Compile Data Set for Download or QSAR

Found 5096 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 3'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM6190 (3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6...) Show SMILES CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FGFR3 by cellular assay				Proc Natl Acad Sci USA 104: 19936-41 (2007) Article DOI: 10.1073/pnas.0707498104 BindingDB Entry DOI: 10.7270/Q24X58QS
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM482158 (BDBM50242742 | TAE684) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1 Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of FGFR3				Proc Natl Acad Sci USA 104: 19936-41 (2007) Article DOI: 10.1073/pnas.0707498104 BindingDB Entry DOI: 10.7270/Q24X58QS
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM286984 (8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dich...) Show SMILES CNc1ncc2cc(-c3c(Cl)c(OC)cc(OC)c3Cl)c(=O)n(CCCN3CCN(CC3)C(=O)C=C)c2n1 |(-6.67,-.77,;-6.67,.77,;-5.33,1.54,;-5.33,3.08,;-4,3.85,;-2.67,3.08,;-1.33,3.85,;,3.08,;1.33,3.85,;1.33,5.39,;,6.16,;2.67,6.16,;2.67,7.7,;1.33,8.47,;4,5.39,;4,3.85,;5.33,3.08,;6.67,3.85,;2.67,3.08,;2.67,1.54,;,1.54,;1.33,.77,;-1.33,.77,;-1.33,-.77,;,-1.54,;,-3.08,;1.33,-3.85,;1.33,-5.39,;2.67,-6.16,;4,-5.39,;4,-3.85,;2.67,-3.08,;5.33,-6.16,;6.67,-5.39,;5.33,-7.7,;6.67,-8.47,;-2.67,1.54,;-4,.77,)| Show InChI InChI=1S/C26H30Cl2N6O4/c1-5-20(35)33-11-9-32(10-12-33)7-6-8-34-24-16(15-30-26(29-2)31-24)13-17(25(34)36)21-22(27)18(37-3)14-19(38-4)23(21)28/h5,13-15H,1,6-12H2,2-4H3,(H,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Principia Biopharma, Inc. Curated by ChEMBL					Assay Description Irreversible inhibition of human FGFR3 preincubated with enzyme followed by peptide substrate addition by caliper capillary electrophoresis method				J Med Chem 60: 6516-6527 (2017) Article DOI: 10.1021/acs.jmedchem.7b00360 BindingDB Entry DOI: 10.7270/Q2C53P3H
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445224 (US10669235, Example 15) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCN(CC(=O)NCCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H35N5O6/c1-21-18-26-27(19-25(21)33(43)44-2)36-31(41)29(26)30(22-6-4-3-5-7-22)35-24-10-8-23(9-11-24)32(42)38-15-13-37(14-16-38)20-28(40)34-12-17-39/h3-11,18-19,35,39H,12-17,20H2,1-2H3,(H,34,40)(H,36,41)/b30-29-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM531233 ((Z)-Methyl 3-(((4-(4-(2-((2-hydroxyethyl)amino)-2-...) Show SMILES COC(=O)c1cc2N(C(C)=O)C(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCN(CC(=O)OC(C)(C)C)CC3)c3ccccc3)c2cc1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445226 (US10669235, Example 17 | US11208381, Example 17) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C30H30N4O4/c1-19-17-24-25(18-23(19)30(37)38-3)32-28(35)26(24)27(20-7-5-4-6-8-20)31-22-11-9-21(10-12-22)29(36)34-15-13-33(2)14-16-34/h4-12,17-18,31H,13-16H2,1-3H3,(H,32,35)/b27-26-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445226 (US10669235, Example 17 | US11208381, Example 17) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C30H30N4O4/c1-19-17-24-25(18-23(19)30(37)38-3)32-28(35)26(24)27(20-7-5-4-6-8-20)31-22-11-9-21(10-12-22)29(36)34-15-13-33(2)14-16-34/h4-12,17-18,31H,13-16H2,1-3H3,(H,32,35)/b27-26-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445223 (US10669235, Example 14 | US10669235, Example 50 | ...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H36N4O5/c1-21-18-27-28(19-26(21)33(41)42-2)36-32(40)29(27)30(23-6-4-3-5-7-23)35-25-10-8-24(9-11-25)31(39)34-20-22-12-14-37(15-13-22)16-17-38/h3-11,18-19,22,35,38H,12-17,20H2,1-2H3,(H,34,39)(H,36,40)/b30-29-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445223 (US10669235, Example 14 | US10669235, Example 50 | ...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H36N4O5/c1-21-18-27-28(19-26(21)33(41)42-2)36-32(40)29(27)30(23-6-4-3-5-7-23)35-25-10-8-24(9-11-25)31(39)34-20-22-12-14-37(15-13-22)16-17-38/h3-11,18-19,22,35,38H,12-17,20H2,1-2H3,(H,34,39)(H,36,40)/b30-29-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445223 (US10669235, Example 14 | US10669235, Example 50 | ...