Compile Data Set for Download or QSAR

Found 1732 hits Enz. Inhib. hit(s) with Target = 'INSR'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin receptor (Homo sapiens (Human))	BDBM50256480 (CHEMBL466397 | N-(2,6-difluorophenyl)-5-(3-(2-(5-e...) Show SMILES CCc1cc(Nc2nccc(n2)-c2c(nc3ccccn23)-c2ccc(OC)c(c2)C(=O)Nc2c(F)cccc2F)c(OC)cc1N1CCC(CC1)N1CCN(CC1)S(C)(=O)=O Show InChI InChI=1S/C44H47F2N9O5S/c1-5-28-26-35(38(60-3)27-36(28)53-19-15-30(16-20-53)52-21-23-54(24-22-52)61(4,57)58)49-44-47-17-14-34(48-44)42-40(50-39-11-6-7-18-55(39)42)29-12-13-37(59-2)31(25-29)43(56)51-41-32(45)9-8-10-33(41)46/h6-14,17-18,25-27,30H,5,15-16,19-24H2,1-4H3,(H,51,56)(H,47,48,49)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Binding affinity to insulin receptor by liquid scintillation counting				Bioorg Med Chem Lett 19: 1004-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.058 BindingDB Entry DOI: 10.7270/Q24T6J8M
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50256478 (CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...) Show SMILES COc1cc(ccc1Nc1nccc(n1)-c1c(nc2ccccn12)-c1cccc(c1)C(=O)Nc1c(F)cccc1F)N1CCC(CC1)N1CCN(CC1)S(C)(=O)=O Show InChI InChI=1S/C41H41F2N9O4S/c1-56-35-26-30(49-19-15-29(16-20-49)50-21-23-51(24-22-50)57(2,54)55)12-13-33(35)45-41-44-17-14-34(46-41)39-37(47-36-11-3-4-18-52(36)39)27-7-5-8-28(25-27)40(53)48-38-31(42)9-6-10-32(38)43/h3-14,17-18,25-26,29H,15-16,19-24H2,1-2H3,(H,48,53)(H,44,45,46)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Binding affinity to insulin receptor by liquid scintillation counting				Bioorg Med Chem Lett 19: 1004-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.058 BindingDB Entry DOI: 10.7270/Q24T6J8M
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50341519 ((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...) Show SMILES CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1 |r| Show InChI InChI=1S/C26H31N7O2/c1-27-24-16-28-15-23(30-24)19-13-22(26(35)29-14-19)31-25(34)18-6-8-20(9-7-18)33-12-4-5-21(33)17-32-10-2-3-11-32/h6-9,13-16,21H,2-5,10-12,17H2,1H3,(H,27,30)(H,29,35)(H,31,34)/t21-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals (Europe) Ltd. Curated by ChEMBL					Assay Description Inhibition of IR				J Med Chem 54: 2341-50 (2011) Article DOI: 10.1021/jm101499u BindingDB Entry DOI: 10.7270/Q2KH0NPW
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50463483 (CHEMBL4245242) Show SMILES O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(cs1)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C26H29N5O2S/c32-24(31-26-30-23(17-34-26)22-16-29-25-21(22)7-2-10-28-25)15-19-4-1-6-20(14-19)33-13-3-5-18-8-11-27-12-9-18/h1-2,4,6-7,10,14,16-18,27H,3,5,8-9,11-13,15H2,(H,28,29)(H,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of INSR (unknown origin)				Bioorg Med Chem Lett 28: 2622-2626 (2018) Article DOI: 10.1016/j.bmcl.2018.06.040 BindingDB Entry DOI: 10.7270/Q2ZC85HX
