Found 333 hits Enz. Inhib. hit(s) with Target = 'Apurinic-apyrimidinic endonuclease 1 (APE-1)' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM26621
(4-[dihydroxy(oxo)--stibanyl]-2-nitrobenzoic acid |...)Show InChI InChI=1S/C7H4NO4.2H2O.O.Sb/c9-7(10)5-3-1-2-4-6(5)8(11)12;;;;/h1,3-4H,(H,9,10);2*1H2;;/q;;;;+2/p-2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
| Article PubMed
| 19 | -43.6 | 4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
The Johns Hopkins University
| Assay Description The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w... |
Mol Pharmacol 73: 669-77 (2008)
Article DOI: 10.1124/mol.107.042622 BindingDB Entry DOI: 10.7270/Q2WS8RJX |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM26622
(Compound 13793 | ethyl 4-{4-[dihydroxy(oxo)--stiba...)Show InChI InChI=1S/C12H15O2.2H2O.O.Sb/c1-2-14-12(13)10-6-9-11-7-4-3-5-8-11;;;;/h4-5,7-8H,2,6,9-10H2,1H3;2*1H2;;/q;;;;+2/p-2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
| Article PubMed
| 36 | -42.1 | 17 | n/a | n/a | n/a | n/a | 7.5 | 22 |
The Johns Hopkins University
| Assay Description The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w... |
Mol Pharmacol 73: 669-77 (2008)
Article DOI: 10.1124/mol.107.042622 BindingDB Entry DOI: 10.7270/Q2WS8RJX |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50453751
(CHEMBL4210534)Show SMILES C1COCCNCc2ccc3ccc(CNCCOCCNCc4ccc5ccc(CN1)cc5c4)cc3c2 Show InChI InChI=1S/C32H40N4O2/c1-5-29-6-2-26-18-31(29)17-25(1)21-33-9-13-37-14-10-35-23-27-3-7-30-8-4-28(20-32(30)19-27)24-36-12-16-38-15-11-34-22-26/h1-8,17-20,33-36H,9-16,21-24H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human APE1 assessed as reduction in abasic sites DNA cleavage using 6-FAM/TAMRA labelled 17-Tphi as substrate by fluorescence-based ass... |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM60996
(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)Show SMILES [#8]-[#6](=O)-[#6]-1=[#6]\[#6](-[#6]=[#6]-[#6]-1=O)=[#6](\c1ccc(-[#8])c(c1)-[#6](-[#8])=O)-c1ccc(-[#8])c(c1)-[#6](-[#8])=O |c:6,t:3| Show InChI InChI=1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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Similars
| Article PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of APE1 (unknown origin) |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM60996
(5-[(3-carboxy-4-hydroxy-phenyl)-(3-carboxy-4-keto-...)Show SMILES [#8]-[#6](=O)-[#6]-1=[#6]\[#6](-[#6]=[#6]-[#6]-1=O)=[#6](\c1ccc(-[#8])c(c1)-[#6](-[#8])=O)-c1ccc(-[#8])c(c1)-[#6](-[#8])=O |c:6,t:3| Show InChI InChI=1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assay |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50453744
(CHEMBL4205402)Show SMILES C1CNCc2ccc3ccc(CNCCNCCNCc4ccc5ccc(CNCCN1)cc5c4)cc3c2 Show InChI InChI=1S/C32H42N6/c1-5-29-6-2-26-18-31(29)17-25(1)21-35-13-9-33-10-14-37-23-27-3-7-30-8-4-28(20-32(30)19-27)24-38-16-12-34-11-15-36-22-26/h1-8,17-20,33-38H,9-16,21-24H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human APE1 assessed as reduction in abasic sites DNA cleavage using 6-FAM/TAMRA labelled 17-Tphi as substrate by fluorescence-based ass... |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50066721
(1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)...)Show InChI InChI=1S/C20H24N2O2S/c1-3-22(4-2)12-11-21-16-10-9-14(13-23)20-18(16)19(24)15-7-5-6-8-17(15)25-20/h5-10,21,23H,3-4,11-13H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of full length human APE1 expressed in Escherichia coli BL21/DE3 assessed as inhibition of incision of depurinated supercoiled pUC18 plasm... |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50436204
