Compile Data Set for Download or QSAR

Found 822 hits Enz. Inhib. hit(s) with Target = 'Polymerase basic protein 2'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050706 (CHEMBL3318002) Show SMILES C[C@@]1(CCCC[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12)C(O)=O |r| Show InChI InChI=1S/C19H19F2N5O2/c1-19(18(27)28)5-3-2-4-14(19)25-17-13(21)9-24-16(26-17)12-8-23-15-11(12)6-10(20)7-22-15/h6-9,14H,2-5H2,1H3,(H,22,23)(H,27,28)(H,24,25,26)/t14-,19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050705 (CHEMBL3318001) Show SMILES C[C@@]1(CCCC[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12)C(O)=O |r| Show InChI InChI=1S/C19H19ClFN5O2/c1-19(18(27)28)5-3-2-4-14(19)25-17-13(21)9-24-16(26-17)12-8-23-15-11(12)6-10(20)7-22-15/h6-9,14H,2-5H2,1H3,(H,22,23)(H,27,28)(H,24,25,26)/t14-,19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050703 (CHEMBL3318000) Show SMILES OC(=O)[C@H]1CCCC[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C18H17ClFN5O2/c19-9-5-11-12(7-22-15(11)21-6-9)16-23-8-13(20)17(25-16)24-14-4-2-1-3-10(14)18(26)27/h5-8,10,14H,1-4H2,(H,21,22)(H,26,27)(H,23,24,25)/t10-,14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050708 (CHEMBL3318004) Show SMILES [H][C@]12CC[C@]([H])(C1)[C@@H]([C@H]2Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12)C(O)=O |r| Show InChI InChI=1S/C19H17ClFN5O2/c20-10-4-11-12(6-23-16(11)22-5-10)17-24-7-13(21)18(26-17)25-15-9-2-1-8(3-9)14(15)19(27)28/h4-9,14-15H,1-3H2,(H,22,23)(H,27,28)(H,24,25,26)/t8-,9+,14+,15+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050709 (CHEMBL3318005) Show SMILES [H][C@@]12CC[C@@]([H])(C1)[C@@H]([C@H]2Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12)C(O)=O |r| Show InChI InChI=1S/C19H17ClFN5O2/c20-10-4-11-12(6-23-16(11)22-5-10)17-24-7-13(21)18(26-17)25-15-9-2-1-8(3-9)14(15)19(27)28/h4-9,14-15H,1-3H2,(H,22,23)(H,27,28)(H,24,25,26)/t8-,9+,14-,15-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	CHEMBL5279168 Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	CHEMBL5280871 Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	CHEMBL5283800 Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	CHEMBL5289925 Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	CHEMBL5280401 Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	CHEMBL5281405 Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050710 (CHEMBL3318006) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r,wU:3.2,wD:10.12,(29.25,-16.63,;27.75,-17,;26.69,-15.88,;27.31,-18.47,;28.37,-19.59,;27.93,-21.07,;26.43,-21.42,;25.38,-20.31,;26.46,-19.21,;26.86,-20.7,;25.82,-18.84,;24.76,-17.72,;23.26,-18.08,;22.83,-19.55,;21.33,-19.91,;20.27,-18.8,;20.71,-17.32,;22.2,-16.96,;22.64,-15.49,;20.89,-21.39,;21.83,-22.61,;20.96,-23.89,;19.49,-23.45,;18.17,-24.25,;16.82,-23.52,;16.78,-21.98,;15.43,-21.24,;18.09,-21.17,;19.44,-21.91,)| Show InChI InChI=1S/C20H19ClFN5O2/c21-11-5-12-13(7-24-17(12)23-6-11)18-25-8-14(22)19(27-18)26-16-10-3-1-9(2-4-10)15(16)20(28)29/h5-10,15-16H,1-4H2,(H,23,24)(H,28,29)(H,25,26,27)/t9?,10?,15-,16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050707 (CHEMBL3318003) Show SMILES COCC[C@@]1(CCCC[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12)C(O)=O |r| Show InChI InChI=1S/C21H23ClFN5O3/c1-31-7-6-21(20(29)30)5-3-2-4-16(21)27-19-15(23)11-26-18(28-19)14-10-25-17-13(14)8-12(22)9-24-17/h8-11,16H,2-7H2,1H3,(H,24,25)(H,29,30)(H,26,27,28)/t16-,21+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050716 (CHEMBL3317990) Show SMILES Cn1cncc1C(=O)N[C@@H]1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C22H22ClFN8O/c1-32-11-25-10-18(32)22(33)30-14-4-2-3-13(6-14)29-21-17(24)9-28-20(31-21)16-8-27-19-15(16)5-12(23)7-26-19/h5,7-11,13-14H,2-4,6H2,1H3,(H,26,27)(H,30,33)(H,28,29,31)/t13-,14+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050702 (CHEMBL3317999) Show SMILES NC(=O)[C@H]1CCCC[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C18H18ClFN6O/c19-9-5-11-12(7-23-16(11)22-6-9)17-24-8-13(20)18(26-17)25-14-4-2-1-3-10(14)15(21)27/h5-8,10,14H,1-4H2,(H2,21,27)(H,22,23)(H,24,25,26)/t10-,14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050712 (CHEMBL3318007) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(15.61,-25.66,;14.11,-26.02,;13.05,-24.9,;13.67,-27.49,;14.73,-28.62,;14.29,-30.09,;12.8,-30.45,;11.74,-29.34,;12.83,-28.23,;13.22,-29.72,;12.18,-27.86,;11.12,-26.75,;9.63,-27.1,;9.19,-28.58,;7.69,-28.94,;6.63,-27.82,;7.06,-26.35,;8.56,-25.99,;9,-24.51,;7.25,-30.41,;8.2,-31.63,;7.32,-32.91,;5.84,-32.47,;4.53,-33.27,;3.18,-32.54,;3.14,-31,;1.79,-30.27,;4.45,-30.19,;5.8,-30.93,)| Show InChI InChI=1S/C20H19F2N5O2/c21-11-5-12-13(7-24-17(12)23-6-11)18-25-8-14(22)19(27-18)26-16-10-3-1-9(2-4-10)15(16)20(28)29/h5-10,15-16H,1-4H2,(H,23,24)(H,28,29)(H,25,26,27)/t9?,10?,15-,16-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to CM5 immobilized N-terminal His/Sumo tagged Influenza A virus (A/WSN/1933(H1N1)) PB2 CBD (318 to 486 residues) expressed in Escher...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116515 BindingDB Entry DOI: 10.7270/Q2JQ14XZ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050697 (CHEMBL3317982) Show SMILES COCC(=O)N[C@@H]1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C20H22ClFN6O2/c1-30-10-17(29)26-12-3-2-4-13(6-12)27-20-16(22)9-25-19(28-20)15-8-24-18-14(15)5-11(21)7-23-18/h5,7-9,12-13H,2-4,6,10H2,1H3,(H,23,24)(H,26,29)(H,25,27,28)/t12-,13+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050760 (CHEMBL3317981) Show SMILES CC(=O)N[C@@H]1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50521200 (CHEMBL4554496) Show SMILES CC\C=C1\C=CC(=O)[C@@H](O)[C@@]11[C@@H](O)[C@](C)(OC)N(OC)C1=O |r,c:4| Show InChI InChI=1S/C15H21NO6/c1-5-6-9-7-8-10(17)11(18)15(9)12(19)14(2,21-3)16(22-4)13(15)20/h6-8,11-12,18-19H,5H2,1-4H3/b9-6-/t11-,12+,14+,15-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to Influenza A virus RNA polymerase PB2 by SPR assay				J Nat Prod 81: 2722-2730 (2018) Article DOI: 10.1021/acs.jnatprod.8b00656 BindingDB Entry DOI: 10.7270/Q2BG2SCR
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050756 (CHEMBL3317977) Show SMILES NC(=O)CN1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C18H19ClFN7O/c19-10-4-12-13(6-23-16(12)22-5-10)17-24-7-14(20)18(26-17)25-11-2-1-3-27(8-11)9-15(21)28/h4-7,11H,1-3,8-9H2,(H2,21,28)(H,22,23)(H,24,25,26)/t11-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050717 (CHEMBL3317991) Show SMILES Cn1cncc1C(=O)N[C@@H]1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r| Show InChI InChI=1S/C22H22F2N8O/c1-32-11-25-10-18(32)22(33)30-14-4-2-3-13(6-14)29-21-17(24)9-28-20(31-21)16-8-27-19-15(16)5-12(23)7-26-19/h5,7-11,13-14H,2-4,6H2,1H3,(H,26,27)(H,30,33)(H,28,29,31)/t13-,14+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050757 (CHEMBL3317978) Show SMILES