Found 242 hits of ki data for polymerid = 5366 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM81885
(2-(3-tert-Butylamino-2-hydroxypropylthio)-4-(5-car...)Show InChI InChI=1S/C15H21N3O2S3/c1-15(2,3)17-6-9(19)7-21-14-18-10(8-22-14)11-4-5-12(23-11)13(16)20/h4-5,8-9,17,19H,6-7H2,1-3H3,(H2,16,20) | PDB
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| 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50019443
(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)Show InChI InChI=1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3 | PDB
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| 0.660 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25761
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3 | PDB
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| 0.690 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25759
(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)Show SMILES COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 Show InChI InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3 | PDB
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| 0.810 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rzeszów University of Technology
Curated by ChEMBL
| Assay Description
Displacement of [3H]CGP12177 from beta1 adrenergic receptor in rat cerebral cortex by liquid scintillation method |
Eur J Med Chem 44: 809-17 (2009)
Article DOI: 10.1016/j.ejmech.2008.05.019
BindingDB Entry DOI: 10.7270/Q29Z94QJ |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25764
(ALPRENOLOL,(+) | ALPRENOLOL,(-) | Alfeprol | Alphe...)Show InChI InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3 | PDB
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| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Italia
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 352: 276-82 (1995)
Article DOI: 10.1007/bf00168557
BindingDB Entry DOI: 10.7270/Q2Q52N48 |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50267197
((2S)-1-(1H-Indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)...)Show SMILES COc1ccccc1OCCNC[C@H](O)COc1cccc2[nH]ccc12 |r| Show InChI InChI=1S/C20H24N2O4/c1-24-19-6-2-3-7-20(19)25-12-11-21-13-15(23)14-26-18-8-4-5-17-16(18)9-10-22-17/h2-10,15,21-23H,11-14H2,1H3/t15-/m0/s1 | PDB
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rzeszów University of Technology
Curated by ChEMBL
| Assay Description
Displacement of [3H]CGP12177 from beta1 adrenergic receptor in rat cerebral cortex by liquid scintillation method |
Eur J Med Chem 44: 809-17 (2009)
Article DOI: 10.1016/j.ejmech.2008.05.019
BindingDB Entry DOI: 10.7270/Q29Z94QJ |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM81886
(CAS_3506-09-0 | CHEMBL287651 | PROPRANOLOL, dl)Show InChI InChI=1S/C17H23NO2/c1-13(2)10-18-11-15(19)12-20-17-9-5-7-14-6-3-4-8-16(14)17/h3-9,13,15,18-19H,10-12H2,1-2H3 | PDB
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| 2.82 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25761
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3 | PDB
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| | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Medical University of Warsaw
| Assay Description
Radioligand receptor binding studies were conducted in the rat brain. |
Medicinal Chemistry Research 17: 507-514 (2008)
BindingDB Entry DOI: 10.7270/Q2Z036S7 |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50267196
((+/-)1-(1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)e...)Show InChI InChI=1S/C20H24N2O4/c1-24-19-6-2-3-7-20(19)25-12-11-21-13-15(23)14-26-18-8-4-5-17-16(18)9-10-22-17/h2-10,15,21-23H,11-14H2,1H3 | PDB
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rzeszów University of Technology
Curated by ChEMBL
| Assay Description
Displacement of [3H]CGP12177 from beta1 adrenergic receptor in rat cerebral cortex by liquid scintillation method |
Eur J Med Chem 44: 809-17 (2009)
Article DOI: 10.1016/j.ejmech.2008.05.019
BindingDB Entry DOI: 10.7270/Q29Z94QJ |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50255223
(4-(3N-(2-Amino-2-methyl-1,3-dihydroxypropyl)-2-hyd...)Show InChI InChI=1S/C20H23NO6/c1-20(11-22,12-23)21-9-13(24)10-26-17-8-4-6-15-18(25)14-5-2-3-7-16(14)27-19(15)17/h2-8,13,21-24H,9-12H2,1H3 | PDB
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| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]CGP12177 from beta1 adrenergic receptor in rat cerebral cortex by liquid scintillation counting |
Bioorg Med Chem 17: 1345-52 (2009)
Article DOI: 10.1016/j.bmc.2008.12.031
BindingDB Entry DOI: 10.7270/Q2KP8213 |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25764
