BindingDB PrimarySearch

Found 9 hits Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily B member 1'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Potassium voltage-gated channel subfamily B member 1 (Homo sapiens (Human))	BDBM50088573 (CHEMBL3577208) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Inhibition of Kv2.1 channel in human INS1 cells assessed as inhibition of outward K+ current by electrophysiology/patch clamp technique				J Nat Prod 78: 363-7 (2015) Article DOI: 10.1021/np5007586 BindingDB Entry DOI: 10.7270/Q20P11R5
Seoul National University Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 1 (Homo sapiens (Human))	BDBM50088572 (CHEMBL3577209) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Inhibition of Kv2.1 channel in human INS1 cells assessed as inhibition of outward K+ current by electrophysiology/patch clamp technique				J Nat Prod 78: 363-7 (2015) Article DOI: 10.1021/np5007586 BindingDB Entry DOI: 10.7270/Q20P11R5
Seoul National University Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 1 (Rattus norvegicus)	BDBM50213094 ((1R,2R)-1-(3,4-dichlorophenethoxy)-2-(4-morpholiny...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cardiome Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of rat potassium channel Kv2.1 by patch-clamp method				J Med Chem 50: 2818-41 (2007) Article DOI: 10.1021/jm0604528 BindingDB Entry DOI: 10.7270/Q29Z95QZ
Cardiome Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 1 (Rattus norvegicus)	BDBM50213092 ((1R,2R)-1-(1-naphthalenethoxy)-2-(4-morpholinyl)cy...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cardiome Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of rat potassium channel Kv2.1 by patch-clamp method				J Med Chem 50: 2818-41 (2007) Article DOI: 10.1021/jm0604528 BindingDB Entry DOI: 10.7270/Q29Z95QZ
Cardiome Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 1 (Rattus norvegicus)	BDBM50213093 ((1R,2R)-1-(1-naphthalenethoxy)-2-(3-ketopyrrolidin...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cardiome Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of rat potassium channel Kv2.1 by patch-clamp method				J Med Chem 50: 2818-41 (2007) Article DOI: 10.1021/jm0604528 BindingDB Entry DOI: 10.7270/Q29Z95QZ
Cardiome Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 1 (Rattus norvegicus)	BDBM50213093 ((1R,2R)-1-(1-naphthalenethoxy)-2-(3-ketopyrrolidin...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cardiome Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of rat potassium channel Kv2.1 by patch-clamp method				J Med Chem 50: 2818-41 (2007) Article DOI: 10.1021/jm0604528 BindingDB Entry DOI: 10.7270/Q29Z95QZ
Cardiome Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 1 (Rattus norvegicus)	BDBM50213095 ((1S,2S)-1-(1-Naphthalenethoxy)-2-(3-ketopyrrolidin...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cardiome Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of rat potassium channel Kv2.1 by patch-clamp method				J Med Chem 50: 2818-41 (2007) Article DOI: 10.1021/jm0604528 BindingDB Entry DOI: 10.7270/Q29Z95QZ
Cardiome Pharma Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 1 (Homo sapiens (Human))	BDBM50593373 (CHEMBL5182581) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1039/d1md00129a BindingDB Entry DOI: 10.7270/Q2Z60T26
TBA					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 1 (Homo sapiens (Human))	BDBM168436 (US9675591, SKA-19) Show SMILES Nc1nc2ccc(SC(F)(F)F)cc2s1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	n/a	n/a	2.23E+4	n/a	n/a	7.35	25
The Regents of the University of California US Patent					Assay Description All experiments were conducted at room temperature (22-24� C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...				US Patent US9675591 (2017) BindingDB Entry DOI: 10.7270/Q26T0JSP
The Regents of the University of California US Patent					More data for this Ligand-Target Pair