Compile Data Set for Download or QSAR

Found 5610 hits Enz. Inhib. hit(s) with Target = 'CBP'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Carboxypeptidase B2 (Homo sapiens (Human))	BDBM50395732 (CHEMBL2164462) Show SMILES Nc1ccc(CC(C[Se][Se]CC(Cc2ccc(N)nc2)C(O)=O)C(O)=O)cn1 Show InChI InChI=1S/C18H22N4O4Se2/c19-15-3-1-11(7-21-15)5-13(17(23)24)9-27-28-10-14(18(25)26)6-12-2-4-16(20)22-8-12/h1-4,7-8,13-14H,5-6,9-10H2,(H2,19,21)(H2,20,22)(H,23,24)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.00200	n/a	n/a	n/a	n/a	n/a	n/a
Showa Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human activated TAFI using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophot...				J Med Chem 55: 7696-705 (2012) Article DOI: 10.1021/jm300735t BindingDB Entry DOI: 10.7270/Q2N58NHV
					More data for this Ligand-Target Pair
Carboxypeptidase B2 (Homo sapiens (Human))	BDBM50395730 (CHEMBL2164450) Show SMILES Nc1ncc(CC(C[Se][Se]CC(Cc2cnc(N)c(Cl)c2)C(O)=O)C(O)=O)cc1Cl Show InChI InChI=1S/C18H20Cl2N4O4Se2/c19-13-3-9(5-23-15(13)21)1-11(17(25)26)7-29-30-8-12(18(27)28)2-10-4-14(20)16(22)24-6-10/h3-6,11-12H,1-2,7-8H2,(H2,21,23)(H2,22,24)(H,25,26)(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0250	n/a	n/a	n/a	n/a	n/a	n/a
Showa Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human activated TAFI using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophot...				J Med Chem 55: 7696-705 (2012) Article DOI: 10.1021/jm300735t BindingDB Entry DOI: 10.7270/Q2N58NHV
					More data for this Ligand-Target Pair
Carboxypeptidase B (Sus scrofa)	BDBM50395732 (CHEMBL2164462) Show SMILES Nc1ccc(CC(C[Se][Se]CC(Cc2ccc(N)nc2)C(O)=O)C(O)=O)cn1 Show InChI InChI=1S/C18H22N4O4Se2/c19-15-3-1-11(7-21-15)5-13(17(23)24)9-27-28-10-14(18(25)26)6-12-2-4-16(20)22-8-12/h1-4,7-8,13-14H,5-6,9-10H2,(H2,19,21)(H2,20,22)(H,23,24)(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
Showa Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of pig pancreatic carboxypeptidase B using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins b...				J Med Chem 55: 7696-705 (2012) Article DOI: 10.1021/jm300735t BindingDB Entry DOI: 10.7270/Q2N58NHV
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM537094 (US11247989, Example 92) Show SMILES CNC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cccc2cc(ncc12)-c1ccc(nc1)C(=O)NC Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.760	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R43
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50453957 (CHEMBL4217213) Show SMILES CNC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cccc2cc(-c3cnn(C)c3)c(cc12)C(F)F Show InChI InChI=1S/C28H30F2N6O2/c1-31-28(37)35-9-6-25-24(16-35)26(33-36(25)19-7-10-38-11-8-19)20-5-3-4-17-12-21(18-14-32-34(2)15-18)23(27(29)30)13-22(17)20/h3-5,12-15,19,27H,6-11,16H2,1-2H3,(H,31,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant His-tagged CBP (unknown origin) by TR-FRET assay				Bioorg Med Chem Lett 28: 15-23 (2018) Article DOI: 10.1016/j.bmcl.2017.11.025 BindingDB Entry DOI: 10.7270/Q2ZG6VVZ
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM537100 (US11247989, Example 93) Show SMILES CNC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cccc2cc(ncc12)-c1cnn(C)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.910	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R43
