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Compile Data Set for Download or QSAR

Found 47 hits Enz. Inhib. hit(s) with Target = 'Asialoglycoprotein receptor 1'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM50304486
PNG
((3R,4R,5R,6R)-3-acetamido-6-(acetoxymethyl)tetrahy...)
Show SMILES CC(=O)N[C@H]1C(OC(C)=O)O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O |r|
Show InChI InChI=1S/C16H23NO10/c1-7(18)17-13-15(25-10(4)21)14(24-9(3)20)12(6-23-8(2)19)27-16(13)26-11(5)22/h12-16H,6H2,1-5H3,(H,17,18)/t12-,13-,14+,15-,16?/m1/s1
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n/an/a 1.13E+5n/an/an/an/an/an/a



University of Basel

Curated by ChEMBL


Assay Description
Inhibition of D-GalNAc-PAA binding to human recombinant ASGPR1 carbohydrate recognition domain expressed in Escherichia coli AD494 by competitive sol...

Bioorg Med Chem 17: 7254-64 (2009)


Article DOI: 10.1016/j.bmc.2009.08.049
BindingDB Entry DOI: 10.7270/Q2NK3G09
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM50077229
PNG
(CHEMBL300520 | beta-D-galactopyranose | beta-D-gal...)
Show SMILES OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6-/m1/s1
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n/an/a 1.05E+6n/an/an/an/an/an/a



University of Basel

Curated by ChEMBL


Assay Description
Inhibition of D-GalNAc-PAA binding to human recombinant ASGPR1 carbohydrate recognition domain expressed in Escherichia coli AD494 by competitive sol...

Bioorg Med Chem 17: 7254-64 (2009)


Article DOI: 10.1016/j.bmc.2009.08.049
BindingDB Entry DOI: 10.7270/Q2NK3G09
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM50304487
PNG
((2R,3R,4S,5S,6R)-2,3,4,5-tetramethoxy-6-(methoxyme...)
Show SMILES COC[C@H]1O[C@@H](OC)[C@H](OC)[C@@H](OC)[C@H]1OC |r|
Show InChI InChI=1S/C11H22O6/c1-12-6-7-8(13-2)9(14-3)10(15-4)11(16-5)17-7/h7-11H,6H2,1-5H3/t7-,8+,9+,10-,11-/m1/s1
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n/an/a 1.83E+6n/an/an/an/an/an/a



University of Basel

Curated by ChEMBL


Assay Description
Inhibition of D-GalNAc-PAA binding to human recombinant ASGPR1 carbohydrate recognition domain expressed in Escherichia coli AD494 by competitive sol...

Bioorg Med Chem 17: 7254-64 (2009)


Article DOI: 10.1016/j.bmc.2009.08.049
BindingDB Entry DOI: 10.7270/Q2NK3G09
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM50304488
PNG
((2S,3R,4S,5S,6R)-2,3,4,5-tetramethoxy-6-(methoxyme...)
Show SMILES COC[C@H]1O[C@H](OC)[C@H](OC)[C@@H](OC)[C@H]1OC |r|
Show InChI InChI=1S/C11H22O6/c1-12-6-7-8(13-2)9(14-3)10(15-4)11(16-5)17-7/h7-11H,6H2,1-5H3/t7-,8+,9+,10-,11+/m1/s1
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n/an/a 2.83E+6n/an/an/an/an/an/a



University of Basel

Curated by ChEMBL


Assay Description
Inhibition of D-GalNAc-PAA binding to human recombinant ASGPR1 carbohydrate recognition domain expressed in Escherichia coli AD494 by competitive sol...

Bioorg Med Chem 17: 7254-64 (2009)


Article DOI: 10.1016/j.bmc.2009.08.049
BindingDB Entry DOI: 10.7270/Q2NK3G09
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM50240803
PNG
(CHEMBL1614854 | Glucoside | beta-D-glucopyranose |...)
Show SMILES OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
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n/an/a>3.00E+7n/an/an/an/an/an/a



University of Basel

Curated by ChEMBL


Assay Description
Inhibition of D-GalNAc-PAA binding to human recombinant ASGPR1 carbohydrate recognition domain expressed in Escherichia coli AD494 by competitive sol...

