BindingDB PrimarySearch

Found 22 hits Enz. Inhib. hit(s) with Target = 'Kynureninase'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Kynureninase (Rattus norvegicus)	BDBM50069732 (2-Amino-3-(2-amino-5-methyl-benzenesulfonyl)-propi...) Show SMILES Cc1ccc(N)c(c1)S(=O)(=O)CC(N)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development Curated by ChEMBL					Assay Description Compound was tested for the inhibition of mammalian kynureninase in rat liver				Bioorg Med Chem Lett 8: 133-8 (1999) BindingDB Entry DOI: 10.7270/Q2639NXW
Glaxo Wellcome Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Rattus norvegicus)	BDBM50069731 (2-Amino-3-(2-amino-3-fluoro-benzenesulfonyl)-propi...) Show SMILES NC(CS(=O)(=O)c1cccc(F)c1N)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development Curated by ChEMBL					Assay Description Compound was tested for the inhibition of mammalian kynureninase in rat liver				Bioorg Med Chem Lett 8: 133-8 (1999) BindingDB Entry DOI: 10.7270/Q2639NXW
Glaxo Wellcome Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Rattus norvegicus)	BDBM50069729 (2-Amino-3-(2-amino-3-methoxy-benzenesulfonyl)-prop...) Show SMILES COc1cccc(c1N)S(=O)(=O)CC(N)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development Curated by ChEMBL					Assay Description Compound was tested for the inhibition of mammalian kynureninase in rat liver				Bioorg Med Chem Lett 8: 133-8 (1999) BindingDB Entry DOI: 10.7270/Q2639NXW
Glaxo Wellcome Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Rattus norvegicus)	BDBM50069730 (2-Amino-3-(2-amino-benzenesulfonyl)-propionic acid...) Show SMILES NC(CS(=O)(=O)c1ccccc1N)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development Curated by ChEMBL					Assay Description Compound was tested for the inhibition of mammalian kynureninase in rat liver				Bioorg Med Chem Lett 8: 133-8 (1999) BindingDB Entry DOI: 10.7270/Q2639NXW
Glaxo Wellcome Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Rattus norvegicus)	BDBM50083950 ((S)-(+)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric a...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for inhibitory activity against kynureninase from rat liver				Bioorg Med Chem Lett 5: 1451-1454 (1995) Article DOI: 10.1016/0960-894X(95)00255-R BindingDB Entry DOI: 10.7270/Q2PR7VZZ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Rattus norvegicus)	BDBM50040567 (CHEMBL158499 \| ortho-nitrobenzoyl)alanine) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Perugia Curated by ChEMBL					Assay Description Ability to inhibit kynureninase was determined in a competitive inhibition assay.				J Med Chem 37: 647-55 (1994) BindingDB Entry DOI: 10.7270/Q2VD703H
Universit£ di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Rattus norvegicus)	BDBM50284766 ((R)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric acid ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for inhibitory activity against kynureninase from rat liver				Bioorg Med Chem Lett 5: 1451-1454 (1995) Article DOI: 10.1016/0960-894X(95)00255-R BindingDB Entry DOI: 10.7270/Q2PR7VZZ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Rattus norvegicus)	BDBM50061907 ((+/-)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric aci...) Show SMILES NC(CC(=O)c1cccc(c1)[N+]([O-])=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Perugia Curated by ChEMBL					Assay Description Ability to inhibit kynureninase was determined in a competitive inhibition assay.				J Med Chem 37: 647-55 (1994) BindingDB Entry DOI: 10.7270/Q2VD703H
Universit£ di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Rattus norvegicus)	BDBM50040570 (CHEMBL160527 \| NICOTINOYLALANINENAL \| nicotinoylal...) Show SMILES [NH3+]C(CC(=O)c1cccnc1)C([O-])=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	8.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Perugia Curated by ChEMBL					Assay Description Ability to inhibit kynureninase was determined in a competitive inhibition assay.				J Med Chem 37: 647-55 (1994) BindingDB Entry DOI: 10.7270/Q2VD703H
Universit£ di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Rattus norvegicus)	BDBM50040568 (CHEMBL157866 \| para-nitrobenzoyl)alanine) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	9.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Perugia Curated by ChEMBL					Assay Description Ability to inhibit kynureninase was determined in a competitive inhibition assay.				J Med Chem 37: 647-55 (1994) BindingDB Entry DOI: 10.7270/Q2VD703H
Universit£ di Perugia Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Homo sapiens (Human))	BDBM50069730 (2-Amino-3-(2-amino-benzenesulfonyl)-propionic acid...) Show SMILES NC(CS(=O)(=O)c1ccccc1N)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development Curated by ChEMBL					Assay Description Compound was tested for the binding affinity against bacterial kynureninase				Bioorg Med Chem Lett 8: 133-8 (1999) BindingDB Entry DOI: 10.7270/Q2639NXW
