Found 2218 hits Enz. Inhib. hit(s) with Target = 'Glucagon receptor' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon receptor
(Rattus norvegicus) | BDBM50059362
(CHEMBL268636 | [des-His1, des-Phe6, Glu9] glucagon...)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C139H212N40O46S/c1-64(2)49-88(123(211)162-87(44-48-226-11)122(210)170-94(55-103(145)192)131(219)178-109(68(8)184)112(146)200)165-127(215)93(54-74-58-153-79-24-16-15-23-77(74)79)169-120(208)85(38-42-102(144)191)163-135(223)108(66(5)6)177-130(218)92(51-71-21-13-12-14-22-71)168-128(216)95(56-106(196)197)171-119(207)84(37-41-101(143)190)156-113(201)67(7)155-116(204)81(26-19-46-151-138(147)148)158-117(205)82(27-20-47-152-139(149)150)160-133(221)98(62-182)174-129(217)96(57-107(198)199)172-124(212)89(50-65(3)4)164-125(213)90(52-72-28-32-75(187)33-29-72)166-118(206)80(25-17-18-45-140)159-132(220)97(61-181)173-126(214)91(53-73-30-34-76(188)35-31-73)167-121(209)86(39-43-105(194)195)161-134(222)99(63-183)175-136(224)111(70(10)186)179-137(225)110(69(9)185)176-104(193)59-154-115(203)83(36-40-100(142)189)157-114(202)78(141)60-180/h12-16,21-24,28-35,58,64-70,78,80-99,108-111,153,180-188H,17-20,25-27,36-57,59-63,140-141H2,1-11H3,(H2,142,189)(H2,143,190)(H2,144,191)(H2,145,192)(H2,146,200)(H,154,203)(H,155,204)(H,156,201)(H,157,202)(H,158,205)(H,159,220)(H,160,221)(H,161,222)(H,162,211)(H,163,223)(H,164,213)(H,165,215)(H,166,206)(H,167,209)(H,168,216)(H,169,208)(H,170,210)(H,171,207)(H,172,212)(H,173,214)(H,174,217)(H,175,224)(H,176,193)(H,177,218)(H,178,219)(H,179,225)(H,194,195)(H,196,197)(H,198,199)(H4,147,148,151)(H4,149,150,152)/t67-,68+,69+,70+,78-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,108-,109-,110-,111-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 6.31 | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
pA2 value against Glucagon Receptor |
J Med Chem 40: 2555-62 (1997)
Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50059363
(CHEMBL437095 | [des-His1,Ala6, Glu9] glucagon-NH2)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C142H217N41O47S/c1-65(2)50-90(126(216)166-89(45-49-231-12)125(215)174-96(56-105(148)196)134(224)182-111(70(9)188)114(149)204)169-130(220)95(55-76-59-156-81-25-17-16-24-79(76)81)173-123(213)87(39-43-104(147)195)167-138(228)110(67(5)6)181-133(223)94(52-73-22-14-13-15-23-73)172-131(221)97(57-108(200)201)175-122(212)86(38-42-103(146)194)160-115(205)68(7)158-119(209)83(27-20-47-154-141(150)151)162-120(210)84(28-21-48-155-142(152)153)164-136(226)100(63-186)178-132(222)98(58-109(202)203)176-127(217)91(51-66(3)4)168-128(218)92(53-74-29-33-77(191)34-30-74)170-121(211)82(26-18-19-46-143)163-135(225)99(62-185)177-129(219)93(54-75-31-35-78(192)36-32-75)171-124(214)88(40-44-107(198)199)165-137(227)101(64-187)179-140(230)113(72(11)190)183-116(206)69(8)159-139(229)112(71(10)189)180-106(197)60-157-118(208)85(37-41-102(145)193)161-117(207)80(144)61-184/h13-17,22-25,29-36,59,65-72,80,82-101,110-113,156,184-192H,18-21,26-28,37-58,60-64,143-144H2,1-12H3,(H2,145,193)(H2,146,194)(H2,147,195)(H2,148,196)(H2,149,204)(H,157,208)(H,158,209)(H,159,229)(H,160,205)(H,161,207)(H,162,210)(H,163,225)(H,164,226)(H,165,227)(H,166,216)(H,167,228)(H,168,218)(H,169,220)(H,170,211)(H,171,214)(H,172,221)(H,173,213)(H,174,215)(H,175,212)(H,176,217)(H,177,219)(H,178,222)(H,179,230)(H,180,197)(H,181,223)(H,182,224)(H,183,206)(H,198,199)(H,200,201)(H,202,203)(H4,150,151,154)(H4,152,153,155)/t68-,69-,70+,71+,72+,80-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,110-,111-,112-,113-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
pA2 value against Glucagon Receptor |
J Med Chem 40: 2555-62 (1997)
Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50059354
(CHEMBL438574 | [des-Phe6] glucagon-NH2)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc1cnc[nH]1)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C144H217N43O47S/c1-66(2)47-90(126(218)168-89(42-46-235-11)125(217)176-96(54-107(150)200)135(227)186-113(70(8)192)116(151)208)171-130(222)95(52-76-58-159-82-24-16-15-23-80(76)82)175-124(216)88(38-41-106(149)199)169-140(232)112(68(5)6)185-134(226)94(49-73-21-13-12-14-22-73)174-131(223)97(55-109(202)203)177-123(215)87(37-40-105(148)198)163-117(209)69(7)162-120(212)84(26-19-44-157-143(152)153)164-121(213)85(27-20-45-158-144(154)155)166-138(230)102(63-190)182-133(225)99(57-111(206)207)178-127(219)91(48-67(3)4)170-128(220)92(50-74-28-32-78(195)33-29-74)172-122(214)83(25-17-18-43-145)165-137(229)101(62-189)181-129(221)93(51-75-30-34-79(196)35-31-75)173-132(224)98(56-110(204)205)179-139(231)103(64-191)183-141(233)115(72(10)194)187-142(234)114(71(9)193)184-108(201)60-160-119(211)86(36-39-104(147)197)167-136(228)100(61-188)180-118(210)81(146)53-77-59-156-65-161-77/h12-16,21-24,28-35,58-59,65-72,81,83-103,112-115,159,188-196H,17-20,25-27,36-57,60-64,145-146H2,1-11H3,(H2,147,197)(H2,148,198)(H2,149,199)(H2,150,200)(H2,151,208)(H,156,161)(H,160,211)(H,162,212)(H,163,209)(H,164,213)(H,165,229)(H,166,230)(H,167,228)(H,168,218)(H,169,232)(H,170,220)(H,171,222)(H,172,214)(H,173,224)(H,174,223)(H,175,216)(H,176,217)(H,177,215)(H,178,219)(H,179,231)(H,180,210)(H,181,221)(H,182,225)(H,183,233)(H,184,201)(H,185,226)(H,186,227)(H,187,234)(H,202,203)(H,204,205)(H,206,207)(H4,152,153,157)(H4,154,155,158)/t69-,70+,71+,72+,81-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,112-,113-,114-,115-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
pA2 value against Glucagon Receptor |
J Med Chem 40: 2555-62 (1997)
Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50059357