(CHEMBL109037)Show InChI InChI=1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Punjab
Curated by ChEMBL
| Assay Description Inhibition of human APE1 after 25 mins by fluorescence assay |
J Med Chem 57: 10241-56 (2014)
Article DOI: 10.1021/jm500865u BindingDB Entry DOI: 10.7270/Q2XW4MD9 |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50436204
(CHEMBL109037)Show InChI InChI=1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assay |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50453740
(CHEMBL4217125)Show InChI InChI=1S/C12H4Br6/c13-7-1-5(2-8(14)11(7)17)6-3-9(15)12(18)10(16)4-6/h1-4H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of nuclease activity of APE1 in human glioblastoma cells assessed as reduction in AP site DNA cleavage |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM26613
((2E)-3-{3-[dihydroxy(oxo)--stibanyl]phenyl}prop-2-...)Show InChI InChI=1S/C9H7O2.2H2O.O.Sb/c10-9(11)7-6-8-4-2-1-3-5-8;;;;/h1-2,4-7H,(H,10,11);2*1H2;;/q;;;;+2/p-2/b7-6+;;;; | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | 7.5 | 22 |
The Johns Hopkins University
| Assay Description The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w... |
Mol Pharmacol 73: 669-77 (2008)
Article DOI: 10.1124/mol.107.042622 BindingDB Entry DOI: 10.7270/Q2WS8RJX |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM203861
((5-(acetylamino)-2-[2-(4-isothiocyanato-3-sulfophe...)Show SMILES CC(=O)Nc1ccc(\C=C\c2ccc(N=C=S)c(c2)S([O-])(=O)=O)c(c1)S([O-])(=O)=O Show InChI InChI=1S/C17H14N2O7S3/c1-11(20)19-14-6-5-13(16(9-14)28(21,22)23)4-2-12-3-7-15(18-10-27)17(8-12)29(24,25)26/h2-9H,1H3,(H,19,20)(H,21,22,23)(H,24,25,26)/p-2/b4-2+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Universidade de Lisboa
| Assay Description In this assay, the complementary single-stranded oligonucleotides at 100
μm were mixed at a 1:1 ratio and annealed in assay buffer (50 mm Tris
pH ... |
Chem Biol Drug Des 88: 915-925 (2016)
Article DOI: 10.1111/cbdd.12826 BindingDB Entry DOI: 10.7270/Q2Q52NGR |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM203861
((5-(acetylamino)-2-[2-(4-isothiocyanato-3-sulfophe...)Show SMILES CC(=O)Nc1ccc(\C=C\c2ccc(N=C=S)c(c2)S([O-])(=O)=O)c(c1)S([O-])(=O)=O Show InChI InChI=1S/C17H14N2O7S3/c1-11(20)19-14-6-5-13(16(9-14)28(21,22)23)4-2-12-3-7-15(18-10-27)17(8-12)29(24,25)26/h2-9H,1H3,(H,19,20)(H,21,22,23)(H,24,25,26)/p-2/b4-2+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant human APE1 using double-stranded DNA as substrate preincubated for 15 mins followed by substrate addition measured at 1 min... |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50029028
((cibacron blue,para isomer)1-Amino-4-{4-[4-chloro-...)Show SMILES Nc1c(cc(Nc2ccc(Nc3nc(Cl)nc(Nc4ccc(cc4)S([O-])(=O)=O)n3)c(c2)S([O-])(=O)=O)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O Show InChI InChI=1S/C29H20ClN7O11S3/c30-27-35-28(33-13-5-8-15(9-6-13)49(40,41)42)37-29(36-27)34-18-10-7-14(11-20(18)50(43,44)45)32-19-12-21(51(46,47)48)24(31)23-22(19)25(38)16-3-1-2-4-17(16)26(23)39/h1-12,32H,31H2,(H,40,41,42)(H,43,44,45)(H,46,47,48)(H2,33,34,35,36,37)/p-3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assay |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM4293
((2E)-3-(3,4-dihydroxyphenyl)-2-[(3,4-dihydroxyphen...)Show InChI InChI=1S/C16H11NO5/c17-8-11(5-9-1-3-12(18)14(20)6-9)16(22)10-2-4-13(19)15(21)7-10/h1-7,18-21H/b11-5+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assay |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM26618
(Compound 15596 | N-{4-[dihydroxy(oxo)--stibanyl]ph...)Show InChI InChI=1S/C13H10NO.2H2O.O.Sb/c15-13(11-7-3-1-4-8-11)14-12-9-5-2-6-10-12;;;;/h1,3-10H,(H,14,15);2*1H2;;/q;;;;+2/p-2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | 7.5 | 22 |
