Found 9 hits Enz. Inhib. hit(s) with Target = 'Pyruvate kinase isozymes M1/M2' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Pyruvate kinase PKM
(Rattus norvegicus) | BDBM50367051
(CHEMBL606059)Show SMILES CCNc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C12H20N6O10P2/c1-2-14-12-17-6-9(13)15-4-16-10(6)18(12)11-8(20)7(19)5(27-11)3-26-30(24,25)28-29(21,22)23/h4-5,7-8,11,19-20H,2-3H2,1H3,(H,14,17)(H,24,25)(H2,13,15,16)(H2,21,22,23)/t5-,7-,8-,11?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rat muscle pyruvate kinase (PK-M) |
J Med Chem 25: 1184-8 (1983)
BindingDB Entry DOI: 10.7270/Q21N81PW |
More data for this Ligand-Target Pair | |
Pyruvate kinase PKM
(Rattus norvegicus) | BDBM50367051
(CHEMBL606059)Show SMILES CCNc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C12H20N6O10P2/c1-2-14-12-17-6-9(13)15-4-16-10(6)18(12)11-8(20)7(19)5(27-11)3-26-30(24,25)28-29(21,22)23/h4-5,7-8,11,19-20H,2-3H2,1H3,(H,14,17)(H,24,25)(H2,13,15,16)(H2,21,22,23)/t5-,7-,8-,11?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rat muscle pyruvate kinase (PK-M) |
J Med Chem 25: 1184-8 (1983)
BindingDB Entry DOI: 10.7270/Q21N81PW |
More data for this Ligand-Target Pair | |
Pyruvate kinase PKM
(Rattus norvegicus) | BDBM50367052
(CHEMBL605425)Show SMILES CCCNc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C13H22N6O10P2/c1-2-3-15-13-18-7-10(14)16-5-17-11(7)19(13)12-9(21)8(20)6(28-12)4-27-31(25,26)29-30(22,23)24/h5-6,8-9,12,20-21H,2-4H2,1H3,(H,15,18)(H,25,26)(H2,14,16,17)(H2,22,23,24)/t6-,8-,9-,12?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 9.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rat muscle pyruvate kinase (PK-M) |
J Med Chem 25: 1184-8 (1983)
BindingDB Entry DOI: 10.7270/Q21N81PW |
More data for this Ligand-Target Pair | |
Pyruvate kinase PKM
(Rattus norvegicus) | BDBM50028624
(CHEMBL3142978 | [6-(6-amino-9H-purin-9-yl)-2-methy...)Show SMILES CC1O[C@@H]2[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]2O1)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C12H17N5O10P2/c1-5-24-8-6(2-23-29(21,22)27-28(18,19)20)26-12(9(8)25-5)17-4-16-7-10(13)14-3-15-11(7)17/h3-6,8-9,12H,2H2,1H3,(H,21,22)(H2,13,14,15)(H2,18,19,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 1.60E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rat muscle pyruvate kinase (PK-M) |
J Med Chem 25: 1184-8 (1983)
BindingDB Entry DOI: 10.7270/Q21N81PW |
More data for this Ligand-Target Pair | |
Pyruvate kinase PKM
(Rattus norvegicus) | BDBM50367054
(CHEMBL606476)Show SMILES CCSc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C12H19N5O10P2S/c1-2-30-12-16-6-9(13)14-4-15-10(6)17(12)11-8(19)7(18)5(26-11)3-25-29(23,24)27-28(20,21)22/h4-5,7-8,11,18-19H,2-3H2,1H3,(H,23,24)(H2,13,14,15)(H2,20,21,22)/t5-,7-,8-,11?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 3.70E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rat muscle pyruvate kinase (PK-M) |
J Med Chem 25: 1184-8 (1983)
BindingDB Entry DOI: 10.7270/Q21N81PW |
More data for this Ligand-Target Pair | |
Pyruvate kinase PKM
(Rattus norvegicus) | BDBM50367053
(CHEMBL605428)Show SMILES CSc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r| Show InChI InChI=1S/C11H17N5O10P2S/c1-29-11-15-5-8(12)13-3-14-9(5)16(11)10-7(18)6(17)4(25-10)2-24-28(22,23)26-27(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H2,12,13,14)(H2,19,20,21)/t4-,6-,7-,10?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 4.30E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rat muscle pyruvate kinase (PK-M) |
J Med Chem 25: 1184-8 (1983)
BindingDB Entry DOI: 10.7270/Q21N81PW |
More data for this Ligand-Target Pair | |
Pyruvate kinase PKM
(Rattus norvegicus) | BDBM50367050
(CHEMBL606006)Show SMILES C[C@@H](OP(O)(=O)OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C11H17N5O10P2/c1-4(25-28(22,23)26-27(19,20)21)8-6(17)7(18)11(24-8)16-3-15-5-9(12)13-2-14-10(5)16/h2-4,6-8,11,17-18H,1H3,(H,22,23)(H2,12,13,14)(H2,19,20,21)/t4-,6+,7-,8-,11?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 4.50E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rat muscle pyruvate kinase (PK-M) at 10 mM |
J Med Chem 25: 1184-8 (1983)
BindingDB Entry DOI: 10.7270/Q21N81PW |
More data for this Ligand-Target Pair | |
Pyruvate kinase PKM
(Rattus norvegicus) | BDBM50367050
(CHEMBL606006)Show SMILES C[C@@H](OP(O)(=O)OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C11H17N5O10P2/c1-4(25-28(22,23)26-27(19,20)21)8-6(17)7(18)11(24-8)16-3-15-5-9(12)13-2-14-10(5)16/h2-4,6-8,11,17-18H,1H3,(H,22,23)(H2,12,13,14)(H2,19,20,21)/t4-,6+,7-,8-,11?/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 7.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rat muscle pyruvate kinase (PK-M) at 6.7 mM |
J Med Chem 25: 1184-8 (1983)
BindingDB Entry DOI: 10.7270/Q21N81PW |
More data for this Ligand-Target Pair | |
Pyruvate kinase PKM
(Rattus norvegicus) | BDBM50028625
(CHEMBL3142968 | [5-(6-amino-9H-purin-9-yl)-4-hydro...)Show SMILES CO[C@@H]1[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C11H17N5O10P2/c1-23-8-5(2-24-28(21,22)26-27(18,19)20)25-11(7(8)17)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17H,2H2,1H3,(H,21,22)(H2,12,13,14)(H2,18,19,20) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| 9.30E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rat muscle pyruvate kinase (PK-M) |
J Med Chem 25: 1184-8 (1983)
BindingDB Entry DOI: 10.7270/Q21N81PW |
More data for this Ligand-Target Pair | |