Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM34529 (US8546404, 479 | US8546404, 489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM34531 (US8546404, 459) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM103289 (US8546404, 336) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 18.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM103292 (US8546404, 1729 | US8546404, 469) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM103293 (US8546404, 480) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM34529 (US8546404, 479 | US8546404, 489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM103300 (US8546404, 571) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 19.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM103291 (US8546404, 413) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 37.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM103290 (US8546404, 412) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 38.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM103295 (US8546404, 462) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM103294 (US8546404, 487) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM103302 (SCH772984 | US8546404, 6) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM103296 (US8546404, 622) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM103297 (US8546404, 613) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM103298 (US8546404, 825) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM34529 (US8546404, 479 | US8546404, 489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM103292 (US8546404, 1729 | US8546404, 469) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme US Patent | Assay Description Activated ERK2 activity was determined in the IMAP assay format. | US Patent US8546404 (2013) BindingDB Entry DOI: 10.7270/Q2959G61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154588 (US8999957, Column 141, Compound 4 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 25 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154589 (US8999957, Column 141, Compound 5 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 443 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154590 (US8999957, Column 141, Compound 6 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 124 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154591 (US8999957, Column 141, Compound 7 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 48.6 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154588 (US8999957, Column 141, Compound 4 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 26.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154589 (US8999957, Column 141, Compound 5 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 275 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154590 (US8999957, Column 141, Compound 6 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 77.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154591 (US8999957, Column 141, Compound 7 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 52.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154592 (US8999957, Column 143, Compound 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154593 (US8999957, Column 143, Compound 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154594 (US8999957, Column 145, Compound 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 195 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154595 (US8999957, Column 148, Compound 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 69.4 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154595 (US8999957, Column 148, Compound 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 124 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154597 (US8999957, Column 152, Compound 2 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 304 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154598 (US8999957, Column 153, Compound 3 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 166 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154599 (US8999957, Column 153, Compound 4 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154600 (US8999957, Column 153, Compound 5 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154597 (US8999957, Column 152, Compound 2 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 485 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154598 (US8999957, Column 153, Compound 3 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 224 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154599 (US8999957, Column 153, Compound 4 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154600 (US8999957, Column 153, Compound 5 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154601 (US8999957, Column 155, Compound 1 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | 7.2 | 25 |
Merck Sharp & Dohme Corp. US Patent | Assay Description Activity of compounds against inactive ERK2 was tested in a coupled MEK1/ERK2 IMAP assay as follows: Compounds were diluted to 25x final test concent... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154601 (US8999957, Column 155, Compound 1 | US8999957, Tab...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154602 (US8999957, Column 162-163, Compound 1 | US8999957,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 591 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154603 (US8999957, Column 162-163, Compound 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154604 (US8999957, Column 162-163, Compound 3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154605 (US8999957, Column 162-163, Compound 4 | US8999957,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 626 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154606 (US8999957, Column 162-163, Compound 5) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 999 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154607 (US8999957, Column 162-163, Compound 6) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154608 (US8999957, Column 162-163, Compound 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154609 (US8999957, Column 162-163, Compound 8) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 173 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154610 (US8999957, Column 162-163, Compound 9) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 22.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 μl of 25× compound was a... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Mus musculus (Mouse)) | BDBM154611 (US8999957, Column 162-163, Compound 10) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 206 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Condition 2: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each comp... | US Patent US8999957 (2015) BindingDB Entry DOI: 10.7270/Q2GB22S9 | |||||||||||
More data for this Ligand-Target Pair |
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