Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM199119 (N-(4-(1-(4,6-bis(methylamino)-1,3,5-triazin-2-yl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 666 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Zhejiang Hospital | Assay Description where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a... | Chem Biol Drug Des 88: 756-765 (2016) Article DOI: 10.1111/cbdd.12807 BindingDB Entry DOI: 10.7270/Q2ZW1JR4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM50310832 (CHEMBL1080779 | Clinopodic acid C) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins | J Nat Prod 72: 1379-84 (2009) Article DOI: 10.1021/np800781t BindingDB Entry DOI: 10.7270/Q2891602 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM199121 (N-(4-(1-(4,6-bis((3-aminopropyl)amino)-1,3,5-triaz...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 189 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Zhejiang Hospital | Assay Description where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a... | Chem Biol Drug Des 88: 756-765 (2016) Article DOI: 10.1111/cbdd.12807 BindingDB Entry DOI: 10.7270/Q2ZW1JR4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM199122 (N-(4-(1-(4,6-bis(phenylamino)-1,3,5-triazin-2-yl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 123 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Zhejiang Hospital | Assay Description where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a... | Chem Biol Drug Des 88: 756-765 (2016) Article DOI: 10.1111/cbdd.12807 BindingDB Entry DOI: 10.7270/Q2ZW1JR4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM199123 (N-(4-(1-(4,6-bis((4-hydroxyphenyl)amino)-1,3,5-tri...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.12 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Zhejiang Hospital | Assay Description where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a... | Chem Biol Drug Des 88: 756-765 (2016) Article DOI: 10.1111/cbdd.12807 BindingDB Entry DOI: 10.7270/Q2ZW1JR4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM199124 (N-(4-(1-(4,6-bis((4-methoxyphenyl)amino)-1,3,5-tri...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 18.6 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Zhejiang Hospital | Assay Description where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a... | Chem Biol Drug Des 88: 756-765 (2016) Article DOI: 10.1111/cbdd.12807 BindingDB Entry DOI: 10.7270/Q2ZW1JR4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM199125 (N-(4-(1-(4,6-bis(o-tolylamino)-1,3,5-triazin-2-yl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 67.1 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Zhejiang Hospital | Assay Description where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a... | Chem Biol Drug Des 88: 756-765 (2016) Article DOI: 10.1111/cbdd.12807 BindingDB Entry DOI: 10.7270/Q2ZW1JR4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM199126 (N-(4-(1-(4,6-bis((4-nitrophenyl)amino)-1,3,5-triaz...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 76.6 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Zhejiang Hospital | Assay Description where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a... | Chem Biol Drug Des 88: 756-765 (2016) Article DOI: 10.1111/cbdd.12807 BindingDB Entry DOI: 10.7270/Q2ZW1JR4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM199127 (N-(4-(1-(4,6-di(piperazin-1-yl)-1,3,5-triazin-2-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 55.3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Zhejiang Hospital | Assay Description where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a... | Chem Biol Drug Des 88: 756-765 (2016) Article DOI: 10.1111/cbdd.12807 BindingDB Entry DOI: 10.7270/Q2ZW1JR4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM199128 (N-(4-(1-(4,6-dimorpholino-1,3,5-triazin-2-yl)-5-(4...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 42.3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Zhejiang Hospital | Assay Description where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a... | Chem Biol Drug Des 88: 756-765 (2016) Article DOI: 10.1111/cbdd.12807 BindingDB Entry DOI: 10.7270/Q2ZW1JR4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM50133496 ((2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.72E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins | J Nat Prod 72: 1379-84 (2009) Article DOI: 10.1021/np800781t BindingDB Entry DOI: 10.7270/Q2891602 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM50310827 (CHEMBL1079357 | clinopodic acid H) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins | J Nat Prod 72: 1379-84 (2009) Article DOI: 10.1021/np800781t BindingDB Entry DOI: 10.7270/Q2891602 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM50310828 (CHEMBL1079356 | clinopodic acid F) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins | J Nat Prod 72: 1379-84 (2009) Article DOI: 10.1021/np800781t BindingDB Entry DOI: 10.7270/Q2891602 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM50310829 (CHEMBL1081512 | clinopodic acid E) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins | J Nat Prod 72: 1379-84 (2009) Article DOI: 10.1021/np800781t BindingDB Entry DOI: 10.7270/Q2891602 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM50310830 (CHEMBL1080778 | Clinopodic acid B) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins | J Nat Prod 72: 1379-84 (2009) Article DOI: 10.1021/np800781t BindingDB Entry DOI: 10.7270/Q2891602 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM50310831 (CHEMBL1079231 | Clinopodic acid A) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins | J Nat Prod 72: 1379-84 (2009) Article DOI: 10.1021/np800781t BindingDB Entry DOI: 10.7270/Q2891602 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM50210054 ((R,E)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins | J Nat Prod 72: 1379-84 (2009) Article DOI: 10.1021/np800781t BindingDB Entry DOI: 10.7270/Q2891602 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM50250808 (CHEMBL518243 | lithospermic acid) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of gelatinolytic activity of MMP2 in rat lung homogenate after 40 mins by SDS-PAGE preincubated for 30 mins | J Nat Prod 72: 1379-84 (2009) Article DOI: 10.1021/np800781t BindingDB Entry DOI: 10.7270/Q2891602 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Rattus norvegicus (Rat)) | BDBM199120 (N-(4-(1-(4,6-bis(ethylamino)-1,3,5-triazin-2-yl)-5...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 332 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Zhejiang Hospital | Assay Description where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a... | Chem Biol Drug Des 88: 756-765 (2016) Article DOI: 10.1111/cbdd.12807 BindingDB Entry DOI: 10.7270/Q2ZW1JR4 | |||||||||||
More data for this Ligand-Target Pair |