Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA (cytosine-5)-methyltransferase 1 (Homo sapiens (Human)) | BDBM50431676 (CHEMBL2349526) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 950 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
EntreMed Inc. Curated by ChEMBL | Assay Description Inhibition of DNMT1 (unknown origin) using [3H]-SAM assessed as inhibition of dsDNA methylation after 1 hr by scintillation proximity assay | Bioorg Med Chem 21: 1787-94 (2013) Article DOI: 10.1016/j.bmc.2013.01.049 BindingDB Entry DOI: 10.7270/Q24F1S41 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA (cytosine-5)-methyltransferase 1 (Homo sapiens (Human)) | BDBM50470562 (CHEMBL1230055) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Medical Sciences and Peking Union Medical College Curated by ChEMBL | Assay Description Inhibition of human DNMT1A using double-stranded hemi-DNA oligonucleotide as substrate measured after 40 mins by [3H]methyl incorporation assay | Eur J Med Chem 157: 994-1004 (2018) Article DOI: 10.1016/j.ejmech.2018.08.057 BindingDB Entry DOI: 10.7270/Q2V98BSZ | |||||||||||
More data for this Ligand-Target Pair |