Compile Data Set for Download or QSAR

Found 22 hits Enz. Inhib. hit(s) with Target = 'Neuronal acetylcholine receptor protein alpha-6 subunit'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50263130 ((+)-7-Methyl-2-exo-[3'-(2-fluoropyridin-3-yl)-5'-p...) Show SMILES CN1[C@@H]2CC[C@@H]1[C@H](C2)c1cncc(c1)-c1cccnc1F |r,TLB:8:6:3.4:1| Show InChI InChI=1S/C17H18FN3/c1-21-13-4-5-16(21)15(8-13)12-7-11(9-19-10-12)14-3-2-6-20-17(14)18/h2-3,6-7,9-10,13,15-16H,4-5,8H2,1H3/t13-,15-,16-/m1/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.0210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Johns Hopkins UniVersity School of Medicine Curated by ChEMBL					Assay Description Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cells				J Med Chem 51: 4751-64 (2008) Article DOI: 10.1021/jm800323d BindingDB Entry DOI: 10.7270/Q23N249J
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50263095 ((+)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'-p...) Show SMILES CN1[C@@H]2CC[C@@H]1[C@H](C2)c1cncc(c1)-c1ccnc(F)c1 |r,TLB:8:6:3.4:1| Show InChI InChI=1S/C17H18FN3/c1-21-14-2-3-16(21)15(8-14)13-6-12(9-19-10-13)11-4-5-20-17(18)7-11/h4-7,9-10,14-16H,2-3,8H2,1H3/t14-,15-,16-/m1/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.0310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Johns Hopkins UniVersity School of Medicine Curated by ChEMBL					Assay Description Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cells				J Med Chem 51: 4751-64 (2008) Article DOI: 10.1021/jm800323d BindingDB Entry DOI: 10.7270/Q23N249J
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50263171 ((+)-2-(6'-[18F]fluoro-3,3'-bipyridin-5-yl)-7-methy...) Show SMILES CN1C2CCC1C(C2)c1cncc(c1)-c1ccc(F)nc1 |TLB:8:6:3.4:1| Show InChI InChI=1S/C17H18FN3/c1-21-14-3-4-16(21)15(7-14)13-6-12(8-19-9-13)11-2-5-17(18)20-10-11/h2,5-6,8-10,14-16H,3-4,7H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.0470	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Johns Hopkins UniVersity School of Medicine Curated by ChEMBL					Assay Description Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cells				J Med Chem 51: 4751-64 (2008) Article DOI: 10.1021/jm800323d BindingDB Entry DOI: 10.7270/Q23N249J
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50263131 ((+)-7-Methyl-2-exo-[3'-(6-fluoropyridin-2-yl)-5'-p...) Show SMILES CN1[C@@H]2CC[C@@H]1[C@H](C2)c1cncc(c1)-c1cccc(F)n1 |r,TLB:8:6:3.4:1| Show InChI InChI=1S/C17H18FN3/c1-21-13-5-6-16(21)14(8-13)11-7-12(10-19-9-11)15-3-2-4-17(18)20-15/h2-4,7,9-10,13-14,16H,5-6,8H2,1H3/t13-,14-,16-/m1/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Johns Hopkins UniVersity School of Medicine Curated by ChEMBL					Assay Description Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cells				J Med Chem 51: 4751-64 (2008) Article DOI: 10.1021/jm800323d BindingDB Entry DOI: 10.7270/Q23N249J
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50045045 (CHEMBL3341965) Show SMILES [H][C@]12C[C@]([H])(CNC1)c1cc(ccc21)C(F)(F)F |r| Show InChI InChI=1S/C12H12F3N/c13-12(14,15)9-1-2-10-7-3-8(6-16-5-7)11(10)4-9/h1-2,4,7-8,16H,3,5-6H2/t7-,8+/m0/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	>300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Partial agonist activity at rat alpha6 nAChR				J Med Chem 57: 8204-23 (2014) Article DOI: 10.1021/jm401937a BindingDB Entry DOI: 10.7270/Q2KW5HPX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50334463 (1,3,5-tri-{5-[1-(3-picolinium)]-pent-1-ynyl}benzen...) Show SMILES Cc1ccc[n+](CCCC#Cc2cc(cc(c2)C#CCCC[n+]2cccc(C)c2)C#CCCC[n+]2cccc(C)c2)c1 Show InChI