(CHEMBL438218 | [des-His1, Asp6, Glu9] glucagon-NH2)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](CC(O)=O)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C143H217N41O49S/c1-65(2)49-89(126(218)166-88(44-48-234-11)125(217)174-95(55-105(149)197)134(226)183-112(69(8)189)115(150)207)169-130(222)94(54-75-59-157-80-24-16-15-23-78(75)80)173-123(215)86(38-42-104(148)196)167-139(231)111(67(5)6)182-133(225)93(51-72-21-13-12-14-22-72)172-131(223)96(56-108(201)202)175-122(214)85(37-41-103(147)195)160-116(208)68(7)159-119(211)82(26-19-46-155-142(151)152)162-120(212)83(27-20-47-156-143(153)154)164-137(229)100(63-187)179-132(224)97(57-109(203)204)176-127(219)90(50-66(3)4)168-128(220)91(52-73-28-32-76(192)33-29-73)170-121(213)81(25-17-18-45-144)163-136(228)99(62-186)178-129(221)92(53-74-30-34-77(193)35-31-74)171-124(216)87(39-43-107(199)200)165-138(230)101(64-188)180-141(233)114(71(10)191)184-135(227)98(58-110(205)206)177-140(232)113(70(9)190)181-106(198)60-158-118(210)84(36-40-102(146)194)161-117(209)79(145)61-185/h12-16,21-24,28-35,59,65-71,79,81-101,111-114,157,185-193H,17-20,25-27,36-58,60-64,144-145H2,1-11H3,(H2,146,194)(H2,147,195)(H2,148,196)(H2,149,197)(H2,150,207)(H,158,210)(H,159,211)(H,160,208)(H,161,209)(H,162,212)(H,163,228)(H,164,229)(H,165,230)(H,166,218)(H,167,231)(H,168,220)(H,169,222)(H,170,213)(H,171,216)(H,172,223)(H,173,215)(H,174,217)(H,175,214)(H,176,219)(H,177,232)(H,178,221)(H,179,224)(H,180,233)(H,181,198)(H,182,225)(H,183,226)(H,184,227)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H4,151,152,155)(H4,153,154,156)/t68-,69+,70+,71+,79-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,111-,112-,113-,114-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
pA2 value against Glucagon Receptor |
J Med Chem 40: 2555-62 (1997)
Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50059356
(CHEMBL2369990 | [des-His1, Nle6, Glu9] glucagon-NH...)Show SMILES CCCCC(NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CO)C(=O)N[C@H](CCCCN)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CO)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](C)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C148H221N41O47S/c1-70(2)54-95(131(221)171-94(49-53-237-11)130(220)179-102(61-111(154)202)140(230)188-117(74(8)194)120(155)210)174-135(225)101(60-81-64-162-86-29-19-18-28-84(81)86)178-128(218)92(43-47-110(153)201)172-144(234)116(72(5)6)187-138(228)99(56-77-24-14-12-15-25-77)177-136(226)103(62-114(206)207)180-127(217)91(42-46-109(152)200)165-121(211)73(7)164-124(214)88(31-22-51-160-147(156)157)167-125(215)89(32-23-52-161-148(158)159)169-142(232)106(68-192)184-137(227)104(63-115(208)209)181-132(222)96(55-71(3)4)173-133(223)97(58-79-33-37-82(197)38-34-79)175-126(216)87(30-20-21-50-149)168-141(231)105(67-191)183-134(224)98(59-80-35-39-83(198)40-36-80)176-129(219)93(44-48-113(204)205)170-143(233)107(69-193)185-146(236)119(76(10)196)189-139(229)100(57-78-26-16-13-17-27-78)182-145(235)118(75(9)195)186-112(203)65-163-123(213)90(41-45-108(151)199)166-122(212)85(150)66-190/h12-19,24-29,33-40,64,70-76,85,87-107,116-119,162,190-198H,20-23,30-32,41-63,65-69,149-150H2,1-11H3,(H2,151,199)(H2,152,200)(H2,153,201)(H2,154,202)(H2,155,210)(H,163,213)(H,164,214)(H,165,211)(H,166,212)(H,167,215)(H,168,231)(H,169,232)(H,170,233)(H,171,221)(H,172,234)(H,173,223)(H,174,225)(H,175,216)(H,176,219)(H,177,226)(H,178,218)(H,179,220)(H,180,217)(H,181,222)(H,182,235)(H,183,224)(H,184,227)(H,185,236)(H,186,203)(H,187,228)(H,188,230)(H,189,229)(H,204,205)(H,206,207)(H,208,209)(H4,156,157,160)(H4,158,159,161)/t73-,74+,75+,76+,85-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100+,101-,102-,103-,104-,105-,106-,107-,116-,117-,118-,119-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
pA2 value against Glucagon Receptor |
J Med Chem 40: 2555-62 (1997)
Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50059360
(CHEMBL429198 | [des-His1, des-Phe6] glucagon-NH2)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C138H210N40O46S/c1-63(2)47-86(121(209)160-85(42-46-225-11)120(208)168-92(53-102(144)191)130(218)177-108(67(8)183)111(145)199)163-125(213)91(52-73-57-152-78-24-16-15-23-76(73)78)167-119(207)84(38-41-101(143)190)161-134(222)107(65(5)6)176-129(217)90(49-70-21-13-12-14-22-70)166-126(214)93(54-104(193)194)169-118(206)83(37-40-100(142)189)155-112(200)66(7)154-115(203)80(26-19-44-150-137(146)147)157-116(204)81(27-20-45-151-138(148)149)159-132(220)97(61-181)173-128(216)95(56-106(197)198)170-122(210)87(48-64(3)4)162-123(211)88(50-71-28-32-74(186)33-29-71)164-117(205)79(25-17-18-43-139)158-131(219)96(60-180)172-124(212)89(51-72-30-34-75(187)35-31-72)165-127(215)94(55-105(195)196)171-133(221)98(62-182)174-135(223)110(69(10)185)178-136(224)109(68(9)184)175-103(192)58-153-114(202)82(36-39-99(141)188)156-113(201)77(140)59-179/h12-16,21-24,28-35,57,63-69,77,79-98,107-110,152,179-187H,17-20,25-27,36-56,58-62,139-140H2,1-11H3,(H2,141,188)(H2,142,189)(H2,143,190)(H2,144,191)(H2,145,199)(H,153,202)(H,154,203)(H,155,200)(H,156,201)(H,157,204)(H,158,219)(H,159,220)(H,160,209)(H,161,222)(H,162,211)(H,163,213)(H,164,205)(H,165,215)(H,166,214)(H,167,207)(H,168,208)(H,169,206)(H,170,210)(H,171,221)(H,172,212)(H,173,216)(H,174,223)(H,175,192)(H,176,217)(H,177,218)(H,178,224)(H,193,194)(H,195,196)(H,197,198)(H4,146,147,150)(H4,148,149,151)/t66-,67+,68+,69+,77-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,107-,108-,109-,110-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 562 | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