Bioorg Med Chem 17: 7254-64 (2009)


Article DOI: 10.1016/j.bmc.2009.08.049
BindingDB Entry DOI: 10.7270/Q2NK3G09
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Mus musculus)		BDBM50074090
PNG
(CHEMBL2368210 | Galactoside analogue)
Show SMILES OC[C@@H]1O[C@@H](OCCCCC(=O)NCCCNC(=O)CCOCC(COCCC(=O)NCCCNC(=O)CCCCO[C@@H]2O[C@@H](CO)[C@H](O)[C@H](O)[C@@H]2O)(COCCC(=O)NCCCNC(=O)CCCCO[C@@H]2O[C@@H](CO)[C@H](O)[C@H](O)[C@@H]2O)NC(=O)CNC(=O)OCc2ccccc2)[C@@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C65H110N8O30/c74-34-42-52(84)55(87)58(90)61(101-42)97-27-7-4-15-45(77)66-21-10-24-69-48(80)18-30-94-38-65(73-51(83)33-72-64(93)100-37-41-13-2-1-3-14-41,39-95-31-19-49(81)70-25-11-22-67-46(78)16-5-8-28-98-62-59(91)56(88)53(85)43(35-75)102-62)40-96-32-20-50(82)71-26-12-23-68-47(79)17-6-9-29-99-63-60(92)57(89)54(86)44(36-76)103-63/h1-3,13-14,42-44,52-63,74-76,84-92H,4-12,15-40H2,(H,66,77)(H,67,78)(H,68,79)(H,69,80)(H,70,81)(H,71,82)(H,72,93)(H,73,83)/t42?,43?,44?,52-,53-,54-,55?,56?,57?,58?,59?,60?,61?,62?,63?,65?/m1/s1
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 93n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Affinity tested by in vitro competition assay of [125I]ASOR binding to parenchymal rat liver cells

J Med Chem 42: 609-18 (1999)


Article DOI: 10.1021/jm981078h
BindingDB Entry DOI: 10.7270/Q2BR8RCC
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Mus musculus)		BDBM50074091
PNG
(CHEMBL2368208 | Galactoside analogue)
Show SMILES OC[C@@H]1O[C@@H](OCCCCC(=O)NCC(=O)NCCCC(=O)OCC(COC(=O)CCCNC(=O)CNC(=O)CCCCO[C@@H]2O[C@@H](CO)[C@H](O)[C@H](O)[C@@H]2O)(COC(=O)CCCNC(=O)CNC(=O)CCCCO[C@@H]2O[C@@H](CO)[C@H](O)[C@H](O)[C@@H]2O)NC(=O)CNC(=O)OCc2ccccc2)[C@@H](O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C65H104N8O33/c74-31-39-52(87)55(90)58(93)61(104-39)97-24-7-4-15-42(77)69-27-45(80)66-21-10-18-49(84)101-35-65(73-48(83)30-72-64(96)100-34-38-13-2-1-3-14-38,36-102-50(85)19-11-22-67-46(81)28-70-43(78)16-5-8-25-98-62-59(94)56(91)53(88)40(32-75)105-62)37-103-51(86)20-12-23-68-47(82)29-71-44(79)17-6-9-26-99-63-60(95)57(92)54(89)41(33-76)106-63/h1-3,13-14,39-41,52-63,74-76,87-95H,4-12,15-37H2,(H,66,80)(H,67,81)(H,68,82)(H,69,77)(H,70,78)(H,71,79)(H,72,96)(H,73,83)/t39?,40?,41?,52-,53-,54-,55?,56?,57?,58?,59?,60?,61?,62?,63?,65?/m1/s1
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 93n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Affinity tested by in vitro competition assay of [125I]ASOR binding to parenchymal rat liver cells

J Med Chem 42: 609-18 (1999)