(ALPRENOLOL,(+) | ALPRENOLOL,(-) | Alfeprol | Alphe...)Show InChI InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3 | PDB
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| 4.17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM81882
(CAS_93633-92-2 | YM-09538)Show InChI InChI=1S/C18H24N2O5S/c1-13-7-8-14(11-18(13)26(19,22)23)15(21)12-20-9-10-25-17-6-4-3-5-16(17)24-2/h3-8,11,15,20-21H,9-10,12H2,1-2H3,(H2,19,22,23) | PDB
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| 4.37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50086666
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4-{3-[4-(2...)Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CSc3c(OCC(O)CNC(C)(C)C)cccc23)CC1 Show InChI InChI=1S/C29H42N4O4S/c1-29(2,3)30-19-22(34)20-37-26-12-7-10-24-28(26)38-21-27(35)33(24)14-8-13-31-15-17-32(18-16-31)23-9-5-6-11-25(23)36-4/h5-7,9-12,22,30,34H,8,13-21H2,1-4H3 | PDB
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| 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Perugia
Curated by ChEMBL
| Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea... |
Bioorg Med Chem Lett 10: 465-8 (2000)
BindingDB Entry DOI: 10.7270/Q2SJ1JVG |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50272484
(CHEMBL4129458)Show InChI InChI=1S/C20H23NO4.ClH/c1-20(2,3)21-11-13(22)12-24-17-10-6-8-15-18(23)14-7-4-5-9-16(14)25-19(15)17;/h4-10,13,21-22H,11-12H2,1-3H3;1H | PDB
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| 5.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-CGP-12177 from adrenergic beta1 receptor in Wistar rat cortex incubated for 60 mins by microbeta liquid scintillation counting a... |
Bioorg Med Chem 26: 3773-3784 (2018)
Article DOI: 10.1016/j.bmc.2018.04.038
BindingDB Entry DOI: 10.7270/Q2XG9TM7 |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25761
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3 | PDB
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| Article
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]CGP-12177 from beta1 adrenergic receptor in rat brain cerebral cortex after 60 mins by microbeta scintillation counting method |
Bioorg Med Chem Lett 26: 5315-5321 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.037
BindingDB Entry DOI: 10.7270/Q24J0H3X |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50240370
(1-(2-(allyloxy)phenoxy)-3-(isopropylamino)propan-2...)Show InChI InChI=1S/C15H23NO3/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3/h4-8,12-13,16-17H,1,9-11H2,2-3H3 | PDB
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| Article
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| 7.76 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50272483
(CHEMBL4128794)Show SMILES Cl.COc1ccccc1CNCC(O)COc1cccc2c1oc1ccccc1c2=O Show InChI InChI=1S/C24H23NO5.ClH/c1-28-20-10-4-2-7-16(20)13-25-14-17(26)15-29-22-12-6-9-19-23(27)18-8-3-5-11-21(18)30-24(19)22;/h2-12,17,25-26H,13-15H2,1H3;1H | PDB
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| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-CGP-12177 from adrenergic beta1 receptor in Wistar rat cortex incubated for 60 mins by microbeta liquid scintillation counting a... |
Bioorg Med Chem 26: 3773-3784 (2018)
Article DOI: 10.1016/j.bmc.2018.04.038
BindingDB Entry DOI: 10.7270/Q2XG9TM7 |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50255803
(5-(3N-(2-Amino-2-methyl-1-hydroxypropyl)-2-hydroxy...)Show SMILES CC(C)(CO)NCC(O)COc1cccc2c1oc1cc(Cl)ccc1c2=O Show InChI InChI=1S/C20H22ClNO5/c1-20(2,11-23)22-9-13(24)10-26-16-5-3-4-15-18(25)14-7-6-12(21)8-17(14)27-19(15)16/h3-8,13,22-24H,9-11H2,1-2H3 | PDB
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| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]CGP12177 from beta1 adrenergic receptor in rat cerebral cortex by liquid scintillation counting |
Bioorg Med Chem 17: 1345-52 (2009)
Article DOI: 10.1016/j.bmc.2008.12.031
BindingDB Entry DOI: 10.7270/Q2KP8213 |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25758
(2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amin...)Show InChI InChI=1S/C19H24N2O3/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24) | PDB
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| 12.0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25752
(Betaxolol | Levobetaxolol | [(2S)-3-{4-[2-(cyclopr...)Show InChI InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3/t17-/m0/s1 | PDB
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| 12.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM81881
(l-Metoprolol)Show InChI InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3/t14-/m0/s1 | PDB
