Compile Data Set for Download or QSAR

Found 27 hits Enz. Inhib. hit(s) with Target = 'Hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT)'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM92358 (HGXPRT Inhibitor, 3) Show SMILES OC[C@H](CCP([O-])([O-])=O)[NH2+]c1c[nH]c2c1nc[nH]c2=O |r| Show InChI InChI=1S/C10H13N4O5P/c15-4-6(1-2-20(17,18)19)14-7-3-11-9-8(7)12-5-13-10(9)16/h3,5-6,14-15H,1-2,4H2,(H2,17,18,19)/p-1/t6-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	0.650	-54.5	n/a	n/a	n/a	n/a	n/a	7.6	37
Albert Einstein College of Medicine					Assay Description PfHGXPRT activity was measured using spectrophotometric assay observing the conversion of xanthine and 5-phospho-alpha-D-ribose-1-pyrophosphate to xa...				Chem Biol 19: 721-30 (2012) Article DOI: 10.1016/j.chembiol.2012.04.012 BindingDB Entry DOI: 10.7270/Q2639NB8
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM92357 (HGXPRT Inhibitor, 2) Show SMILES [O-]P([O-])(=O)CCC[NH2+]c1c[nH]c2c1nc[nH]c2=O Show InChI InChI=1S/C9H11N4O4P/c14-9-8-7(12-5-13-9)6(4-11-8)10-2-1-3-18(15,16)17/h4-5,10H,1-3H2,(H2,15,16,17)/p-1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	10.6	-47.3	n/a	n/a	n/a	n/a	n/a	7.6	37
Albert Einstein College of Medicine					Assay Description PfHGXPRT activity was measured using spectrophotometric assay observing the conversion of xanthine and 5-phospho-alpha-D-ribose-1-pyrophosphate to xa...				Chem Biol 19: 721-30 (2012) Article DOI: 10.1016/j.chembiol.2012.04.012 BindingDB Entry DOI: 10.7270/Q2639NB8
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM194490 (US9200020, Table 1, Compound 1) Show SMILES Nc1nc2n(CCOCCP(O)(O)=O)c[nH]c2c(=O)[nH]1 Show InChI InChI=1S/C4H12BO4P/c5-1-2-9-3-4-10(6,7)8/h1-5H2,(H2,6,7,8)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	100	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM194500 (US9200020, Table 3 compound 9) Show SMILES Nc1nc2n(CCN(CCCC(O)=O)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1 Show InChI InChI=1S/C9H21BNO5P/c10-4-7-11(5-1-3-9(12)13)6-2-8-17(14,15)16/h1-8,10H2,(H,12,13)(H2,14,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	100	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM60887 (US9200020, Table 3, Compound 2B) Show SMILES COC(=O)CCN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	100	-41.6	n/a	n/a	n/a	n/a	n/a	n/a	37
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM194493 (US9200020, Table 3 compound 2) Show SMILES COC(=O)CCN(CCn1c[nH]c2c1nc(N)[nH]c2=O)CCP(O)(O)=O Show InChI InChI=1S/C9H21BNO5P/c1-16-9(12)3-6-11(7-4-10)5-2-8-17(13,14)15/h2-8,10H2,1H3,(H2,13,14,15)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	100	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM194499 (US9200020, Table 3 compound 8) Show SMILES Nc1nc2n(CCN(CCC(O)=O)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1 Show InChI InChI=1S/C8H19BNO5P/c9-3-6-10(5-2-8(11)12)4-1-7-16(13,14)15/h1-7,9H2,(H,11,12)(H2,13,14,15)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	200	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM194496 (US9200020, Table 3 compound 5) Show SMILES Nc1nc2n(CCN(CCC#N)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1 Show InChI InChI=1S/C8H18BN2O3P/c9-3-7-11(5-1-4-10)6-2-8-15(12,13)14/h1-3,5-9H2,(H2,12,13,14)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	200	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM194501 (US9200020, Table 3 compound 10) Show SMILES Nc1nc2n(CCN(CCO)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1 Show InChI InChI=1S/C7H19BNO4P/c8-2-4-9(5-6-10)3-1-7-14(11,12)13/h10H,1-8H2,(H2,11,12,13)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	200	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM60890 (US9200020, Table 3 compound 5B) Show SMILES OP(O)(=O)CCN(CCC#N)CCn1c[nH]c2c1nc[nH]c2=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	200	-39.8	n/a	n/a	n/a	n/a	n/a	n/a	37
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM60880 (US9200020, Table 1, Compound 1B) Show SMILES OP(O)(=O)CCOCCn1c[nH]c2c1nc[nH]c2=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	300	-38.7	n/a	n/a	n/a	n/a	n/a	n/a	37
