,;-6.25,-30.07,;-7.02,-28.73,;-7.02,-31.4,;-3.94,-31.4,;-2.4,-31.4,;-4.71,-32.73,;-3.94,-34.07,;-4.71,-35.4,;-6.25,-35.4,;-7.15,-34.16,;-8.62,-34.63,;-8.62,-36.17,;-7.15,-36.65,;-2.4,-34.07,;-1.63,-32.73,;-1.63,-35.4,;-2.26,-36.81,;-1.12,-37.84,;.22,-37.07,;-.1,-35.56,;.93,-34.42,;.45,-32.95,;2.42,-34.82,;3.5,-33.73,;3.11,-32.24,;5,-34.13,;6.09,-33.04,;5.39,-35.61,)| Show InChI InChI=1S/C42H65N13O10/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39(62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41(64)65/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,43,44,47)/t24-,28-,29-,30-,31-,33-,34-/m0/s1 | PDB
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| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 272: 963-9 (1995)
BindingDB Entry DOI: 10.7270/Q2J38R2N |
More data for this
Ligand-Target Pair | |
Type-2 angiotensin II receptor
(RAT) | BDBM82432
(L-159,530 | L-159530 | N-Propyl-N-[[2-propyl-3-[[2...)Show SMILES CCCN(C(=O)OCC(C)C)c1ccc2nc(CCC)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c(=O)c2c1 Show InChI InChI=1S/C33H37N7O3/c1-5-9-30-34-29-17-16-25(39(18-6-2)33(42)43-21-22(3)4)19-28(29)32(41)40(30)20-23-12-14-24(15-13-23)26-10-7-8-11-27(26)31-35-37-38-36-31/h7-8,10-17,19,22H,5-6,9,18,20-21H2,1-4H3,(H,35,36,37,38) | PDB
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| 1.66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 272: 612-8 (1995)
BindingDB Entry DOI: 10.7270/Q2FB51GP |
More data for this
Ligand-Target Pair | |
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