InChI=1S/C39H42N3/c1-34-16-13-25-40(31-34)22-10-4-7-19-37-28-38(20-8-5-11-23-41-26-14-17-35(2)32-41)30-39(29-37)21-9-6-12-24-42-27-15-18-36(3)33-42/h13-18,25-33H,4-6,10-12,22-24H2,1-3H3/q+3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50334472 (1,3,5-tris(5-(3,4-dihydroisoquinolin-2(1H)-yl)pent...) Show SMILES C(CCN1CCc2ccccc2C1)CCc1cc(CCCCCN2CCc3ccccc3C2)cc(CCCCCN2CCc3ccccc3C2)c1 Show InChI InChI=1S/C48H63N3/c1(13-28-49-31-25-43-19-7-10-22-46(43)37-49)4-16-40-34-41(17-5-2-14-29-50-32-26-44-20-8-11-23-47(44)38-50)36-42(35-40)18-6-3-15-30-51-33-27-45-21-9-12-24-48(45)39-51/h7-12,19-24,34-36H,1-6,13-18,25-33,37-39H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50334464 (1,12-bis(3-methyl-5,6-dihydropyridin-1(2H)-yl)dode...) Show SMILES CC1=CCCN(CCCCCCCCCCCCN2CCC=C(C)C2)C1 |t:1,21| Show InChI InChI=1S/C24H44N2/c1-23-15-13-19-25(21-23)17-11-9-7-5-3-4-6-8-10-12-18-26-20-14-16-24(2)22-26/h15-16H,3-14,17-22H2,1-2H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.950	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50119774 (1,1'-(dodecane-1,12-diyl)bis(3-methylpyridinium)br...) Show SMILES Cc1ccc[n+](CCCCCCCCCCCC[n+]2cccc(C)c2)c1 Show InChI InChI=1S/C24H38N2/c1-23-15-13-19-25(21-23)17-11-9-7-5-3-4-6-8-10-12-18-26-20-14-16-24(2)22-26/h13-16,19-22H,3-12,17-18H2,1-2H3/q+2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50119774 (1,1'-(dodecane-1,12-diyl)bis(3-methylpyridinium)br...) Show SMILES Cc1ccc[n+](CCCCCCCCCCCC[n+]2cccc(C)c2)c1 Show InChI InChI=1S/C24H38N2/c1-23-15-13-19-25(21-23)17-11-9-7-5-3-4-6-8-10-12-18-26-20-14-16-24(2)22-26/h13-16,19-22H,3-12,17-18H2,1-2H3/q+2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at nAChRalpha6beta2 in Sprague-Dawley rat striatal slices assessed as inhibition of nicotine-evoked [3H]dopamine uptake by liquid...				Bioorg Med Chem 17: 4477-85 (2009) Article DOI: 10.1016/j.bmc.2009.05.010 BindingDB Entry DOI: 10.7270/Q2XG9R5K
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50334474 (1,1',1'',1'''-(5,5',5'',5'''-(benzene-1,2,4,5-tetr...) Show SMILES OCCCc1ccc[n+](CCCCCc2cc(CCCCC[n+]3cccc(CCCO)c3)c(CCCCC[n+]3cccc(CCCO)c3)cc2CCCCC[n+]2cccc(CCCO)c2)c1 Show InChI InChI=1S/C58H86N4O4/c63-41-17-25-51-21-13-37-59(47-51)33-9-1-5-29-55-45-57(31-7-3-11-35-61-39-15-23-53(49-61)27-19-43-65)58(32-8-4-12-36-62-40-16-24-54(50-62)28-20-44-66)46-56(55)30-6-2-10-34-60-38-14-22-52(48-60)26-18-42-64/h13-16,21-24,37-40,45-50,63-66H,1-12,17-20,25-36,41-44H2/q+4	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50334466 (1,3,5-tris(5-(3-methyl-5,6-dihydropyridin-1(2H)-yl...) Show SMILES CC1=CCCN(CCCC#Cc2cc(cc(c2)C#CCCCN2CCC=C(C)C2)C#CCCCN2CCC=C(C)C2)C1 |t:1,26,39| Show InChI InChI=1S/C39H51N3/c1-34-16-13-25-40(31-34)22-10-4-7-19-37-28-38(20-8-5-11-23-41-26-14-17-35(2)32-41)30-39(29-37)21-9-6-12-24-42-27-15-18-36(3)33-42/h16-18,28-30H,4-6,10-15,22-27,31-33H2,1-3H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.22	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50334470 (1,12-bis(3,4-dihydroisoquinolin-2(1H)-yl)dodecane ...) Show SMILES C(CCCCCCN1CCc2ccccc2C1)CCCCCN1CCc2ccccc2C1 Show InChI InChI=1S/C30H44N2/c1(3-5-7-13-21-31-23-19-27-15-9-11-17-29(27)25-31)2-4-6-8-14-22-32-24-20-28-16-10-12-18-30(28)26-32/h9-12,15-18H,1-8,13-14,19-26H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.59	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50334471 (1,10-bis(3,4-dihydroisoquinolin-2(1H)-yl)decane | ...) Show SMILES C(CCCCCN1CCc2ccccc2C1)CCCCN1CCc2ccccc2C1 Show InChI InChI=1S/C28H40N2/c1(3-5-11-19-29-21-17-25-13-7-9-15-27(25)23-29)2-4-6-12-20-30-22-18-26-14-8-10-16-28(26)24-30/h7-10,13-16H,1-6,11-12,17-24H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.91	