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| 13.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25761
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3 | PDB
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| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-CGP-12177 from beta1-adrenergic receptor in rat brain cortex after 1 hr by Microbeta scintillation counting method |
Eur J Med Chem 147: 102-114 (2018)
Article DOI: 10.1016/j.ejmech.2018.01.093
BindingDB Entry DOI: 10.7270/Q29P346S |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50086673
(8-(3-tert-Butylamino-2-hydroxy-propoxy)-4H-benzo[1...)Show InChI InChI=1S/C15H22N2O3S/c1-15(2,3)16-7-10(18)8-20-12-6-4-5-11-14(12)21-9-13(19)17-11/h4-6,10,16,18H,7-9H2,1-3H3,(H,17,19) | PDB
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| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Perugia
Curated by ChEMBL
| Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea... |
Bioorg Med Chem Lett 10: 465-8 (2000)
BindingDB Entry DOI: 10.7270/Q2SJ1JVG |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50255804
(5-(3N-(2-Amino-2-methyl-1,3-dihydroxypropyl)-2-hyd...)Show SMILES CC(CO)(CO)NCC(O)COc1cccc2c1oc1cc(Cl)ccc1c2=O Show InChI InChI=1S/C20H22ClNO6/c1-20(10-23,11-24)22-8-13(25)9-27-16-4-2-3-15-18(26)14-6-5-12(21)7-17(14)28-19(15)16/h2-7,13,22-25H,8-11H2,1H3 | PDB
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| 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]CGP12177 from beta1 adrenergic receptor in rat cerebral cortex by liquid scintillation counting |
Bioorg Med Chem 17: 1345-52 (2009)
Article DOI: 10.1016/j.bmc.2008.12.031
BindingDB Entry DOI: 10.7270/Q2KP8213 |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50036835
(1-(3,4-Dichloro-phenyl)-2-isopropylamino-ethanol |...)Show InChI InChI=1S/C11H15Cl2NO/c1-7(2)14-6-11(15)8-3-4-9(12)10(13)5-8/h3-5,7,11,14-15H,6H2,1-2H3 | PDB
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| 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universitá di Pisa
Curated by ChEMBL
| Assay Description
Binding affinity against beta1-adrenergic receptor in rat brain |
J Med Chem 37: 1518-25 (1994)
BindingDB Entry DOI: 10.7270/Q2V69HM4 |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50036835
(1-(3,4-Dichloro-phenyl)-2-isopropylamino-ethanol |...)Show InChI InChI=1S/C11H15Cl2NO/c1-7(2)14-6-11(15)8-3-4-9(12)10(13)5-8/h3-5,7,11,14-15H,6H2,1-2H3 | PDB
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| | 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50007477
(4-(3-tert-Butylamino-2-hydroxy-propoxy)-3-fluoro-b...)Show InChI InChI=1S/C13H20FNO4/c1-13(2,3)15-6-8(16)7-19-10-5-4-9(17)12(18)11(10)14/h4-5,8,15-18H,6-7H2,1-3H3 | PDB
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| 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibition of binding of [3H]-dihydroalprenolol from beta-1 adrenergic receptor of rat cerebral cortical membranes |
J Med Chem 34: 1063-8 (1991)
BindingDB Entry DOI: 10.7270/Q2765D9R |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25756
((2R,3R)-2,3-dihydroxysuccinic acid;1-(isopropylami...)Show InChI InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3 | PDB
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| 63.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50352113
(CHEMBL1824263)Show SMILES COc1ccc2nc(-c3ccc(OCC(O)CNC(C)(C)C)cc3)n(C)c(=O)c2c1 Show InChI InChI=1S/C23H29N3O4/c1-23(2,3)24-13-16(27)14-30-17-8-6-15(7-9-17)21-25-20-11-10-18(29-5)12-19(20)22(28)26(21)4/h6-12,16,24,27H,13-14H2,1-5H3 | PDB
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| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description
Displacement of [3H]-CGP12177 from beta1-adrenergic receptor in rat heart membranes |
Bioorg Med Chem Lett 21: 5506-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.06.106
BindingDB Entry DOI: 10.7270/Q25B02VN |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Compound was evaluated for beta adrenergic binding affinity towards Beta-1 adrenergic receptor of rat brain |
J Med Chem 35: 1009-18 (1992)
BindingDB Entry DOI: 10.7270/Q2J38T5T |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25392
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3 | PDB
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| 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Tested for binding affinity against beta-1 adrenergic receptor in rat brain using [3H]-CGP- 26505 as radioligand |
J Med Chem 36: 3077-86 (1993)
BindingDB Entry DOI: 10.7270/Q2PG1SB1 |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25761