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H36N4O5/c1-21-18-27-28(19-26(21)33(41)42-2)36-32(40)29(27)30(23-6-4-3-5-7-23)35-25-10-8-24(9-11-25)31(39)34-20-22-12-14-37(15-13-22)16-17-38/h3-11,18-19,22,35,38H,12-17,20H2,1-2H3,(H,34,39)(H,36,40)/b30-29-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445223 (US10669235, Example 14 | US10669235, Example 50 | ...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCC3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H36N4O5/c1-21-18-27-28(19-26(21)33(41)42-2)36-32(40)29(27)30(23-6-4-3-5-7-23)35-25-10-8-24(9-11-25)31(39)34-20-22-12-14-37(15-13-22)16-17-38/h3-11,18-19,22,35,38H,12-17,20H2,1-2H3,(H,34,39)(H,36,40)/b30-29-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445209 (US10669235, Nintedanib) Show SMILES COC(=O)c1ccc2c(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)c(O)[nH]c2c1 |w:10.10| Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,33,38H,15-18,20H2,1-3H3/b32-29+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	5.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM50026612 (BIBF-1120 | Nintedanib | US10981896, Compound Nint...) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	5.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM50026612 (BIBF-1120 | Nintedanib | US10981896, Compound Nint...) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	5.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				Citation and Details BindingDB Entry DOI: 10.7270/Q27084K3
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM507116 (US11046672, Example 66) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CC4CC(C3)N4)c3ccccc3)c2cc1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				Citation and Details BindingDB Entry DOI: 10.7270/Q27084K3
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445241 (US10669235, Example 32 | US11208381, Example 32) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(CCO)CCN(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H34N4O5/c1-20-18-25-26(19-24(20)31(39)40-4)33-29(37)27(25)28(21-8-6-5-7-9-21)32-23-12-10-22(11-13-23)30(38)35(16-17-36)15-14-34(2)3/h5-13,18-19,32,36H,14-17H2,1-4H3,(H,33,37)/b28-27-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.65	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445241 (US10669235, Example 32 | US11208381, Example 32) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(CCO)CCN(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H34N4O5/c1-20-18-25-26(19-24(20)31(39)40-4)33-29(37)27(25)28(21-8-6-5-7-9-21)32-23-12-10-22(11-13-23)30(38)35(16-17-36)15-14-34(2)3/h5-13,18-19,32,36H,14-17H2,1-4H3,(H,33,37)/b28-27-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.65	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM507113 (US11046672, Example 62) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCN[C@@H](C)C3)c3ccccc3)c2cc1C |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.78	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				Citation and Details BindingDB Entry DOI: 10.7270/Q27084K3
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM507056 ((Z)-Methyl 3-(((4-((2-(dimethylamino)ethoxy)carbam...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(C(=O)NOCCN(C)C)c(C)c3)c3ccccc3)c2cc1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.78	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				Citation and Details BindingDB Entry DOI: 10.7270/Q27084K3