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50334475 (3,3',3'',3'''-(1,1',1'',1'''-(5,5',5'',5'''-(benze...) Show SMILES OCCCC1=CCCN(CCCCCc2cc(CCCCCN3CCC=C(CCCO)C3)c(CCCCCN3CCC=C(CCCO)C3)cc2CCCCCN2CCC=C(CCCO)C2)C1 |t:4,25,42,61| Show InChI InChI=1S/C58H98N4O4/c63-41-17-25-51-21-13-37-59(47-51)33-9-1-5-29-55-45-57(31-7-3-11-35-61-39-15-23-53(49-61)27-19-43-65)58(32-8-4-12-36-62-40-16-24-54(50-62)28-20-44-66)46-56(55)30-6-2-10-34-60-38-14-22-52(48-60)26-18-42-64/h21-24,45-46,63-66H,1-20,25-44,47-50H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50334465 (1,10-bis(3-methyl-5,6-dihydropyridin-1(2H)-yl)deca...) Show SMILES CC1=CCCN(CCCCCCCCCCN2CCC=C(C)C2)C1 |t:1,19| Show InChI InChI=1S/C22H40N2/c1-21-13-11-17-23(19-21)15-9-7-5-3-4-6-8-10-16-24-18-12-14-22(2)20-24/h13-14H,3-12,15-20H2,1-2H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37.4	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50119805 (1,12-di(2-isoquinoliniumyl)dodecane; with dibromid...) Show SMILES C(CCCCCC[n+]1ccc2ccccc2c1)CCCCC[n+]1ccc2ccccc2c1 Show InChI InChI=1S/C30H38N2/c1(3-5-7-13-21-31-23-19-27-15-9-11-17-29(27)25-31)2-4-6-8-14-22-32-24-20-28-16-10-12-18-30(28)26-32/h9-12,15-20,23-26H,1-8,13-14,21-22H2/q+2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50334469 (2,2',2'',2'''-(5,5',5'',5'''-(benzene-1,2,4,5-tetr...) Show SMILES C(CCc1cc(CCCCC[n+]2ccc3ccccc3c2)c(CCCCC[n+]2ccc3ccccc3c2)cc1CCCCC[n+]1ccc2ccccc2c1)CC[n+]1ccc2ccccc2c1 Show InChI InChI=1S/C62H70N4/c1(17-37-63-41-33-51-21-9-13-29-59(51)47-63)5-25-55-45-57(27-7-3-19-39-65-43-35-53-23-11-15-31-61(53)49-65)58(28-8-4-20-40-66-44-36-54-24-12-16-32-62(54)50-66)46-56(55)26-6-2-18-38-64-42-34-52-22-10-14-30-60(52)48-64/h9-16,21-24,29-36,41-50H,1-8,17-20,25-28,37-40H2/q+4	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50334467 (1,2-bis-(5-isoquinolinium-pent-1-ynyl)benzene dibr...) Show SMILES C(CC#Cc1ccccc1C#CCCC[n+]1ccc2ccccc2c1)C[n+]1ccc2ccccc2c1 Show InChI InChI=1S/C34H30N2/c1(11-23-35-25-21-31-17-7-9-19-33(31)27-35)3-13-29-15-5-6-16-30(29)14-4-2-12-24-36-26-22-32-18-8-10-20-34(32)28-36/h5-10,15-22,25-28H,1-2,11-12,23-24H2/q+2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50119780 (1,10-di(2-isoquinoliniumyl)decane; with diiodide i...) Show SMILES C(CCCCC[n+]1ccc2ccccc2c1)CCCC[n+]1ccc2ccccc2c1 Show InChI InChI=1S/C28H34N2/c1(3-5-11-19-29-21-17-25-13-7-9-15-27(25)23-29)2-4-6-12-20-30-22-18-26-14-8-10-16-28(26)24-30/h7-10,13-18,21-24H,1-6,11-12,19-20H2/q+2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50119782 (1,1''-(decane-1,10-diyl)bis(3-methylpyridinium)iod...) Show SMILES Cc1ccc[n+](CCCCCCCCCC[n+]2cccc(C)c2)c1 Show InChI InChI=1S/C22H34N2/c1-21-13-11-17-23(19-21)15-9-7-5-3-4-6-8-10-16-24-18-12-14-22(2)20-24/h11-14,17-20H,3-10,15-16H2,1-2H3/q+2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-6 (Rattus norvegicus)	BDBM50334473 (1,2,4,5-tetrakis(5-(3,4-dihydroisoquinolin-2(1H)-y...) Show SMILES C(CCN1CCc2ccccc2C1)CCc1cc(CCCCCN2CCc3ccccc3C2)c(CCCCCN2CCc3ccccc3C2)cc1CCCCCN1CCc2ccccc2C1 Show InChI InChI=1S/C62H82N4/c1(17-37-63-41-33-51-21-9-13-29-59(51)47-63)5-25-55-45-57(27-7-3-19-39-65-43-35-53-23-11-15-31-61(53)49-65)58(28-8-4-20-40-66-44-36-54-24-12-16-32-62(54)50-66)46-56(55)26-6-2-18-38-64-42-34-52-22-10-14-30-60(52)48-64/h9-16,21-24,29-32,45-46H,1-8,17-20,25-28,33-44,47-50H2	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	205	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release				Bioorg Med Chem Lett 21: 88-91 (2010) Article DOI: 10.1016/j.bmcl.2010.11.070 BindingDB Entry DOI: 10.7270/Q2VT1SDX
					More data for this Ligand-Target Pair