BindingDB PrimarySearch

Found 12 hits Enz. Inhib. hit(s) with Target = 'Low affinity neurotrophin receptor p75NTR'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tumor necrosis factor receptor superfamily member 16 (Homo sapiens (Human))	BDBM50180054 (CHEMBL199824 \| [O-methyl-11C]2-{4-[4-(7-methoxynap...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Columbia University College of Physicians and Surgeons Curated by ChEMBL					Assay Description Binding affinity to neurotrophin receptor				J Med Chem 49: 125-34 (2006) Article DOI: 10.1021/jm050725j BindingDB Entry DOI: 10.7270/Q2R49QBD
					More data for this Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16 (Homo sapiens (Human))	BDBM50182020 (2-(4-(4-(3-methoxyphenyl)piperazin-1-yl)butyl)-4-m...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Columbia University College of Physicians and Surgeons Curated by ChEMBL					Assay Description Binding affinity to NT by radioligand binding assay				Bioorg Med Chem Lett 16: 2101-4 (2006) Article DOI: 10.1016/j.bmcl.2006.01.052 BindingDB Entry DOI: 10.7270/Q2ZC82FS
					More data for this Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16 (Homo sapiens (Human))	BDBM50029495 (7-Benzoylamino-4-methyl-9-oxo-4,9-dihydro-pyrazolo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of [125I]- NGF binding to extracellular domain of p75 receptor				J Med Chem 38: 4439-45 (1995) BindingDB Entry DOI: 10.7270/Q2W37V9R
Warner-Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16 (Homo sapiens (Human))	BDBM50029497 (2-Methyl-7-oxo-5-(tetrazol-1-ylcarbamoyl)-4,7-dihy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of [125I]- NGF binding to extracellular domain of p75 receptor				J Med Chem 38: 4439-45 (1995) BindingDB Entry DOI: 10.7270/Q2W37V9R
Warner-Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16 (Homo sapiens (Human))	BDBM50029494 (2-Methyl-7-oxo-4,7-dihydro-thieno[3,2-b]pyridine-3...) Show SMILES COC(=O)c1c(C)sc2c(O)cc(nc12)C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of [125I]- NGF binding to extracellular domain of p75 receptor				J Med Chem 38: 4439-45 (1995) BindingDB Entry DOI: 10.7270/Q2W37V9R
Warner-Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16 (Homo sapiens (Human))	BDBM50029496 (6-Amino-4-oxo-1,4-dihydro-quinoline-2-carboxylic a...) Show SMILES Nc1ccc2nc(cc(O)c2c1)C(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of [125I]- NGF binding to extracellular domain of p75 receptor				J Med Chem 38: 4439-45 (1995) BindingDB Entry DOI: 10.7270/Q2W37V9R
Warner-Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16 (Homo sapiens (Human))	BDBM50111443 (2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	PubMed	n/a	n/a	3.72E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Competitive binding against Nerve growth factor to p75-NGF receptor in PC12 cells				J Med Chem 45: 1543-58 (2002) BindingDB Entry DOI: 10.7270/Q2CN74ND
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16 (Homo sapiens (Human))	BDBM50029495 (7-Benzoylamino-4-methyl-9-oxo-4,9-dihydro-pyrazolo...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse NGF binding to p75 (unknown origin) by SPR method				J Med Chem 60: 66-88 (2017) Article DOI: 10.1021/acs.jmedchem.6b00964 BindingDB Entry DOI: 10.7270/Q2C24ZCR
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16 (Homo sapiens (Human))	BDBM50396070 (CHEMBL1397270) Show SMILES Cc1cc2nc3c(nc(=O)[nH]c3=O)n(C)c2cc1C=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.44E+5	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse NGF binding to p75 (unknown origin) by SPR method				J Med Chem 60: 66-88 (2017) Article DOI: 10.1021/acs.jmedchem.6b00964 BindingDB Entry DOI: 10.7270/Q2C24ZCR
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16 (Homo sapiens (Human))	BDBM50111443 (2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse NGF binding to p75 (unknown origin) by SPR method				J Med Chem 60: 66-88 (2017) Article DOI: 10.1021/acs.jmedchem.6b00964 BindingDB Entry DOI: 10.7270/Q2C24ZCR
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16 (Mus musculus)	BDBM50535058 (CHEMBL4439582) Show SMILES CCC(C)C(N)C(=O)NCCN1CCOCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
University of British Columbia Curated by ChEMBL					Assay Description Activation of p75NTR in mouse hippocampal neurons assessed as increase in cell survival after 48 hrs by MTT assay				Bioorg Med Chem 24: 4759-4765 (2016) Article DOI: 10.1016/j.bmc.2016.08.020 BindingDB Entry DOI: 10.7270/Q20K2D23
University of British Columbia Curated by ChEMBL					More data for this Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16 (Mus musculus)	BDBM50535059 (CHEMBL4446977) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<10	n/a	n/a	n/a	n/a
University of British Columbia Curated by ChEMBL					Assay Description Activation of p75NTR in C57BL/6 mouse brain assessed as suppression of carbachol-mediated persistant firing of entorhinal cortex after 15 mins by cur...				Bioorg Med Chem 24: 4759-4765 (2016) Article DOI: 10.1016/j.bmc.2016.08.020 BindingDB Entry DOI: 10.7270/Q20K2D23
University of British Columbia Curated by ChEMBL					More data for this Ligand-Target Pair