pA2 value against Glucagon Receptor |
J Med Chem 40: 2555-62 (1997)
Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50059355
(CHEMBL409611 | [des-Phe6] glucagon)Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc1cnc[nH]1)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CCS)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](C=O)[C@H](C)O Show InChI InChI=1S/C143H214N42O47S/c1-66(2)46-90(125(216)166-89(41-45-233)124(215)174-96(53-108(149)199)130(221)178-100(60-186)70(8)191)169-129(220)95(51-76-57-157-82-23-15-14-22-80(76)82)173-123(214)88(37-40-107(148)198)167-139(230)113(68(5)6)184-134(225)94(48-73-20-12-11-13-21-73)172-131(222)97(54-110(201)202)175-122(213)87(36-39-106(147)197)161-116(207)69(7)160-119(210)84(25-18-43-155-142(150)151)162-120(211)85(26-19-44-156-143(152)153)164-137(228)103(63-189)181-133(224)99(56-112(205)206)176-126(217)91(47-67(3)4)168-127(218)92(49-74-27-31-78(194)32-28-74)170-121(212)83(24-16-17-42-144)163-136(227)102(62-188)180-128(219)93(50-75-29-33-79(195)34-30-75)171-132(223)98(55-111(203)204)177-138(229)104(64-190)182-140(231)115(72(10)193)185-141(232)114(71(9)192)183-109(200)59-158-118(209)86(35-38-105(146)196)165-135(226)101(61-187)179-117(208)81(145)52-77-58-154-65-159-77/h11-15,20-23,27-34,57-58,60,65-72,81,83-104,113-115,157,187-195,233H,16-19,24-26,35-56,59,61-64,144-145H2,1-10H3,(H2,146,196)(H2,147,197)(H2,148,198)(H2,149,199)(H,154,159)(H,158,209)(H,160,210)(H,161,207)(H,162,211)(H,163,227)(H,164,228)(H,165,226)(H,166,216)(H,167,230)(H,168,218)(H,169,220)(H,170,212)(H,171,223)(H,172,222)(H,173,214)(H,174,215)(H,175,213)(H,176,217)(H,177,229)(H,178,221)(H,179,208)(H,180,219)(H,181,224)(H,182,231)(H,183,200)(H,184,225)(H,185,232)(H,201,202)(H,203,204)(H,205,206)(H4,150,151,155)(H4,152,153,156)/t69-,70+,71+,72+,81-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100+,101-,102-,103-,104-,113-,114-,115-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 562 | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
pA2 value against Glucagon Receptor |
J Med Chem 40: 2555-62 (1997)
Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50059352
(CHEMBL442499 | [des-His1, Trp6, Glu9] glucagon-NH2)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C150H222N42O47S/c1-70(2)53-97(133(224)174-96(48-52-240-11)132(223)182-104(60-113(156)205)142(233)191-119(74(8)197)122(157)213)177-137(228)102(58-80-63-164-87-27-17-15-25-84(80)87)181-130(221)94(42-46-112(155)204)175-146(237)118(72(5)6)190-140(231)101(55-77-23-13-12-14-24-77)180-138(229)105(61-116(209)210)183-129(220)93(41-45-111(154)203)168-123(214)73(7)167-126(217)90(30-21-50-162-149(158)159)170-127(218)91(31-22-51-163-150(160)161)172-144(235)108(68-195)187-139(230)106(62-117(211)212)184-134(225)98(54-71(3)4)176-135(226)99(56-78-32-36-82(200)37-33-78)178-128(219)89(29-19-20-49-151)171-143(234)107(67-194)186-136(227)100(57-79-34-38-83(201)39-35-79)179-131(222)95(43-47-115(207)208)173-145(236)109(69-196)188-148(239)121(76(10)199)192-141(232)103(59-81-64-165-88-28-18-16-26-85(81)88)185-147(238)120(75(9)198)189-114(206)65-166-125(216)92(40-44-110(153)202)169-124(215)86(152)66-193/h12-18,23-28,32-39,63-64,70-76,86,89-109,118-121,164-165,193-201H,19-22,29-31,40-62,65-69,151-152H2,1-11H3,(H2,153,202)(H2,154,203)(H2,155,204)(H2,156,205)(H2,157,213)(H,166,216)(H,167,217)(H,168,214)(H,169,215)(H,170,218)(H,171,234)(H,172,235)(H,173,236)(H,174,224)(H,175,237)(H,176,226)(H,177,228)(H,178,219)(H,179,222)(H,180,229)(H,181,221)(H,182,223)(H,183,220)(H,184,225)(H,185,238)(H,186,227)(H,187,230)(H,188,239)(H,189,206)(H,190,231)(H,191,233)(H,192,232)(H,207,208)(H,209,210)(H,211,212)(H4,158,159,162)(H4,160,161,163)/t73-,74+,75+,76+,86-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,118-,119-,120-,121-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 562 | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
pA2 value against Glucagon Receptor |
J Med Chem 40: 2555-62 (1997)
Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50059358
(CHEMBL267885 | [des-His1, Tyr6,Glu9] glucagon-NH2)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C148H221N41O48S/c1-69(2)53-95(131(222)171-94(48-52-238-11)130(221)179-102(60-111(154)203)140(231)188-117(73(8)194)120(155)211)174-135(226)101(59-80-63-162-86-24-16-15-23-84(80)86)178-128(219)92(42-46-110(153)202)172-144(235)116(71(5)6)187-138(229)99(55-76-21-13-12-14-22-76)177-136(227)103(61-114(207)208)180-127(218)91(41-45-109(152)201)165-121(212)72(7)164-124(215)88(26-19-50-160-147(156)157)167-125(216)89(27-20-51-161-148(158)159)169-142(233)106(67-192)184-137(228)104(62-115(209)210)181-132(223)96(54-70(3)4)173-133(224)97(56-77-28-34-81(197)35-29-77)175-126(217)87(25-17-18-49-149)168-141(232)105(66-191)183-134(225)98(57-78-30-36-82(198)37-31-78)176-129(220)93(43-47-113(205)206)170-143(234)107(68-193)185-146(237)119(75(10)196)189-139(230)100(58-79-32-38-83(199)39-33-79)182-145(236)118(74(9)195)186-112(204)64-163-123(214)90(40-44-108(151)200)166-122(213)85(150)65-190/h12-16,21-24,28-39,63,69-75,85,87-107,116-119,162,190-199H,17-20,25-27,40-62,64-68,149-150H2,1-11H3,(H2,151,200)(H2,152,201)(H2,153,202)(H2,154,203)(H2,155,211)(H,163,214)(H,164,215)(H,165,212)(H,166,213)(H,167,216)(H,168,232)(H,169,233)(H,170,234)(H,171,222)(H,172,235)(H,173,224)(H,174,226)(H,175,217)(H,176,220)(H,177,227)(H,178,219)(H,179,221)(H,180,218)(H,181,223)(H,182,236)(H,183,225)(H,184,228)(H,185,237)(H,186,204)(H,187,229)(H,188,231)(H,189,230)(H,205,206)(H,207,208)(H,209,210)(H4,156,157,160)(H4,158,159,161)/t72-,73+,74+,75+,85-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,116-,117-,118-,119-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 631 | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