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50463479 (CHEMBL4249925) Show SMILES CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(cs2)-c2c[nH]c3ncccc23)c1 Show InChI InChI=1S/C19H17N5O3S2/c1-29(26,27)24-13-5-2-4-12(8-13)9-17(25)23-19-22-16(11-28-19)15-10-21-18-14(15)6-3-7-20-18/h2-8,10-11,24H,9H2,1H3,(H,20,21)(H,22,23,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of INSR (unknown origin)				Bioorg Med Chem Lett 28: 2622-2626 (2018) Article DOI: 10.1016/j.bmcl.2018.06.040 BindingDB Entry DOI: 10.7270/Q2ZC85HX
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM15236 (3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...) Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of insulin receptor				J Nat Prod 55: 1529-1560 (1992) Article DOI: 10.1021/np50089a001 BindingDB Entry DOI: 10.7270/Q2J966CC
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50237710 (4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...) Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by PDSP Ki Database									Proc Natl Acad Sci U S A 103: 3153-8 (2006) Article DOI: 10.1073/pnas.0511292103 BindingDB Entry DOI: 10.7270/Q21Z430B
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50224883 (7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...) Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3 Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>5.24E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of INSR				Bioorg Med Chem Lett 17: 6593-601 (2007) Article DOI: 10.1016/j.bmcl.2007.09.063 BindingDB Entry DOI: 10.7270/Q2X067WT
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50181669 (5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...) Show SMILES CN1CCN(Cc2ccc(NC(=O)c3cc(c[nH]c3=O)-c3ccc4OCOc4c3)cc2)CC1 Show InChI InChI=1S/C25H26N4O4/c1-28-8-10-29(11-9-28)15-17-2-5-20(6-3-17)27-25(31)21-12-19(14-26-24(21)30)18-4-7-22-23(13-18)33-16-32-22/h2-7,12-14H,8-11,15-16H2,1H3,(H,26,30)(H,27,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ChemBridge Research Laboratories and ChemBridge Corporation Curated by ChEMBL					Assay Description Inhibitory activity against IRK				J Med Chem 49: 1006-15 (2006) Article DOI: 10.1021/jm050824x BindingDB Entry DOI: 10.7270/Q2H994T6
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50181670 (5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...) Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2cc(c[nH]c2=O)-c2ccc3OCOc3c2)cc1 Show InChI InChI=1S/C24H24N4O4/c1-27-8-10-28(11-9-27)19-5-3-18(4-6-19)26-24(30)20-12-17(14-25-23(20)29)16-2-7-21-22(13-16)32-15-31-21/h2-7,12-14H,8-11,15H2,1H3,(H,25,29)(H,26,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ChemBridge Research Laboratories and ChemBridge Corporation Curated by ChEMBL					Assay Description Inhibitory activity against IRK				J Med Chem 49: 1006-15 (2006) Article DOI: 10.1021/jm050824x BindingDB Entry DOI: 10.7270/Q2H994T6
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50181675 (5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...) Show SMILES CN1CCN(CCCc2ccc(NC(=O)c3cc(c[nH]c3=O)-c3ccc4OCOc4c3)cc2)CC1 Show InChI InChI=1S/C27H30N4O4/c1-30-11-13-31(14-12-30)10-2-3-19-4-7-22(8-5-19)29-27(33)23-15-21(17-28-26(23)32)20-6-9-24-25(16-20)35-18-34-24/h4-9,15-17H,2-3,10-14,18H2,1H3,(H,28,32)(H,29,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
