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Compile Data Set for Download or QSAR

Found 46 hits of ki data for polymerid = 6311   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM41999
PNG
(3-(3,4,5-trihydroxy-6-keto-xanthen-9-yl)propionic ...)
Show SMILES OC(=O)CCc1c2ccc(O)c(O)c2oc2c(O)c(=O)ccc12
Show InChI InChI=1S/C16H12O7/c17-10-4-1-8-7(3-6-12(19)20)9-2-5-11(18)14(22)16(9)23-15(8)13(10)21/h1-2,4-5,17,21-22H,3,6H2,(H,19,20)
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 80n/an/an/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate...

J Med Chem 55: 4142-58 (2012)


Article DOI: 10.1021/jm201624h
BindingDB Entry DOI: 10.7270/Q2X34ZJ9
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50106497
PNG
(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)
Show SMILES Oc1c(Cl)c(N=CCN2CCOCC2)c(O)c2ncccc12 |w:6.6|
Show InChI InChI=1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-4,20-21H,5-9H2
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 95n/an/an/an/an/an/an/an/a



Max-Planck-Institute of Molecular Physiology

Curated by ChEMBL


Assay Description
Inhibition of human Cdc25B

Bioorg Med Chem 19: 2145-55 (2011)


Article DOI: 10.1016/j.bmc.2011.02.047
BindingDB Entry DOI: 10.7270/Q2BR8SHK
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM26613
PNG
((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)
Show SMILES OC(=O)\C=C\c1cccc(c1)[Sb](O)(O)=O
Show InChI InChI=1S/C9H7O2.2H2O.O.Sb/c10-9(11)7-6-8-4-2-1-3-5-8;;;;/h1-2,4-7H,(H,10,11);2*1H2;;/q;;;;+2/p-2/b7-6+;;;;
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 369n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...

Bioorg Med Chem 20: 4371-6 (2012)


Article DOI: 10.1016/j.bmc.2012.05.040
BindingDB Entry DOI: 10.7270/Q2RB75N4
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50129580
PNG
(3-[4,6-Dichloro-7-(3-methyl-but-2-enyl)-1H-indol-3...)
Show SMILES CC(C)=CCc1c(Cl)cc(Cl)c2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O |(-2.72,-7.25,;-1.19,-7.49,;-.63,-8.92,;-.23,-6.3,;-.78,-4.85,;.19,-3.66,;-.39,-2.22,;-1.93,-1.99,;.58,-1.03,;2.1,-1.27,;2.87,.07,;2.66,-2.69,;4.09,-3.24,;4.03,-4.76,;2.55,-5.16,;1.71,-3.89,;5.41,-2.45,;5.39,-.89,;4.03,-.12,;6.71,-.12,;6.67,1.42,;8.06,-.87,;8.08,-2.41,;9.44,-3.18,;6.76,-3.2,;6.76,-4.74,)|
Show InChI InChI=1S/C19H15Cl2NO4/c1-8(2)3-4-9-11(20)5-12(21)15-10(7-22-17(9)15)16-18(25)13(23)6-14(24)19(16)26/h3,5,7,16,22H,4,6H2,1-2H3
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 430n/an/an/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Inhibitory constant of compound against Cell division cycle 25B was determined using mFP as a substrate

J Med Chem 46: 2580-8 (2003)


Article DOI: 10.1021/jm0300835
BindingDB Entry DOI: 10.7270/Q2RJ4HVW
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50129574
PNG
(2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-...)
Show SMILES CC(C)=CCc1cccc2c(c[nH]c12)C1C(=O)C(=O)CC(=O)C1=O |(-1.02,-4.51,;.5,-4.74,;1.06,-6.18,;1.45,-3.53,;2.98,-3.76,;3.94,-2.56,;3.37,-1.13,;4.32,.06,;5.86,-.17,;6.42,-1.59,;7.86,-2.15,;7.79,-3.67,;6.3,-4.06,;5.46,-2.8,;9.17,-1.35,;9.15,.2,;7.79,.97,;10.47,.98,;10.43,2.52,;11.82,.23,;11.84,-1.31,;13.2,-2.08,;10.52,-2.11,;10.52,-3.65,)|
Show InChI InChI=1S/C19H17NO4/c1-10(2)6-7-11-4-3-5-12-13(9-20-17(11)12)16-18(23)14(21)8-15(22)19(16)24/h3-6,9,16,20H,7-8H2,1-2H3
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 640n/an/an/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Inhibitory constant of compound against Cell division cycle 25B was determined using mFP as a substrate

