Found 8 hits Enz. Inhib. hit(s) with Target = 'Poly(A)-specific ribonuclease (PARN)' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Poly(A)-specific ribonuclease PARN
(Homo sapiens (Human)) | BDBM50119716
(CHEMBL3616525)Show InChI InChI=1S/C18H23N5O3/c1-20(2)10-6-11-22-16-15(17(24)23(26)18(22)25)21(13-19-16)12-9-14-7-4-3-5-8-14/h3-5,7-8,13,26H,6,9-12H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.39E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of PARN (unknown origin) |
Bioorg Med Chem Lett 25: 4219-24 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.095 BindingDB Entry DOI: 10.7270/Q2BV7JFF |
More data for this Ligand-Target Pair | |
Poly(A)-specific ribonuclease PARN
(Homo sapiens (Human)) | BDBM50119651
(CHEMBL3616505)Show InChI InChI=1S/C12H10N4O3/c17-11-9-10(14-12(18)16(11)19)13-7-15(9)6-8-4-2-1-3-5-8/h1-5,7,19H,6H2,(H,14,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of PARN (unknown origin) |
Bioorg Med Chem Lett 25: 4219-24 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.095 BindingDB Entry DOI: 10.7270/Q2BV7JFF |
More data for this Ligand-Target Pair | |
Poly(A)-specific ribonuclease PARN
(Homo sapiens (Human)) | BDBM50119654
(CHEMBL3616507)Show InChI InChI=1S/C11H9N5O3/c17-10-8-9(14-11(18)16(10)19)13-6-15(8)5-7-3-1-2-4-12-7/h1-4,6,19H,5H2,(H,14,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.19E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of PARN (unknown origin) |
Bioorg Med Chem Lett 25: 4219-24 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.095 BindingDB Entry DOI: 10.7270/Q2BV7JFF |
More data for this Ligand-Target Pair | |
Poly(A)-specific ribonuclease PARN
(Homo sapiens (Human)) | BDBM50119655
(CHEMBL3616508)Show InChI InChI=1S/C11H9N5O3/c17-10-8-9(14-11(18)16(10)19)13-6-15(8)5-7-2-1-3-12-4-7/h1-4,6,19H,5H2,(H,14,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.25E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of PARN (unknown origin) |
Bioorg Med Chem Lett 25: 4219-24 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.095 BindingDB Entry DOI: 10.7270/Q2BV7JFF |
More data for this Ligand-Target Pair | |
Poly(A)-specific ribonuclease PARN
(Homo sapiens (Human)) | BDBM50119656
(CHEMBL3616509)Show InChI InChI=1S/C11H9N5O3/c17-10-8-9(14-11(18)16(10)19)13-6-15(8)5-7-1-3-12-4-2-7/h1-4,6,19H,5H2,(H,14,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.45E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of PARN (unknown origin) |
Bioorg Med Chem Lett 25: 4219-24 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.095 BindingDB Entry DOI: 10.7270/Q2BV7JFF |
More data for this Ligand-Target Pair | |
Poly(A)-specific ribonuclease PARN
(Homo sapiens (Human)) | BDBM92910
(Nucleoside, A6)Show SMILES OCC1OC(C(O)C(F)C1O)n1ccc(NC(=O)c2ccccc2)nc1=O Show InChI InChI=1S/C17H18FN3O6/c18-12-13(23)10(8-22)27-16(14(12)24)21-7-6-11(20-17(21)26)19-15(25)9-4-2-1-3-5-9/h1-7,10,12-14,16,22-24H,8H2,(H,19,20,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 2.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Thessaly
| Assay Description The enzymatic activity was determined by the methylene blue assay. |
Biochemistry 48: 6044-51 (2009)
Article DOI: 10.1021/bi900236k BindingDB Entry DOI: 10.7270/Q21V5CJ5 |
More data for this Ligand-Target Pair | |
Poly(A)-specific ribonuclease PARN
(Homo sapiens (Human)) | BDBM92909
(Nucleoside, A2)Show SMILES OC1OC(C(O)C(F)C1O)n1cnc2c(NC(=O)c3ccccc3)ncnc12 Show InChI InChI=1S/C17H16FN5O5/c18-9-11(24)16(28-17(27)12(9)25)23-7-21-10-13(19-6-20-14(10)23)22-15(26)8-4-2-1-3-5-8/h1-7,9,11-12,16-17,24-25,27H,(H,19,20,22,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 5.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Thessaly
| Assay Description The enzymatic activity was determined by the methylene blue assay. |
Biochemistry 48: 6044-51 (2009)
Article DOI: 10.1021/bi900236k BindingDB Entry DOI: 10.7270/Q21V5CJ5 |
More data for this Ligand-Target Pair | |
Poly(A)-specific ribonuclease PARN
(Homo sapiens (Human)) | BDBM92911
(Nucleoside, C6)Show InChI InChI=1S/C10H14FN3O5/c11-6-7(16)4(3-15)19-9(8(6)17)14-2-1-5(12)13-10(14)18/h1-2,4,6-9,15-17H,3H2,(H2,12,13,18) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 6.45E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Thessaly
| Assay Description The enzymatic activity was determined by the methylene blue assay. |
Biochemistry 48: 6044-51 (2009)
Article DOI: 10.1021/bi900236k BindingDB Entry DOI: 10.7270/Q21V5CJ5 |
More data for this Ligand-Target Pair | |