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50269847 (CHEMBL4097025) Show SMILES CNC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F Show InChI InChI=1S/C27H33F2N7O2/c1-30-27(37)34-9-5-23-22(16-34)26(32-36(23)19-6-10-38-11-7-19)35-8-3-4-17-12-20(18-14-31-33(2)15-18)21(25(28)29)13-24(17)35/h12-15,19,25H,3-11,16H2,1-2H3,(H,30,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	0.940	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States. Curated by ChEMBL					Assay Description Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assay				J Med Chem 60: 9162-9183 (2017) Article DOI: 10.1021/acs.jmedchem.7b00796 BindingDB Entry DOI: 10.7270/Q23F4S4V
					More data for this Ligand-Target Pair				3D Structure (crystal)
CREB-binding protein (Homo sapiens (Human))	BDBM536872 (1-(1-acetylpiperidin-4-yl)-N-methyl-3-(3-(2-methyl...) Show SMILES CNC(=O)N1CCc2c(C1)c(nn2C1CCN(CC1)C(C)=O)-c1cccc2cc(ncc12)-c1cnc(C)s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.970	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R43
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50453949 (CHEMBL4208820 | US11247989, Example 87) Show SMILES CNC(=O)c1ccc(cn1)-c1cc2cccc(-c3nn(C4CCOCC4)c4CCN(Cc34)C(C)=O)c2cn1 Show InChI InChI=1S/C29H30N6O3/c1-18(36)34-11-8-27-24(17-34)28(33-35(27)21-9-12-38-13-10-21)22-5-3-4-19-14-26(32-16-23(19)22)20-6-7-25(31-15-20)29(37)30-2/h3-7,14-16,21H,8-13,17H2,1-2H3,(H,30,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	0.997	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R43
					More data for this Ligand-Target Pair
CREB-binding protein [1081-1197] (Homo sapiens (Human))	BDBM511322 (3-Cyclopropyl-N-methyl-1-(3-(2-methylthiazol-5-yl)...) Show SMILES CNC(=O)N1CCn2c(C1)c(nc2C1CC1)-c1cccc2cc(ncc12)-c1cnc(C)s1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CC13VN
					More data for this Ligand-Target Pair
CREB-binding protein [1081-1197] (Homo sapiens (Human))	BDBM511316 (3-Cyclopropyl-N-methyl-1-(3-(6-(methylcarbamoyl)py...) Show SMILES CNC(=O)N1CCn2c(C1)c(nc2C1CC1)-c1cccc2cc(ncc12)-c1ccc(nc1)C(=O)NC Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CC13VN
					More data for this Ligand-Target Pair
Carboxypeptidase B2 (Homo sapiens (Human))	BDBM50575776 (CHEMBL4868605) Show SMILES Cc1ccc(cc1)-c1cc(F)ccc1CN1CCP(O)(=O)[C@@](CCCCN)(C1)C(O)=O |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human activated TAFI incubated for 45 mins using hippuryl-arginine as substrate by spectrophotometry				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02072 BindingDB Entry DOI: 10.7270/Q2SB49JM
					More data for this Ligand-Target Pair
Carboxypeptidase B (Homo sapiens (Human))	BDBM50089691 (CHEMBL3577425) Show SMILES CC1(C)C2CCC1(C)CC2NC(=O)[C@@H](CC1CCCCC1)NC(=O)N[C@@H](CCCCN)C(O)=O |r,TLB:10:9:5.4:1| Show InChI InChI=1S/C26H46N4O4/c1-25(2)18-12-13-26(25,3)16-21(18)28-22(31)20(15-17-9-5-4-6-10-17)30-24(34)29-19(23(32)33)11-7-8-14-27/h17-21H,4-16,27H2,1-3H3,(H,28,31)(H,32,33)(H2,29,30,34)/t18?,19-,20+,21?,26?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Infection Research Curated by ChEMBL					Assay Description Inhibition of CBP (unknown origin)				J Med Chem 58: 4839-44 (2015) Article DOI: 10.1021/jm501840b BindingDB Entry DOI: 10.7270/Q24B3314
					More data for this Ligand-Target Pair