J Med Chem 46: 2580-8 (2003)


Article DOI: 10.1021/jm0300835
BindingDB Entry DOI: 10.7270/Q2RJ4HVW
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504064
PNG
(CHEMBL4438316)
Show SMILES Cl.Nc1cccc2c(Nc3cccc(c3)C(O)=O)cccc12
Show InChI InChI=1S/C17H14N2O2/c18-15-8-2-7-14-13(15)6-3-9-16(14)19-12-5-1-4-11(10-12)17(20)21/h1-10,19H,18H2,(H,20,21)
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 800n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504065
PNG
(CHEMBL4438470)
Show SMILES Cl.Nc1ccc(Nc2cccc(c2)C(O)=O)c2ccccc12
Show InChI InChI=1S/C17H14N2O2/c18-15-8-9-16(14-7-2-1-6-13(14)15)19-12-5-3-4-11(10-12)17(20)21/h1-10,19H,18H2,(H,20,21)
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 1.40E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50084504
PNG
(CHEMBL3426991)
Show SMILES Nc1cccc(c1)-c1ccc2c(cc(Nc3ccccc3)[nH]c2=O)c1
Show InChI InChI=1S/C21H17N3O/c22-17-6-4-5-14(12-17)15-9-10-19-16(11-15)13-20(24-21(19)25)23-18-7-2-1-3-8-18/h1-13H,22H2,(H2,23,24,25)
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 1.90E+3n/an/an/an/an/an/an/an/a



University of Pittsburgh

Curated by ChEMBL


Assay Description
Competitive inhibition of His6-tagged human recombinant Cdc25B catalytic domain (350 to 566 residues) expressed in Escherichia coli BL21 (D3) after 2...

Bioorg Med Chem 23: 2810-8 (2015)


Article DOI: 10.1016/j.bmc.2015.01.043
BindingDB Entry DOI: 10.7270/Q2CJ8G62
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50571956
PNG
(CHEMBL4874608)
Show SMILES OC(=O)C[C@H](Nc1nc(NCCCCCNC(=O)CCCNc2nc(N[C@@H](CC(O)=O)C(O)=O)nc(N[C@@H](Cc3ccc(O)cc3)C(O)=O)n2)nc(N[C@@H](Cc2c[nH]c3ccccc23)C(O)=O)n1)C(O)=O |r|
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 2.60E+3n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition of recombinant human Cdc25B (351 to 380 residues) assessed as hydrolysis of substrate O-methylfluorescein phosphate by Linewea...

Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128265
BindingDB Entry DOI: 10.7270/Q26M3BNG
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504087
PNG
(CHEMBL4587130)
Show SMILES OC(=O)c1ccccc1Nc1ccc(O)c2ccccc12
Show InChI InChI=1S/C17H13NO3/c19-16-10-9-15(11-5-1-2-6-12(11)16)18-14-8-4-3-7-13(14)17(20)21/h1-10,18-19H,(H,20,21)
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 2.70E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504063
PNG
(CHEMBL4570006)
Show SMILES CCOC(=O)c1ccccc1Nc1cccc2ccccc12
Show InChI InChI=1S/C19H17NO2/c1-2-22-19(21)16-11-5-6-12-18(16)20-17-13-7-9-14-8-3-4-10-15(14)17/h3-13,20H,2H2,1H3
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 2.80E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504067
PNG
(CHEMBL4437577)
Show SMILES OC(=O)c1cccc(Nc2cccc3c(O)cccc23)c1
Show InChI InChI=1S/C17H13NO3/c19-16-9-3-6-13-14(16)7-2-8-15(13)18-12-5-1-4-11(10-12)17(20)21/h1-10,18-19H,(H,20,21)
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 2.90E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50096680
PNG
((E)-2-(2-Chloro-phenyl)-ethenesulfonic acid [4-(4-...)
Show SMILES CCCc1sc(NS(=O)(=O)\C=C\c2ccccc2Cl)nc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N2O2S2/c1-2-5-18-19(15-8-10-16(21)11-9-15)23-20(27-18)24-28(25,26)13-12-14-6-3-4-7-17(14)22/h3-4,6-13H,2,5H2,1H3,(H,23,24)/b13-12+
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 4.60E+3n/an/an/an/an/an/an/an/a