The Johns Hopkins University
| Assay Description The screening assay was performed using 384-well microtiter plate first spotted with test compounds. Then Ape1 in reaction buffer was added to each w... |
Mol Pharmacol 73: 669-77 (2008)
Article DOI: 10.1124/mol.107.042622 BindingDB Entry DOI: 10.7270/Q2WS8RJX |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM15236
(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assay |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM114257
(3,8,9,10-tetrahydroxypyran[3,2-c]isochromene-2,6-q...)Show InChI InChI=1S/C12H6O8/c13-4-1-3-7(9(16)8(4)15)10-6(19-11(3)17)2-5(14)12(18)20-10/h1-2,13-16H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human APE1 using a 5'-TAMRA labelled THF abasic site double-stranded oligodeoxynucleotide as substrate in presence of Mg2+ by fluoresce... |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50579
(3,6,7-trimethoxyphenanthrene-2,5-diol | MLS0008635...)Show InChI InChI=1S/C17H16O5/c1-20-13-8-11-9(6-12(13)18)4-5-10-7-14(21-2)17(22-3)16(19)15(10)11/h4-8,18-19H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human APE1 using a 5'-TAMRA labelled THF abasic site double-stranded oligodeoxynucleotide as substrate in presence of Mg2+ by fluoresce... |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM81347
(L2037 (beta-lapachone))Show InChI InChI=1S/C7H8N2O3/c1-9(8-12)5-2-3-6(10)7(11)4-5/h2-4,10-11H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assay |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50453747
(CHEMBL4211672)Show SMILES CC(C)(C)c1ccc(OC(=O)c2sc3ccccc3c2Cl)c(c1)C(C)(C)C Show InChI InChI=1S/C23H25ClO2S/c1-22(2,3)14-11-12-17(16(13-14)23(4,5)6)26-21(25)20-19(24)15-9-7-8-10-18(15)27-20/h7-13H,1-6H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of nuclease activity of APE1 in human glioblastoma cells assessed as reduction in AP site DNA cleavage |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50453750
(CHEMBL4203747)Show SMILES Cc1sc(Nc2cc(Cl)cc(Cl)c2)nc1-c1ccc(cc1)-c1ccccc1F Show InChI InChI=1S/C22H15Cl2FN2S/c1-13-21(27-22(28-13)26-18-11-16(23)10-17(24)12-18)15-8-6-14(7-9-15)19-4-2-3-5-20(19)25/h2-12H,1H3,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of nuclease activity of APE1 in human glioblastoma cells assessed as reduction in AP site DNA cleavage |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50303964
((E)-3-(3-Methoxy-1,4-naphthoquinon-2-yl)-2-methylp...)Show SMILES COC1=C(\C=C(/C)C(O)=O)C(=O)c2ccccc2C1=O |c:2| Show InChI InChI=1S/C15H12O5/c1-8(15(18)19)7-11-12(16)9-5-3-4-6-10(9)13(17)14(11)20-2/h3-7H,1-2H3,(H,18,19)/b8-7+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSA |
J Med Chem 53: 1200-10 (2010)
Article DOI: 10.1021/jm9014857 BindingDB Entry DOI: 10.7270/Q2HD7VR8 |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50303965
((E)-3-(3-Methylthio-1,4-naphthoquinon-2-yl)-2-meth...)Show SMILES CSC1=C(\C=C(/C)C(O)=O)C(=O)c2ccccc2C1=O |c:2| Show InChI InChI=1S/C15H12O4S/c1-8(15(18)19)7-11-12(16)9-5-3-4-6-10(9)13(17)14(11)20-2/h3-7H,1-2H3,(H,18,19)/b8-7+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSA |
J Med Chem 53: 1200-10 (2010)
Article DOI: 10.1021/jm9014857 BindingDB Entry DOI: 10.7270/Q2HD7VR8 |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50303967
((E)-3-(3-Chloro-1,4-naphthoquinon-2-yl)-2-methylpr...)Show SMILES C\C(=C/C1=C(Cl)C(=O)c2ccccc2C1=O)C(O)=O |c:3| Show InChI InChI=1S/C14H9ClO4/c1-7(14(18)19)6-10-11(15)13(17)9-5-3-2-4-8(9)12(10)16/h2-6H,1H3,(H,18,19)/b7-6+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSA |
J Med Chem 53: 1200-10 (2010)
Article DOI: 10.1021/jm9014857 BindingDB Entry DOI: 10.7270/Q2HD7VR8 |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50241313
((5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1...)Show InChI InChI=1S/C11H14O2S/c1-5-7(2)6-11(4)9(12)8(3)10(13)14-11/h5-6,8H,1H2,2-4H3/b7-6+/t8?,11-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assay |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50303973
((E)-N-(2-Hydroxyethyl)-3-(3-chloro-1,4-dioxonaphth...)Show SMILES C\C(=C/C1=C(Cl)C(=O)c2ccccc2C1=O)C(=O)NCCO |c:3| Show InChI InChI=1S/C16H14ClNO4/c1-9(16(22)18-6-7-19)8-12-13(17)15(21)11-5-3-2-4-10(11)14(12)20/h2-5,8,19H,6-7H2,1H3,(H,18,22)/b9-8+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSA |
J Med Chem 53: 1200-10 (2010)
Article DOI: 10.1021/jm9014857 BindingDB Entry DOI: 10.7270/Q2HD7VR8 |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM114652
(CHEMBL1706858 | MLS003178551 | N-[3-(1,3-benzothia...)Show InChI InChI=1S/C15H13N3OS2/c1-8(19)17-14-13(9-6-16-7-12(9)21-14)15-18-10-4-2-3-5-11(10)20-15/h2-5,16H,6-7H2,1H3,(H,17,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant APE1 using [35P]-5'-AP-DNA as substrate incubated for 15 mins prior to substrate addition measured after 5 mins by PAGE ana... |
J Med Chem 55: 3101-12 (2012)
Article DOI: 10.1021/jm201537d BindingDB Entry DOI: 10.7270/Q2V98941 |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50303972
((E)-3-(3-Bromo-1,4-naphthoquinon-2-yl)-2-methoxyet...)Show SMILES COCC\C(=C/C1=C(Br)C(=O)c2ccccc2C1=O)C(O)=O |c:6| Show InChI InChI=1S/C16H13BrO5/c1-22-7-6-9(16(20)21)8-12-13(17)15(19)11-5-3-2-4-10(11)14(12)18/h2-5,8H,6-7H2,1H3,(H,20,21)/b9-8+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University
Curated by ChEMBL
| Assay Description Inhibition of Ape1/ref-1 redox activity in presence of 0.02 mM DTT and human Hey-C2 cells nuclear extracts by EMSA |
J Med Chem 53: 1200-10 (2010)
Article DOI: 10.1021/jm9014857 BindingDB Entry DOI: 10.7270/Q2HD7VR8 |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50530042
(CHEMBL4517868)Show SMILES C[C@H]1\C=C\CC(=O)OCCC(c2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1cccn1S(=O)(=O)c1ccc(C)cc1 |r,t:2| Show InChI InChI=1S/C39H40N4O6S/c1-26-17-19-30(20-18-26)50(47,48)43-22-9-15-35(43)37-27(2)10-8-16-36(44)49-23-21-32(28-11-4-3-5-12-28)38(45)41-34(39(46)42-37)24-29-25-40-33-14-7-6-13-31(29)33/h3-15,17-20,22,25,27,32,34,37,40H,16,21,23-24H2,1-2H3,(H,41,45)(H,42,46)/b10-8+/t27-,32?,34-,37+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boston University
Curated by ChEMBL
| Assay Description Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw... |
J Med Chem 62: 1971-1988 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01529 BindingDB Entry DOI: 10.7270/Q2G73J6T |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50530042
(CHEMBL4517868)Show SMILES C[C@H]1\C=C\CC(=O)OCCC(c2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1cccn1S(=O)(=O)c1ccc(C)cc1 |r,t:2| Show InChI InChI=1S/C39H40N4O6S/c1-26-17-19-30(20-18-26)50(47,48)43-22-9-15-35(43)37-27(2)10-8-16-36(44)49-23-21-32(28-11-4-3-5-12-28)38(45)41-34(39(46)42-37)24-29-25-40-33-14-7-6-13-31(29)33/h3-15,17-20,22,25,27,32,34,37,40H,16,21,23-24H2,1-2H3,(H,41,45)(H,42,46)/b10-8+/t27-,32?,34-,37+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boston University
Curated by ChEMBL
| Assay Description Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw... |
J Med Chem 62: 1971-1988 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01529 BindingDB Entry DOI: 10.7270/Q2G73J6T |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50453738