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445247 (US10669235, Example 38 | US11208381, Example 38) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC(CO)(CN(C)C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C34H38N4O5/c1-22-18-27-28(19-26(22)33(42)43-4)36-31(40)29(27)30(23-8-6-5-7-9-23)35-25-12-10-24(11-13-25)32(41)38-16-14-34(21-39,15-17-38)20-37(2)3/h5-13,18-19,35,39H,14-17,20-21H2,1-4H3,(H,36,40)/b30-29-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.93	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445247 (US10669235, Example 38 | US11208381, Example 38) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCC(CO)(CN(C)C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C34H38N4O5/c1-22-18-27-28(19-26(22)33(42)43-4)36-31(40)29(27)30(23-8-6-5-7-9-23)35-25-12-10-24(11-13-25)32(41)38-16-14-34(21-39,15-17-38)20-37(2)3/h5-13,18-19,35,39H,14-17,20-21H2,1-4H3,(H,36,40)/b30-29-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	6.93	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM507090 (US11046672, Example 39) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CCN(CCO)CC3)c3ccccc3)C(=O)Nc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.06	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				Citation and Details BindingDB Entry DOI: 10.7270/Q27084K3
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445222 (US10669235, Example 13 | US10669235, Example 49 | ...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O5/c1-20-18-26-27(19-25(20)32(40)41-2)35-31(39)28(26)29(21-6-4-3-5-7-21)33-23-10-8-22(9-11-23)30(38)34-24-12-14-36(15-13-24)16-17-37/h3-11,18-19,24,33,37H,12-17H2,1-2H3,(H,34,38)(H,35,39)/b29-28-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445222 (US10669235, Example 13 | US10669235, Example 49 | ...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O5/c1-20-18-26-27(19-25(20)32(40)41-2)35-31(39)28(26)29(21-6-4-3-5-7-21)33-23-10-8-22(9-11-23)30(38)34-24-12-14-36(15-13-24)16-17-37/h3-11,18-19,24,33,37H,12-17H2,1-2H3,(H,34,38)(H,35,39)/b29-28-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445222 (US10669235, Example 13 | US10669235, Example 49 | ...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O5/c1-20-18-26-27(19-25(20)32(40)41-2)35-31(39)28(26)29(21-6-4-3-5-7-21)33-23-10-8-22(9-11-23)30(38)34-24-12-14-36(15-13-24)16-17-37/h3-11,18-19,24,33,37H,12-17H2,1-2H3,(H,34,38)(H,35,39)/b29-28-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445222 (US10669235, Example 13 | US10669235, Example 49 | ...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NC3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O5/c1-20-18-26-27(19-25(20)32(40)41-2)35-31(39)28(26)29(21-6-4-3-5-7-21)33-23-10-8-22(9-11-23)30(38)34-24-12-14-36(15-13-24)16-17-37/h3-11,18-19,24,33,37H,12-17H2,1-2H3,(H,34,38)(H,35,39)/b29-28-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445215 (US10669235, Example 6 | US11208381, Example 6) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCC(CC3)N(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C34H39N5O4/c1-22-20-28-29(21-27(22)34(42)43-4)37-33(41)30(28)31(23-8-6-5-7-9-23)36-25-12-10-24(11-13-25)32(40)35-16-19-39-17-14-26(15-18-39)38(2)3/h5-13,20-21,26,36H,14-19H2,1-4H3,(H,35,40)(H,37,41)/b31-30-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445215 (US10669235, Example 6 | US11208381, Example 6) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCC(CC3)N(C)C)c3ccccc3)c2cc1C Show InChI InChI=1S/C34H39N5O4/c1-22-20-28-29(21-27(22)34(42)43-4)37-33(41)30(28)31(23-8-6-5-7-9-23)36-25-12-10-24(11-13-25)32(40)35-16-19-39-17-14-26(15-18-39)38(2)3/h5-13,20-21,26,36H,14-19H2,1-4H3,(H,35,40)(H,37,41)/b31-30-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445242 (US10669235, Example 33 | US11208381, Example 33) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CC[C@@H](CN(C)C)[C@H](O)C3)c3ccccc3)c2cc1C |r| Show InChI InChI=1S/C33H36N4O5/c1-20-16-26-27(17-25(20)33(41)42-4)35-31(39)29(26)30(21-8-6-5-7-9-21)34-24-12-10-22(11-13-24)32(40)37-15-14-23(18-36(2)3)28(38)19-37/h5-13,16-17,23,28,34,38H,14-15,18-19H2,1-4H3,(H,35,39)/b30-29-/t23-,28+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445242 (US10669235, Example 33 | US11208381, Example 33) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CC[C@@H](CN(C)C)[C@H](O)C3)c3ccccc3)c2cc1C |r| Show InChI InChI=1S/C33H36N4O5/c1-20-16-26-27(17-25(20)33(41)42-4)35-31(39)29(26)30(21-8-6-5-7-9-21)34-24-12-10-22(11-13-24)32(40)37-15-14-23(18-36(2)3)28(38)19-37/h5-13,16-17,23,28,34,38H,14-15,18-19H2,1-4H3,(H,35,39)/b30-29-/t23-,28+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM507069 (US11046672, Example 18) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(C(=O)N(C)OCCN4CCN(C)CC4)c(C)c3)c3ccccc3)C(=O)Nc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.42	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				Citation and Details BindingDB Entry DOI: 10.7270/Q27084K3