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3 | PDB
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| 81.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50255222
(4-(3-(Allylamino)-2-hydroxypropoxy)-9H-xanthen-9-o...)Show InChI InChI=1S/C19H19NO4/c1-2-10-20-11-13(21)12-23-17-9-5-7-15-18(22)14-6-3-4-8-16(14)24-19(15)17/h2-9,13,20-21H,1,10-12H2 | PDB
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| 84 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]CGP12177 from beta1 adrenergic receptor in rat cerebral cortex by liquid scintillation counting |
Bioorg Med Chem 17: 1345-52 (2009)
Article DOI: 10.1016/j.bmc.2008.12.031
BindingDB Entry DOI: 10.7270/Q2KP8213 |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25753
(2-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl...)Show InChI InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18) | PDB
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| 97.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50007476
(4-(3-tert-Butylamino-2-hydroxy-propoxy)-benzene-1,...)Show InChI InChI=1S/C13H21NO4/c1-13(2,3)14-7-9(15)8-18-10-4-5-11(16)12(17)6-10/h4-6,9,14-17H,7-8H2,1-3H3 | PDB
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| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description
Compound was evaluated for the inhibition of binding of [3H]-dihydroalprenolol from beta-1 adrenergic receptor of rat cerebral cortical membranes |
J Med Chem 34: 1063-8 (1991)
BindingDB Entry DOI: 10.7270/Q2765D9R |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25755
(Acebutolol | Acetobutolol | N-{3-acetyl-4-[2-hydro...)Show InChI InChI=1S/C18H28N2O4/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23) | PDB
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| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50029051
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1 | PDB
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| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Compound was evaluated for beta adrenergic binding affinity towards Beta-1 adrenergic receptor of rat brain |
J Med Chem 35: 1009-18 (1992)
BindingDB Entry DOI: 10.7270/Q2J38T5T |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50029051
((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)Show InChI InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1 | PDB
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| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description
Tested for binding affinity against beta-1 adrenergic receptor in rat brain using [3H]-CGP- 26505 as radioligand |
J Med Chem 36: 3077-86 (1993)
BindingDB Entry DOI: 10.7270/Q2PG1SB1 |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50087518
((R)4-(2-Amino-1-hydroxy-ethyl)-3-fluoro-benzene-1,...)Show InChI InChI=1S/C8H10FNO3/c9-7-4(6(12)3-10)1-2-5(11)8(7)13/h1-2,6,11-13H,3,10H2/t6-/m0/s1 | PDB
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| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
| Assay Description
Binding of [3H]-dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes |
J Med Chem 43: 1611-9 (2000)
BindingDB Entry DOI: 10.7270/Q25M64ZV |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50267198
((2R)-1-(1H-Indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)...)Show SMILES COc1ccccc1OCCNC[C@@H](O)COc1cccc2[nH]ccc12 |r| Show InChI InChI=1S/C20H24N2O4/c1-24-19-6-2-3-7-20(19)25-12-11-21-13-15(23)14-26-18-8-4-5-17-16(18)9-10-22-17/h2-10,15,21-23H,11-14H2,1H3/t15-/m1/s1 | PDB
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| 143 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rzeszów University of Technology
Curated by ChEMBL
| Assay Description
Displacement of [3H]CGP12177 from beta1 adrenergic receptor in rat cerebral cortex by liquid scintillation method |
Eur J Med Chem 44: 809-17 (2009)
Article DOI: 10.1016/j.ejmech.2008.05.019
BindingDB Entry DOI: 10.7270/Q29Z94QJ |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25768
(1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-(pro...)Show InChI InChI=1S/C17H27NO2/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3 | PDB
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| 195 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50019060
((+/-)4-(2-Amino-1-hydroxy-ethyl)-3-fluoro-benzene-...)Show InChI InChI=1S/C8H10FNO3/c9-7-4(6(12)3-10)1-2-5(11)8(7)13/h1-2,6,11-13H,3,10H2 | PDB
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| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
| Assay Description