(CHEMBL4212274)Show SMILES Cc1sc(nc1-c1ccc(cc1)-c1ccccc1F)-c1ccc(Cl)cc1 Show InChI InChI=1S/C22H15ClFNS/c1-14-21(25-22(26-14)17-10-12-18(23)13-11-17)16-8-6-15(7-9-16)19-4-2-3-5-20(19)24/h2-13H,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of nuclease activity of APE1 in human glioblastoma cells assessed as reduction in AP site DNA cleavage |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50530037
(CHEMBL4473257)Show SMILES C[C@H]1\C=C\CC(=O)N[C@@H](CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1cccn1S(=O)(=O)c1ccc(C)cc1)c1ccc(cc1)C(F)(F)F |r,t:2| Show InChI InChI=1S/C39H38F3N5O5S/c1-24-12-18-29(19-13-24)53(51,52)47-20-6-10-34(47)37-25(2)7-5-11-35(48)44-32(26-14-16-28(17-15-26)39(40,41)42)22-36(49)45-33(38(50)46-37)21-27-23-43-31-9-4-3-8-30(27)31/h3-10,12-20,23,25,32-33,37,43H,11,21-22H2,1-2H3,(H,44,48)(H,45,49)(H,46,50)/b7-5+/t25-,32-,33-,37+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boston University
Curated by ChEMBL
| Assay Description Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw... |
J Med Chem 62: 1971-1988 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01529 BindingDB Entry DOI: 10.7270/Q2G73J6T |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50530037
(CHEMBL4473257)Show SMILES C[C@H]1\C=C\CC(=O)N[C@@H](CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1cccn1S(=O)(=O)c1ccc(C)cc1)c1ccc(cc1)C(F)(F)F |r,t:2| Show InChI InChI=1S/C39H38F3N5O5S/c1-24-12-18-29(19-13-24)53(51,52)47-20-6-10-34(47)37-25(2)7-5-11-35(48)44-32(26-14-16-28(17-15-26)39(40,41)42)22-36(49)45-33(38(50)46-37)21-27-23-43-31-9-4-3-8-30(27)31/h3-10,12-20,23,25,32-33,37,43H,11,21-22H2,1-2H3,(H,44,48)(H,45,49)(H,46,50)/b7-5+/t25-,32-,33-,37+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boston University
Curated by ChEMBL
| Assay Description Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw... |
J Med Chem 62: 1971-1988 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01529 BindingDB Entry DOI: 10.7270/Q2G73J6T |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM26616
(2-aminobenzene-1,3,5-trisulfonamide | Compound 258...)Show SMILES Nc1c(cc(cc1S(N)(=O)=O)S(N)(=O)=O)S(N)(=O)=O Show InChI InChI=1S/C6H10N4O6S3/c7-6-4(18(9,13)14)1-3(17(8,11)12)2-5(6)19(10,15)16/h1-2H,7H2,(H2,8,11,12)(H2,9,13,14)(H2,10,15,16) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human APE1 measured every 5 mins for 60 mins by FAM fluorophore based fluorescence assay |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM58109
((3-chloranyl-1-benzothiophen-2-yl)-[2-(2-chlorophe...)Show SMILES Clc1c(sc2ccccc12)C(=O)N1\C(SC(=C)C11CCCCC1)=N\c1ccccc1Cl Show InChI InChI=1S/C24H20Cl2N2OS2/c1-15-24(13-7-2-8-14-24)28(23(30-15)27-18-11-5-4-10-17(18)25)22(29)21-20(26)16-9-3-6-12-19(16)31-21/h3-6,9-12H,1-2,7-8,13-14H2/b27-23- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of nuclease activity of APE1 in human glioblastoma cells assessed as reduction in AP site DNA cleavage |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM83759
((2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-yl)ami...)Show InChI InChI=1S/C15H15N3/c1-8-5-4-6-11-13(16)12-9(2)7-10(3)17-15(12)18-14(8)11/h4-7H,1-3H3,(H2,16,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description Inhibition of human APE1 expressed in Escherichia coli rosetta using fluorescein-dabcyl-containing oligonucleotide as substrate after 5 mins by fluor... |
J Med Chem 55: 3101-12 (2012)
Article DOI: 10.1021/jm201537d BindingDB Entry DOI: 10.7270/Q2V98941 |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50431702