pA2 value against Glucagon Receptor |
J Med Chem 40: 2555-62 (1997)
Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50059365
(CHEMBL412352 | [des-Phe6, Glu9] glucagon-NH2)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc1c[nH]cn1)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C145H219N43O47S/c1-67(2)49-92(128(220)170-91(44-48-236-11)127(219)178-98(56-108(151)201)136(228)187-114(71(8)193)117(152)209)173-132(224)97(54-77-59-160-83-24-16-15-23-81(77)83)177-125(217)89(38-42-107(150)200)171-141(233)113(69(5)6)186-135(227)96(51-74-21-13-12-14-22-74)176-133(225)99(57-111(205)206)179-124(216)88(37-41-106(149)199)164-118(210)70(7)163-121(213)85(26-19-46-158-144(153)154)165-122(214)86(27-20-47-159-145(155)156)167-139(231)103(64-191)183-134(226)100(58-112(207)208)180-129(221)93(50-68(3)4)172-130(222)94(52-75-28-32-79(196)33-29-75)174-123(215)84(25-17-18-45-146)166-138(230)102(63-190)182-131(223)95(53-76-30-34-80(197)35-31-76)175-126(218)90(39-43-110(203)204)169-140(232)104(65-192)184-142(234)116(73(10)195)188-143(235)115(72(9)194)185-109(202)61-161-120(212)87(36-40-105(148)198)168-137(229)101(62-189)181-119(211)82(147)55-78-60-157-66-162-78/h12-16,21-24,28-35,59-60,66-73,82,84-104,113-116,160,189-197H,17-20,25-27,36-58,61-65,146-147H2,1-11H3,(H2,148,198)(H2,149,199)(H2,150,200)(H2,151,201)(H2,152,209)(H,157,162)(H,161,212)(H,163,213)(H,164,210)(H,165,214)(H,166,230)(H,167,231)(H,168,229)(H,169,232)(H,170,220)(H,171,233)(H,172,222)(H,173,224)(H,174,215)(H,175,218)(H,176,225)(H,177,217)(H,178,219)(H,179,216)(H,180,221)(H,181,211)(H,182,223)(H,183,226)(H,184,234)(H,185,202)(H,186,227)(H,187,228)(H,188,235)(H,203,204)(H,205,206)(H,207,208)(H4,153,154,158)(H4,155,156,159)/t70-,71+,72+,73+,82-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,113-,114-,115-,116-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 631 | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
pA2 value against Glucagon Receptor |
J Med Chem 40: 2555-62 (1997)
Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50059361
(CHEMBL439271 | [des-His1, des-Phe6] glucagon)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(O)=O Show InChI InChI=1S/C138H209N39O47S/c1-63(2)47-86(120(207)159-85(42-46-225-11)119(206)167-92(53-102(144)190)129(216)177-110(69(10)184)136(223)224)162-124(211)91(52-73-57-151-78-24-16-15-23-76(73)78)166-118(205)84(38-41-101(143)189)160-133(220)107(65(5)6)175-128(215)90(49-70-21-13-12-14-22-70)165-125(212)93(54-104(192)193)168-117(204)83(37-40-100(142)188)154-111(198)66(7)153-114(201)80(26-19-44-149-137(145)146)156-115(202)81(27-20-45-150-138(147)148)158-131(218)97(61-180)172-127(214)95(56-106(196)197)169-121(208)87(48-64(3)4)161-122(209)88(50-71-28-32-74(185)33-29-71)163-116(203)79(25-17-18-43-139)157-130(217)96(60-179)171-123(210)89(51-72-30-34-75(186)35-31-72)164-126(213)94(55-105(194)195)170-132(219)98(62-181)173-134(221)109(68(9)183)176-135(222)108(67(8)182)174-103(191)58-152-113(200)82(36-39-99(141)187)155-112(199)77(140)59-178/h12-16,21-24,28-35,57,63-69,77,79-98,107-110,151,178-186H,17-20,25-27,36-56,58-62,139-140H2,1-11H3,(H2,141,187)(H2,142,188)(H2,143,189)(H2,144,190)(H,152,200)(H,153,201)(H,154,198)(H,155,199)(H,156,202)(H,157,217)(H,158,218)(H,159,207)(H,160,220)(H,161,209)(H,162,211)(H,163,203)(H,164,213)(H,165,212)(H,166,205)(H,167,206)(H,168,204)(H,169,208)(H,170,219)(H,171,210)(H,172,214)(H,173,221)(H,174,191)(H,175,215)(H,176,222)(H,177,216)(H,192,193)(H,194,195)(H,196,197)(H,223,224)(H4,145,146,149)(H4,147,148,150)/t66-,67+,68+,69+,77-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,107-,108-,109-,110-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 708 | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
pA2 value against Glucagon Receptor |
J Med Chem 40: 2555-62 (1997)
Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50059351
(CHEMBL427744 | [des-His1, des-Phe6, Glu9] glucagon...)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(O)=O Show InChI InChI=1S/C139H211N39O47S/c1-64(2)49-88(122(209)161-87(44-48-226-11)121(208)169-94(55-103(145)191)130(217)178-111(70(10)185)137(224)225)164-126(213)93(54-74-58-152-79-24-16-15-23-77(74)79)168-119(206)85(38-42-102(144)190)162-134(221)108(66(5)6)176-129(216)92(51-71-21-13-12-14-22-71)167-127(214)95(56-106(195)196)170-118(205)84(37-41-101(143)189)155-112(199)67(7)154-115(202)81(26-19-46-150-138(146)147)157-116(203)82(27-20-47-151-139(148)149)159-132(219)98(62-181)173-128(215)96(57-107(197)198)171-123(210)89(50-65(3)4)163-124(211)90(52-72-28-32-75(186)33-29-72)165-117(204)80(25-17-18-45-140)158-131(218)97(61-180)172-125(212)91(53-73-30-34-76(187)35-31-73)166-120(207)86(39-43-105(193)194)160-133(220)99(63-182)174-135(222)110(69(9)184)177-136(223)109(68(8)183)175-104(192)59-153-114(201)83(36-40-100(142)188)156-113(200)78(141)60-179/h12-16,21-24,28-35,58,64-70,78,80-99,108-111,152,179-187H,17-20,25-27,36-57,59-63,140-141H2,1-11H3,(H2,142,188)(H2,143,189)(H2,144,190)(H2,145,191)(H,153,201)(H,154,202)(H,155,199)(H,156,200)(H,157,203)(H,158,218)(H,159,219)(H,160,220)(H,161,209)(H,162,221)(H,163,211)(H,164,213)(H,165,204)(H,166,207)(H,167,214)(H,168,206)(H,169,208)(H,170,205)(H,171,210)(H,172,212)(H,173,215)(H,174,222)(H,175,192)(H,176,216)(H,177,223)(H,178,217)(H,193,194)(H,195,196)(H,197,198)(H,224,225)(H4,146,147,150)(H4,148,149,151)/t67-,68+,69+,70+,78-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,108-,109-,110-,111-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
