Compile Data Set for Download or QSAR

Found 16452 hits Enz. Inhib. hit(s) with Target = 'SRC'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50242740 (CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...) Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of Lck by cellular assay				Proc Natl Acad Sci USA 104: 19936-41 (2007) Article DOI: 10.1073/pnas.0707498104 BindingDB Entry DOI: 10.7270/Q24X58QS
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50242740 (CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...) Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of Src by cellular assay				Proc Natl Acad Sci USA 104: 19936-41 (2007) Article DOI: 10.1073/pnas.0707498104 BindingDB Entry DOI: 10.7270/Q24X58QS
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340095 ((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...) Show SMILES CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2nccs2)c2c(N)nccn12 |r| Show InChI InChI=1S/C24H21N7O2S/c1-2-4-18(32)30-12-3-5-17(30)22-28-19(20-21(25)26-10-13-31(20)22)15-6-8-16(9-7-15)23(33)29-24-27-11-14-34-24/h6-11,13-14,17H,3,5,12H2,1H3,(H2,25,26)(H,27,29,33)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340196 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)-c3ccccc3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C31H27N7O2/c1-2-26(39)37-17-6-9-24(37)30-36-27(28-29(32)34-16-18-38(28)30)21-10-12-22(13-11-21)31(40)35-25-19-23(14-15-33-25)20-7-4-3-5-8-20/h2-5,7-8,10-16,18-19,24H,1,6,9,17H2,(H2,32,34)(H,33,35,40)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340162 ((S)-4-(8-amino-3-(1-but-2- ynoylpiperidin-2-yl)imi...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCCN3C(=O)C#CC)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C30H31N7O2/c1-3-7-20-14-15-32-24(19-20)34-30(39)22-12-10-21(11-13-22)26-27-28(31)33-16-18-37(27)29(35-26)23-9-5-6-17-36(23)25(38)8-4-2/h10-16,18-19,23H,3,5-7,9,17H2,1-2H3,(H2,31,33)(H,32,34,39)/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340167 ((S,E)-4-(8-amino-3-(1-(4- (dimethylamino)-N-methyl...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@H](C)N(C)C(=O)\C=C\CN(C)C)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C30H36N8O2/c1-6-8-21-14-15-32-24(19-21)34-30(40)23-12-10-22(11-13-23)26-27-28(31)33-16-18-38(27)29(35-26)20(2)37(5)25(39)9-7-17-36(3)4/h7,9-16,18-20H,6,8,17H2,1-5H3,(H2,31,33)(H,32,34,40)/b9-7+/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340079 ((S,E)-4-(8-amino-3-(1- cinnamoylpyrrolidin-2- yl)i...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)[C@@H]1CCCN1C(=O)\C=C\c1ccccc1 |r| Show InChI InChI=1S/C31H27N7O2/c32-29-28-27(22-12-14-23(15-13-22)31(40)35-25-10-4-5-17-33-25)36-30(38(28)20-18-34-29)24-9-6-19-37(24)26(39)16-11-21-7-2-1-3-8-21/h1-5,7-8,10-18,20,24H,6,9,19H2,(H2,32,34)(H,33,35,40)/b16-11+/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340185 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C#N)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C26H22N8O2/c1-2-21(35)33-12-3-4-19(33)25-32-22(23-24(28)30-11-13-34(23)25)17-5-7-18(8-6-17)26(36)31-20-14-16(15-27)9-10-29-20/h2,5-11,13-14,19H,1,3-4,12H2,(H2,28,30)(H,29,31,36)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340187 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Cc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C26H25N7O2/c1-3-21(34)32-13-4-5-19(32)25-31-22(23-24(27)29-12-14-33(23)25)17-6-8-18(9-7-17)26(35)30-20-15-16(2)10-11-28-20/h3,6-12,14-15,19H,1,4-5,13H2,2H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340188 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C28H29N7O2/c1-3-6-18-12-13-30-22(17-18)32-28(37)20-10-8-19(9-11-20)24-25-26(29)31-14-16-35(25)27(33-24)21-7-5-15-34(21)23(36)4-2/h4,8-14,16-17,21H,2-3,5-7,15H2,1H3,(H2,29,31)(H,30,32,37)/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340189 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES CCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C27H27N7O2/c1-3-17-11-12-29-21(16-17)31-27(36)19-9-7-18(8-10-19)23-24-25(28)30-13-15-34(24)26(32-23)20-6-5-14-33(20)22(35)4-2/h4,7-13,15-16,20H,2-3,5-6,14H2,1H3,(H2,28,30)(H,29,31,36)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340195 ((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...) Show SMILES CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)-c2ccccc2)c2c(N)nccn12 |r| Show InChI InChI=1S/C32H27N7O2/c1-2-7-27(40)38-18-6-10-25(38)31-37-28(29-30(33)35-17-19-39(29)31)22-11-13-23(14-12-22)32(41)36-26-20-24(15-16-34-26)21-8-4-3-5-9-21/h3-5,8-9,11-17,19-20,25H,6,10,18H2,1H3,(H2,33,35)(H,34,36,41)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340196 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)-c3ccccc3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C31H27N7O2/c1-2-26(39)37-17-6-9-24(37)30-36-27(28-29(32)34-16-18-38(28)30)21-10-12-22(13-11-21)31(40)35-25-19-23(14-15-33-25)20-7-4-3-5-8-20/h2-5,7-8,10-16,18-19,24H,1,6,9,17H2,(H2,32,34)(H,33,35,40)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340095 ((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...) Show SMILES CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2nccs2)c2c(N)nccn12 |r| Show InChI InChI=1S/C24H21N7O2S/c1-2-4-18(32)30-12-3-5-17(30)22-28-19(20-21(25)26-10-13-31(20)22)15-6-8-16(9-7-15)23(33)29-24-27-11-14-34-24/h6-11,13-14,17H,3,5,12H2,1H3,(H2,25,26)(H,27,29,33)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340160 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C26H22F3N7O2/c1-2-20(37)35-12-3-4-18(35)24-34-21(22-23(30)32-11-13-36(22)24)15-5-7-16(8-6-15)25(38)33-19-14-17(9-10-31-19)26(27,28)29/h2,5-11,13-14,18H,1,3-4,12H2,(H2,30,32)(H,31,33,38)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340162 ((S)-4-(8-amino-3-(1-but-2- ynoylpiperidin-2-yl)imi...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCCN3C(=O)C#CC)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C30H31N7O2/c1-3-7-20-14-15-32-24(19-20)34-30(39)22-12-10-21(11-13-22)26-27-28(31)33-16-18-37(27)29(35-26)23-9-5-6-17-36(23)25(38)8-4-2/h10-16,18-19,23H,3,5-7,9,17H2,1-2H3,(H2,31,33)(H,32,34,39)/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340167 ((S,E)-4-(8-amino-3-(1-(4- (dimethylamino)-N-methyl...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@H](C)N(C)C(=O)\C=C\CN(C)C)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C30H36N8O2/c1-6-8-21-14-15-32-24(19-21)34-30(40)23-12-10-22(11-13-23)26-27-28(31)33-16-18-38(27)29(35-26)20(2)37(5)25(39)9-7-17-36(3)4/h7,9-16,18-20H,6,8,17H2,1-5H3,(H2,31,33)(H,32,34,40)/b9-7+/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340079 ((S,E)-4-(8-amino-3-(1- cinnamoylpyrrolidin-2- yl)i...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)[C@@H]1CCCN1C(=O)\C=C\c1ccccc1 |r| Show InChI InChI=1S/C31H27N7O2/c32-29-28-27(22-12-14-23(15-13-22)31(40)35-25-10-4-5-17-33-25)36-30(38(28)20-18-34-29)24-9-6-19-37(24)26(39)16-11-21-7-2-1-3-8-21/h1-5,7-8,10-18,20,24H,6,9,19H2,(H2,32,34)(H,33,35,40)/b16-11+/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340185 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C#N)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C26H22N8O2/c1-2-21(35)33-12-3-4-19(33)25-32-22(23-24(28)30-11-13-34(23)25)17-5-7-18(8-6-17)26(36)31-20-14-16(15-27)9-10-29-20/h2,5-11,13-14,19H,1,3-4,12H2,(H2,28,30)(H,29,31,36)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340187 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Cc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C26H25N7O2/c1-3-21(34)32-13-4-5-19(32)25-31-22(23-24(27)29-12-14-33(23)25)17-6-8-18(9-7-17)26(35)30-20-15-16(2)10-11-28-20/h3,6-12,14-15,19H,1,4-5,13H2,2H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340188 