ChemBridge Research Laboratories and ChemBridge Corporation Curated by ChEMBL					Assay Description Inhibitory activity against IRK				J Med Chem 49: 1006-15 (2006) Article DOI: 10.1021/jm050824x BindingDB Entry DOI: 10.7270/Q2H994T6
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM13530 (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by PDSP Ki Database									Proc Natl Acad Sci U S A 103: 3153-8 (2006) Article DOI: 10.1073/pnas.0511292103 BindingDB Entry DOI: 10.7270/Q21Z430B
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50011995 ((Hydroxy-naphthalen-2-yl-methyl)-phosphonic acid |...) Show SMILES OP(O)(O)C(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C11H11O4P/c12-11(16(13,14)15)10-6-5-8-3-1-2-4-9(8)7-10/h1-7,13-16H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Athenex Inc. Curated by ChEMBL					Assay Description Non-competitive inhibition of human placental insulin receptor expressed in CHO cell membrane assessed as decrease in insulin-stimulated A2 phosphory...				J Med Chem 61: 4704-4719 (2018) Article DOI: 10.1021/acs.jmedchem.8b00164 BindingDB Entry DOI: 10.7270/Q2Z89GT1
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184383 (US9150578, I-031) Show SMILES CN1CCN(CCn2ccc(Nc3ncc4CCc5nn(C)c(c5-c4n3)-c3ccc(cc3)-c3cnn(C)c3)n2)CC1 Show InChI InChI=1S/C30H35N11/c1-37-12-14-40(15-13-37)16-17-41-11-10-26(36-41)33-30-31-18-23-8-9-25-27(28(23)34-30)29(39(3)35-25)22-6-4-21(5-7-22)24-19-32-38(2)20-24/h4-7,10-11,18-20H,8-9,12-17H2,1-3H3,(H,31,33,34,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184545 (US9150578, I-172) Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(CC1)C(C)C Show InChI InChI=1S/C34H39N9O/c1-22(2)42-14-16-43(17-15-42)27-11-13-28(30(18-27)44-5)37-34-35-19-25-10-12-29-31(32(25)38-34)33(41(4)39-29)24-8-6-23(7-9-24)26-20-36-40(3)21-26/h6-9,11,13,18-22H,10,12,14-17H2,1-5H3,(H,35,37,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184544 (US9150578, I-171) Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(CC1)C1CCOCC1 Show InChI InChI=1S/C36H41N9O2/c1-42-23-27(22-38-42)24-4-6-25(7-5-24)35-33-31(41-43(35)2)10-8-26-21-37-36(40-34(26)33)39-30-11-9-29(20-32(30)46-3)45-16-14-44(15-17-45)28-12-18-47-19-13-28/h4-7,9,11,20-23,28H,8,10,12-19H2,1-3H3,(H,37,39,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184520 (US9150578, I-149) Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4cccc(c4)-c4cnn(C)c4)c3-c2n1)C(=O)NCCCN(C)C Show InChI InChI=1S/C34H39N9O2/c1-41(2)15-7-14-35-33(44)24-10-12-27(30(18-24)45-5)38-34-36-19-25-11-13-28-31(32(25)39-34)29(43(4)40-28)17-22-8-6-9-23(16-22)26-20-37-42(3)21-26/h6,8-10,12,16,18-21H,7,11,13-15,17H2,1-5H3,(H,35,44)(H,36,38,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184387 (US9150578, I-035) Show SMILES Cn1cc(cn1)-c1cccc(Cc2c-3c(CCc4cnc(Nc5ccn(CCCN6CCCC6)n5)nc-34)nn2C)c1 Show InChI InChI=1S/C31H36N10/c1-38-21-25(20-33-38)23-8-5-7-22(17-23)18-27-29-26(36-39(27)2)10-9-24-19-32-31(35-30(24)29)34-28-11-16-41(37-28)15-6-14-40-12-3-4-13-40/h5,7-8,11,16-17,19-21H,3-4,6,9-10,12-15,18H2,1-2H3,(H,32,34,35,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184548 (US9150578, I-174) Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(CCO)CC1 Show InChI InChI=1S/C33H37N9O2/c1-39-21-25(20-35-39)22-4-6-23(7-5-22)32-30-28(38-40(32)2)10-8-24-19-34-33(37-31(24)30)36-27-11-9-26(18-29(27)44-3)42-14-12-41(13-15-42)16-17-43/h4-7,9,11,18-21,43H,8,10,12-17H2,1-3H3,(H,34,36,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0800	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184543 (US9150578, I-170) Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)c(OC)c1 Show InChI InChI=1S/C33H37N9O/c1-5-41-14-16-42(17-15-41)26-11-13-27(29(18-26)43-4)36-33-34-19-24-10-12-28-30(31(24)37-33)32(40(3)38-28)23-8-6-22(7-9-23)25-20-35-39(2)21-25/h6-9,11,13,18-21H,5,10,12,14-17H2,1-4H3,(H,34,36,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184486 (US9150578, I-119) Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN3CCC(CC3)N(C)C)c2)n1 Show InChI InChI=1S/C33H41N11/c1-5-43-17-14-29(39-43)36-33-34-20-25-10-11-28-30(31(25)37-33)32(41(4)38-28)24-8-6-23(7-9-24)26-21-35-44(22-26)19-18-42-15-12-27(13-16-42)40(2)3/h6-9,14,17,20-22,27H,5,10-13,15-16,18-19H2,1-4H3,(H,34,36,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184480 (US9150578, I-113) Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN3CCN(C)CC3)c2)n1 Show InChI InChI=1S/C31H37N11/c1-4-41-12-11-27(37-41)34-31-32-19-24-9-10-26-28(29(24)35-31)30(39(3)36-26)23-7-5-22(6-8-23)25-20-33-42(21-25)18-17-40-15-13-38(2)14-16-40/h5-8,11-12,19-21H,4,9-10,13-18H2,1-3H3,(H,32,34,35,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184542 (US9150578, I-169 | US9150578, I-173) Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)N1CCN(C)CC1 Show InChI InChI=1S/C32H35N9O/c1-38-13-15-41(16-14-38)25-10-12-26(28(17-25)42-4)35-32-33-18-23-9-11-27-29(30(23)36-32)31(40(3)37-27)22-7-5-21(6-8-22)24-19-34-39(2)20-24/h5-8,10,12,17-20H,9,11,13-16H2,1-4H3,(H,33,35,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184357 (US9150578, I-005) Show SMILES CN(C)C(=O)Cn1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)cn1 Show InChI InChI=1S/C27H28N10O/c1-34(2)23(38)16-37-15-21(13-30-37)31-27-28-11-19-9-10-22-24(25(19)32-27)26(36(4)33-22)18-7-5-17(6-8-18)20-12-29-35(3)14-20/h5-8,11-15H,9-10,16H2,1-4H3,(H,28,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184485 (US9150578, I-118) Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN3CCNCC3)c2)n1 Show InChI InChI=1S/C30H35N11/c1-3-40-13-10-26(37-40)34-30-32-18-23-8-9-25-27(28(23)35-30)29(38(2)36-25)22-6-4-21(5-7-22)24-19-33-41(20-24)17-16-39-14-11-31-12-15-39/h4-7,10,13,18-20,31H,3,8-9,11-12,14-17H2,1-2H3,(H,32,34,35,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184440 (US9150578, I-074) Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(CCOC)c5)c4-c3n2)n1 Show InChI InChI=1S/C28H31N9O/c1-4-36-11-10-25(34-36)31-28-29-16-21-8-9-23-26(27(21)32-28)24(35(2)33-23)15-19-6-5-7-20(14-19)22-17-30-37(18-22)12-13-38-3/h5-7,10-11,14,16-18H,4,8-9,12-13,15H2,1-3H3,(H,29,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184382 (US9150578, I-030) Show SMILES