Article DOI: 10.1021/jm981078h
BindingDB Entry DOI: 10.7270/Q2BR8RCC
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Mus musculus)		BDBM50074089
PNG
(CHEMBL2368207 | TG(20)C-Galactoside analogue)
Show SMILES [H][C@@]12CC[C@H](C(C)CCCC(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OC(=O)CNC(=O)CCCCC(=O)NCC(=O)NC(COCOCCOCCOCCOCCO[C@@H]1O[C@@H](CO)[C@H](O)[C@H](O)[C@@H]1O)(COCOCCOCCOCCOCCO[C@@H]1O[C@@H](CO)[C@H](O)[C@H](O)[C@@H]1O)COCOCCOCCOCCOCCO[C@@H]1O[C@@H](CO)[C@H](O)[C@H](O)[C@@H]1O |t:24|
Show InChI InChI=1S/C86H153N3O38/c1-57(2)9-8-10-58(3)62-15-16-63-61-14-13-59-45-60(17-19-84(59,4)64(61)18-20-85(62,63)5)124-71(96)47-88-69(94)12-7-6-11-68(93)87-46-70(95)89-86(51-118-54-115-36-33-109-24-21-106-27-30-112-39-42-121-81-78(103)75(100)72(97)65(48-90)125-81,52-119-55-116-37-34-110-25-22-107-28-31-113-40-43-122-82-79(104)76(101)73(98)66(49-91)126-82)53-120-56-117-38-35-111-26-23-108-29-32-114-41-44-123-83-80(105)77(102)74(99)67(50-92)127-83/h13,57-58,60-67,72-83,90-92,97-105H,6-12,14-56H2,1-5H3,(H,87,93)(H,88,94)(H,89,95)/t58?,60-,61?,62+,63?,64?,65?,66?,67?,72+,73+,74+,75?,76?,77?,78?,79?,80?,81?,82?,83?,84-,85+,86?/m0/s1
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 200n/an/an/an/an/an/an/an/a



Leiden University

Curated by ChEMBL


Assay Description
Affinity tested by in vitro competition assay of [125I]ASOR binding to parenchymal rat liver cells

J Med Chem 42: 609-18 (1999)