Glaxo Wellcome Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Homo sapiens (Human))	BDBM50288256 ((R)-2-Amino-3-(2-amino-benzenesulfonyl)-propionic ...) Show SMILES N[C@H](CS(=O)(=O)c1ccccc1N)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against kynureninase isolated from Pseudomonas fluorescence				Bioorg Med Chem Lett 6: 2643-2646 (1996) Article DOI: 10.1016/S0960-894X(96)00483-0 BindingDB Entry DOI: 10.7270/Q2HM5903
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Homo sapiens (Human))	BDBM50109155 (2-Amino-4-hydroxy-4-(3-hydroxy-phenyl)-butyric aci...) Show SMILES NC(CC(O)c1cccc(O)c1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Georgia Curated by ChEMBL					Assay Description Inhibition of human kynureninase				J Med Chem 52: 389-96 (2009) Article DOI: 10.1021/jm8010806 BindingDB Entry DOI: 10.7270/Q2DZ0860
University of Georgia Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Homo sapiens (Human))	BDBM50109155 (2-Amino-4-hydroxy-4-(3-hydroxy-phenyl)-butyric aci...) Show SMILES NC(CC(O)c1cccc(O)c1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of St Andrews Curated by ChEMBL					Assay Description Tested for binding affinity of the compound against kynureninase enzyme from human				Bioorg Med Chem Lett 12: 361-3 (2002) BindingDB Entry DOI: 10.7270/Q2P26XFS
University of St Andrews Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Rattus norvegicus)	BDBM50109155 (2-Amino-4-hydroxy-4-(3-hydroxy-phenyl)-butyric aci...) Show SMILES NC(CC(O)c1cccc(O)c1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of St Andrews Curated by ChEMBL					Assay Description Tested for binding affinity of the compound against kynureninase enzyme from rat				Bioorg Med Chem Lett 12: 361-3 (2002) BindingDB Entry DOI: 10.7270/Q2P26XFS
University of St Andrews Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Homo sapiens (Human))	BDBM50288255 (2-ammonio-4-(2-ammoniophenyl)-4-oxo-(2S)-butanoate) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid PDB UniChem Similars	Article	4.28E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against kynureninase isolated from Pseudomonas fluorescence				Bioorg Med Chem Lett 6: 2643-2646 (1996) Article DOI: 10.1016/S0960-894X(96)00483-0 BindingDB Entry DOI: 10.7270/Q2HM5903
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Homo sapiens (Human))	BDBM50288257 ((R)-2-Benzyloxycarbonylamino-3-(methoxy-phenyl-pho...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against kynureninase isolated from Pseudomonas fluorescence				Bioorg Med Chem Lett 6: 2643-2646 (1996) Article DOI: 10.1016/S0960-894X(96)00483-0 BindingDB Entry DOI: 10.7270/Q2HM5903
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Homo sapiens (Human))	BDBM50109155 (2-Amino-4-hydroxy-4-(3-hydroxy-phenyl)-butyric aci...) Show SMILES NC(CC(O)c1cccc(O)c1)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of St Andrews Curated by ChEMBL					Assay Description Tested for binding affinity of the compound against kynureninase enzyme from bacterial cells				Bioorg Med Chem Lett 12: 361-3 (2002) BindingDB Entry DOI: 10.7270/Q2P26XFS
University of St Andrews Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Rattus norvegicus)	BDBM50069730 (2-Amino-3-(2-amino-benzenesulfonyl)-propionic acid...) Show SMILES NC(CS(=O)(=O)c1ccccc1N)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Glaxo Wellcome Research and Development Curated by ChEMBL					Assay Description Compound was tested for the binding affinity against kynureninase in rat liver				Bioorg Med Chem Lett 8: 133-8 (1999) BindingDB Entry DOI: 10.7270/Q2639NXW
Glaxo Wellcome Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Homo sapiens (Human))	BDBM50288254 (2-ammonio-4-oxo-4-phenyl-(2S)-butanoate \| CHEMBL31...) Show SMILES [NH3+][C@@H](CC(=O)c1ccccc1)C([O-])=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem	Article	2.34E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against kynureninase isolated from Pseudomonas fluorescence				Bioorg Med Chem Lett 6: 2643-2646 (1996) Article DOI: 10.1016/S0960-894X(96)00483-0 BindingDB Entry DOI: 10.7270/Q2HM5903
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Kynureninase (Homo sapiens (Human))	BDBM50265459 (3-Hydroxyhippuric acid \| CHEMBL447627) Show SMILES OC(=O)CNC(=O)c1cccc(O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	6.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Georgia Curated by ChEMBL					Assay Description Inhibition of human kynureninase				J Med Chem 52: 389-96 (2009) Article DOI: 10.1021/jm8010806 BindingDB Entry DOI: 10.7270/Q2DZ0860
University of Georgia Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Kynureninase (Homo sapiens (Human))	BDBM50288258 ((R)-2-Benzyloxycarbonylamino-3-(methoxy-phenyl-pho...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	8.80E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for its binding affinity against kynureninase isolated from Pseudomonas fluorescence				Bioorg Med Chem Lett 6: 2643-2646 (1996) Article DOI: 10.1016/S0960-894X(96)00483-0 BindingDB Entry DOI: 10.7270/Q2HM5903
TBA Curated by ChEMBL					More data for this Ligand-Target Pair