Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM50139137 (CHEMBL3759162) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
In£n£ University Curated by ChEMBL | Assay Description Competitive inhibition of human serum PON1 using paraoxon as substrate by Lineweaver-Burk plot analysis | Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM92331 (Lornoxicam) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 9.00E+3 | -28.8 | 1.36E+5 | n/a | n/a | n/a | n/a | 10.5 | 25 |
Atatürk University | Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy... | J Enzyme Inhib Med Chem 24: 1034-9 (2009) Article DOI: 10.1080/14756360802608351 BindingDB Entry DOI: 10.7270/Q2TT4PKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM50001839 (CHEMBL428647 | PACLITAXEL | taxol) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.65E+4 | n/a | 4.20E+4 | n/a | n/a | n/a | n/a | 10.5 | n/a |
Ahi Evran University | Assay Description Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ... | Chem Biol Drug Des 88: 188-96 (2016) Article DOI: 10.1111/cbdd.12746 BindingDB Entry DOI: 10.7270/Q2SB44JJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM50316126 (Bleph-10 | Bleph-30 | Blephamide | CHEMBL455 | Cet...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents | Article PubMed | 8.60E+4 | n/a | 1.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Atatürk University | Assay Description The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi... | Chem Biol Drug Des 76: 552-8 (2010) Article DOI: 10.1111/j.1747-0285.2010.01036.x BindingDB Entry DOI: 10.7270/Q2Q52N3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 9.70E+4 | -22.9 | 1.95E+5 | n/a | n/a | n/a | n/a | 10.5 | 25 |
Atatürk University | Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy... | J Enzyme Inhib Med Chem 24: 1034-9 (2009) Article DOI: 10.1080/14756360802608351 BindingDB Entry DOI: 10.7270/Q2TT4PKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM50127140 ((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.31E+5 | n/a | 2.26E+5 | n/a | n/a | n/a | n/a | 10.5 | n/a |
Ahi Evran University | Assay Description Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ... | Chem Biol Drug Des 88: 188-96 (2016) Article DOI: 10.1111/cbdd.12746 BindingDB Entry DOI: 10.7270/Q2SB44JJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM241973 (Oxytetracycline hydrochloride) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Atatürk University | Assay Description PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E... | J Enzyme Inhib Med Chem 28: 758-64 (2013) Article DOI: 10.3109/14756366.2012.681653 BindingDB Entry DOI: 10.7270/Q25B01CZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM36351 (CID148124 | Docetaxel) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 2.91E+5 | n/a | 6.65E+5 | n/a | n/a | n/a | n/a | 10.5 | n/a |
Ahi Evran University | Assay Description Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ... | Chem Biol Drug Des 88: 188-96 (2016) Article DOI: 10.1111/cbdd.12746 BindingDB Entry DOI: 10.7270/Q2SB44JJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM92332 (Tenoxicam) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 3.06E+5 | -20.1 | 3.40E+5 | n/a | n/a | n/a | n/a | 10.5 | 25 |
Atatürk University | Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy... | J Enzyme Inhib Med Chem 24: 1034-9 (2009) Article DOI: 10.1080/14756360802608351 BindingDB Entry DOI: 10.7270/Q2TT4PKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM10860 (4-(aminomethyl)benzene-1-sulfonamide | CHEMBL419 |...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 3.40E+5 | n/a | 1.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Atatürk University | Assay Description The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi... | Chem Biol Drug Des 76: 552-8 (2010) Article DOI: 10.1111/j.1747-0285.2010.01036.x BindingDB Entry DOI: 10.7270/Q2Q52N3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM82185 (Sulfosalazine, 3) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 5.70E+5 | n/a | 2.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Atatürk University | Assay Description The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi... | Chem Biol Drug Des 76: 552-8 (2010) Article DOI: 10.1111/j.1747-0285.2010.01036.x BindingDB Entry DOI: 10.7270/Q2Q52N3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | 7.02E+5 | n/a | 3.