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM194502 (US9200020, Table 3 compound 11) Show SMILES Nc1nc2n(CCN(CCP(O)(O)=O)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1 Show InChI InChI=1S/C7H20BNO6P2/c8-2-4-9(5-7-17(13,14)15)3-1-6-16(10,11)12/h1-8H2,(H2,10,11,12)(H2,13,14,15)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	300	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM60893 (US9200020, Table 3 compound 8B) Show SMILES OC(=O)CCN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	400	-38.0	n/a	n/a	n/a	n/a	n/a	n/a	37
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM60897 (US9200020, Table 3 compound 11B) Show SMILES OP(O)(=O)CCN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	400	-38.0	n/a	n/a	n/a	n/a	n/a	n/a	37
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM60892 (US9200020, Table 3 compound 7B) Show SMILES OC(=O)CN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	600	-36.9	n/a	n/a	n/a	n/a	n/a	n/a	37
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM194498 (US9200020, Table 3 compound 7) Show SMILES Nc1nc2n(CCN(CCP(O)(O)=O)CC(O)=O)c[nH]c2c(=O)[nH]1 Show InChI InChI=1S/C7H17BNO5P/c8-2-4-9(6-7(10)11)3-1-5-15(12,13)14/h1-6,8H2,(H,10,11)(H2,12,13,14)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	700	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM194494 (US9200020, Table 3 compound 3) Show SMILES COC(=O)CCCN(CCn1c[nH]c2c1nc(N)[nH]c2=O)CCP(O)(O)=O Show InChI InChI=1S/C10H23BNO5P/c1-17-10(13)4-2-6-12(8-5-11)7-3-9-18(14,15)16/h2-9,11H2,1H3,(H2,14,15,16)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM194492 (US9200020, Table 3 compound 1) Show SMILES CCOC(=O)CN(CCn1c[nH]c2c1nc(N)[nH]c2=O)CCP(O)(O)=O Show InChI InChI=1S/C9H21BNO5P/c1-2-16-9(12)8-11(6-4-10)5-3-7-17(13,14)15/h2-8,10H2,1H3,(H2,13,14,15)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM60886 (US9200020, Table 3, Compound 1B) Show SMILES CCOC(=O)CN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.90E+3	-34.0	n/a	n/a	n/a	n/a	n/a	n/a	37
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM60896 (US9200020, Table 3 compound 10B) Show SMILES OCCN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	2.60E+3	-33.2	n/a	n/a	n/a	n/a	n/a	n/a	37
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM194497 (US9200020, Table 3 compound 6) Show SMILES Nc1nc2n(CCN(CCCC#N)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1 Show InChI InChI=1S/C9H20BN2O3P/c10-4-8-12(6-2-1-5-11)7-3-9-16(13,14)15/h1-4,6-10H2,(H2,13,14,15)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM60891 (US9200020, Table 3 compound 6B) Show SMILES OP(O)(=O)CCN(CCCC#N)CCn1c[nH]c2c1nc[nH]c2=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	6.00E+3	-31.0	n/a	n/a	n/a	n/a	n/a	n/a	37
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM194491 (US9200020, Table 1, Compound 2) Show SMILES Nc1nc2n(CCNCCP(O)(O)=O)c[nH]c2c(=O)[nH]1 Show InChI InChI=1S/C4H13BNO3P/c5-1-2-6-3-4-10(7,8)9/h6H,1-5H2,(H2,7,8,9)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM60884 (US9200020, Table 1, Compound 2B) Show SMILES OP(O)(=O)CCNCCn1c[nH]c2c1nc[nH]c2=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>2.00E+5	>-22.0	n/a	n/a	n/a	n/a	n/a	n/a	37
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM60894 (US9200020, Table 3 compound 9B) Show SMILES OC(=O)CCCN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>2.10E+5	>-21.8	n/a	n/a	n/a	n/a	n/a	n/a	37
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM60888 (US9200020, Table 3, Compound 3B) Show SMILES COC(=O)CCCN(CCn1c[nH]c2c1nc[nH]c2=O)CCP(O)(O)=O Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	>2.20E+5	>-21.7	n/a	n/a	n/a	n/a	n/a	n/a	37
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (Plasmodium falciparum)	BDBM194495 (US9200020, Table 3 compound 4) Show SMILES OP(O)(=O)CCN(CCn1c[nH]c2c1nc[nH]c2=O)CC#N Show InChI InChI=1S/C7H16BN2O3P/c8-2-5-10(6-3-9)4-1-7-14(11,12)13/h1-2,4-8H2,(H2,11,12,13)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	>2.50E+5	>-21.4	n/a	n/a	n/a	n/a	n/a	n/a	37
THE UNIVERSITY OF QUEENSLAND; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I. US Patent					Assay Description The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...				US Patent US9200020 (2015) BindingDB Entry DOI: 10.7270/Q2TM78XB
					More data for this Ligand-Target Pair