pA2 value against Glucagon Receptor |
J Med Chem 40: 2555-62 (1997)
Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50059359
(CHEMBL411289 | [des-His1, des-Gly4, Glu9] glucagon...)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](N)CO)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C146H218N40O46S/c1-69(2)54-94(129(217)168-93(49-53-233-11)127(215)176-101(61-110(152)199)138(226)184-115(73(8)191)118(153)206)171-133(221)100(60-80-64-160-85-29-19-18-28-83(80)85)175-125(213)90(42-46-108(150)197)169-142(230)114(71(5)6)183-136(224)98(56-76-24-14-12-15-25-76)174-134(222)102(62-112(202)203)177-124(212)89(41-45-107(149)196)162-119(207)72(7)161-121(209)87(31-22-51-158-145(154)155)164-122(210)88(32-23-52-159-146(156)157)166-140(228)105(67-189)181-135(223)103(63-113(204)205)178-130(218)95(55-70(3)4)170-131(219)96(58-78-33-37-81(194)38-34-78)172-123(211)86(30-20-21-50-147)165-139(227)104(66-188)180-132(220)97(59-79-35-39-82(195)40-36-79)173-126(214)92(44-48-111(200)201)167-141(229)106(68-190)182-144(232)117(75(10)193)186-137(225)99(57-77-26-16-13-17-27-77)179-143(231)116(74(9)192)185-128(216)91(43-47-109(151)198)163-120(208)84(148)65-187/h12-19,24-29,33-40,64,69-75,84,86-106,114-117,160,187-195H,20-23,30-32,41-63,65-68,147-148H2,1-11H3,(H2,149,196)(H2,150,197)(H2,151,198)(H2,152,199)(H2,153,206)(H,161,209)(H,162,207)(H,163,208)(H,164,210)(H,165,227)(H,166,228)(H,167,229)(H,168,217)(H,169,230)(H,170,219)(H,171,221)(H,172,211)(H,173,214)(H,174,222)(H,175,213)(H,176,215)(H,177,212)(H,178,218)(H,179,231)(H,180,220)(H,181,223)(H,182,232)(H,183,224)(H,184,226)(H,185,216)(H,186,225)(H,200,201)(H,202,203)(H,204,205)(H4,154,155,158)(H4,156,157,159)/t72-,73+,74+,75+,84-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,114-,115-,116-,117-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 891 | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
pA2 value against Glucagon Receptor |
J Med Chem 40: 2555-62 (1997)
Article DOI: 10.1021/jm960800d
BindingDB Entry DOI: 10.7270/Q2CC11CJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50144020
(3-{4-[1-(4-Benzofuran-2-yl-phenylcarbamoyl)-heptyl...)Show SMILES CCCCCCC(Oc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1cc2ccccc2o1 Show InChI InChI=1S/C32H34N2O6/c1-2-3-4-5-10-28(39-26-17-13-23(14-18-26)31(37)33-20-19-30(35)36)32(38)34-25-15-11-22(12-16-25)29-21-24-8-6-7-9-27(24)40-29/h6-9,11-18,21,28H,2-5,10,19-20H2,1H3,(H,33,37)(H,34,38)(H,35,36) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity against human glucagon receptor (h-GlucR) was determined |
Bioorg Med Chem Lett 14: 2047-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50360584
(CHEMBL1933350)Show SMILES CCC[C@@H]([C@@H](c1c[nH]c2c(F)cc(C)cc12)c1ccc(Cl)cc1)c1ccc(cc1)C(=O)NCCC(O)=O |r| Show InChI InChI=1S/C30H30ClFN2O3/c1-3-4-23(19-5-7-21(8-6-19)30(37)33-14-13-27(35)36)28(20-9-11-22(31)12-10-20)25-17-34-29-24(25)15-18(2)16-26(29)32/h5-12,15-17,23,28,34H,3-4,13-14H2,1-2H3,(H,33,37)(H,35,36)/t23-,28+/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Glucagon-Cex from human GCGR |
Bioorg Med Chem Lett 22: 415-20 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.113
BindingDB Entry DOI: 10.7270/Q2H70G82 |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50144008
(3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-2-(4-t...)Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1cc2ccccc2o1 Show InChI InChI=1S/C37H36N2O5/c1-37(2,3)29-16-12-25(13-17-29)31(22-24-8-10-27(11-9-24)35(42)38-21-20-34(40)41)36(43)39-30-18-14-26(15-19-30)33-23-28-6-4-5-7-32(28)44-33/h4-19,23,31H,20-22H2,1-3H3,(H,38,42)(H,39,43)(H,40,41) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity against human glucagon receptor (h-GlucR) was determined |
Bioorg Med Chem Lett 14: 2047-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH |
More data for this
Ligand-Target Pair | |
Pro-glucagon
(Homo sapiens (Human)) | BDBM2437
(US8507533, 157)Show SMILES CC1(C)CC(C1)C(Nc1cnc(nc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C25H27F3N6O3/c1-24(2)9-17(10-24)21(15-3-5-16(6-4-15)22(37)29-8-7-20(35)36)33-19-12-30-23(31-13-19)34-14-18(11-32-34)25(26,27)28/h3-6,11-14,17,21,33H,7-10H2,1-2H3,(H,29,37)(H,35,36) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 5.55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors. |
US Patent US8507533 (2013)
BindingDB Entry DOI: 10.7270/Q23R0RGH |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM2437
(US8507533, 157)Show SMILES CC1(C)CC(C1)C(Nc1cnc(nc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C25H27F3N6O3/c1-24(2)9-17(10-24)21(15-3-5-16(6-4-15)22(37)29-8-7-20(35)36)33-19-12-30-23(31-13-19)34-14-18(11-32-34)25(26,27)28/h3-6,11-14,17,21,33H,7-10H2,1-2H3,(H,29,37)(H,35,36) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in Chem-1 cell membranes after 6 to 10 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 25: 4057-64 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N |
More data for this
Ligand-Target Pair | |
Pro-glucagon
(Homo sapiens (Human)) | BDBM100827
(US8507533, 138 | US8507533, 151 | US8507533, 374)Show SMILES Cc1cc(OC(C2CCC2)c2ccc(cc2)C(=O)NCCC(O)=O)cc(C)c1-n1cc(cn1)C(F)(F)F Show InChI InChI=1S/C27H28F3N3O4/c1-16-12-22(13-17(2)24(16)33-15-21(14-32-33)27(28,29)30)37-25(18-4-3-5-18)19-6-8-20(9-7-19)26(36)31-11-10-23(34)35/h6-9,12-15,18,25H,3-5,10-11H2,1-2H3,(H,31,36)(H,34,35) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 5.75 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Inc.