University of Pittsburgh

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human recombinant Cdc25B phosphatase enzyme

Bioorg Med Chem Lett 11: 313-7 (2001)


BindingDB Entry DOI: 10.7270/Q2DR2TRG
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50388723
PNG
(CHEMBL2057662)
Show SMILES OC(=O)CCc1cccc(c1)[Sb](O)(O)=O
Show InChI InChI=1S/C9H9O2.2H2O.O.Sb/c10-9(11)7-6-8-4-2-1-3-5-8;;;;/h1-2,4-5H,6-7H2,(H,10,11);2*1H2;;/q;;;;+2/p-2
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 4.70E+3n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His-tagged Cdc25b catalytic domain expressed in Escherichia coli BL21(DE3) using 3-O-Methylfluorescein phosphate as substrat...

Bioorg Med Chem 20: 4371-6 (2012)


Article DOI: 10.1016/j.bmc.2012.05.040
BindingDB Entry DOI: 10.7270/Q2RB75N4
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504080
PNG
(CHEMBL4525255)
Show SMILES CCOC(=O)c1cccc(Nc2cccc3c(O)cccc23)c1
Show InChI InChI=1S/C19H17NO3/c1-2-23-19(22)13-6-3-7-14(12-13)20-17-10-4-9-16-15(17)8-5-11-18(16)21/h3-12,20-21H,2H2,1H3
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 4.90E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504081
PNG
(CHEMBL4442999)
Show SMILES OC(=O)c1ccccc1Nc1cc(O)cc2ccccc12
Show InChI InChI=1S/C17H13NO3/c19-12-9-11-5-1-2-6-13(11)16(10-12)18-15-8-4-3-7-14(15)17(20)21/h1-10,18-19H,(H,20,21)
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 5.10E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM26617
PNG
(4-[(2-carboxyphenyl)carbonyl]benzene-1,2-dicarboxy...)
Show SMILES OC(=O)c1ccccc1C(=O)c1ccc(C(O)=O)c(c1)C(O)=O
Show InChI InChI=1S/C16H10O7/c17-13(9-3-1-2-4-10(9)14(18)19)8-5-6-11(15(20)21)12(7-8)16(22)23/h1-7H,(H,18,19)(H,20,21)(H,22,23)
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 5.30E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Competitive reversible inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OM...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM26617
PNG
(4-[(2-carboxyphenyl)carbonyl]benzene-1,2-dicarboxy...)
Show SMILES OC(=O)c1ccccc1C(=O)c1ccc(C(O)=O)c(c1)C(O)=O
Show InChI InChI=1S/C16H10O7/c17-13(9-3-1-2-4-10(9)14(18)19)8-5-6-11(15(20)21)12(7-8)16(22)23/h1-7H,(H,18,19)(H,20,21)(H,22,23)
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 5.30E+3n/an/an/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate...

J Med Chem 55: 4142-58 (2012)