Carboxypeptidase B (Homo sapiens (Human))	BDBM50144342 (3-((1R,3S)-3-Amino-cyclopentyl)-2-[1-(3,3-dimethyl...) Show SMILES CC(C)(C)CCn1cnc(c1)C(C[C@H]1CC[C@H](N)C1)C(O)=O Show InChI InChI=1S/C17H29N3O2/c1-17(2,3)6-7-20-10-15(19-11-20)14(16(21)22)9-12-4-5-13(18)8-12/h10-14H,4-9,18H2,1-3H3,(H,21,22)/t12-,13-,14?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human carboxypeptidase B (CPB)				Bioorg Med Chem Lett 14: 2141-5 (2004) Article DOI: 10.1016/j.bmcl.2004.02.033 BindingDB Entry DOI: 10.7270/Q2N8797S
					More data for this Ligand-Target Pair
Carboxypeptidase B2 (Homo sapiens (Human))	BDBM50144342 (3-((1R,3S)-3-Amino-cyclopentyl)-2-[1-(3,3-dimethyl...) Show SMILES CC(C)(C)CCn1cnc(c1)C(C[C@H]1CC[C@H](N)C1)C(O)=O Show InChI InChI=1S/C17H29N3O2/c1-17(2,3)6-7-20-10-15(19-11-20)14(16(21)22)9-12-4-5-13(18)8-12/h10-14H,4-9,18H2,1-3H3,(H,21,22)/t12-,13-,14?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory potency against human TAFIa (thrombin-activatable fibrinolysis inhibitor)				Bioorg Med Chem Lett 14: 2141-5 (2004) Article DOI: 10.1016/j.bmcl.2004.02.033 BindingDB Entry DOI: 10.7270/Q2N8797S
					More data for this Ligand-Target Pair
Carboxypeptidase B (Homo sapiens (Human))	BDBM50144336 (3-(6-Amino-5-methyl-pyridin-3-yl)-2-[1-(3-methyl-b...) Show SMILES CC(C)CCn1cnc(c1)C(Cc1cnc(N)c(C)c1)C(O)=O Show InChI InChI=1S/C17H24N4O2/c1-11(2)4-5-21-9-15(20-10-21)14(17(22)23)7-13-6-12(3)16(18)19-8-13/h6,8-11,14H,4-5,7H2,1-3H3,(H2,18,19)(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human carboxypeptidase B (CPB)				Bioorg Med Chem Lett 14: 2141-5 (2004) Article DOI: 10.1016/j.bmcl.2004.02.033 BindingDB Entry DOI: 10.7270/Q2N8797S
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM537101 (US11247989, Example 94) Show SMILES CNC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cccc2cc(ncc12)-c1cnc(C)s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R43
					More data for this Ligand-Target Pair
Carboxypeptidase B (Homo sapiens (Human))	BDBM50144333 (3-(6-Amino-5-methyl-pyridin-3-yl)-2-[1-(4-methyl-p...) Show SMILES CC(C)CCCn1cnc(c1)C(Cc1cnc(N)c(C)c1)C(O)=O Show InChI InChI=1S/C18H26N4O2/c1-12(2)5-4-6-22-10-16(21-11-22)15(18(23)24)8-14-7-13(3)17(19)20-9-14/h7,9-12,15H,4-6,8H2,1-3H3,(H2,19,20)(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human carboxypeptidase B (CPB)				Bioorg Med Chem Lett 14: 2141-5 (2004) Article DOI: 10.1016/j.bmcl.2004.02.033 BindingDB Entry DOI: 10.7270/Q2N8797S
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM340748 (US9763922, Example 274) Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1CCN(CC1)C(C)=O Show InChI InChI=1S/C26H31F3N8O2/c1-15(38)35-7-4-17(5-8-35)37-23-6-9-36(26(39)30-2)14-20(23)25(33-37)32-22-11-19(24(28)29)18(10-21(22)27)16-12-31-34(3)13-16/h10-13,17,24H,4-9,14H2,1-3H3,(H,30,39)(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				US Patent US9763922 (2017) BindingDB Entry DOI: 10.7270/Q23N25G6
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM340734 (3-[5-(difluoromethyl)-2-fluoro-4-(1-methylpyrazol-...) Show SMILES CNC(=O)N1CCc2c(C1)c(Nc1cc(C(F)F)c(cc1F)-c1cnn(C)c1)nn2C1CCOCC1 Show InChI InChI=1S/C24H28F3N7O2/c1-28-24(35)33-6-3-21-18(13-33)23(31-34(21)15-4-7-36-8-5-15)30-20-10-17(22(26)27)16(9-19(20)25)14-11-29-32(2)12-14/h9-12,15,22H,3-8,13H2,1-2H3,(H,28,35)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				US Patent US9763922 (2017) BindingDB Entry DOI: 10.7270/Q23N25G6