Article DOI: 10.1021/jm981078h
BindingDB Entry DOI: 10.7270/Q2BR8RCC
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408856
PNG
(US10376531, Compound 18 | US10813942, Compound 18)
Show SMILES CCCOC[C@@]12CO[C@@H](O1)[C@H](NC(C)=O)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C12H21NO6/c1-3-4-17-5-12-6-18-11(19-12)8(13-7(2)14)9(15)10(12)16/h8-11,15-16H,3-6H2,1-2H3,(H,13,14)/t8-,9-,10-,11?,12+/m1/s1
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n/an/an/a 3.10E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408857
PNG
(US10376531, Compound 17 | US10813942, Compound 17)
Show SMILES CCOC[C@@]12CO[C@@H](O1)[C@H](NC(C)=O)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C11H19NO6/c1-3-16-4-11-5-17-10(18-11)7(12-6(2)13)8(14)9(11)15/h7-10,14-15H,3-5H2,1-2H3,(H,12,13)/t7-,8-,9-,10?,11+/m1/s1
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n/an/an/a 5.30E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408858
PNG
(US10376531, Compound 20 | US10813942, Compound 20)
Show SMILES CCCCCOC[C@@]12CO[C@@H](O1)[C@H](NC(C)=O)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C14H25NO6/c1-3-4-5-6-19-7-14-8-20-13(21-14)10(15-9(2)16)11(17)12(14)18/h10-13,17-18H,3-8H2,1-2H3,(H,15,16)/t10-,11-,12-,13?,14+/m1/s1
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n/an/an/a 2.18E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408859
PNG
(US10376531, Compound 19 | US10813942, Compound 19)
Show SMILES CCCCOC[C@@]12CO[C@@H](O1)[C@H](NC(C)=O)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C13H23NO6/c1-3-4-5-18-6-13-7-19-12(20-13)9(14-8(2)15)10(16)11(13)17/h9-12,16-17H,3-7H2,1-2H3,(H,14,15)/t9-,10-,11-,12?,13+/m1/s1
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n/an/an/a 3.30E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408860
PNG
(US10376531, Compound 21 | US10813942, Compound 21)
Show SMILES CCCCCCOC[C@@]12CO[C@@H](O1)[C@H](NC(C)=O)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C15H27NO6/c1-3-4-5-6-7-20-8-15-9-21-14(22-15)11(16-10(2)17)12(18)13(15)19/h11-14,18-19H,3-9H2,1-2H3,(H,16,17)/t11-,12-,13-,14?,15+/m1/s1
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n/an/an/a 3.40E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408861
PNG
(US10376531, Compound 22 | US10813942, Compound 22)
Show SMILES COCCOCCOCCOCCOC[C@@]12CO[C@@H](O1)[C@H](NC(C)=O)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C18H33NO10/c1-13(20)19-14-15(21)16(22)18(12-28-17(14)29-18)11-27-10-9-26-8-7-25-6-5-24-4-3-23-2/h14-17,21-22H,3-12H2,1-2H3,(H,19,20)/t14-,15-,16-,17?,18+/m1/s1
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n/an/an/a 5.50E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408862
PNG
(US10376531, Compound 25 | US10813942, Compound 25)
Show SMILES CCC(=O)N[C@H]1[C@H]2OC[C@](CO)(O2)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C10H17NO6/c1-2-5(13)11-6-7(14)8(15)10(3-12)4-16-9(6)17-10/h6-9,12,14-15H,2-4H2,1H3,(H,11,13)/t6-,7-,8-,9?,10+/m1/s1
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n/an/an/a 2.20E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408869
PNG
(US10376531, Compound 31 | US10813942, Compound 31)
Show SMILES CN([C@H]1[C@H]2OC[C@](CO)(O2)[C@H](O)[C@@H]1O)C(=O)OC(C)(C)C |r|
Show InChI InChI=1S/C13H23NO7/c1-12(2,3)21-11(18)14(4)7-8(16)9(17)13(5-15)6-19-10(7)20-13/h7-10,15-17H,5-6H2,1-4H3/t7-,8-,9-,10?,13+/m1/s1
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n/an/an/a 1.37E+4n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408864
PNG
(US10376531, Compound 26 | US10813942, Compound 26)
Show SMILES CS(=O)(=O)N[C@H]1[C@H]2OC[C@](CO)(O2)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C8H15NO7S/c1-17(13,14)9-4-5(11)6(12)8(2-10)3-15-7(4)16-8/h4-7,9-12H,2-3H2,1H3/t4-,5-,6-,7?,8+/m1/s1
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n/an/an/a 6.00E+4n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408865
PNG
(US10376531, Compound 29 | US10813942, Compound 29)
Show SMILES CN([C@H]1[C@H]2OC[C@](CO)(O2)[C@H](O)[C@@H]1O)C(C)=O |r|
Show InChI InChI=1S/C10H17NO6/c1-5(13)11(2)6-7(14)8(15)10(3-12)4-16-9(6)17-10/h6-9,12,14-15H,3-4H2,1-2H3/t6-,7-,8-,9?,10+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/an/a 6.90E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408866
PNG
(US10376531, Compound 30 | US10813942, Compound 30)
Show SMILES CN([C@H]1[C@H]2OC[C@](CO)(O2)[C@H](O)[C@@H]1O)S(C)(=O)=O |r|
Show InChI InChI=1S/C9H17NO7S/c1-10(18(2,14)15)5-6(12)7(13)9(3-11)4-16-8(5)17-9/h5-8,11-13H,3-4H2,1-2H3/t5-,6-,7-,8?,9+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