(CHEMBL2349528)Show InChI InChI=1S/C13H11ClN2O2/c14-8-3-1-4-9(7-8)15-13(17)12-10-5-2-6-11(10)18-16-12/h1,3-4,7H,2,5-6H2,(H,15,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of N-terminal hexa-His tagged human APE1 expressed in Escherichia coli BL21 (Rosetta) using fluorescein-dabcyl-containing oligonucleotide ... |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM222128
(7-Chloro-2-(2-fluorophenyl)-4H-3,1-benzoxazin-4-on...)Show InChI InChI=1S/C14H7ClFNO2/c15-8-5-6-10-12(7-8)17-13(19-14(10)18)9-3-1-2-4-11(9)16/h1-7H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of nuclease activity of APE1 in human glioblastoma cells assessed as reduction in AP site DNA cleavage |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM42119
(2-[4-(2,5-dimethyl-1-pyrrolyl)phenoxy]acetic acid ...)Show InChI InChI=1S/C14H15NO3/c1-10-3-4-11(2)15(10)12-5-7-13(8-6-12)18-9-14(16)17/h3-8H,9H2,1-2H3,(H,16,17) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of N-terminal hexa-His tagged human APE1 expressed in Escherichia coli BL21 (Rosetta) using fluorescein-dabcyl-containing oligonucleotide ... |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM26614
(2-[(4-hydroxy-3-methylphenyl)[(1Z)-3-methyl-4-oxoc...)Show SMILES CC1=C\C(C=CC1=O)=C(\c1ccc(O)c(C)c1)c1ccccc1C(O)=O |c:4,t:1| Show InChI InChI=1S/C22H18O4/c1-13-11-15(7-9-19(13)23)21(16-8-10-20(24)14(2)12-16)17-5-3-4-6-18(17)22(25)26/h3-12,23H,1-2H3,(H,25,26)/b21-16- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human APE1 measured every 5 mins for 60 mins by FAM fluorophore based fluorescence assay |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50453737
(CHEMBL4207457)Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Oc1ccc(cc1)-c1ccc(Oc2c(Cl)cccc2[N+]([O-])=O)cc1 Show InChI InChI=1S/C28H24ClNO6S/c1-28(2,3)21-11-17-24(18-12-21)37(33,34)36-23-15-9-20(10-16-23)19-7-13-22(14-8-19)35-27-25(29)5-4-6-26(27)30(31)32/h4-18H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of nuclease activity of APE1 in human glioblastoma cells assessed as reduction in AP site DNA cleavage |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50453735
(CHEMBL4210283)Show SMILES [H][C@]12[C@@H](CCC(O)=O)N[C@@]3(C(=O)Nc4c3cccc4Cl)[C@@]1([H])C(=O)N(Cc1ccc3OCOc3c1)C2=O |r| Show InChI InChI=1S/C24H20ClN3O7/c25-13-3-1-2-12-20(13)26-23(33)24(12)19-18(14(27-24)5-7-17(29)30)21(31)28(22(19)32)9-11-4-6-15-16(8-11)35-10-34-15/h1-4,6,8,14,18-19,27H,5,7,9-10H2,(H,26,33)(H,29,30)/t14-,18+,19-,24-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant human APE1 using a 5'-FAM/3'-Dabsyl labelled double-stranded DNA as substrate after 30 mins by fluorescence-based assay |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50530043
(CHEMBL4458126)Show SMILES C[C@H]1\C=C\CC(=O)OCCC(Oc2ccc3OCOc3c2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1ccccc1 |r,t:2| Show InChI InChI=1S/C35H35N3O7/c1-22-8-7-13-32(39)42-17-16-30(45-25-14-15-29-31(19-25)44-21-43-29)35(41)37-28(18-24-20-36-27-12-6-5-11-26(24)27)34(40)38-33(22)23-9-3-2-4-10-23/h2-12,14-15,19-20,22,28,30,33,36H,13,16-18,21H2,1H3,(H,37,41)(H,38,40)/b8-7+/t22-,28-,30?,33+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boston University
Curated by ChEMBL
| Assay Description Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw... |
J Med Chem 62: 1971-1988 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01529 BindingDB Entry DOI: 10.7270/Q2G73J6T |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50530043
(CHEMBL4458126)Show SMILES C[C@H]1\C=C\CC(=O)OCCC(Oc2ccc3OCOc3c2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1ccccc1 |r,t:2| Show InChI InChI=1S/C35H35N3O7/c1-22-8-7-13-32(39)42-17-16-30(45-25-14-15-29-31(19-25)44-21-43-29)35(41)37-28(18-24-20-36-27-12-6-5-11-26(24)27)34(40)38-33(22)23-9-3-2-4-10-23/h2-12,14-15,19-20,22,28,30,33,36H,13,16-18,21H2,1H3,(H,37,41)(H,38,40)/b8-7+/t22-,28-,30?,33+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boston University
