Found 21 hits Enz. Inhib. hit(s) with Target = 'Kynurenine Aminotransferase 1/Glutamine Transaminase K' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50426341
(CHEMBL2321944)Show InChI InChI=1S/C15H14N2O3/c16-13-9-10-8-12(20-11-4-2-1-3-5-11)6-7-14(10)17(19)15(13)18/h1-8,13,19H,9,16H2/t13-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human KAT1 using L-kynurenine as substrate measured after 16 hrs by SpectraMax plate reader analysis |
ACS Med Chem Lett 4: 37-40 (2013)
Article DOI: 10.1021/ml300237v BindingDB Entry DOI: 10.7270/Q2KH0PNV |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50386310
(CHEMBL2049092)Show InChI InChI=1S/C10H12N2O3/c1-15-7-3-2-6-4-8(11)10(13)12(14)9(6)5-7/h2-3,5,8,14H,4,11H2,1H3/t8-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human KAT1 using L-kynurenine as substrate measured after 16 hrs by SpectraMax plate reader analysis |
ACS Med Chem Lett 4: 37-40 (2013)
Article DOI: 10.1021/ml300237v BindingDB Entry DOI: 10.7270/Q2KH0PNV |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50364911
(CHEMBL1950173)Show SMILES CCOC(=O)C(CCCC(O)=O)=NNc1ccc(Cl)cc1 |w:12.12| Show InChI InChI=1S/C14H17ClN2O4/c1-2-21-14(20)12(4-3-5-13(18)19)17-16-11-8-6-10(15)7-9-11/h6-9,16H,2-5H2,1H3,(H,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
Curated by ChEMBL
| Assay Description Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysis |
Bioorg Med Chem Lett 22: 1579-81 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.138 BindingDB Entry DOI: 10.7270/Q2891693 |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50364914
(CHEMBL1950178)Show SMILES CCOC(=O)C(CCCC(O)=O)=NNc1cccc(Cl)c1 |w:12.12| Show InChI InChI=1S/C14H17ClN2O4/c1-2-21-14(20)12(7-4-8-13(18)19)17-16-11-6-3-5-10(15)9-11/h3,5-6,9,16H,2,4,7-8H2,1H3,(H,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
Curated by ChEMBL
| Assay Description Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysis |
Bioorg Med Chem Lett 22: 1579-81 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.138 BindingDB Entry DOI: 10.7270/Q2891693 |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50364910
(CHEMBL1950174)Show SMILES CCOC(=O)C(CCCC(O)=O)=NNc1ccc(Br)cc1 |w:12.12| Show InChI InChI=1S/C14H17BrN2O4/c1-2-21-14(20)12(4-3-5-13(18)19)17-16-11-8-6-10(15)7-9-11/h6-9,16H,2-5H2,1H3,(H,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
Curated by ChEMBL
| Assay Description Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysis |
Bioorg Med Chem Lett 22: 1579-81 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.138 BindingDB Entry DOI: 10.7270/Q2891693 |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50386292
(CHEMBL2047851)Show InChI InChI=1S/C9H10N2O2/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12/h1-4,7,13H,5,10H2/t7-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of human KAT1 |
ACS Med Chem Lett 3: 187-192 (2012)
Article DOI: 10.1021/ml200204m BindingDB Entry DOI: 10.7270/Q2MC9135 |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50324539
((S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methy...)Show SMILES C[C@H]1COc2c(N3CCN(N)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O |r| Show InChI InChI=1S/C17H19FN4O4/c1-9-8-26-16-13-10(15(23)11(17(24)25)7-22(9)13)6-12(18)14(16)20-2-4-21(19)5-3-20/h6-7,9H,2-5,8,19H2,1H3,(H,24,25)/t9-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Piemonte Orientale Amedeo Avogadro
Curated by ChEMBL
| Assay Description Inhibition of KAT1 in human prefrontal cortex homogenates |
J Med Chem 53: 5684-9 (2010)
Article DOI: 10.1021/jm100464k BindingDB Entry DOI: 10.7270/Q2HM58N6 |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50324539
