Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50607111 (CHEMBL5218807) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50256796 (6,7-Dihydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphen...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Modena and R.E. Curated by ChEMBL | Assay Description Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 by competitive inhibition assay | Bioorg Med Chem 17: 2658-72 (2009) Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50256796 (6,7-Dihydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphen...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Modena and R.E. Curated by ChEMBL | Assay Description Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 by competitive inhibition assay | Bioorg Med Chem 17: 2658-72 (2009) Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM199180 (US9217012, 10) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+3 | >-34.2 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Indiana University Research and Technology Corporation US Patent | Assay Description PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in DMG buffer (50 mM DMG, pH 7.0, 1 mM EDTA, 150 mM NaCl, 2 mM DTT, 0.1 ... | US Patent US9217012 (2015) BindingDB Entry DOI: 10.7270/Q2FX788H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50558461 (CHEMBL4760367) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Competitive inhibition of His-tagged LMW-PTP isoform A (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00993 BindingDB Entry DOI: 10.7270/Q2DN48Q4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50558482 (CHEMBL4742123) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Competitive inhibition of LMW-PTP isoform B (unknown origin) using para-nitrophenyl phosphate as substrate by Lineweaver-Burk plot analysis | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00993 BindingDB Entry DOI: 10.7270/Q2DN48Q4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50257418 (7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(3'',4''-dihydro...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.23E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Modena and R.E. Curated by ChEMBL | Assay Description Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 by mixed type inhibition assay | Bioorg Med Chem 17: 2658-72 (2009) Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50257294 (7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Modena and R.E. Curated by ChEMBL | Assay Description Inhibition of human cloned LMW-PTP isoform 1 expressed in Escherichia coli TB1 by mixed type inhibition assay | Bioorg Med Chem 17: 2658-72 (2009) Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50257418 (7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(3'',4''-dihydro...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Modena and R.E. Curated by ChEMBL | Assay Description Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 by mixed type inhibition assay | Bioorg Med Chem 17: 2658-72 (2009) Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50558482 (CHEMBL4742123) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Competitive inhibition of His-tagged LMW-PTP isoform A (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00993 BindingDB Entry DOI: 10.7270/Q2DN48Q4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50250606 (CHEMBL4077342) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University Curated by ChEMBL | Assay Description Inhibition of LMW-PTP (unknown origin) using pNPP as substrate preincubated for 5 mins followed by substrate addition measured for 20 mins by spectro... | J Med Chem 60: 9299-9319 (2017) Article DOI: 10.1021/acs.jmedchem.7b01292 BindingDB Entry DOI: 10.7270/Q2NZ8B27 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50257294 (7-Hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Modena and R.E. Curated by ChEMBL | Assay Description Inhibition of human cloned LMW-PTP isoform 2 expressed in Escherichia coli TB1 by mixed type inhibition assay | Bioorg Med Chem 17: 2658-72 (2009) Article DOI: 10.1016/j.bmc.2009.02.060 BindingDB Entry DOI: 10.7270/Q2K0745F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50118216 ((4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl di...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Saint John's University Curated by ChEMBL | Assay Description Competitive inhibition of LMW-PTP isoform A (unknown origin) | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.127342 BindingDB Entry DOI: 10.7270/Q2FJ2MBV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50312261 ((4-(4-bromo-3,5-bis(trifluoromethyl)phenylcarbamoy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of human HCPTPA | Bioorg Med Chem Lett 19: 6851-4 (2009) Article DOI: 10.1016/j.bmcl.2009.10.090 BindingDB Entry DOI: 10.7270/Q21G0MDK | |||||||||||
More data for this Ligand-Target Pair |