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UniChem
US Patent
n/an/an/a 1.10E+5n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408867
PNG
(US10376531, Compound 27 | US10813942, Compound 27)
Show SMILES OC[C@@]12CO[C@@H](O1)[C@H](NC(=O)C(F)F)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C9H13F2NO6/c10-6(11)7(16)12-3-4(14)5(15)9(1-13)2-17-8(3)18-9/h3-6,8,13-15H,1-2H2,(H,12,16)/t3-,4-,5-,8?,9+/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

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US Patent
n/an/an/a 700n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408868
PNG
(US10376531, Compound 28 | US10813942, Compound 28)
Show SMILES OC[C@@]12CO[C@@H](O1)[C@H](NC(=O)CC(F)(F)F)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C10H14F3NO6/c11-10(12,13)1-4(16)14-5-6(17)7(18)9(2-15)3-19-8(5)20-9/h5-8,15,17-18H,1-3H2,(H,14,16)/t5-,6-,7-,8?,9+/m1/s1
PDB
MMDB

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US Patent
n/an/an/a 1.20E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408869
PNG
(US10376531, Compound 31 | US10813942, Compound 31)
Show SMILES CN([C@H]1[C@H]2OC[C@](CO)(O2)[C@H](O)[C@@H]1O)C(=O)OC(C)(C)C |r|
Show InChI InChI=1S/C13H23NO7/c1-12(2,3)21-11(18)14(4)7-8(16)9(17)13(5-15)6-19-10(7)20-13/h7-10,15-17H,5-6H2,1-4H3/t7-,8-,9-,10?,13+/m1/s1
PDB
MMDB

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US Patent
n/an/an/a 1.23E+4n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408853
PNG
(US10376531, Compound 3 | US10813942, Compound 3)
Show SMILES CC(=O)N[C@H]1[C@H]2OC[C@](CO)(O2)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C9H15NO6/c1-4(12)10-5-6(13)7(14)9(2-11)3-15-8(5)16-9/h5-8,11,13-14H,2-3H2,1H3,(H,10,12)/t5-,6-,7-,8?,9+/m1/s1
PDB
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US Patent
n/an/an/a 7.18E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408854
PNG
(US10376531, Compound II-b | US10813942, Compound I...)
Show SMILES CO[C@H]1OC(CO)(CO)[C@H](O)[C@H](O)[C@H]1NC(C)=O |r|
Show InChI InChI=1S/C10H19NO7/c1-5(14)11-6-7(15)8(16)10(3-12,4-13)18-9(6)17-2/h6-9,12-13,15-16H,3-4H2,1-2H3,(H,11,14)/t6-,7-,8-,9+/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

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US Patent
n/an/an/a 2.50E+5n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408855
PNG
(US10376531, Compound 1 | US10813942, Compound 1)
Show SMILES OC[C@@]12CO[C@@H](O1)[C@H](N=[N+]=[N-])[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C7H11N3O5/c8-10-9-3-4(12)5(13)7(1-11)2-14-6(3)15-7/h3-6,11-13H,1-2H2/t3-,4-,5-,6?,7+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

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US Patent
n/an/an/a 9.00E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408856
PNG
(US10376531, Compound 18 | US10813942, Compound 18)
Show SMILES CCCOC[C@@]12CO[C@@H](O1)[C@H](NC(C)=O)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C12H21NO6/c1-3-4-17-5-12-6-18-11(19-12)8(13-7(2)14)9(15)10(12)16/h8-11,15-16H,3-6H2,1-2H3,(H,13,14)/t8-,9-,10-,11?,12+/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