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM507089 (US11046672, Example 38) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN3CC[C@@H](C3)N(C)C)c3ccccc3)C(=O)Nc2c1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.68	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				Citation and Details BindingDB Entry DOI: 10.7270/Q27084K3
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445255 (US10669235, Example 46 | US11208381, Example 46) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O5/c1-21-19-26-27(20-25(21)32(40)41-2)34-30(38)28(26)29(22-7-4-3-5-8-22)33-24-11-9-23(10-12-24)31(39)36-14-6-13-35(15-16-36)17-18-37/h3-5,7-12,19-20,33,37H,6,13-18H2,1-2H3,(H,34,38)/b29-28-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.78	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445255 (US10669235, Example 46 | US11208381, Example 46) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H34N4O5/c1-21-19-26-27(20-25(21)32(40)41-2)34-30(38)28(26)29(22-7-4-3-5-8-22)33-24-11-9-23(10-12-24)31(39)36-14-6-13-35(15-16-36)17-18-37/h3-5,7-12,19-20,33,37H,6,13-18H2,1-2H3,(H,34,38)/b29-28-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.78	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM507122 (US11046672, Example 73) Show SMILES CNC(=O)CN1CCN(CCONC(=O)c2ccc(N\C(=C3/C(=O)Nc4cc(C(=O)OC)c(C)cc34)c3ccccc3)cc2)CC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				Citation and Details BindingDB Entry DOI: 10.7270/Q27084K3
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM507115 (US11046672, Example 65) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCN[C@H](C)C3)c3ccccc3)c2cc1C |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	7.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				Citation and Details BindingDB Entry DOI: 10.7270/Q27084K3
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445213 (US10669235, Example 4 | US11208381, Example 4) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H35N5O4/c1-21-19-26-27(20-25(21)32(40)41-3)35-31(39)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(38)33-13-14-37-17-15-36(2)16-18-37/h4-12,19-20,34H,13-18H2,1-3H3,(H,33,38)(H,35,39)/b29-28-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.07	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445213 (US10669235, Example 4 | US11208381, Example 4) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NCCN3CCN(C)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C32H35N5O4/c1-21-19-26-27(20-25(21)32(40)41-3)35-31(39)28(26)29(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)30(38)33-13-14-37-17-15-36(2)16-18-37/h4-12,19-20,34H,13-18H2,1-3H3,(H,33,38)(H,35,39)/b29-28-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.07	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM507073 (US11046672, Example 22) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(C(=O)N(C)OCCN(C)C)c(C)c3)c3ccccc3)C(=O)Nc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				Citation and Details BindingDB Entry DOI: 10.7270/Q27084K3
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM507054 ((Z)-Methyl 3-(((4-((2-(dimethylamino)ethoxy)carbam...) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN(C)C)c3ccccc3)C(=O)Nc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				Citation and Details BindingDB Entry DOI: 10.7270/Q27084K3