					More data for this Ligand-Target Pair
Carboxypeptidase B2 (Homo sapiens (Human))	BDBM50089758 (CHEMBL3577442) Show SMILES CC12CCC(C(C1)NC(=O)[C@@H](CC1CCCCC1)NC(=O)N[C@@H](Cc1ccc(N)nc1)C(O)=O)C2(C)C |r,THB:7:5:34:2.3| Show InChI InChI=1S/C28H43N5O4/c1-27(2)19-11-12-28(27,3)15-22(19)31-24(34)20(13-17-7-5-4-6-8-17)32-26(37)33-21(25(35)36)14-18-9-10-23(29)30-16-18/h9-10,16-17,19-22H,4-8,11-15H2,1-3H3,(H2,29,30)(H,31,34)(H,35,36)(H2,32,33,37)/t19?,20-,21+,22?,28?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Infection Research Curated by ChEMBL					Assay Description Inhibition of human activated TAFI incubated for 15 mins by microtiter plate reader based assay				J Med Chem 58: 4839-44 (2015) Article DOI: 10.1021/jm501840b BindingDB Entry DOI: 10.7270/Q24B3314
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50269857 (CHEMBL4088793) Show SMILES CC(=O)N1CCC(CC1)n1nc(N2CCCc3cc(-c4cnn(C)c4)c(cc23)C(F)F)c2CN(CCc12)C(C)=O Show InChI InChI=1S/C29H35F2N7O2/c1-18(39)35-10-6-22(7-11-35)38-26-8-12-36(19(2)40)17-25(26)29(33-38)37-9-4-5-20-13-23(21-15-32-34(3)16-21)24(28(30)31)14-27(20)37/h13-16,22,28H,4-12,17H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States. Curated by ChEMBL					Assay Description Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assay				J Med Chem 60: 9162-9183 (2017) Article DOI: 10.1021/acs.jmedchem.7b00796 BindingDB Entry DOI: 10.7270/Q23F4S4V
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50269848 (CHEMBL4069831) Show SMILES Cn1cc(cn1)-c1cc2CCCN(c3nn(C4CCOCC4)c4CCN(Cc34)C(N)=O)c2cc1C(F)F Show InChI InChI=1S/C26H31F2N7O2/c1-32-14-17(13-30-32)19-11-16-3-2-7-34(23(16)12-20(19)24(27)28)25-21-15-33(26(29)36)8-4-22(21)35(31-25)18-5-9-37-10-6-18/h11-14,18,24H,2-10,15H2,1H3,(H2,29,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States. Curated by ChEMBL					Assay Description Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assay				J Med Chem 60: 9162-9183 (2017) Article DOI: 10.1021/acs.jmedchem.7b00796 BindingDB Entry DOI: 10.7270/Q23F4S4V
					More data for this Ligand-Target Pair
CREB-binding protein [1081-1197] (Homo sapiens (Human))	BDBM511394 (3-(4,4- difluorocyclohexyl)-1-(7- fluoro-3-(2-meth...) Show SMILES CNC(=O)N1CCn2c(C1)c(nc2C1CCC(F)(F)CC1)-c1c(F)ccc2cc(ncc12)-c1cnc(C)s1 |(-5.55,-.48,;-4.22,.29,;-2.89,-.48,;-2.89,-2.02,;-1.55,.29,;-1.55,1.83,;-.22,2.6,;1.11,1.83,;1.11,.29,;-.22,-.48,;2.58,-.19,;3.48,1.06,;2.58,2.3,;2.98,3.79,;4.47,4.19,;4.86,5.68,;3.77,6.77,;4.86,7.85,;3.38,8.25,;2.29,6.37,;1.89,4.88,;2.98,-1.68,;4.47,-2.08,;5.55,-.99,;4.86,-3.56,;3.77,-4.65,;2.29,-4.25,;1.2,-5.34,;-.29,-4.94,;-.69,-3.46,;.4,-2.37,;1.89,-2.77,;-1.38,-6.03,;-1.14,-7.55,;-2.51,-8.25,;-3.6,-7.16,;-5.09,-7.56,;-2.9,-5.79,)| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CC13VN
					More data for this Ligand-Target Pair
CREB-binding protein [1081-1197] (Homo sapiens (Human))	BDBM511390 (1-(7-fluoro-3-(2- methylthiazol-5- yl)isoquinolin-...) Show SMILES CNC(=O)N1CCn2c(C1)c(nc2C1CCOCC1)-c1c(F)ccc2cc(ncc12)-c1cnc(C)s1 |(-5.55,.26,;-4.22,1.03,;-2.89,.26,;-2.89,-1.28,;-1.55,1.03,;-1.55,2.57,;-.22,3.34,;1.11,2.57,;1.11,1.03,;-.22,.26,;2.58,.55,;3.48,1.8,;2.58,3.05,;2.98,4.53,;4.47,4.93,;4.86,6.42,;3.77,7.51,;2.29,7.11,;1.89,5.62,;2.98,-.93,;4.47,-1.33,;5.55,-.24,;4.86,-2.82,;3.77,-3.91,;2.29,-3.51,;1.2,-4.6,;-.29,-4.2,;-.69,-2.71,;.4,-1.62,;1.89,-2.02,;-1.38,-5.29,;-1.14,-6.81,;-2.51,-7.51,;-3.6,-6.42,;-5.09,-6.82,;-2.9,-5.05,)| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CC13VN