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C28H29N7O2/c1-3-6-18-12-13-30-22(17-18)32-28(37)20-10-8-19(9-11-20)24-25-26(29)31-14-16-35(25)27(33-24)21-7-5-15-34(21)23(36)4-2/h4,8-14,16-17,21H,2-3,5-7,15H2,1H3,(H2,29,31)(H,30,32,37)/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340189 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES CCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C27H27N7O2/c1-3-17-11-12-29-21(16-17)31-27(36)19-9-7-18(8-10-19)23-24-25(28)30-13-15-34(24)26(32-23)20-6-5-14-33(20)22(35)4-2/h4,7-13,15-16,20H,2-3,5-6,14H2,1H3,(H2,28,30)(H,29,31,36)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340195 ((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...) Show SMILES CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)-c2ccccc2)c2c(N)nccn12 |r| Show InChI InChI=1S/C32H27N7O2/c1-2-7-27(40)38-18-6-10-25(38)31-37-28(29-30(33)35-17-19-39(29)31)22-11-13-23(14-12-22)32(41)36-26-20-24(15-16-34-26)21-8-4-3-5-9-21/h3-5,8-9,11-17,19-20,25H,6,10,18H2,1H3,(H2,33,35)(H,34,36,41)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340196 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)-c3ccccc3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C31H27N7O2/c1-2-26(39)37-17-6-9-24(37)30-36-27(28-29(32)34-16-18-38(28)30)21-10-12-22(13-11-21)31(40)35-25-19-23(14-15-33-25)20-7-4-3-5-8-20/h2-5,7-8,10-16,18-19,24H,1,6,9,17H2,(H2,32,34)(H,33,35,40)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340095 ((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...) Show SMILES CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2nccs2)c2c(N)nccn12 |r| Show InChI InChI=1S/C24H21N7O2S/c1-2-4-18(32)30-12-3-5-17(30)22-28-19(20-21(25)26-10-13-31(20)22)15-6-8-16(9-7-15)23(33)29-24-27-11-14-34-24/h6-11,13-14,17H,3,5,12H2,1H3,(H2,25,26)(H,27,29,33)/t17-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340160 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C26H22F3N7O2/c1-2-20(37)35-12-3-4-18(35)24-34-21(22-23(30)32-11-13-36(22)24)15-5-7-16(8-6-15)25(38)33-19-14-17(9-10-31-19)26(27,28)29/h2,5-11,13-14,18H,1,3-4,12H2,(H2,30,32)(H,31,33,38)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340162 ((S)-4-(8-amino-3-(1-but-2- ynoylpiperidin-2-yl)imi...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCCN3C(=O)C#CC)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C30H31N7O2/c1-3-7-20-14-15-32-24(19-20)34-30(39)22-12-10-21(11-13-22)26-27-28(31)33-16-18-37(27)29(35-26)23-9-5-6-17-36(23)25(38)8-4-2/h10-16,18-19,23H,3,5-7,9,17H2,1-2H3,(H2,31,33)(H,32,34,39)/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340167 ((S,E)-4-(8-amino-3-(1-(4- (dimethylamino)-N-methyl...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@H](C)N(C)C(=O)\C=C\CN(C)C)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C30H36N8O2/c1-6-8-21-14-15-32-24(19-21)34-30(40)23-12-10-22(11-13-23)26-27-28(31)33-16-18-38(27)29(35-26)20(2)37(5)25(39)9-7-17-36(3)4/h7,9-16,18-20H,6,8,17H2,1-5H3,(H2,31,33)(H,32,34,40)/b9-7+/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340079 ((S,E)-4-(8-amino-3-(1- cinnamoylpyrrolidin-2- yl)i...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)[C@@H]1CCCN1C(=O)\C=C\c1ccccc1 |r| Show InChI InChI=1S/C31H27N7O2/c32-29-28-27(22-12-14-23(15-13-22)31(40)35-25-10-4-5-17-33-25)36-30(38(28)20-18-34-29)24-9-6-19-37(24)26(39)16-11-21-7-2-1-3-8-21/h1-5,7-8,10-18,20,24H,6,9,19H2,(H2,32,34)(H,33,35,40)/b16-11+/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340185 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C#N)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C26H22N8O2/c1-2-21(35)33-12-3-4-19(33)25-32-22(23-24(28)30-11-13-34(23)25)17-5-7-18(8-6-17)26(36)31-20-14-16(15-27)9-10-29-20/h2,5-11,13-14,19H,1,3-4,12H2,(H2,28,30)(H,29,31,36)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340187 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Cc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C26H25N7O2/c1-3-21(34)32-13-4-5-19(32)25-31-22(23-24(27)29-12-14-33(23)25)17-6-8-18(9-7-17)26(35)30-20-15-16(2)10-11-28-20/h3,6-12,14-15,19H,1,4-5,13H2,2H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340188 