US Patent
| Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors. |
US Patent US8507533 (2013)
BindingDB Entry DOI: 10.7270/Q23R0RGH |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50144015
(3-{4-[2-(4-Benzofuran-2-yl-phenylcarbamoyl)-octyl]...)Show SMILES CCCCCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1cc2ccccc2o1 Show InChI InChI=1S/C33H36N2O5/c1-2-3-4-5-9-27(21-23-11-13-25(14-12-23)32(38)34-20-19-31(36)37)33(39)35-28-17-15-24(16-18-28)30-22-26-8-6-7-10-29(26)40-30/h6-8,10-18,22,27H,2-5,9,19-21H2,1H3,(H,34,38)(H,35,39)(H,36,37) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity against human glucagon receptor (h-GlucR) was determined |
Bioorg Med Chem Lett 14: 2047-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50144002
(3-{4-[2-(4-tert-Butyl-phenyl)-2-(2',4'-dichloro-bi...)Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C35H34Cl2N2O4/c1-35(2,3)26-12-8-24(9-13-26)30(20-22-4-6-25(7-5-22)33(42)38-19-18-32(40)41)34(43)39-28-15-10-23(11-16-28)29-17-14-27(36)21-31(29)37/h4-17,21,30H,18-20H2,1-3H3,(H,38,42)(H,39,43)(H,40,41) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity against human glucagon receptor (h-GlucR) was determined |
Bioorg Med Chem Lett 14: 2047-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50144001
(3-{4-[1-(2',4'-Dichloro-biphenyl-4-ylcarbamoyl)-he...)Show SMILES CCCCCCC(Oc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C30H32Cl2N2O5/c1-2-3-4-5-6-27(39-24-14-9-21(10-15-24)29(37)33-18-17-28(35)36)30(38)34-23-12-7-20(8-13-23)25-16-11-22(31)19-26(25)32/h7-16,19,27H,2-6,17-18H2,1H3,(H,33,37)(H,34,38)(H,35,36) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity against human glucagon receptor (h-GlucR) was determined |
Bioorg Med Chem Lett 14: 2047-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | ADOMEGLIVANT
(Adomeglivant | Adomeglivant, (-)- | LY-2409021 | L...) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| UniChem
| | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Pro-glucagon
(Homo sapiens (Human)) | BDBM100806
(US8507533, 114 | US8507533, 115 | US8507533, 330)Show SMILES CC1(C)CC(C1)C(Nc1ccc(nc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C26H28F3N5O3/c1-25(2)11-18(12-25)23(16-3-5-17(6-4-16)24(37)30-10-9-22(35)36)33-20-7-8-21(31-14-20)34-15-19(13-32-34)26(27,28)29/h3-8,13-15,18,23,33H,9-12H2,1-2H3,(H,30,37)(H,35,36) | PDB
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| PC cid
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UniChem
Similars
| US Patent
| 7.60 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Inc.
US Patent
| Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors. |
US Patent US8507533 (2013)
BindingDB Entry DOI: 10.7270/Q23R0RGH |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50360599
(CHEMBL1933365)Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)C(Nc1cnn(c1)-c1ccc(cc1)C(F)(F)F)C1CCCC1 Show InChI InChI=1S/C26H27F3N4O3/c27-26(28,29)20-9-11-22(12-10-20)33-16-21(15-31-33)32-24(17-3-1-2-4-17)18-5-7-19(8-6-18)25(36)30-14-13-23(34)35/h5-12,15-17,24,32H,1-4,13-14H2,(H,30,36)(H,34,35) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Glucagon-Cex from human GCGR |
Bioorg Med Chem Lett 22: 415-20 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.113
BindingDB Entry DOI: 10.7270/Q2H70G82 |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50360599
(CHEMBL1933365)Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)C(Nc1cnn(c1)-c1ccc(cc1)C(F)(F)F)C1CCCC1 Show InChI InChI=1S/C26H27F3N4O3/c27-26(28,29)20-9-11-22(12-10-20)33-16-21(15-31-33)32-24(17-3-1-2-4-17)18-5-7-19(8-6-18)25(36)30-14-13-23(34)35/h5-12,15-17,24,32H,1-4,13-14H2,(H,30,36)(H,34,35) | PDB
MMDB
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B.MOAD
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Glucagon-Cex from human GCGR |
Bioorg Med Chem Lett 22: 415-20 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.113
BindingDB Entry DOI: 10.7270/Q2H70G82 |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50144016
(3-{4-[(Biphenyl-4-ylcarbamoyl)-(4-tert-butyl-pheny...)Show SMILES CC(C)(C)c1ccc(cc1)C(Oc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C34H34N2O5/c1-34(2,3)27-15-9-25(10-16-27)31(41-29-19-13-26(14-20-29)32(39)35-22-21-30(37)38)33(40)36-28-17-11-24(12-18-28)23-7-5-4-6-8-23/h4-20,31H,21-22H2,1-3H3,(H,35,39)(H,36,40)(H,37,38) | PDB
MMDB
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity against human glucagon receptor (h-GlucR) was determined |
Bioorg Med Chem Lett 14: 2047-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH |
More data for this
Ligand-Target Pair | |
Pro-glucagon
(Homo sapiens (Human)) | BDBM2390
(US8507533, 146)Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)[C@@H](Nc1ccc(nc1)-n1cc(cn1)C(F)(F)F)C1CCCCC1 |r| Show InChI InChI=1S/C26H28F3N5O3/c27-26(28,29)20-14-32-34(16-20)22-11-10-21(15-31-22)33-24(17-4-2-1-3-5-17)18-6-8-19(9-7-18)25(37)30-13-12-23(35)36/h6-11,14-17,24,33H,1-5,12-13H2,(H,30,37)(H,35,36)/t24-/m0/s1 | PDB
Reactome pathway
KEGG
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| PC cid
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Similars
| US Patent
| 9.05 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
US Patent
| Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors. |
US Patent US8507533 (2013)
BindingDB Entry DOI: 10.7270/Q23R0RGH |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50144006
(3-{4-[2-(4-tert-Butyl-phenyl)-2-(quinolin-3-ylcarb...)Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1cnc2ccccc2c1 Show InChI InChI=1S/C32H33N3O4/c1-32(2,3)25-14-12-22(13-15-25)27(31(39)35-26-19-24-6-4-5-7-28(24)34-20-26)18-21-8-10-23(11-9-21)30(38)33-17-16-29(36)37/h4-15,19-20,27H,16-18H2,1-3H3,(H,33,38)(H,35,39)(H,36,37) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity against human glucagon receptor (h-GlucR) was determined |
Bioorg Med Chem Lett 14: 2047-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50144004
(3-{4-[2-(Biphenyl-4-ylcarbamoyl)-2-(4-tert-butyl-p...)Show SMILES CC(C)(C)c1ccc(cc1)C(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)Nc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C35H36N2O4/c1-35(2,3)29-17-13-27(14-18-29)31(23-24-9-11-28(12-10-24)33(40)36-22-21-32(38)39)34(41)37-30-19-15-26(16-20-30)25-7-5-4-6-8-25/h4-20,31H,21-23H2,1-3H3,(H,36,40)(H,37,41)(H,38,39) | PDB
MMDB
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B.MOAD
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro binding affinity against human glucagon receptor (h-GlucR) was determined |
Bioorg Med Chem Lett 14: 2047-50 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.056
BindingDB Entry DOI: 10.7270/Q2XS5TTH |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50360598
(CHEMBL1933364)Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)C(CCC(F)(F)F)Nc1cnn(c1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C24H22F6N4O3/c25-23(26,27)11-9-20(15-1-3-16(4-2-15)22(37)31-12-10-21(35)36)33-18-13-32-34(14-18)19-7-5-17(6-8-19)24(28,29)30/h1-8,13-14,20,33H,9-12H2,(H,31,37)(H,35,36) | PDB
MMDB
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B.MOAD
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Glucagon-Cex from human GCGR |
Bioorg Med Chem Lett 22: 415-20 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.113
BindingDB Entry DOI: 10.7270/Q2H70G82 |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50433595
(CHEMBL2381827)Show SMILES CCCC(Nc1cc(C)c(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C26H29F3N4O3/c1-4-5-22(18-6-8-19(9-7-18)25(36)30-11-10-23(34)35)32-21-12-16(2)24(17(3)13-21)33-15-20(14-31-33)26(27,28)29/h6-9,12-15,22,32H,4-5,10-11H2,1-3H3,(H,30,36)(H,34,35) | PDB