Article DOI: 10.1021/jm201624h
BindingDB Entry DOI: 10.7270/Q2X34ZJ9
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504068
PNG
(CHEMBL4465468)
Show SMILES OC(=O)c1cccc(Nc2cc(O)cc3ccccc23)c1
Show InChI InChI=1S/C17H13NO3/c19-14-9-11-4-1-2-7-15(11)16(10-14)18-13-6-3-5-12(8-13)17(20)21/h1-10,18-19H,(H,20,21)
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 5.80E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504075
PNG
(CHEMBL4521134)
Show SMILES COc1ccc(Nc2ccccc2C(O)=O)c2ccccc12
Show InChI InChI=1S/C18H15NO3/c1-22-17-11-10-16(12-6-2-3-7-13(12)17)19-15-9-5-4-8-14(15)18(20)21/h2-11,19H,1H3,(H,20,21)
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 6.10E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504085
PNG
(CHEMBL4585545)
Show SMILES OC(=O)c1cccc(Nc2ccc(O)c3ccccc23)c1
Show InChI InChI=1S/C17H13NO3/c19-16-9-8-15(13-6-1-2-7-14(13)16)18-12-5-3-4-11(10-12)17(20)21/h1-10,18-19H,(H,20,21)
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 6.40E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504088
PNG
(CHEMBL4434749)
Show SMILES Nc1cccc2c(Nc3ccccc3C(O)=O)cccc12
Show InChI InChI=1S/C17H14N2O2/c18-14-8-3-7-12-11(14)6-4-10-15(12)19-16-9-2-1-5-13(16)17(20)21/h1-10,19H,18H2,(H,20,21)
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 6.50E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504070
PNG
(CHEMBL4473428)
Show SMILES CCOC(=O)c1ccccc1Nc1ccc(OC)c2ccccc12
Show InChI InChI=1S/C20H19NO3/c1-3-24-20(22)16-10-6-7-11-17(16)21-18-12-13-19(23-2)15-9-5-4-8-14(15)18/h4-13,21H,3H2,1-2H3
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 6.90E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504071
PNG
(CHEMBL4470428)
Show SMILES COc1ccc(C(=O)c2ccccc2C(O)=O)c2ccccc12
Show InChI InChI=1S/C19H14O4/c1-23-17-11-10-15(12-6-2-3-7-13(12)17)18(20)14-8-4-5-9-16(14)19(21)22/h2-11H,1H3,(H,21,22)
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 7.10E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504086
PNG
(CHEMBL4520431)
Show SMILES CCOC(=O)c1cccc(Nc2cccc3ccccc23)c1
Show InChI InChI=1S/C19H17NO2/c1-2-22-19(21)15-9-5-10-16(13-15)20-18-12-6-8-14-7-3-4-11-17(14)18/h3-13,20H,2H2,1H3
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 7.30E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504066
PNG
(CHEMBL4566865)
Show SMILES CCOC(=O)c1ccccc1Nc1cccc2c(O)cccc12
Show InChI InChI=1S/C19H17NO3/c1-2-23-19(22)15-7-3-4-10-17(15)20-16-11-5-9-14-13(16)8-6-12-18(14)21/h3-12,20-21H,2H2,1H3
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 7.40E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504074
PNG
(CHEMBL4447602)
Show SMILES CCOC(=O)c1cccc(Nc2cc(OC)cc3ccccc23)c1
Show InChI InChI=1S/C20H19NO3/c1-3-24-20(22)15-8-6-9-16(11-15)21-19-13-17(23-2)12-14-7-4-5-10-18(14)19/h4-13,21H,3H2,1-2H3
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 8.50E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504079
PNG
(CHEMBL4464552)
Show SMILES Cl.CCOC(=O)c1ccccc1Nc1cccc2c(N)cccc12
Show InChI InChI=1S/C19H18N2O2/c1-2-23-19(22)15-7-3-4-11-18(15)21-17-12-6-8-13-14(17)9-5-10-16(13)20/h3-12,21H,2,20H2,1H3
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 9.90E+3n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504089
PNG
(CHEMBL4449432)
Show SMILES CCOC(=O)c1cccc(Nc2ccc(OC)c3ccccc23)c1
Show InChI InChI=1S/C20H19NO3/c1-3-24-20(22)14-7-6-8-15(13-14)21-18-11-12-19(23-2)17-10-5-4-9-16(17)18/h4-13,21H,3H2,1-2H3
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 1.19E+4n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504078
PNG
(CHEMBL4551836)
Show SMILES CCOC(=O)c1ccccc1Nc1cc(OC)cc2ccccc12
Show InChI InChI=1S/C20H19NO3/c1-3-24-20(22)17-10-6-7-11-18(17)21-19-13-15(23-2)12-14-8-4-5-9-16(14)19/h4-13,21H,3H2,1-2H3
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 1.25E+4n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50129575
PNG
(2,5-Dihydroxy-3-(1H-indol-3-yl)-[1,4]benzoquinone ...)
Show SMILES O=C1CC(=O)C(=O)C(c2c[nH]c3ccccc23)C1=O
Show InChI InChI=1S/C14H9NO4/c16-10-5-11(17)14(19)12(13(10)18)8-6-15-9-4-2-1-3-7(8)9/h1-4,6,12,15H,5H2
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 1.30E+4n/an/an/an/an/an/an/an/a