					More data for this Ligand-Target Pair
CREB-binding protein [1081-1197] (Homo sapiens (Human))	BDBM511377 (3-(4,4- difluorocyclohexyl)-N- methyl-1-(2-(1-meth...) Show SMILES CNC(=O)N1CCn2c(C1)c(nc2C1CCC(F)(F)CC1)-c1cccc2nc(-c3cnn(C)c3)c(cc12)C(F)(F)F Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CC13VN
					More data for this Ligand-Target Pair
CREB-binding protein [1081-1197] (Homo sapiens (Human))	BDBM511356 (N-methyl-1-(3-(6- (methylcarbamoyl)pyridin- 3-yl)i...) Show SMILES CNC(=O)N1CCn2c(C1)c(nc2C1CCOCC1)-c1cccc2cc(ncc12)-c1ccc(nc1)C(=O)NC Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in 15 &...				Citation and Details BindingDB Entry DOI: 10.7270/Q2CC13VN
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM536819 (3-(6-(difluoromethyl)-7-(1-methyl-1H-pyrazol-4-yl)...) Show SMILES CNC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cncc2cc(-c3cnn(C)c3)c(cc12)C(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	1.07	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R43
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM537087 (US11247989, Example 90) Show SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cccc2cc(ncc12)-c1cnn(C)c1C Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R43
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50269849 (CHEMBL4076748) Show SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F Show InChI InChI=1S/C27H32F2N6O2/c1-17(36)33-9-5-24-23(16-33)27(31-35(24)20-6-10-37-11-7-20)34-8-3-4-18-12-21(19-14-30-32(2)15-19)22(26(28)29)13-25(18)34/h12-15,20,26H,3-11,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States. Curated by ChEMBL					Assay Description Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assay				J Med Chem 60: 9162-9183 (2017) Article DOI: 10.1021/acs.jmedchem.7b00796 BindingDB Entry DOI: 10.7270/Q23F4S4V
					More data for this Ligand-Target Pair				3D Structure (crystal)
Carboxypeptidase B (Sus scrofa)	BDBM50395737 (CHEMBL2164457) Show SMILES NCCCCCC(C[Se][Se]CC(CCCCCN)C(O)=O)C(O)=O Show InChI InChI=1S/C16H32N2O4Se2/c17-9-5-1-3-7-13(15(19)20)11-23-24-12-14(16(21)22)8-4-2-6-10-18/h13-14H,1-12,17-18H2,(H,19,20)(H,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Showa Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of pig pancreatic carboxypeptidase B using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins b...				J Med Chem 55: 7696-705 (2012) Article DOI: 10.1021/jm300735t BindingDB Entry DOI: 10.7270/Q2N58NHV
					More data for this Ligand-Target Pair
Carboxypeptidase B (Sus scrofa)	BDBM50395735 (CHEMBL2164459) Show SMILES CCC(=O)[Se]CC(CCCCCN)C(O)=O Show InChI InChI=1S/C11H21NO3Se/c1-2-10(13)16-8-9(11(14)15)6-4-3-5-7-12/h9H,2-8,12H2,1H3,(H,14,15)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Showa Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of pig pancreatic carboxypeptidase B using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins b...				J Med Chem 55: 7696-705 (2012) Article DOI: 10.1021/jm300735t BindingDB Entry DOI: 10.7270/Q2N58NHV
					More data for this Ligand-Target Pair
Carboxypeptidase B2 (Homo sapiens (Human))	BDBM50395735 (CHEMBL2164459) Show SMILES CCC(=O)[Se]CC(CCCCCN)C(O)=O Show InChI InChI=1S/C11H21NO3Se/c1-2-10(13)16-8-9(11(14)15)6-4-3-5-7-12/h9H,2-8,12H2,1H3,(H,14,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