MMDB
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B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin |
Bioorg Med Chem Lett 23: 3051-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50360598
(CHEMBL1933364)Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)C(CCC(F)(F)F)Nc1cnn(c1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C24H22F6N4O3/c25-23(26,27)11-9-20(15-1-3-16(4-2-15)22(37)31-12-10-21(35)36)33-18-13-32-34(14-18)19-7-5-17(6-8-19)24(28,29)30/h1-8,13-14,20,33H,9-12H2,(H,31,37)(H,35,36) | PDB
MMDB
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]Glucagon-Cex from human GCGR |
Bioorg Med Chem Lett 22: 415-20 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.113
BindingDB Entry DOI: 10.7270/Q2H70G82 |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM123630
(US8748624, 144)Show SMILES OC(=O)CCNC(=O)c1ccc(cn1)-c1cc(Cl)ccc1CNc1ccc(c(Cl)c1)-c1ccc(F)c(c1)C(F)(F)F Show InChI InChI=1S/C29H21Cl2F4N3O3/c30-19-4-1-17(22(12-19)18-3-8-26(38-15-18)28(41)36-10-9-27(39)40)14-37-20-5-6-21(24(31)13-20)16-2-7-25(32)23(11-16)29(33,34)35/h1-8,11-13,15,37H,9-10,14H2,(H,36,41)(H,39,40) | PDB
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| PC cid
PC sid
UniChem
Similars
| US Patent
| 12.4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba... |
US Patent US8748624 (2014)
BindingDB Entry DOI: 10.7270/Q29885QP |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50525881
(CHEMBL4513792)Show SMILES CC(C)C[C@@H](c1ccc(cc1)C(=O)NCCC(O)=O)n1ncc2cc(c(C)cc12)-c1ccc(cc1C)C(F)(F)F |r| Show InChI InChI=1S/C31H32F3N3O3/c1-18(2)13-27(21-5-7-22(8-6-21)30(40)35-12-11-29(38)39)37-28-15-20(4)26(16-23(28)17-36-37)25-10-9-24(14-19(25)3)31(32,33)34/h5-10,14-18,27H,11-13H2,1-4H3,(H,35,40)(H,38,39)/t27-/m0/s1 | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research & Development, L.L.C.
Curated by ChEMBL
| Assay Description
Inhibition of human full length GCGR transfected in HEK293 cells assessed as reduction in glucagon-induced cAMP response by LANCE TR-FRET assay |
Bioorg Med Chem Lett 29: (2019)
Article DOI: 10.1016/j.bmcl.2019.126668
BindingDB Entry DOI: 10.7270/Q2902776 |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM142039
(US8927577, 118 | US8927577, 20 | US8927577, 35)Show SMILES Cc1cc2cc(F)ccc2nc1NC(C1CC(C)(C)C1)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C27H30FN3O3/c1-16-12-19-13-21(28)8-9-22(19)30-25(16)31-24(20-14-27(2,3)15-20)17-4-6-18(7-5-17)26(34)29-11-10-23(32)33/h4-9,12-13,20,24H,10-11,14-15H2,1-3H3,(H,29,34)(H,30,31)(H,32,33) | PDB
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antibodypedia
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in Chem-1 cell membranes after 6 to 10 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 25: 4057-64 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50433577
(CHEMBL2381848)Show SMILES CCC[C@H](Oc1cc(C)c(c(C)c1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O |r| Show InChI InChI=1S/C26H28F3N3O4/c1-4-5-22(18-6-8-19(9-7-18)25(35)30-11-10-23(33)34)36-21-12-16(2)24(17(3)13-21)32-15-20(14-31-32)26(27,28)29/h6-9,12-15,22H,4-5,10-11H2,1-3H3,(H,30,35)(H,33,34)/t22-/m0/s1 | PDB
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antibodypedia
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| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albumin |
Bioorg Med Chem Lett 23: 3051-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.014
BindingDB Entry DOI: 10.7270/Q27M099R |
More data for this
Ligand-Target Pair | |
Pro-glucagon
(Homo sapiens (Human)) | BDBM142039
(US8927577, 118 | US8927577, 20 | US8927577, 35)Show SMILES Cc1cc2cc(F)ccc2nc1NC(C1CC(C)(C)C1)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C27H30FN3O3/c1-16-12-19-13-21(28)8-9-22(19)30-25(16)31-24(20-14-27(2,3)15-20)17-4-6-18(7-5-17)26(34)29-11-10-23(32)33/h4-9,12-13,20,24H,10-11,14-15H2,1-3H3,(H,29,34)(H,30,31)(H,32,33) | PDB
Reactome pathway
KEGG
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antibodypedia
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| PC cid
PC sid
UniChem
Similars
| US Patent
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Inc.
US Patent
| Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptor. Test compoun... |
US Patent US8927577 (2015)
BindingDB Entry DOI: 10.7270/Q29S1PRV |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM123549
(US8748624, 35)Show SMILES OC(=O)CCNC(=O)c1ccc(cn1)-c1cc(ccc1CNc1ccc(c(Cl)c1)-c1ccc(F)c(Cl)c1)C(F)(F)F Show InChI InChI=1S/C29H21Cl2F4N3O3/c30-23-13-20(5-6-21(23)16-2-7-25(32)24(31)11-16)37-14-17-1-4-19(29(33,34)35)12-22(17)18-3-8-26(38-15-18)28(41)36-10-9-27(39)40/h1-8,11-13,15,37H,9-10,14H2,(H,36,41)(H,39,40) | PDB
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| PC cid
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Similars
| US Patent
| 14.4 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba... |
US Patent US8748624 (2014)
BindingDB Entry DOI: 10.7270/Q29885QP |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM123582
(US8748624, 74)Show SMILES OC(=O)CCNC(=O)c1ccc(cn1)-c1cc(cc(Cl)c1CNc1ccc(c(Cl)c1)-c1ccc(Cl)cc1)C(F)(F)F Show InChI InChI=1S/C29H21Cl3F3N3O3/c30-19-4-1-16(2-5-19)21-7-6-20(13-25(21)32)37-15-23-22(11-18(12-24(23)31)29(33,34)35)17-3-8-26(38-14-17)28(41)36-10-9-27(39)40/h1-8,11-14,37H,9-10,15H2,(H,36,41)(H,39,40) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 14.9 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba... |
US Patent US8748624 (2014)
BindingDB Entry DOI: 10.7270/Q29885QP |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50119555
(CHEMBL3617571)Show SMILES CC(C)C[C@H](Nc1ccc(cn1)C(=O)NCCC(O)=O)c1cnc(nc1)-c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H26F3N5O3/c1-15(2)11-20(33-21-8-5-17(12-30-21)24(36)29-10-9-22(34)35)18-13-31-23(32-14-18)16-3-6-19(7-4-16)25(26,27)28/h3-8,12-15,20H,9-11H2,1-2H3,(H,29,36)(H,30,33)(H,34,35)/t20-/m0/s1 | PDB
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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Similars
| Article
PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in Chem-1 cell membranes after 6 to 10 hrs by scintillation proximity assay |
Bioorg Med Chem Lett 25: 4057-64 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM123633
(US8748624, 147)Show SMILES OC(=O)CCNC(=O)c1ccc(cn1)-c1cc(Cl)ccc1CNc1ccc(cc1)-c1ccc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C29H22Cl2F3N3O3/c30-21-6-1-18(24(14-21)19-4-10-26(37-16-19)28(40)35-12-11-27(38)39)15-36-22-7-2-17(3-8-22)23-9-5-20(13-25(23)31)29(32,33)34/h1-10,13-14,16,36H,11-12,15H2,(H,35,40)(H,38,39) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 15.7 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba... |
US Patent US8748624 (2014)
BindingDB Entry DOI: 10.7270/Q29885QP |
More data for this
Ligand-Target Pair | |
Pro-glucagon
(Homo sapiens (Human)) | BDBM100806
(US8507533, 114 | US8507533, 115 | US8507533, 330)Show SMILES CC1(C)CC(C1)C(Nc1ccc(nc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O Show InChI InChI=1S/C26H28F3N5O3/c1-25(2)11-18(12-25)23(16-3-5-17(6-4-16)24(37)30-10-9-22(35)36)33-20-7-8-21(31-14-20)34-15-19(13-32-34)26(27,28)29/h3-8,13-15,18,23,33H,9-12H2,1-2H3,(H,30,37)(H,35,36) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
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| PC cid
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UniChem
Similars
| US Patent
| 15.8 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Inc.