Duke University

Curated by ChEMBL


Assay Description
Inhibitory constant of compound against Cdc25B phosphatase was determined using mFP as a substrate

J Med Chem 46: 2580-8 (2003)


Article DOI: 10.1021/jm0300835
BindingDB Entry DOI: 10.7270/Q2RJ4HVW
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504060
PNG
(CHEMBL4592345)
Show SMILES OC(=O)c1ccccc1Nc1cccc2c(O)cccc12
Show InChI InChI=1S/C17H13NO3/c19-16-10-4-6-11-12(16)7-3-9-14(11)18-15-8-2-1-5-13(15)17(20)21/h1-10,18-19H,(H,20,21)
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 1.34E+4n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504069
PNG
(CHEMBL4552533)
Show SMILES COc1cc(Nc2ccccc2C(O)=O)c2ccccc2c1
Show InChI InChI=1S/C18H15NO3/c1-22-13-10-12-6-2-3-7-14(12)17(11-13)19-16-9-5-4-8-15(16)18(20)21/h2-11,19H,1H3,(H,20,21)
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 1.69E+4n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504084
PNG
(CHEMBL4443206)
Show SMILES OC(=O)c1ccccc1Nc1cccc2ccccc12
Show InChI InChI=1S/C17H13NO2/c19-17(20)14-9-3-4-10-16(14)18-15-11-5-7-12-6-1-2-8-13(12)15/h1-11,18H,(H,19,20)
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 2.20E+4n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504072
PNG
(CHEMBL4561981)
Show SMILES OC(=O)c1cccc(Nc2cccc3ccccc23)c1
Show InChI InChI=1S/C17H13NO2/c19-17(20)13-7-3-8-14(11-13)18-16-10-4-6-12-5-1-2-9-15(12)16/h1-11,18H,(H,19,20)
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 3.00E+4n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Mixed inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate b...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504083
PNG
(CHEBI:34876 | CHEMBL170408)
Show SMILES N(c1ccccc1)c1cccc2ccccc12
Show InChI InChI=1S/C16H13N/c1-2-9-14(10-3-1)17-16-12-6-8-13-7-4-5-11-15(13)16/h1-12,17H
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 3.20E+4n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Mixed inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate b...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504082
PNG
(CHEMBL4437090)
Show SMILES OC(=O)c1ccccc1C(=O)c1cc(O)cc2ccccc12
Show InChI InChI=1S/C18H12O4/c19-12-9-11-5-1-2-6-13(11)16(10-12)17(20)14-7-3-4-8-15(14)18(21)22/h1-10,19H,(H,21,22)
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 3.40E+4n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504073
PNG
(CHEMBL4472907)
Show SMILES COc1cc(C(=O)c2ccccc2C(O)=O)c2ccccc2c1
Show InChI InChI=1S/C19H14O4/c1-23-13-10-12-6-2-3-7-14(12)17(11-13)18(20)15-8-4-5-9-16(15)19(21)22/h2-11H,1H3,(H,21,22)
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 3.60E+4n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Mixed inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate b...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50096693
PNG
((E)-2-Naphthalen-2-yl-ethenesulfonic acid (4,5-dip...)
Show SMILES O=S(=O)(Nc1nc(c(s1)-c1ccccc1)-c1ccccc1)\C=C\c1ccc2ccccc2c1
Show InChI InChI=1S/C27H20N2O2S2/c30-33(31,18-17-20-15-16-21-9-7-8-14-24(21)19-20)29-27-28-25(22-10-3-1-4-11-22)26(32-27)23-12-5-2-6-13-23/h1-19H,(H,28,29)/b18-17+
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 3.60E+4n/an/an/an/an/an/an/an/a



University of Pittsburgh

Curated by ChEMBL


Assay Description
Inhibitory activity against human recombinant Cdc25B phosphatase enzyme