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Atatürk University | Assay Description The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi... | Chem Biol Drug Des 76: 552-8 (2010) Article DOI: 10.1111/j.1747-0285.2010.01036.x BindingDB Entry DOI: 10.7270/Q2Q52N3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM10880 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 7.43E+5 | n/a | 8.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Atatürk University | Assay Description The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi... | Chem Biol Drug Des 76: 552-8 (2010) Article DOI: 10.1111/j.1747-0285.2010.01036.x BindingDB Entry DOI: 10.7270/Q2Q52N3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM50174201 (ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 8.05E+5 | -17.7 | 1.64E+6 | n/a | n/a | n/a | n/a | 10.5 | 25 |
Atatürk University | Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy... | J Enzyme Inhib Med Chem 24: 1034-9 (2009) Article DOI: 10.1080/14756360802608351 BindingDB Entry DOI: 10.7270/Q2TT4PKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM10868 (1,3,4-Thiadiazole-2-sulfonamide, 6 | 1,3,4-thiadia...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents | Article PubMed | 2.00E+6 | n/a | 1.24E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Atatürk University | Assay Description The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi... | Chem Biol Drug Des 76: 552-8 (2010) Article DOI: 10.1111/j.1747-0285.2010.01036.x BindingDB Entry DOI: 10.7270/Q2Q52N3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM241974 (Netilmycin sulfate) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | 3.73E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Atatürk University | Assay Description PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E... | J Enzyme Inhib Med Chem 28: 758-64 (2013) Article DOI: 10.3109/14756366.2012.681653 BindingDB Entry DOI: 10.7270/Q25B01CZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM189358 (Asta Z 4942 | Ifosfamide | Iphosphamide | N,3-bis(...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid UniChem | Article PubMed | 8.97E+6 | n/a | 2.33E+7 | n/a | n/a | n/a | n/a | 10.5 | n/a |
Ahi Evran University | Assay Description Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ... | Chem Biol Drug Des 88: 188-96 (2016) Article DOI: 10.1111/cbdd.12746 BindingDB Entry DOI: 10.7270/Q2SB44JJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM92333 (Lincomycine) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | 1.11E+7 | -11.2 | 1.30E+7 | n/a | n/a | n/a | n/a | 10.5 | 25 |
Atatürk University | Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy... | J Enzyme Inhib Med Chem 24: 1034-9 (2009) Article DOI: 10.1080/14756360802608351 BindingDB Entry DOI: 10.7270/Q2TT4PKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM50022271 (2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.30E+7 | -10.8 | 6.23E+6 | n/a | n/a | n/a | n/a | 10.5 | 25 |
Atatürk University | Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy... | J Enzyme Inhib Med Chem 24: 1034-9 (2009) Article DOI: 10.1080/14756360802608351 BindingDB Entry DOI: 10.7270/Q2TT4PKR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM50335522 ((2S,4R)-N-((1R,2R)-2-hydroxy-1-((2R,3R,4S,5R,6R)-3...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.83E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Atatürk University | Assay Description PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E... | J Enzyme Inhib Med Chem 28: 758-64 (2013) Article DOI: 10.3109/14756366.2012.681653 BindingDB Entry DOI: 10.7270/Q25B01CZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM241975 (Clindamycin phosphate) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | 3.58E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Atatürk University | Assay Description PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E... | J Enzyme Inhib Med Chem 28: 758-64 (2013) Article DOI: 10.3109/14756366.2012.681653 BindingDB Entry DOI: 10.7270/Q25B01CZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human)) | BDBM241976 (Streptomycin sulfate) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 5.63E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Atatürk University | Assay Description PON activities were measured in the presence of different drug concentrations. Control activity was assumed to be 100% in the absence of inhibitor. E... | J Enzyme Inhib Med Chem 28: 758-64 (2013) Article DOI: 10.3109/14756366.2012.681653 BindingDB Entry DOI: 10.7270/Q25B01CZ | |||||||||||
More data for this Ligand-Target Pair |