COCCN1CCN(CCn2ccc(Nc3ncc4CCc5nn(C)c(c5-c4n3)-c3ccc(cc3)-c3cnn(C)c3)n2)CC1 Show InChI InChI=1S/C32H39N11O/c1-39-22-26(21-34-39)23-4-6-24(7-5-23)31-29-27(37-40(31)2)9-8-25-20-33-32(36-30(25)29)35-28-10-11-43(38-28)17-16-41-12-14-42(15-13-41)18-19-44-3/h4-7,10-11,20-22H,8-9,12-19H2,1-3H3,(H,33,35,36,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184483 (US9150578, I-116) Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN3CCCC3)c2)n1 Show InChI InChI=1S/C30H34N10/c1-3-39-15-12-26(36-39)33-30-31-18-23-10-11-25-27(28(23)34-30)29(37(2)35-25)22-8-6-21(7-9-22)24-19-32-40(20-24)17-16-38-13-4-5-14-38/h6-9,12,15,18-20H,3-5,10-11,13-14,16-17H2,1-2H3,(H,31,33,34,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184482 (US9150578, I-115) Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCNCCOC)c2)n1 Show InChI InChI=1S/C29H34N10O/c1-4-38-14-11-25(36-38)33-29-31-17-22-9-10-24-26(27(22)34-29)28(37(2)35-24)21-7-5-20(6-8-21)23-18-32-39(19-23)15-12-30-13-16-40-3/h5-8,11,14,17-19,30H,4,9-10,12-13,15-16H2,1-3H3,(H,31,33,34,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.110	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184373 (US9150578, I-021) Show SMILES CC(C)n1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCN(C)C)n4)nc-23)nn1C Show InChI InChI=1S/C29H34N10/c1-19(2)39-18-23(17-31-39)20-6-8-21(9-7-20)28-26-24(34-37(28)5)11-10-22-16-30-29(33-27(22)26)32-25-12-13-38(35-25)15-14-36(3)4/h6-9,12-13,16-19H,10-11,14-15H2,1-5H3,(H,30,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184425 (US9150578, I-059) Show SMILES COCCn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCN(C)C)n4)nc-23)nn1C Show InChI InChI=1S/C29H34N10O/c1-36(2)13-14-38-12-11-25(35-38)32-29-30-17-22-9-10-24-26(27(22)33-29)28(37(3)34-24)21-7-5-20(6-8-21)23-18-31-39(19-23)15-16-40-4/h5-8,11-12,17-19H,9-10,13-16H2,1-4H3,(H,30,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184505 (US9150578, I-134) Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NCCN(C)C Show InChI InChI=1S/C32H35N9O2/c1-39(2)15-14-33-31(42)22-10-12-25(27(16-22)43-5)36-32-34-17-23-11-13-26-28(29(23)37-32)30(41(4)38-26)21-8-6-20(7-9-21)24-18-35-40(3)19-24/h6-10,12,16-19H,11,13-15H2,1-5H3,(H,33,42)(H,34,36,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184484 (US9150578, I-117) Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN3CCN(CCOC)CC3)c2)n1 Show InChI InChI=1S/C33H41N11O/c1-4-43-12-11-29(39-43)36-33-34-21-26-9-10-28-30(31(26)37-33)32(40(2)38-28)25-7-5-24(6-8-25)27-22-35-44(23-27)18-17-41-13-15-42(16-14-41)19-20-45-3/h5-8,11-12,21-23H,4,9-10,13-20H2,1-3H3,(H,34,36,37,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184428 (US9150578, I-062) Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN(C)C)c2)n1 Show InChI InChI=1S/C28H32N10/c1-5-37-13-12-24(34-37)31-28-29-16-21-10-11-23-25(26(21)32-28)27(36(4)33-23)20-8-6-19(7-9-20)22-17-30-38(18-22)15-14-35(2)3/h6-9,12-13,16-18H,5,10-11,14-15H2,1-4H3,(H,29,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184481 (US9150578, I-114) Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN3CCN(CCO)CC3)c2)n1 Show InChI