Showa Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human activated TAFI using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophot...				J Med Chem 55: 7696-705 (2012) Article DOI: 10.1021/jm300735t BindingDB Entry DOI: 10.7270/Q2N58NHV
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM536735 (US11247989, Example 9) Show SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1ccc(C)c2cc(ncc12)-c1cnn(C)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.13	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R43
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM536741 (US11247989, Example 10) Show SMILES CNC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1ccc(C)c2cc(ncc12)-c1cnn(C)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.15	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R43
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50453950 (CHEMBL4203082 | US11247989, Example 88) Show SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cccc2cc(ncc12)-c1cnn(C)c1 Show InChI InChI=1S/C26H28N6O2/c1-17(33)31-9-6-25-23(16-31)26(29-32(25)20-7-10-34-11-8-20)21-5-3-4-18-12-24(27-14-22(18)21)19-13-28-30(2)15-19/h3-5,12-15,20H,6-11,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	1.16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R43
					More data for this Ligand-Target Pair				3D Structure (crystal)
CREB-binding protein (Homo sapiens (Human))	BDBM537088 (US11247989, Example 91) Show SMILES CNC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1c(F)ccc2cc(ncc12)-c1cnn(C)c1 |(-9.15,-1.5,;-7.82,-.73,;-6.49,-1.5,;-6.49,-3.04,;-5.15,-.73,;-5.15,.81,;-3.82,1.58,;-2.49,.81,;-2.49,-.73,;-3.82,-1.5,;-1.02,-1.2,;-.12,.04,;-1.02,1.29,;-.62,2.78,;.87,3.17,;1.26,4.66,;.18,5.75,;-1.31,5.35,;-1.71,3.86,;-.62,-2.69,;-1.71,-3.78,;-3.2,-3.38,;-1.31,-5.27,;.18,-5.67,;1.26,-4.58,;2.75,-4.98,;3.84,-3.89,;3.44,-2.4,;1.95,-2,;.87,-3.09,;5.33,-4.29,;5.8,-5.75,;7.34,-5.75,;7.82,-4.29,;9.15,-3.52,;6.57,-3.38,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.17	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R43
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50269855 (CHEMBL4061161) Show SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCS(=O)(=O)CC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F Show InChI InChI=1S/C27H32F2N6O3S/c1-17(36)33-9-5-24-23(16-33)27(31-35(24)20-6-10-39(37,38)11-7-20)34-8-3-4-18-12-21(19-14-30-32(2)15-19)22(26(28)29)13-25(18)34/h12-15,20,26H,3-11,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States. Curated by ChEMBL					Assay Description Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assay				J Med Chem 60: 9162-9183 (2017) Article DOI: 10.1021/acs.jmedchem.7b00796 BindingDB Entry DOI: 10.7270/Q23F4S4V
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50269856 (CHEMBL4060566) Show SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCN(CC1)S(C)(=O)=O)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F Show InChI InChI=1S/C28H35F2N7O3S/c1-18(38)34-10-8-25-24(17-34)28(32-37(25)21-6-11-35(12-7-21)41(3,39)40)36-9-4-5-19-13-22(20-15-31-33(2)16-20)23(27(29)30)14-26(19)36/h13-16,21,27H,4-12,17H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States. Curated by ChEMBL					Assay Description Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assay				J Med Chem 60: 9162-9183 (2017) Article DOI: 10.1021/acs.jmedchem.7b00796 BindingDB Entry DOI: 10.7270/Q23F4S4V