Binding of [3H]-dihydroalprenolol to beta-1 adrenergic receptor of rat cerebral cortical membranes |
J Med Chem 43: 1611-9 (2000)
BindingDB Entry DOI: 10.7270/Q25M64ZV |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50272473
(CHEMBL4126588)Show SMILES Cl.OC(COc1cccc2c1oc1ccccc1c2=O)CN1CCN(CC1)c1ccccn1 Show InChI InChI=1S/C25H25N3O4.ClH/c29-18(16-27-12-14-28(15-13-27)23-10-3-4-11-26-23)17-31-22-9-5-7-20-24(30)19-6-1-2-8-21(19)32-25(20)22;/h1-11,18,29H,12-17H2;1H | PDB
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| 213 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-CGP-12177 from adrenergic beta1 receptor in Wistar rat cortex incubated for 60 mins by microbeta liquid scintillation counting a... |
Bioorg Med Chem 26: 3773-3784 (2018)
Article DOI: 10.1016/j.bmc.2018.04.038
BindingDB Entry DOI: 10.7270/Q2XG9TM7 |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM25749
(CHEMBL6995 | N-{4-[2-hydroxy-3-(propan-2-ylamino)p...)Show InChI InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17) | PDB
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| 245 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Niigata College of Pharmacy
Curated by PDSP Ki Database
| |
Jpn J Pharmacol 52: 195-200 (1990)
Article DOI: 10.1254/jjp.52.195
BindingDB Entry DOI: 10.7270/Q2H41PXD |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50086670
(8-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-y...)Show SMILES COc1ccccc1N1CCN(CC(O)COc2cccc3NC(=O)CSc23)CC1 Show InChI InChI=1S/C22H27N3O4S/c1-28-19-7-3-2-6-18(19)25-11-9-24(10-12-25)13-16(26)14-29-20-8-4-5-17-22(20)30-15-21(27)23-17/h2-8,16,26H,9-15H2,1H3,(H,23,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Perugia
Curated by ChEMBL
| Assay Description
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea... |
Bioorg Med Chem Lett 10: 465-8 (2000)
BindingDB Entry DOI: 10.7270/Q2SJ1JVG |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50272481
(CHEMBL4128940)Show SMILES Cl.COc1ccc(CCNCC(O)COc2cccc3c2oc2ccccc2c3=O)cc1OC Show InChI InChI=1S/C26H27NO6.ClH/c1-30-22-11-10-17(14-24(22)31-2)12-13-27-15-18(28)16-32-23-9-5-7-20-25(29)19-6-3-4-8-21(19)33-26(20)23;/h3-11,14,18,27-28H,12-13,15-16H2,1-2H3;1H | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 357 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-CGP-12177 from adrenergic beta1 receptor in Wistar rat cortex incubated for 60 mins by microbeta liquid scintillation counting a... |
Bioorg Med Chem 26: 3773-3784 (2018)
Article DOI: 10.1016/j.bmc.2018.04.038
BindingDB Entry DOI: 10.7270/Q2XG9TM7 |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50272482
(CHEMBL4130151)Show SMILES Cl.COc1ccccc1CCNCC(O)COc1cccc2c1oc1ccccc1c2=O Show InChI InChI=1S/C25H25NO5.ClH/c1-29-21-10-4-2-7-17(21)13-14-26-15-18(27)16-30-23-12-6-9-20-24(28)19-8-3-5-11-22(19)31-25(20)23;/h2-12,18,26-27H,13-16H2,1H3;1H | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 359 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Medical College
Curated by ChEMBL
| Assay Description
Displacement of [3H]-CGP-12177 from adrenergic beta1 receptor in Wistar rat cortex incubated for 60 mins by microbeta liquid scintillation counting a... |
Bioorg Med Chem 26: 3773-3784 (2018)
Article DOI: 10.1016/j.bmc.2018.04.038
BindingDB Entry DOI: 10.7270/Q2XG9TM7 |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50035057
((eltoprazine)1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)...)Show InChI InChI=1S/C12H16N2O2/c1-2-10(14-6-4-13-5-7-14)12-11(3-1)15-8-9-16-12/h1-3,13H,4-9H2 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 420 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duphar B.V.
Curated by PDSP Ki Database
| |
Drug Metabol Drug Interact 8: 85-114 (1990)
Article DOI: 10.1515/dmdi.1990.8.1-2.85
BindingDB Entry DOI: 10.7270/Q27M06DV |
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50036840
(CHEMBL38033 | Propionaldehyde O-(3-tert-butylamino...)Show InChI InChI=1S/C10H22N2O2/c1-5-6-12-14-8-9(13)7-11-10(2,3)4/h6,9,11,13H,5,7-8H2,1-4H3/b12-6+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| | 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50036840
(CHEMBL38033 | Propionaldehyde O-(3-tert-butylamino...)Show InChI InChI=1S/C10H22N2O2/c1-5-6-12-14-8-9(13)7-11-10(2,3)4/h6,9,11,13H,5,7-8H2,1-4H3/b12-6+ | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universitá di Pisa
Curated by ChEMBL
| Assay Description
Binding affinity against beta1-adrenergic receptor in rat brain |
J Med Chem 37: 1518-25 (1994)
BindingDB Entry DOI: 10.7270/Q2V69HM4 |
More data for this
Ligand-Target Pair | |
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