InChI=1S/C32H39N11O/c1-3-42-11-10-28(38-42)35-32-33-20-25-8-9-27-29(30(25)36-32)31(39(2)37-27)24-6-4-23(5-7-24)26-21-34-43(22-26)17-16-40-12-14-41(15-13-40)18-19-44/h4-7,10-11,20-22,44H,3,8-9,12-19H2,1-2H3,(H,33,35,36,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184507 (US9150578, I-136) Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NCCCN(C)C Show InChI InChI=1S/C33H37N9O2/c1-40(2)16-6-15-34-32(43)23-11-13-26(28(17-23)44-5)37-33-35-18-24-12-14-27-29(30(24)38-33)31(42(4)39-27)22-9-7-21(8-10-22)25-19-36-41(3)20-25/h7-11,13,17-20H,6,12,14-16H2,1-5H3,(H,34,43)(H,35,37,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184532 (US9150578, I-161) Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)N(C)C1CCN(C)CC1 Show InChI InChI=1S/C35H39N9O2/c1-41-16-14-27(15-17-41)43(3)34(45)24-10-12-28(30(18-24)46-5)38-35-36-19-25-11-13-29-31(32(25)39-35)33(44(4)40-29)23-8-6-22(7-9-23)26-20-37-42(2)21-26/h6-10,12,18-21,27H,11,13-17H2,1-5H3,(H,36,38,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184506 (US9150578, I-135) Show SMILES COCCN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)c(OC)c1 Show InChI InChI=1S/C36H41N9O3/c1-43-22-27(21-38-43)23-5-7-24(8-6-23)34-32-30(42-44(34)2)12-10-26-20-37-36(41-33(26)32)40-29-11-9-25(19-31(29)48-4)35(46)39-28-13-15-45(16-14-28)17-18-47-3/h5-9,11,19-22,28H,10,12-18H2,1-4H3,(H,39,46)(H,37,40,41)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184504 (US9150578, I-133) Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NC1CCN(C)CC1 Show InChI InChI=1S/C34H37N9O2/c1-41-15-13-26(14-16-41)37-33(44)23-9-11-27(29(17-23)45-4)38-34-35-18-24-10-12-28-30(31(24)39-34)32(43(3)40-28)22-7-5-21(6-8-22)25-19-36-42(2)20-25/h5-9,11,17-20,26H,10,12-16H2,1-4H3,(H,37,44)(H,35,38,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184521 (US9150578, I-150) Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(Cc4cccc(c4)-c4cnn(C)c4)c3-c2n1)C(=O)NCCN1CCCC1 Show InChI InChI=1S/C35H39N9O2/c1-42-22-27(21-38-42)24-8-6-7-23(17-24)18-30-32-29(41-43(30)2)12-10-26-20-37-35(40-33(26)32)39-28-11-9-25(19-31(28)46-3)34(45)36-13-16-44-14-4-5-15-44/h6-9,11,17,19-22H,4-5,10,12-16,18H2,1-3H3,(H,36,45)(H,37,39,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184526 (US9150578, I-155) Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)N(C)CCN(C)C Show InChI InChI=1S/C33H37N9O2/c1-39(2)15-16-40(3)32(43)23-11-13-26(28(17-23)44-6)36-33-34-18-24-12-14-27-29(30(24)37-33)31(42(5)38-27)22-9-7-21(8-10-22)25-19-35-41(4)20-25/h7-11,13,17-20H,12,14-16H2,1-6H3,(H,34,36,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184519 (US9150578, I-148) Show SMILES CNC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)c(OC)c1 Show InChI InChI=1S/C30H30N8O2/c1-31-29(39)20-8-10-23(26(14-20)40-4)34-30-32-15-21-9-11-24-27(28(21)35-30)25(38(3)36-24)13-18-6-5-7-19(12-18)22-16-33-37(2)17-22/h5-8,10,12,14-17H,9,11,13H2,1-4H3,(H,31,39)(H,32,34,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184427 (US9150578, I-061) Show SMILES CCCn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCN(C)C)n4)nc-23)nn1C Show InChI