Bioorg Med Chem Lett 11: 313-7 (2001)


BindingDB Entry DOI: 10.7270/Q2DR2TRG
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504059
PNG
(CHEMBL4465589)
Show SMILES Cl.CCOC(=O)c1cccc(Nc2cccc3c(N)cccc23)c1
Show InChI InChI=1S/C19H18N2O2/c1-2-23-19(22)13-6-3-7-14(12-13)21-18-11-5-8-15-16(18)9-4-10-17(15)20/h3-12,21H,2,20H2,1H3
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 3.60E+4n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Non-competitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as s...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504062
PNG
(CHEMBL4439019)
Show SMILES COc1ccc(Nc2cccc(c2)C(O)=O)c2ccccc12
Show InChI InChI=1S/C18H15NO3/c1-22-17-10-9-16(14-7-2-3-8-15(14)17)19-13-6-4-5-12(11-13)18(20)21/h2-11,19H,1H3,(H,20,21)
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 4.50E+4n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504061
PNG
(CHEMBL4452849)
Show SMILES CCOC(=O)c1ccccc1C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H16O3/c1-2-23-20(22)18-12-6-5-11-17(18)19(21)16-13-7-9-14-8-3-4-10-15(14)16/h3-13H,2H2,1H3
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 5.40E+4n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Mixed inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate b...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50504076
PNG
(CHEMBL4543585)
Show SMILES COc1cc(Nc2cccc(c2)C(O)=O)c2ccccc2c1
Show InChI InChI=1S/C18H15NO3/c1-22-15-10-12-5-2-3-8-16(12)17(11-15)19-14-7-4-6-13(9-14)18(20)21/h2-11,19H,1H3,(H,20,21)
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 5.50E+4n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Uncompetitive inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as sub...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM52026
PNG
(2-(1-naphthoyl)benzoic acid | 2-(naphthalene-1-car...)
Show SMILES OC(=O)c1ccccc1C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C18H12O3/c19-17(15-9-3-4-10-16(15)18(20)21)14-11-5-7-12-6-1-2-8-13(12)14/h1-11H,(H,20,21)
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PubMed
 6.90E+4n/an/an/an/an/an/an/an/a



University of Naples Federico II

Curated by ChEMBL


Assay Description
Mixed inhibition of N-terminal His6-tagged human CDC25B (377 to 550 residues) expressed in Escherichia coli BL21(DE3) cells using OMFP as substrate b...

J Med Chem 62: 7089-7110 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00632
BindingDB Entry DOI: 10.7270/Q20005B5
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50388538
PNG
(CHEMBL507159)
Show SMILES COc1ccc(Cc2ccc3[nH]c(=O)cc(C)c3c2)cc1S(O)(=O)=O
Show InChI InChI=1S/C18H17NO5S/c1-11-7-18(20)19-15-5-3-12(9-14(11)15)8-13-4-6-16(24-2)17(10-13)25(21,22)23/h3-7,9-10H,8H2,1-2H3,(H,19,20)(H,21,22,23)
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 8.40E+4n/an/an/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate...

J Med Chem 55: 4142-58 (2012)


Article DOI: 10.1021/jm201624h
BindingDB Entry DOI: 10.7270/Q2X34ZJ9
More data for this
Ligand-Target Pair
M-phase inducer phosphatase 2


(Homo sapiens (Human))		BDBM50328823
PNG
(5,5'-(3-(pyridin-2-yl)-1,2,4-triazine-5,6-diyl)dif...)
Show SMILES OS(=O)(=O)c1ccc(o1)-c1nnc(nc1-c1ccc(o1)S(O)(=O)=O)-c1ccccn1
Show InChI InChI=1S/C16H10N4O8S2/c21-29(22,23)12-6-4-10(27-12)14-15(11-5-7-13(28-11)30(24,25)26)19-20-16(18-14)9-3-1-2-8-17-9/h1-8H,(H,21,22,23)(H,24,25,26)
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 1.59E+5n/an/an/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate...

J Med Chem 55: 4142-58 (2012)


Article DOI: 10.1021/jm201624h
BindingDB Entry DOI: 10.7270/Q2X34ZJ9
More data for this
Ligand-Target Pair