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445257 (US10669235, Example 48 | US11208381, Example 48) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)[C@H]3CN(C)C[C@@H]3O)c3ccccc3)c2cc1C |r| Show InChI InChI=1S/C31H32N4O5/c1-18-14-23-24(15-22(18)31(39)40-4)33-29(37)27(23)28(19-8-6-5-7-9-19)32-21-12-10-20(11-13-21)30(38)35(3)25-16-34(2)17-26(25)36/h5-15,25-26,32,36H,16-17H2,1-4H3,(H,33,37)/b28-27-/t25-,26-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.47	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445257 (US10669235, Example 48 | US11208381, Example 48) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)[C@H]3CN(C)C[C@@H]3O)c3ccccc3)c2cc1C |r| Show InChI InChI=1S/C31H32N4O5/c1-18-14-23-24(15-22(18)31(39)40-4)33-29(37)27(23)28(19-8-6-5-7-9-19)32-21-12-10-20(11-13-21)30(38)35(3)25-16-34(2)17-26(25)36/h5-15,25-26,32,36H,16-17H2,1-4H3,(H,33,37)/b28-27-/t25-,26-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.47	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM507054 ((Z)-Methyl 3-(((4-((2-(dimethylamino)ethoxy)carbam...) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)C(=O)NOCCN(C)C)c3ccccc3)C(=O)Nc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.65	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				Citation and Details BindingDB Entry DOI: 10.7270/Q27084K3
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM507058 ((Z)-Methyl 3-(((4-((2-(4-(2-hydroxyethyl)piperazin...) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.85	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				Citation and Details BindingDB Entry DOI: 10.7270/Q27084K3
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM507109 (US11046672, Example 58) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)OCCN3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.96	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				Citation and Details BindingDB Entry DOI: 10.7270/Q27084K3
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445228 (US10669235, Example 19 | US11208381, Example 19) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O5/c1-20-18-25-26(19-24(20)31(39)40-2)33-29(37)27(25)28(21-6-4-3-5-7-21)32-23-10-8-22(9-11-23)30(38)35-14-12-34(13-15-35)16-17-36/h3-11,18-19,32,36H,12-17H2,1-2H3,(H,33,37)/b28-27-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.04	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445228 (US10669235, Example 19 | US11208381, Example 19) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C31H32N4O5/c1-20-18-25-26(19-24(20)31(39)40-2)33-29(37)27(25)28(21-6-4-3-5-7-21)32-23-10-8-22(9-11-23)30(38)35-14-12-34(13-15-35)16-17-36/h3-11,18-19,32,36H,12-17H2,1-2H3,(H,33,37)/b28-27-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.04	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445250 (US10669235, Example 41 | US11208381, Example 41) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)C3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H36N4O5/c1-21-19-27-28(20-26(21)33(41)42-3)35-31(39)29(27)30(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)32(40)36(2)25-13-15-37(16-14-25)17-18-38/h4-12,19-20,25,34,38H,13-18H2,1-3H3,(H,35,39)/b30-29-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Assay was performed in buffer containing 40 mM Tris pH 7.5, 20 mM MgCl2, 0.1 mg/mL BSA, 1 mM DTT and 2 mM MnCl2. The inhibitory activities of compoun...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XP784N
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM445250 (US10669235, Example 41 | US11208381, Example 41) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)N(C)C3CCN(CCO)CC3)c3ccccc3)c2cc1C Show InChI InChI=1S/C33H36N4O5/c1-21-19-27-28(20-26(21)33(41)42-3)35-31(39)29(27)30(22-7-5-4-6-8-22)34-24-11-9-23(10-12-24)32(40)36(2)25-13-15-37(16-14-25)17-18-38/h4-12,19-20,25,34,38H,13-18H2,1-3H3,(H,35,39)/b30-29-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				US Patent US10669235 (2020) BindingDB Entry DOI: 10.7270/Q2XW4NVJ
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM507102 (US11046672, Example 51) Show SMILES COC(=O)c1cc2NC(=O)\C(=C(/Nc3ccc(cc3)C(=O)NOCCN3CC[C@@H](C3)N(C)C)c3ccccc3)c2cc1C |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	9.39	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibitory activities of compounds of the invention against FGFR3 (FGFR3 Kinase Enzyme System: Promega), were evaluated by mixing the FGFR3 prote...				Citation and Details BindingDB Entry DOI: 10.7270/Q27084K3
					More data for this Ligand-Target Pair

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