BindingDB PrimarySearch

Found 9 hits Enz. Inhib. hit(s) with Target = 'Catalytic domain 2 (zCD2)'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histone deacetylase 6 [440-798] (Danio rerio)	BDBM19149 (CHEMBL98 \| N-hydroxy-N'-phenyloctanediamide \| SAHA...) Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.600	-52.6	1.10	n/a	n/a	n/a	n/a	n/a	25
University of Pennsylvania,					Assay Description The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...				Nat Chem Biol 12: 741-747 (2016) Article DOI: 10.1038/nchembio.2134 BindingDB Entry DOI: 10.7270/Q2TH8KH1
University of Pennsylvania,					More data for this Ligand-Target Pair
Histone deacetylase 6 [440-798] (Danio rerio)	BDBM198120 (TSA) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.800	-51.9	1.40	n/a	n/a	n/a	n/a	n/a	25
University of Pennsylvania,					Assay Description The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...				Nat Chem Biol 12: 741-747 (2016) Article DOI: 10.1038/nchembio.2134 BindingDB Entry DOI: 10.7270/Q2TH8KH1
University of Pennsylvania,					More data for this Ligand-Target Pair
Histone deacetylase 6 [440-798] (Danio rerio)	BDBM198121 (HPOB) Show SMILES OCCN(C(=O)Cc1ccc(cc1)C(=O)NO)c1ccccc1 Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	1	-51.4	1.80	n/a	n/a	n/a	n/a	n/a	25
University of Pennsylvania,					Assay Description The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...				Nat Chem Biol 12: 741-747 (2016) Article DOI: 10.1038/nchembio.2134 BindingDB Entry DOI: 10.7270/Q2TH8KH1
University of Pennsylvania,					More data for this Ligand-Target Pair
Histone deacetylase 6 [440-798] (Danio rerio)	BDBM25150 ((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.10	-51.1	1.90	n/a	n/a	n/a	n/a	n/a	25
University of Pennsylvania,					Assay Description The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...				Nat Chem Biol 12: 741-747 (2016) Article DOI: 10.1038/nchembio.2134 BindingDB Entry DOI: 10.7270/Q2TH8KH1
University of Pennsylvania,					More data for this Ligand-Target Pair
Histone deacetylase 6 [440-798] (Danio rerio)	BDBM198124 (Panobinostat) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	Article PubMed	1.40	-50.5	2.5	n/a	n/a	n/a	n/a	n/a	25
University of Pennsylvania,					Assay Description The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...				Nat Chem Biol 12: 741-747 (2016) Article DOI: 10.1038/nchembio.2134 BindingDB Entry DOI: 10.7270/Q2TH8KH1
University of Pennsylvania,					More data for this Ligand-Target Pair
Histone deacetylase 6 [440-798] (Danio rerio)	BDBM50123957 ((E)-5-(3-Benzenesulfonylamino-phenyl)-pent-2-en-4-...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.30	-47.8	7.5	n/a	n/a	n/a	n/a	n/a	25
University of Pennsylvania,					Assay Description The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...				Nat Chem Biol 12: 741-747 (2016) Article DOI: 10.1038/nchembio.2134 BindingDB Entry DOI: 10.7270/Q2TH8KH1
University of Pennsylvania,					More data for this Ligand-Target Pair
Histone deacetylase 6 [440-798] (Danio rerio)	BDBM198122 (HC toxin) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	350	-36.8	600	n/a	n/a	n/a	n/a	n/a	25
University of Pennsylvania,					Assay Description The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...				Nat Chem Biol 12: 741-747 (2016) Article DOI: 10.1038/nchembio.2134 BindingDB Entry DOI: 10.7270/Q2TH8KH1
University of Pennsylvania,					More data for this Ligand-Target Pair
Histone deacetylase 6 [440-798] (Danio rerio)	BDBM198123 (Trifluoroketone) Show SMILES CC(=O)C(F)(F)F Show InChI InChI=1S/C3H3F3O/c1-2(7)3(4,5)6/h1H3	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	Article PubMed	800	-34.8	1.40E+3	n/a	n/a	n/a	n/a	n/a	25
University of Pennsylvania,					Assay Description The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...				Nat Chem Biol 12: 741-747 (2016) Article DOI: 10.1038/nchembio.2134 BindingDB Entry DOI: 10.7270/Q2TH8KH1
University of Pennsylvania,					More data for this Ligand-Target Pair
Histone deacetylase 6 [440-798] (Danio rerio)	BDBM198125 (fl-SAHA) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a	25
University of Pennsylvania,					Assay Description The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...				Nat Chem Biol 12: 741-747 (2016) Article DOI: 10.1038/nchembio.2134 BindingDB Entry DOI: 10.7270/Q2TH8KH1
University of Pennsylvania,					More data for this Ligand-Target Pair