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50453949 (CHEMBL4208820 | US11247989, Example 87) Show SMILES CNC(=O)c1ccc(cn1)-c1cc2cccc(-c3nn(C4CCOCC4)c4CCN(Cc34)C(C)=O)c2cn1 Show InChI InChI=1S/C29H30N6O3/c1-18(36)34-11-8-27-24(17-34)28(33-35(27)21-9-12-38-13-10-21)22-5-3-4-19-14-26(32-16-23(19)22)20-6-7-25(31-15-20)29(37)30-2/h3-7,14-16,21H,8-13,17H2,1-2H3,(H,30,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant His-tagged CBP (unknown origin) by TR-FRET assay				Bioorg Med Chem Lett 28: 15-23 (2018) Article DOI: 10.1016/j.bmcl.2017.11.025 BindingDB Entry DOI: 10.7270/Q2ZG6VVZ
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50453950 (CHEMBL4203082 | US11247989, Example 88) Show SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cccc2cc(ncc12)-c1cnn(C)c1 Show InChI InChI=1S/C26H28N6O2/c1-17(33)31-9-6-25-23(16-31)26(29-32(25)20-7-10-34-11-8-20)21-5-3-4-18-12-24(27-14-22(18)21)19-13-28-30(2)15-19/h3-5,12-15,20H,6-11,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant His-tagged CBP (unknown origin) by TR-FRET assay				Bioorg Med Chem Lett 28: 15-23 (2018) Article DOI: 10.1016/j.bmcl.2017.11.025 BindingDB Entry DOI: 10.7270/Q2ZG6VVZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
CREB-binding protein (Homo sapiens (Human))	BDBM536862 ((S)-1-(3-(6-(1-methyl-1H-pyrazol-4-yl)naphthalen-1...) Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1CCOC1)-c1cccc2cc(ccc12)-c1cnn(C)c1 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.39	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R43
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50269850 (CHEMBL4061600) Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1CCOC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F |r| Show InChI InChI=1S/C26H30F2N6O2/c1-16(35)32-8-5-23-22(14-32)26(30-34(23)19-6-9-36-15-19)33-7-3-4-17-10-20(18-12-29-31(2)13-18)21(25(27)28)11-24(17)33/h10-13,19,25H,3-9,14-15H2,1-2H3/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States. Curated by ChEMBL					Assay Description Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assay				J Med Chem 60: 9162-9183 (2017) Article DOI: 10.1021/acs.jmedchem.7b00796 BindingDB Entry DOI: 10.7270/Q23F4S4V
					More data for this Ligand-Target Pair				3D Structure (crystal)
CREB-binding protein (Homo sapiens (Human))	BDBM536875 (2-cyano-N-methyl-3-(3-(1-methyl-1H-pyrazol-4-yl)is...) Show SMILES CNC(=O)N1CCc2c(C1)c(c(C#N)n2C1CCOCC1)-c1cccc2cc(ncc12)-c1cnn(C)c1 |(-9.26,-1.54,;-7.93,-.77,;-6.59,-1.54,;-6.59,-3.08,;-5.26,-.77,;-5.26,.77,;-3.92,1.54,;-2.59,.77,;-2.59,-.77,;-3.92,-1.54,;-1.13,-1.25,;-.22,,;1.32,,;2.86,,;-1.13,1.25,;-.65,2.71,;.86,3.03,;1.33,4.5,;.3,5.64,;-1.21,5.32,;-1.68,3.86,;-.65,-2.71,;-1.68,-3.86,;-1.21,-5.32,;.3,-5.64,;1.33,-4.5,;2.84,-4.82,;3.87,-3.67,;3.39,-2.21,;1.89,-1.89,;.86,-3.03,;5.37,-3.99,;6,-5.4,;7.53,-5.24,;7.85,-3.73,;9.26,-3.1,;6.52,-2.96,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.42	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R43
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM536860 (N-methyl-3-(4-methyl-3-(1-methyl-1H-pyrazol-4-yl)i...) Show SMILES CNC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)-c1cccc2c(C)c(ncc12)-c1cnn(C)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.45	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2X63R43