InChI=1S/C29H34N10/c1-5-13-39-19-23(18-31-39)20-6-8-21(9-7-20)28-26-24(34-37(28)4)11-10-22-17-30-29(33-27(22)26)32-25-12-14-38(35-25)16-15-36(2)3/h6-9,12,14,17-19H,5,10-11,13,15-16H2,1-4H3,(H,30,32,33,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.150	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184530 (US9150578, I-159) Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)NCC1CCN(C)CC1 Show InChI InChI=1S/C35H39N9O2/c1-42-15-13-22(14-16-42)18-36-34(45)25-9-11-28(30(17-25)46-4)39-35-37-19-26-10-12-29-31(32(26)40-35)33(44(3)41-29)24-7-5-23(6-8-24)27-20-38-43(2)21-27/h5-9,11,17,19-22H,10,12-16,18H2,1-4H3,(H,36,45)(H,37,39,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184549 (US9150578, I-175) Show SMILES COCCN1CCC(CC1)n1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)cn1 Show InChI InChI=1S/C31H36N10O/c1-38-19-24(17-33-38)21-4-6-22(7-5-21)30-28-27(37-39(30)2)9-8-23-16-32-31(36-29(23)28)35-25-18-34-41(20-25)26-10-12-40(13-11-26)14-15-42-3/h4-7,16-20,26H,8-15H2,1-3H3,(H,32,35,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184356 (US9150578, I-004) Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCCO)n4)nc-23)nn1C Show InChI InChI=1S/C26H27N9O/c1-33-16-20(15-28-33)17-4-6-18(7-5-17)25-23-21(31-34(25)2)9-8-19-14-27-26(30-24(19)23)29-22-10-12-35(32-22)11-3-13-36/h4-7,10,12,14-16,36H,3,8-9,11,13H2,1-2H3,(H,27,29,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184367 (US9150578, I-015) Show SMILES CN(C)CCn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)n1 Show InChI InChI=1S/C28H32N10/c1-35(2)12-13-38-11-10-25(34-38)31-28-29-16-21-8-9-23-26(27(21)32-28)24(37(4)33-23)15-19-6-5-7-20(14-19)22-17-30-36(3)18-22/h5-7,10-11,14,16-18H,8-9,12-13,15H2,1-4H3,(H,29,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184447 (US9150578, I-081) Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCO)c2)n1 Show InChI InChI=1S/C26H27N9O/c1-3-34-11-10-22(32-34)29-26-27-14-19-8-9-21-23(24(19)30-26)25(33(2)31-21)18-6-4-17(5-7-18)20-15-28-35(16-20)12-13-36/h4-7,10-11,14-16,36H,3,8-9,12-13H2,1-2H3,(H,27,29,30,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184518 (US9150578, I-147) Show SMILES COCCN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)c(OC)c1 Show InChI InChI=1S/C37H43N9O3/c1-44-23-28(22-39-44)25-7-5-6-24(18-25)19-32-34-31(43-45(32)2)11-9-27-21-38-37(42-35(27)34)41-30-10-8-26(20-33(30)49-4)36(47)40-29-12-14-46(15-13-29)16-17-48-3/h5-8,10,18,20-23,29H,9,11-17,19H2,1-4H3,(H,40,47)(H,38,41,42)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair
Insulin receptor [964-1370] (Homo sapiens (Human))	BDBM184500 (US9150578, I-129) Show SMILES COc1cc(ccc1Nc1ncc2CCc3nn(C)c(c3-c2n1)-c1ccc(cc1)-c1cnn(C)c1)C(=O)N1CCN(C)CC1 Show InChI InChI=1S/C33H35N9O2/c1-39-13-15-42(16-14-39)32(43)23-9-11-26(28(17-23)44-4)36-33-34-18-24-10-12-27-29(30(24)37-33)31(41(3)38-27)22-7-5-21(6-8-22)25-19-35-40(2)20-25/h5-9,11,17-20H,10,12-16H2,1-4H3,(H,34,36,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	7.4	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...				US Patent US9150578 (2015) BindingDB Entry DOI: 10.7270/Q2BK1B4W
					More data for this Ligand-Target Pair

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