((S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methy...)Show SMILES C[C@H]1COc2c(N3CCN(N)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O |r| Show InChI InChI=1S/C17H19FN4O4/c1-9-8-26-16-13-10(15(23)11(17(24)25)7-22(9)13)6-12(18)14(16)20-2-4-21(19)5-3-20/h6-7,9H,2-5,8,19H2,1H3,(H,24,25)/t9-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Piemonte Orientale Amedeo Avogadro
Curated by ChEMBL
| Assay Description Inhibition of human recombinant MBP-KAT1 expressed in HEK293 cells assessed as conversion of L-kynurenine to kynurenic acid after 1 hr |
J Med Chem 53: 5684-9 (2010)
Article DOI: 10.1021/jm100464k BindingDB Entry DOI: 10.7270/Q2HM58N6 |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50386292
(CHEMBL2047851)Show InChI InChI=1S/C9H10N2O2/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12/h1-4,7,13H,5,10H2/t7-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human KAT1 using L-kynurenine as substrate measured after 16 hrs by SpectraMax plate reader analysis |
ACS Med Chem Lett 4: 37-40 (2013)
Article DOI: 10.1021/ml300237v BindingDB Entry DOI: 10.7270/Q2KH0PNV |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50364912
(CHEMBL1950176)Show SMILES CCOC(=O)C(CCCC(O)=O)=NNc1ccc(C)cc1 |w:12.12| Show InChI InChI=1S/C15H20N2O4/c1-3-21-15(20)13(5-4-6-14(18)19)17-16-12-9-7-11(2)8-10-12/h7-10,16H,3-6H2,1-2H3,(H,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
Curated by ChEMBL
| Assay Description Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysis |
Bioorg Med Chem Lett 22: 1579-81 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.138 BindingDB Entry DOI: 10.7270/Q2891693 |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50364915
(CHEMBL1950179)Show SMILES CCOC(=O)C(CCCC(O)=O)=NNc1ccc(I)cc1 |w:12.12| Show InChI InChI=1S/C14H17IN2O4/c1-2-21-14(20)12(4-3-5-13(18)19)17-16-11-8-6-10(15)7-9-11/h6-9,16H,2-5H2,1H3,(H,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
Curated by ChEMBL
| Assay Description Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysis |
Bioorg Med Chem Lett 22: 1579-81 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.138 BindingDB Entry DOI: 10.7270/Q2891693 |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50426340
(CHEMBL2321943)Show SMILES COc1cc2N(O)C(=O)[C@@H](N)Cc2cc1Oc1ccccc1 |r| Show InChI InChI=1S/C16H16N2O4/c1-21-14-9-13-10(7-12(17)16(19)18(13)20)8-15(14)22-11-5-3-2-4-6-11/h2-6,8-9,12,20H,7,17H2,1H3/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Inhibition of human KAT1 using L-kynurenine as substrate measured after 16 hrs by SpectraMax plate reader analysis |
ACS Med Chem Lett 4: 37-40 (2013)
Article DOI: 10.1021/ml300237v BindingDB Entry DOI: 10.7270/Q2KH0PNV |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50364913
(CHEMBL1950177)Show SMILES CCOC(=O)C(CCCC(O)=O)=NNc1ccc(OC)cc1 |w:12.12| Show InChI InChI=1S/C15H20N2O5/c1-3-22-15(20)13(5-4-6-14(18)19)17-16-11-7-9-12(21-2)10-8-11/h7-10,16H,3-6H2,1-2H3,(H,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
Curated by ChEMBL
| Assay Description Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysis |
Bioorg Med Chem Lett 22: 1579-81 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.138 BindingDB Entry DOI: 10.7270/Q2891693 |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM31879
(3-indolepropionic acid | Acid, 7)Show InChI InChI=1S/C11H11NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6H2,(H,13,14) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.40E+5 | n/a | n/a | n/a | n/a | 7.5 | 38 |
Virginia Tech
| Assay Description A typical reaction mixture contains kynurenine, alpha-ketobutyrate, PLP and hKAT-I in the presence of test compound. The reaction mixture was incubat... |
J Med Chem 52: 2786-93 (2009)
Article DOI: 10.1021/jm9000874 BindingDB Entry DOI: 10.7270/Q2GH9G8X |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50364909