					More data for this Ligand-Target Pair
Carboxypeptidase B2 (Homo sapiens (Human))	BDBM50275212 (CHEMBL4127473) Show SMILES [#6]-[#6]-[#6](=O)[Se;v2][#6]-[#6](-[#6]-c1cnc(-[#7])c(Cl)c1)-[#6](-[#8])=O Show InChI InChI=1S/C12H15ClN2O3Se/c1-2-10(16)19-6-8(12(17)18)3-7-4-9(13)11(14)15-5-7/h4-5,8H,2-3,6H2,1H3,(H2,14,15)(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Showa Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human plasma activated thrombin-activatable fibrinolysis inhibitor after 10 mins in presence of DTT				Bioorg Med Chem Lett 28: 2256-2260 (2018) Article DOI: 10.1016/j.bmcl.2018.05.042 BindingDB Entry DOI: 10.7270/Q25M686N
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50269907 (CHEMBL4080905) Show SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCNCC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F Show InChI InChI=1S/C27H33F2N7O/c1-17(37)34-11-7-24-23(16-34)27(32-36(24)20-5-8-30-9-6-20)35-10-3-4-18-12-21(19-14-31-33(2)15-19)22(26(28)29)13-25(18)35/h12-15,20,26,30H,3-11,16H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States. Curated by ChEMBL					Assay Description Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assay				J Med Chem 60: 9162-9183 (2017) Article DOI: 10.1021/acs.jmedchem.7b00796 BindingDB Entry DOI: 10.7270/Q23F4S4V
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50269914 (CHEMBL4083416) Show SMILES CC(=O)N1CCc2c(C1)c(nn2[C@H]1CCOC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)(F)F |r| Show InChI InChI=1S/C26H29F3N6O2/c1-16(36)33-8-5-23-21(14-33)25(31-35(23)19-6-9-37-15-19)34-7-3-4-17-10-20(18-12-30-32(2)13-18)22(11-24(17)34)26(27,28)29/h10-13,19H,3-9,14-15H2,1-2H3/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States. Curated by ChEMBL					Assay Description Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assay				J Med Chem 60: 9162-9183 (2017) Article DOI: 10.1021/acs.jmedchem.7b00796 BindingDB Entry DOI: 10.7270/Q23F4S4V
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM50602881 (CHEMBL5204688) Show SMILES CC(O)c1cc(NC(=O)c2cc(C(C)=O)n3ccc(N)cc23)c(F)c(c1)-c1cnn(c1)C1CC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01864 BindingDB Entry DOI: 10.7270/Q2VT1X5F
					More data for this Ligand-Target Pair
Carboxypeptidase B2 (Homo sapiens (Human))	BDBM50089688 (ANABAENOPEPTIN B) Show SMILES CC(C)[C@@H]1NC(=O)[C@@H](CCCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C(=O)[C@H](CCc2ccc(O)cc2)NC1=O)NC(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r| Show InChI InChI=1S/C41H60N10O9/c1-24(2)33-37(56)46-30(20-17-26-15-18-28(52)19-16-26)38(57)51(4)25(3)34(53)47-32(23-27-11-6-5-7-12-27)35(54)44-21-9-8-13-29(36(55)50-33)48-41(60)49-31(39(58)59)14-10-22-45-40(42)43/h5-7,11-12,15-16,18-19,24-25,29-33,52H,8-10,13-14,17,20-23H2,1-4H3,(H,44,54)(H,46,56)(H,47,53)(H,50,55)(H,58,59)(H4,42,43,45)(H2,48,49,60)/t25-,29+,30-,31-,32-,33-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Infection Research Curated by ChEMBL					Assay Description Inhibition of human activated TAFI incubated for 15 mins by microtiter plate reader based assay				J Med Chem 58: 4839-44 (2015) Article DOI: 10.1021/jm501840b BindingDB Entry DOI: 10.7270/Q24B3314
					More data for this Ligand-Target Pair

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