Curated by ChEMBL
| Assay Description Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw... |
J Med Chem 62: 1971-1988 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01529 BindingDB Entry DOI: 10.7270/Q2G73J6T |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50453739
(CHEMBL4207384)Show SMILES Clc1ccc(cc1Cl)S(=O)(=O)Oc1ccc(cc1)-c1ccc(OS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 Show InChI InChI=1S/C24H14Cl4O6S2/c25-21-11-9-19(13-23(21)27)35(29,30)33-17-5-1-15(2-6-17)16-3-7-18(8-4-16)34-36(31,32)20-10-12-22(26)24(28)14-20/h1-14H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of nuclease activity of APE1 in human glioblastoma cells assessed as reduction in AP site DNA cleavage |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50530040
(CHEMBL4581229)Show SMILES C[C@H]1\C=C\CC(=O)N[C@H](Cc2ccc(Cl)cc2)CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1cccn1S(=O)(=O)c1ccc(C)cc1 |r,t:2| Show InChI InChI=1S/C39H40ClN5O5S/c1-25-12-18-31(19-13-25)51(49,50)45-20-6-10-35(45)38-26(2)7-5-11-36(46)42-30(21-27-14-16-29(40)17-15-27)23-37(47)43-34(39(48)44-38)22-28-24-41-33-9-4-3-8-32(28)33/h3-10,12-20,24,26,30,34,38,41H,11,21-23H2,1-2H3,(H,42,46)(H,43,47)(H,44,48)/b7-5+/t26-,30+,34-,38+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boston University
Curated by ChEMBL
| Assay Description Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw... |
J Med Chem 62: 1971-1988 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01529 BindingDB Entry DOI: 10.7270/Q2G73J6T |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50530040
(CHEMBL4581229)Show SMILES C[C@H]1\C=C\CC(=O)N[C@H](Cc2ccc(Cl)cc2)CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1c1cccn1S(=O)(=O)c1ccc(C)cc1 |r,t:2| Show InChI InChI=1S/C39H40ClN5O5S/c1-25-12-18-31(19-13-25)51(49,50)45-20-6-10-35(45)38-26(2)7-5-11-36(46)42-30(21-27-14-16-29(40)17-15-27)23-37(47)43-34(39(48)44-38)22-28-24-41-33-9-4-3-8-32(28)33/h3-10,12-20,24,26,30,34,38,41H,11,21-23H2,1-2H3,(H,42,46)(H,43,47)(H,44,48)/b7-5+/t26-,30+,34-,38+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boston University
Curated by ChEMBL
| Assay Description Inhibition of full length human APE1 assessed as reduction in endonuclease activity by measuring DNA cleavage of abasic sites using 6-FAM labelled tw... |
J Med Chem 62: 1971-1988 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01529 BindingDB Entry DOI: 10.7270/Q2G73J6T |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM67690
(1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8-bis...)Show SMILES OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12 Show InChI InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human APE1 preincubated for 15 mins followed by substrate addition by HTS assay |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |
DNA-(apurinic or apyrimidinic site) endonuclease
(Homo sapiens (Human)) | BDBM50453736
(CHEMBL4213457)Show SMILES [O-][N+](=O)c1ccc2nc(oc(=O)c2c1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C14H6Cl2N2O4/c15-7-1-3-9(11(16)5-7)13-17-12-4-2-8(18(20)21)6-10(12)14(19)22-13/h1-6H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Russian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of nuclease activity of APE1 in human glioblastoma cells assessed as reduction in AP site DNA cleavage |
Bioorg Med Chem 25: 2531-2544 (2017)
Article DOI: 10.1016/j.bmc.2017.01.028 BindingDB Entry DOI: 10.7270/Q2P55R4B |
More data for this Ligand-Target Pair | |