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C28H29N7O2/c1-3-6-18-12-13-30-22(17-18)32-28(37)20-10-8-19(9-11-20)24-25-26(29)31-14-16-35(25)27(33-24)21-7-5-15-34(21)23(36)4-2/h4,8-14,16-17,21H,2-3,5-7,15H2,1H3,(H2,29,31)(H,30,32,37)/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340189 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES CCc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C27H27N7O2/c1-3-17-11-12-29-21(16-17)31-27(36)19-9-7-18(8-10-19)23-24-25(28)30-13-15-34(24)26(32-23)20-6-5-14-33(20)22(35)4-2/h4,7-13,15-16,20H,2-3,5-6,14H2,1H3,(H2,28,30)(H,29,31,36)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340195 ((S)-4-(8-amino-3-(1-but-2- ynoylpyrrolidin-2-yl)im...) Show SMILES CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)-c2ccccc2)c2c(N)nccn12 |r| Show InChI InChI=1S/C32H27N7O2/c1-2-7-27(40)38-18-6-10-25(38)31-37-28(29-30(33)35-17-19-39(29)31)22-11-13-23(14-12-22)32(41)36-26-20-24(15-16-34-26)21-8-4-3-5-9-21/h3-5,8-9,11-17,19-20,25H,6,10,18H2,1H3,(H2,33,35)(H,34,36,41)/t25-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340160 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C26H22F3N7O2/c1-2-20(37)35-12-3-4-18(35)24-34-21(22-23(30)32-11-13-36(22)24)15-5-7-16(8-6-15)25(38)33-19-14-17(9-10-31-19)26(27,28)29/h2,5-11,13-14,18H,1,3-4,12H2,(H2,30,32)(H,31,33,38)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM340092 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)pyrro...) Show SMILES COC\C=C\C(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2cc(C)ccn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C28H29N7O3/c1-18-11-12-30-22(17-18)32-28(37)20-9-7-19(8-10-20)24-25-26(29)31-13-15-35(25)27(33-24)21-5-3-14-34(21)23(36)6-4-16-38-2/h4,6-13,15,17,21H,3,5,14,16H2,1-2H3,(H2,29,31)(H,30,32,37)/b6-4+/t21-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Src enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Src enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM482158 (BDBM50242742 | TAE684) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1 Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of Lck by cellular assay				Proc Natl Acad Sci USA 104: 19936-41 (2007) Article DOI: 10.1073/pnas.0707498104 BindingDB Entry DOI: 10.7270/Q24X58QS
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM482158 (BDBM50242742 | TAE684) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1 Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of Src by cellular assay				Proc Natl Acad Sci USA 104: 19936-41 (2007) Article DOI: 10.1073/pnas.0707498104 BindingDB Entry DOI: 10.7270/Q24X58QS
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340104 ((S)-4-(8-amino-3-(1-(2- chloropyrimidine-4- carbon...) Show SMILES Nc1nccn2c(nc(-c3ccc(C(=O)Nc4ccccn4)c(F)c3)c12)[C@@H]1CCCN1C(=O)c1ccnc(Cl)n1 |r| Show InChI InChI=1S/C27H21ClFN9O2/c28-27-33-10-8-18(34-27)26(40)37-12-3-4-19(37)24-36-21(22-23(30)32-11-13-38(22)24)15-6-7-16(17(29)14-15)25(39)35-20-5-1-2-9-31-20/h1-2,5-11,13-14,19H,3-4,12H2,(H2,30,32)(H,31,35,39)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340071 (4-(8-amino-3-((S)-1-((E)-4- methoxybut-2-enoyl)pip...) Show SMILES COC\C=C\C(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2C)C(=O)Nc2ccccn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C29H31N7O3/c1-19-18-20(29(38)33-23-9-3-5-13-31-23)11-12-21(19)25-26-27(30)32-14-16-36(26)28(34-25)22-8-4-6-15-35(22)24(37)10-7-17-39-2/h3,5,7,9-14,16,18,22H,4,6,8,15,17H2,1-2H3,(H2,30,32)(H,31,33,38)/b10-7+/t22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340072 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) Show SMILES COC\C=C\C(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccncn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C27H28N8O3/c1-38-16-4-6-22(36)34-14-3-2-5-20(34)26-33-23(24-25(28)30-13-15-35(24)26)18-7-9-19(10-8-18)27(37)32-21-11-12-29-17-31-21/h4,6-13,15,17,20H,2-3,5,14,16H2,1H3,(H2,28,30)(H,29,31,32,37)/b6-4+/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340073 (4-(8-amino-3-((S)-1-((E)-4- methoxybut-2-enoyl)pyr...