US Patent
| Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors. |
US Patent US8507533 (2013)
BindingDB Entry DOI: 10.7270/Q23R0RGH |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM123637
(US8748624, 151)Show SMILES Cc1cc(F)ccc1-c1ccc(NCc2ccc(Cl)cc2-c2ccc(nc2)C(=O)NCCC(O)=O)cc1 Show InChI InChI=1S/C29H25ClFN3O3/c1-18-14-23(31)7-10-25(18)19-3-8-24(9-4-19)33-16-20-2-6-22(30)15-26(20)21-5-11-27(34-17-21)29(37)32-13-12-28(35)36/h2-11,14-15,17,33H,12-13,16H2,1H3,(H,32,37)(H,35,36) | PDB
MMDB
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B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 16.5 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba... |
US Patent US8748624 (2014)
BindingDB Entry DOI: 10.7270/Q29885QP |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM123556
(US8748624, 42)Show SMILES OC(=O)CCNC(=O)c1ccc(cn1)-c1cc(ccc1CNc1ccc(c(Cl)c1)-c1ccc(cc1Cl)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C30H21Cl2F6N3O3/c31-24-12-19(30(36,37)38)4-6-21(24)22-7-5-20(13-25(22)32)40-14-16-1-3-18(29(33,34)35)11-23(16)17-2-8-26(41-15-17)28(44)39-10-9-27(42)43/h1-8,11-13,15,40H,9-10,14H2,(H,39,44)(H,42,43) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 16.5 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba... |
US Patent US8748624 (2014)
BindingDB Entry DOI: 10.7270/Q29885QP |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM123559
(US8748624, 51)Show SMILES OC(=O)CCNC(=O)c1ccc(cn1)-c1cc(Cl)ccc1CNc1ccc(c(Cl)c1)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C28H21Cl4N3O3/c29-18-3-1-16(23(11-18)17-2-8-26(35-15-17)28(38)33-10-9-27(36)37)14-34-20-5-7-22(25(32)13-20)21-6-4-19(30)12-24(21)31/h1-8,11-13,15,34H,9-10,14H2,(H,33,38)(H,36,37) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 16.8 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba... |
US Patent US8748624 (2014)
BindingDB Entry DOI: 10.7270/Q29885QP |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM123557
(US8748624, 43)Show SMILES Cc1cc(ccc1-c1ccc(NCc2ccc(cc2-c2ccc(nc2)C(=O)NCCC(O)=O)C(F)(F)F)cc1Cl)C(F)(F)F Show InChI InChI=1S/C31H24ClF6N3O3/c1-17-12-20(30(33,34)35)5-7-23(17)24-8-6-22(14-26(24)32)40-15-18-2-4-21(31(36,37)38)13-25(18)19-3-9-27(41-16-19)29(44)39-11-10-28(42)43/h2-9,12-14,16,40H,10-11,15H2,1H3,(H,39,44)(H,42,43) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]-glucagon from full length human glucagon receptor expressed in HEK293 cell membranes after 2 hrs by scintillation counting ana... |
Bioorg Med Chem Lett 25: 4057-64 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N |
More data for this
Ligand-Target Pair | |
Pro-glucagon
(Homo sapiens (Human)) | BDBM100796
(US8507533, 101)Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)C(Nc1ccc(nc1)-n1cc(cn1)C(F)(F)F)C1CCCCC1 Show InChI InChI=1S/C26H28F3N5O3/c27-26(28,29)20-14-32-34(16-20)22-11-10-21(15-31-22)33-24(17-4-2-1-3-5-17)18-6-8-19(9-7-18)25(37)30-13-12-23(35)36/h6-11,14-17,24,33H,1-5,12-13H2,(H,30,37)(H,35,36) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Inc.
US Patent
| Assay Description
The Glucagon SPA assay is used to determine the ability of test compounds to block the binding of glucagon-cex to the glucagon receptors. |
US Patent US8507533 (2013)
BindingDB Entry DOI: 10.7270/Q23R0RGH |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM123557
(US8748624, 43)Show SMILES Cc1cc(ccc1-c1ccc(NCc2ccc(cc2-c2ccc(nc2)C(=O)NCCC(O)=O)C(F)(F)F)cc1Cl)C(F)(F)F Show InChI InChI=1S/C31H24ClF6N3O3/c1-17-12-20(30(33,34)35)5-7-23(17)24-8-6-22(14-26(24)32)40-15-18-2-4-21(31(36,37)38)13-25(18)19-3-9-27(41-16-19)29(44)39-11-10-28(42)43/h2-9,12-14,16,40H,10-11,15H2,1H3,(H,39,44)(H,42,43) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| 17.2 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba... |
US Patent US8748624 (2014)
BindingDB Entry DOI: 10.7270/Q29885QP |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM123651
(US8748624, 174)Show SMILES OC(=O)CCNC(=O)c1ccc(cn1)-c1cc(ccc1CNc1ccc(cc1)-c1ccc(F)cc1)C1=CCCCC1 |t:39| Show InChI InChI=1S/C34H32FN3O3/c35-29-13-8-24(9-14-29)25-10-15-30(16-11-25)37-21-27-7-6-26(23-4-2-1-3-5-23)20-31(27)28-12-17-32(38-22-28)34(41)36-19-18-33(39)40/h4,6-17,20,22,37H,1-3,5,18-19,21H2,(H,36,41)(H,39,40) | PDB
MMDB
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antibodypedia
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| PC cid
PC sid
UniChem
Similars
| US Patent
| 18.3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description
The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba... |
US Patent US8748624 (2014)
BindingDB Entry DOI: 10.7270/Q29885QP |
More data for this
Ligand-Target Pair | |
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