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US Patent
n/an/an/a 3.00E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408857
PNG
(US10376531, Compound 17 | US10813942, Compound 17)
Show SMILES CCOC[C@@]12CO[C@@H](O1)[C@H](NC(C)=O)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C11H19NO6/c1-3-16-4-11-5-17-10(18-11)7(12-6(2)13)8(14)9(11)15/h7-10,14-15H,3-5H2,1-2H3,(H,12,13)/t7-,8-,9-,10?,11+/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/an/a 3.80E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408858
PNG
(US10376531, Compound 20 | US10813942, Compound 20)
Show SMILES CCCCCOC[C@@]12CO[C@@H](O1)[C@H](NC(C)=O)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C14H25NO6/c1-3-4-5-6-19-7-14-8-20-13(21-14)10(15-9(2)16)11(17)12(14)18/h10-13,17-18H,3-8H2,1-2H3,(H,15,16)/t10-,11-,12-,13?,14+/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/an/a 3.40E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408859
PNG
(US10376531, Compound 19 | US10813942, Compound 19)
Show SMILES CCCCOC[C@@]12CO[C@@H](O1)[C@H](NC(C)=O)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C13H23NO6/c1-3-4-5-18-6-13-7-19-12(20-13)9(14-8(2)15)10(16)11(13)17/h9-12,16-17H,3-7H2,1-2H3,(H,14,15)/t9-,10-,11-,12?,13+/m1/s1
PDB
MMDB

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US Patent
n/an/an/a 4.70E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408860
PNG
(US10376531, Compound 21 | US10813942, Compound 21)
Show SMILES CCCCCCOC[C@@]12CO[C@@H](O1)[C@H](NC(C)=O)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C15H27NO6/c1-3-4-5-6-7-20-8-15-9-21-14(22-15)11(16-10(2)17)12(18)13(15)19/h11-14,18-19H,3-9H2,1-2H3,(H,16,17)/t11-,12-,13-,14?,15+/m1/s1
PDB
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US Patent
n/an/an/a 2.60E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408861
PNG
(US10376531, Compound 22 | US10813942, Compound 22)
Show SMILES COCCOCCOCCOCCOC[C@@]12CO[C@@H](O1)[C@H](NC(C)=O)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C18H33NO10/c1-13(20)19-14-15(21)16(22)18(12-28-17(14)29-18)11-27-10-9-26-8-7-25-6-5-24-4-3-23-2/h14-17,21-22H,3-12H2,1-2H3,(H,19,20)/t14-,15-,16-,17?,18+/m1/s1
PDB
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US Patent
n/an/an/a 6.50E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408862
PNG
(US10376531, Compound 25 | US10813942, Compound 25)
Show SMILES CCC(=O)N[C@H]1[C@H]2OC[C@](CO)(O2)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C10H17NO6/c1-2-5(13)11-6-7(14)8(15)10(3-12)4-16-9(6)17-10/h6-9,12,14-15H,2-4H2,1H3,(H,11,13)/t6-,7-,8-,9?,10+/m1/s1
PDB
MMDB

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US Patent
n/an/an/a 3.10E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408863
PNG
(US10376531, Compound 24 | US10813942, Compound 24)
Show SMILES OC[C@@]12CO[C@@H](O1)[C@H](NC(=O)C(F)(F)F)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C9H12F3NO6/c10-9(11,12)7(17)13-3-4(15)5(16)8(1-14)2-18-6(3)19-8/h3-6,14-16H,1-2H2,(H,13,17)/t3-,4-,5-,6?,8+/m1/s1
PDB
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n/an/an/a 1.40E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408864
PNG
(US10376531, Compound 26 | US10813942, Compound 26)
Show SMILES CS(=O)(=O)N[C@H]1[C@H]2OC[C@](CO)(O2)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C8H15NO7S/c1-17(13,14)9-4-5(11)6(12)8(2-10)3-15-7(4)16-8/h4-7,9-12H,2-3H2,1H3/t4-,5-,6-,7?,8+/m1/s1
PDB
MMDB

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n/an/an/a 1.12E+5n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408865
PNG
(US10376531, Compound 29 | US10813942, Compound 29)
Show SMILES CN([C@H]1[C@H]2OC[C@](CO)(O2)[C@H](O)[C@@H]1O)C(C)=O |r|
Show InChI InChI=1S/C10H17NO6/c1-5(13)11(2)6-7(14)8(15)10(3-12)4-16-9(6)17-10/h6-9,12,14-15H,3-4H2,1-2H3/t6-,7-,8-,9?,10+/m1/s1
PDB
MMDB

