BindingDB PrimarySearch

Found 8 hits Enz. Inhib. hit(s) with Target = 'Malate Dehydrogenase (pfMDH)'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
L-lactate dehydrogenase (Plasmodium falciparum)	BDBM23223 (7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MDH was assayed spectrophotometrically for reduction of oxaloacetic acid using NADH by recording the changed in absorbance at 340 nm. The reaction wa...				J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV
University of Mississippi					More data for this Ligand-Target Pair
L-lactate dehydrogenase (Plasmodium falciparum)	BDBM23229 (Oxamic acid derivative, 7 \| [(4-{2-[(5-hydroxy-2-{...) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MDH was assayed spectrophotometrically for reduction of oxaloacetic acid using NADH by recording the changed in absorbance at 340 nm. The reaction wa...				J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV
University of Mississippi					More data for this Ligand-Target Pair
L-lactate dehydrogenase (Plasmodium falciparum)	BDBM23227 (Oxamic acid derivative, 5 \| [(4-{2-[(5-hydroxy-2-{...) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MDH was assayed spectrophotometrically for reduction of oxaloacetic acid using NADH by recording the changed in absorbance at 340 nm. The reaction wa...				J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV
University of Mississippi					More data for this Ligand-Target Pair
L-lactate dehydrogenase (Plasmodium falciparum)	BDBM23224 (7-{[4-(formamidoformic acid)-3-methoxyphenyl]metho...) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.83E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MDH was assayed spectrophotometrically for reduction of oxaloacetic acid using NADH by recording the changed in absorbance at 340 nm. The reaction wa...				J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV
University of Mississippi					More data for this Ligand-Target Pair
L-lactate dehydrogenase (Plasmodium falciparum)	BDBM23228 (Oxamic acid derivative, 6 \| [(2-cyano-4-{2-[(5-hyd...) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.69E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MDH was assayed spectrophotometrically for reduction of oxaloacetic acid using NADH by recording the changed in absorbance at 340 nm. The reaction wa...				J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV
University of Mississippi					More data for this Ligand-Target Pair
L-lactate dehydrogenase (Plasmodium falciparum)	BDBM23226 (7-{2-[4-(formamidoformic acid)-3-methoxyphenyl]eth...) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MDH was assayed spectrophotometrically for reduction of oxaloacetic acid using NADH by recording the changed in absorbance at 340 nm. The reaction wa...				J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV
University of Mississippi					More data for this Ligand-Target Pair
L-lactate dehydrogenase (Plasmodium falciparum)	BDBM23225 (7-{2-[4-(formamidoformic acid)phenyl]ethoxy}-5-hyd...) Show SMILES Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.41E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MDH was assayed spectrophotometrically for reduction of oxaloacetic acid using NADH by recording the changed in absorbance at 340 nm. The reaction wa...				J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV
University of Mississippi					More data for this Ligand-Target Pair
L-lactate dehydrogenase (Plasmodium falciparum)	BDBM23222 (Oxalamic acid \| Oxamate \| Oxamate, 3 \| Oxamidic Ac...) Show SMILES NC(=O)C(O)=O Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>2.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description MDH was assayed spectrophotometrically for reduction of oxaloacetic acid using NADH by recording the changed in absorbance at 340 nm. The reaction wa...				J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV
University of Mississippi					More data for this Ligand-Target Pair