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CCCN4C(=O)\C=C\COC)n4ccnc(N)c34)c(C)c2)c1 |r| Show InChI InChI=1S/C31H35N7O3/c1-4-7-21-12-13-33-25(19-21)35-31(40)22-10-11-23(20(2)18-22)27-28-29(32)34-14-16-38(28)30(36-27)24-8-5-15-37(24)26(39)9-6-17-41-3/h6,9-14,16,18-19,24H,4-5,7-8,15,17H2,1-3H3,(H2,32,34)(H,33,35,40)/b9-6+/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340074 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) Show SMILES COC\C=C\C(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2nccc(C)n2)c2c(N)nccn12 |r| Show InChI InChI=1S/C28H30N8O3/c1-18-12-13-31-28(32-18)34-27(38)20-10-8-19(9-11-20)23-24-25(29)30-14-16-36(24)26(33-23)21-6-3-4-15-35(21)22(37)7-5-17-39-2/h5,7-14,16,21H,3-4,6,15,17H2,1-2H3,(H2,29,30)(H,31,32,34,38)/b7-5+/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340105 ((S)-4-(8-amino-3-(1-but-2- ynoylpiperidin-2-yl)imi...) Show SMILES CC#CC(=O)N1CCCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2nccc(C)n2)c2c(N)nccn12 |r| Show InChI InChI=1S/C27H26N8O2/c1-3-6-21(36)34-15-5-4-7-20(34)25-32-22(23-24(28)29-14-16-35(23)25)18-8-10-19(11-9-18)26(37)33-27-30-13-12-17(2)31-27/h8-14,16,20H,4-5,7,15H2,1-2H3,(H2,28,29)(H,30,31,33,37)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340075 ((S)-4-(8-amino-3-(1-(2- chloropyrimidine-4- carbon...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ncccn3)c12)[C@@H]1CCCCN1C(=O)c1ccnc(Cl)n1 |r| Show InChI InChI=1S/C27H23ClN10O2/c28-26-31-12-9-18(34-26)25(40)37-14-2-1-4-19(37)23-35-20(21-22(29)30-13-15-38(21)23)16-5-7-17(8-6-16)24(39)36-27-32-10-3-11-33-27/h3,5-13,15,19H,1-2,4,14H2,(H2,29,30)(H,32,33,36,39)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340062 ((S)-4-(8-amino-3-(1- methacryloylpyrrolidin-2- yl)...) Show SMILES CC(=C)C(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C26H25N7O2/c1-16(2)26(35)32-14-5-6-19(32)24-31-21(22-23(27)29-13-15-33(22)24)17-8-10-18(11-9-17)25(34)30-20-7-3-4-12-28-20/h3-4,7-13,15,19H,1,5-6,14H2,2H3,(H2,27,29)(H,28,30,34)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340076 ((S)-4-(8-amino-3-(1-(2- (trifluoromethyl)acryloyl)...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)[C@@H]1CCCN1C(=O)C(=C)C(F)(F)F |r| Show InChI InChI=1S/C26H22F3N7O2/c1-15(26(27,28)29)25(38)35-13-4-5-18(35)23-34-20(21-22(30)32-12-14-36(21)23)16-7-9-17(10-8-16)24(37)33-19-6-2-3-11-31-19/h2-3,6-12,14,18H,1,4-5,13H2,(H2,30,32)(H,31,33,37)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340077 ((S,E)-4-(8-amino-3-(1-but-2- enoylpyrrolidin-2-yl)...) Show SMILES C\C=C\C(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12 |r| Show InChI InChI=1S/C26H25N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h2-4,6,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/b6-2+/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340078 ((S)-4-(8-amino-3-(1- (cyanomethyl)pyrrolidin-2- yl...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3ccccn3)c12)[C@@H]1CCCN1CC#N |r| Show InChI InChI=1S/C24H22N8O/c25-10-14-31-13-3-4-18(31)23-30-20(21-22(26)28-12-15-32(21)23)16-6-8-17(9-7-16)24(33)29-19-5-1-2-11-27-19/h1-2,5-9,11-12,15,18H,3-4,13-14H2,(H2,26,28)(H,27,29,33)/t18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340106 ((E)-4-(8-amino-3-((4-methoxybut-2- enamido)methyl)...) Show SMILES COC\C=C\C(=O)NCc1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12 Show InChI InChI=1S/C24H23N7O3/c1-34-14-4-6-20(32)28-15-19-30-21(22-23(25)27-12-13-31(19)22)16-7-9-17(10-8-16)24(33)29-18-5-2-3-11-26-18/h2-13H,14-15H2,1H3,(H2,25,27)(H,28,32)(H,26,29,33)/b6-4+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair

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