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n/an/an/a 1.02E+4n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408866
PNG
(US10376531, Compound 30 | US10813942, Compound 30)
Show SMILES CN([C@H]1[C@H]2OC[C@](CO)(O2)[C@H](O)[C@@H]1O)S(C)(=O)=O |r|
Show InChI InChI=1S/C9H17NO7S/c1-10(18(2,14)15)5-6(12)7(13)9(3-11)4-16-8(5)17-9/h5-8,11-13H,3-4H2,1-2H3/t5-,6-,7-,8?,9+/m1/s1
PDB
MMDB

KEGG

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US Patent
n/an/an/a 1.61E+5n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408867
PNG
(US10376531, Compound 27 | US10813942, Compound 27)
Show SMILES OC[C@@]12CO[C@@H](O1)[C@H](NC(=O)C(F)F)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C9H13F2NO6/c10-6(11)7(16)12-3-4(14)5(15)9(1-13)2-17-8(3)18-9/h3-6,8,13-15H,1-2H2,(H,12,16)/t3-,4-,5-,8?,9+/m1/s1
PDB
MMDB

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n/an/an/a 1.10E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408868
PNG
(US10376531, Compound 28 | US10813942, Compound 28)
Show SMILES OC[C@@]12CO[C@@H](O1)[C@H](NC(=O)CC(F)(F)F)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C10H14F3NO6/c11-10(12,13)1-4(16)14-5-6(17)7(18)9(2-15)3-19-8(5)20-9/h5-8,15,17-18H,1-3H2,(H,14,16)/t5-,6-,7-,8?,9+/m1/s1
PDB
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US Patent
n/an/an/a 2.00E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10813942 (2020)


BindingDB Entry DOI: 10.7270/Q28G8PSJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408855
PNG
(US10376531, Compound 1 | US10813942, Compound 1)
Show SMILES OC[C@@]12CO[C@@H](O1)[C@H](N=[N+]=[N-])[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C7H11N3O5/c8-10-9-3-4(12)5(13)7(1-11)2-14-6(3)15-7/h3-6,11-13H,1-2H2/t3-,4-,5-,6?,7+/m1/s1
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n/an/an/a 9.00E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408854
PNG
(US10376531, Compound II-b | US10813942, Compound I...)
Show SMILES CO[C@H]1OC(CO)(CO)[C@H](O)[C@H](O)[C@H]1NC(C)=O |r|
Show InChI InChI=1S/C10H19NO7/c1-5(14)11-6-7(15)8(16)10(3-12,4-13)18-9(6)17-2/h6-9,12-13,15-16H,3-4H2,1-2H3,(H,11,14)/t6-,7-,8-,9+/m1/s1
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n/an/an/a 1.99E+5n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408853
PNG
(US10376531, Compound 3 | US10813942, Compound 3)
Show SMILES CC(=O)N[C@H]1[C@H]2OC[C@](CO)(O2)[C@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C9H15NO6/c1-4(12)10-5-6(13)7(14)9(2-11)3-15-8(5)16-9/h5-8,11,13-14H,2-3H2,1H3,(H,10,12)/t5-,6-,7-,8?,9+/m1/s1
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n/an/an/a 7.18E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM50240803
PNG
(CHEMBL1614854 | Glucoside | beta-D-glucopyranose |...)
Show SMILES OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O |r|
Show InChI InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
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n/an/an/a>1.00E+7n/an/an/an/an/a



University of Basel

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant ASGPR1 carbohydrate recognition domain expressed in Escherichia coli AD494 by surface plasmon resonance spectro...

Bioorg Med Chem 17: 7254-64 (2009)


Article DOI: 10.1016/j.bmc.2009.08.049
BindingDB Entry DOI: 10.7270/Q2NK3G09
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM50304488
PNG
((2S,3R,4S,5S,6R)-2,3,4,5-tetramethoxy-6-(methoxyme...)
Show SMILES COC[C@H]1O[C@H](OC)[C@H](OC)[C@@H](OC)[C@H]1OC |r|
Show InChI InChI=1S/C11H22O6/c1-12-6-7-8(13-2)9(14-3)10(15-4)11(16-5)17-7/h7-11H,6H2,1-5H3/t7-,8+,9+,10-,11+/m1/s1
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n/an/an/a 2.76E+6n/an/an/an/an/a



University of Basel

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant ASGPR1 carbohydrate recognition domain expressed in Escherichia coli AD494 by surface plasmon resonance spectro...

