Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Homoserine kinase'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homoserine kinase (Escherichia coli)	BDBM85124 (Thr1 inhibitor, 4) Show SMILES Oc1c(CC2C(=O)OC3C=CCC=C3C2=O)c(=O)oc2ccccc12 |c:9,12| Show InChI InChI=1S/C19H14O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1,3-8,13,15,20H,2,9H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	460	-37.6	n/a	n/a	n/a	n/a	n/a	7.5	37
McMaster University					Assay Description The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...				Chembiochem 12: 1179-82 (2011) Article DOI: 10.1002/cbic.201100121 BindingDB Entry DOI: 10.7270/Q24T6GWV
					More data for this Ligand-Target Pair
Homoserine kinase (Escherichia coli)	BDBM85126 (Thr1 inhibitor, 6) Show SMILES CC1NN(c2nc(cc(O)c12)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C14H12F3N3O/c1-8-12-10(21)7-11(14(15,16)17)18-13(12)20(19-8)9-5-3-2-4-6-9/h2-8,19H,1H3,(H,18,21)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	8.60E+3	-30.1	n/a	n/a	n/a	n/a	n/a	7.5	37
McMaster University					Assay Description The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...				Chembiochem 12: 1179-82 (2011) Article DOI: 10.1002/cbic.201100121 BindingDB Entry DOI: 10.7270/Q24T6GWV
					More data for this Ligand-Target Pair
Homoserine kinase (Escherichia coli)	BDBM24941 ((2Z)-2-{[(2,5-dibromophenyl)amino](hydroxy)methyli...) Show SMILES CC(=O)C(C#N)C(=O)Nc1cc(Br)ccc1Br Show InChI InChI=1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,8H,1H3,(H,15,17)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1.20E+4	-29.2	n/a	n/a	n/a	n/a	n/a	7.5	37
McMaster University					Assay Description The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...				Chembiochem 12: 1179-82 (2011) Article DOI: 10.1002/cbic.201100121 BindingDB Entry DOI: 10.7270/Q24T6GWV
					More data for this Ligand-Target Pair
Homoserine kinase (Escherichia coli)	BDBM85123 (Thr1 inhibitor, 3 | cid_235240) Show SMILES OC1C(=O)C(Oc2cc(O)c(O)cc12)c1ccc(O)c(O)c1 Show InChI InChI=1S/C15H12O7/c16-8-2-1-6(3-9(8)17)15-14(21)13(20)7-4-10(18)11(19)5-12(7)22-15/h1-5,13,15-20H	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.71E+4	-27.1	n/a	n/a	n/a	n/a	n/a	7.5	37
McMaster University					Assay Description The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...				Chembiochem 12: 1179-82 (2011) Article DOI: 10.1002/cbic.201100121 BindingDB Entry DOI: 10.7270/Q24T6GWV
					More data for this Ligand-Target Pair
Homoserine kinase (Escherichia coli)	BDBM85122 (Thr1 inhibitor, 1) Show SMILES C=CC(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	3.20E+4	-26.7	n/a	n/a	n/a	n/a	n/a	7.5	37
McMaster University					Assay Description The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...				Chembiochem 12: 1179-82 (2011) Article DOI: 10.1002/cbic.201100121 BindingDB Entry DOI: 10.7270/Q24T6GWV
					More data for this Ligand-Target Pair
Homoserine kinase (Escherichia coli)	BDBM85125 (Thr1 inhibitor, 5) Show SMILES CC(C)Cc1nc2sc3CCCCCc3c2c(=O)o1 Show InChI InChI=1S/C15H19NO2S/c1-9(2)8-12-16-14-13(15(17)18-12)10-6-4-3-5-7-11(10)19-14/h9H,3-8H2,1-2H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	3.58E+4	-26.4	n/a	n/a	n/a	n/a	n/a	7.5	37
McMaster University					Assay Description The phosphorylation of L-Hse was monitored by coupling the formation of ADP with pyruvate kinase and lactate dehydrogenase (PK/LDH). The resulting o...				Chembiochem 12: 1179-82 (2011) Article DOI: 10.1002/cbic.201100121 BindingDB Entry DOI: 10.7270/Q24T6GWV
					More data for this Ligand-Target Pair