(CHEMBL1950175)Show SMILES CCOC(=O)C(CCCC(O)=O)=NNc1ccc(cc1)[N+]([O-])=O |w:12.12| Show InChI InChI=1S/C14H17N3O6/c1-2-23-14(20)12(4-3-5-13(18)19)16-15-10-6-8-11(9-7-10)17(21)22/h6-9,15H,2-5H2,1H3,(H,18,19) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.79E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
Curated by ChEMBL
| Assay Description Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysis |
Bioorg Med Chem Lett 22: 1579-81 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.138 BindingDB Entry DOI: 10.7270/Q2891693 |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM31881
(DL-indole-3-lactic acid)Show InChI InChI=1S/C11H11NO3/c13-10(11(14)15)5-7-6-12-9-4-2-1-3-8(7)9/h1-4,6,10,12-13H,5H2,(H,14,15) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.20E+5 | n/a | n/a | n/a | n/a | 7.5 | 38 |
Virginia Tech
| Assay Description A typical reaction mixture contains kynurenine, alpha-ketobutyrate, PLP and hKAT-I in the presence of test compound. The reaction mixture was incubat... |
J Med Chem 52: 2786-93 (2009)
Article DOI: 10.1021/jm9000874 BindingDB Entry DOI: 10.7270/Q2GH9G8X |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50364916
(CHEMBL1950315)Show InChI InChI=1S/C12H10BrNO4/c13-6-1-3-9-8(5-6)7(2-4-10(15)16)11(14-9)12(17)18/h1,3,5,14H,2,4H2,(H,15,16)(H,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.71E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
Curated by ChEMBL
| Assay Description Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysis |
Bioorg Med Chem Lett 22: 1579-81 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.138 BindingDB Entry DOI: 10.7270/Q2891693 |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50004956
(3-(2-Carboxy-ethyl)-5-chloro-1H-indole-2-carboxyli...)Show InChI InChI=1S/C12H10ClNO4/c13-6-1-3-9-8(5-6)7(2-4-10(15)16)11(14-9)12(17)18/h1,3,5,14H,2,4H2,(H,15,16)(H,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.93E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
Curated by ChEMBL
| Assay Description Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysis |
Bioorg Med Chem Lett 22: 1579-81 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.138 BindingDB Entry DOI: 10.7270/Q2891693 |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50364917
(CHEMBL1950316)Show SMILES OC(=O)CCc1c([nH]c2ccc(cc12)[N+]([O-])=O)C(O)=O Show InChI InChI=1S/C12H10N2O6/c15-10(16)4-2-7-8-5-6(14(19)20)1-3-9(8)13-11(7)12(17)18/h1,3,5,13H,2,4H2,(H,15,16)(H,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.66E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
Curated by ChEMBL
| Assay Description Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysis |
Bioorg Med Chem Lett 22: 1579-81 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.138 BindingDB Entry DOI: 10.7270/Q2891693 |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50364918
(CHEMBL1950317)Show InChI InChI=1S/C13H13NO4/c1-7-2-4-10-9(6-7)8(3-5-11(15)16)12(14-10)13(17)18/h2,4,6,14H,3,5H2,1H3,(H,15,16)(H,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
Curated by ChEMBL
| Assay Description Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysis |
Bioorg Med Chem Lett 22: 1579-81 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.138 BindingDB Entry DOI: 10.7270/Q2891693 |
More data for this Ligand-Target Pair | |
Kynurenine--oxoglutarate transaminase 1
(Homo sapiens (Human)) | BDBM50364919
(CHEMBL1508899)Show InChI InChI=1S/C13H13NO5/c1-19-7-2-4-10-9(6-7)8(3-5-11(15)16)12(14-10)13(17)18/h2,4,6,14H,3,5H2,1H3,(H,15,16)(H,17,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >6.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
Curated by ChEMBL
| Assay Description Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysis |
Bioorg Med Chem Lett 22: 1579-81 (2012)
Article DOI: 10.1016/j.bmcl.2011.12.138 BindingDB Entry DOI: 10.7270/Q2891693 |
More data for this Ligand-Target Pair | |