Bioorg Med Chem 17: 7254-64 (2009)


Article DOI: 10.1016/j.bmc.2009.08.049
BindingDB Entry DOI: 10.7270/Q2NK3G09
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM50304487
PNG
((2R,3R,4S,5S,6R)-2,3,4,5-tetramethoxy-6-(methoxyme...)
Show SMILES COC[C@H]1O[C@@H](OC)[C@H](OC)[C@@H](OC)[C@H]1OC |r|
Show InChI InChI=1S/C11H22O6/c1-12-6-7-8(13-2)9(14-3)10(15-4)11(16-5)17-7/h7-11H,6H2,1-5H3/t7-,8+,9+,10-,11-/m1/s1
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n/an/an/a 2.20E+6n/an/an/an/an/a



University of Basel

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant ASGPR1 carbohydrate recognition domain expressed in Escherichia coli AD494 by surface plasmon resonance spectro...

Bioorg Med Chem 17: 7254-64 (2009)


Article DOI: 10.1016/j.bmc.2009.08.049
BindingDB Entry DOI: 10.7270/Q2NK3G09
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM50077229
PNG
(CHEMBL300520 | beta-D-galactopyranose | beta-D-gal...)
Show SMILES OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6-/m1/s1
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n/an/an/a 1.46E+6n/an/an/an/an/a



University of Basel

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant ASGPR1 carbohydrate recognition domain expressed in Escherichia coli AD494 by surface plasmon resonance spectro...

Bioorg Med Chem 17: 7254-64 (2009)


Article DOI: 10.1016/j.bmc.2009.08.049
BindingDB Entry DOI: 10.7270/Q2NK3G09
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM50304486
PNG
((3R,4R,5R,6R)-3-acetamido-6-(acetoxymethyl)tetrahy...)
Show SMILES CC(=O)N[C@H]1C(OC(C)=O)O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@@H]1OC(C)=O |r|
Show InChI InChI=1S/C16H23NO10/c1-7(18)17-13-15(25-10(4)21)14(24-9(3)20)12(6-23-8(2)19)27-16(13)26-11(5)22/h12-16H,6H2,1-5H3,(H,17,18)/t12-,13-,14+,15-,16?/m1/s1
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n/an/an/a 1.50E+5n/an/an/an/an/a



University of Basel

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant ASGPR1 carbohydrate recognition domain expressed in Escherichia coli AD494 by surface plasmon resonance spectro...

Bioorg Med Chem 17: 7254-64 (2009)


Article DOI: 10.1016/j.bmc.2009.08.049
BindingDB Entry DOI: 10.7270/Q2NK3G09
More data for this
Ligand-Target Pair
Asialoglycoprotein receptor 1


(Homo sapiens (Human))		BDBM408863
PNG
(US10376531, Compound 24 | US10813942, Compound 24)
Show SMILES OC[C@@]12CO[C@@H](O1)[C@H](NC(=O)C(F)(F)F)[C@@H](O)[C@H]2O |r|
Show InChI InChI=1S/C9H12F3NO6/c10-9(11,12)7(17)13-3-4(15)5(16)8(1-14)2-18-6(3)19-8/h3-6,14-16H,1-2H2,(H,13,17)/t3-,4-,5-,6?,8+/m1/s1
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n/an/an/a 1.10E+3n/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
All SPR measurements with compounds were performed using a Biacore 3000 (GE Healthcare) at 25° C. Biotinylated ASGPR was immobilized typically at 200...

US Patent US10376531 (2019)


BindingDB Entry DOI: 10.7270/Q2542QZJ
More data for this
Ligand-Target Pair