N[C@H]1CCCC[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C17H18ClFN6/c18-9-5-10-11(7-22-15(10)21-6-9)16-23-8-12(19)17(25-16)24-14-4-2-1-3-13(14)20/h5-8,13-14H,1-4,20H2,(H,21,22)(H,23,24,25)/t13-,14-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050722 (CHEMBL3317974) Show SMILES CS(=O)(=O)N1CCCC[C@@H]1CNc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C18H20ClFN6O2S/c1-29(27,28)26-5-3-2-4-12(26)8-22-18-15(20)10-24-17(25-18)14-9-23-16-13(14)6-11(19)7-21-16/h6-7,9-10,12H,2-5,8H2,1H3,(H,21,23)(H,22,24,25)/t12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050718 (CHEMBL3317969) Show SMILES C[C@H](Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12)C(=O)N(C)C |r| Show InChI InChI=1S/C16H16ClFN6O/c1-8(16(25)24(2)3)22-15-12(18)7-21-14(23-15)11-6-20-13-10(11)4-9(17)5-19-13/h4-8H,1-3H3,(H,19,20)(H,21,22,23)/t8-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair				3D Structure (crystal)
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050750 (CHEMBL3317975) Show SMILES COCCC(=O)N1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C20H22ClFN6O2/c1-30-6-4-17(29)28-5-2-3-13(11-28)26-20-16(22)10-25-19(27-20)15-9-24-18-14(15)7-12(21)8-23-18/h7-10,13H,2-6,11H2,1H3,(H,23,24)(H,25,26,27)/t13-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050759 (CHEMBL3317980) Show SMILES CC(=O)N[C@H]1CCCC[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50586990 (CHEMBL5091340) Show SMILES Cc1c(O[C@H](C(O)=O)c2ccccc2)ccc2c1oc(=O)c1ccccc21 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to CM5 immobilized N-terminal His/Sumo tagged Influenza A virus (A/WSN/1933(H1N1)) PB2 CBD (318 to 486 residues) expressed in Escher...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116515 BindingDB Entry DOI: 10.7270/Q2JQ14XZ
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	CHEMBL5289034 Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050700 (CHEMBL3317985) Show SMILES Fc1cnc(nc1N[C@H]1CCC[C@H](C1)NC(=O)CN1CCOCC1)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C23H27ClFN7O2/c24-14-8-17-18(11-27-21(17)26-10-14)22-28-12-19(25)23(31-22)30-16-3-1-2-15(9-16)29-20(33)13-32-4-6-34-7-5-32/h8,10-12,15-16H,1-7,9,13H2,(H,26,27)(H,29,33)(H,28,30,31)/t15-,16+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050698 (CHEMBL3317983) Show SMILES COCC(=O)N[C@@H]1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r| Show InChI InChI=1S/C20H22F2N6O2/c1-30-10-17(29)26-12-3-2-4-13(6-12)27-20-16(22)9-25-19(28-20)15-8-24-18-14(15)5-11(21)7-23-18/h5,7-9,12-13H,2-4,6,10H2,1H3,(H,23,24)(H,26,29)(H,25,27,28)/t12-,13+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	CHEMBL5272653 Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM62536 ((2-Phenyl-benzo[4,5]furo[3,2-d]pyrimidin-4-ylsulfa...) Show SMILES OC(=O)CSc1nc(nc2c3ccccc3oc12)-c1ccccc1 Show InChI InChI=1S/C18H12N2O3S/c21-14(22)10-24-18-16-15(12-8-4-5-9-13(12)23-16)19-17(20-18)11-6-2-1-3-7-11/h1-9H,10H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to CM5 immobilized N-terminal His/Sumo tagged Influenza A virus (A/WSN/1933(H1N1)) PB2 CBD (318 to 486 residues) expressed in Escher...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116515 BindingDB Entry DOI: 10.7270/Q2JQ14XZ
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050721 (CHEMBL3317973) Show SMILES CC(=O)N1CCC[C@H](CNc2nc(ncc2F)-c2c[nH]c3ncc(Cl)cc23)C1 |r| Show InChI InChI=1S/C19H20ClFN6O/c1-11(28)27-4-2-3-12(10-27)6-22-19-16(21)9-25-18(26-19)15-8-24-17-14(15)5-13(20)7-23-17/h5,7-9,12H,2-4,6,10H2,1H3,(H,23,24)(H,22,25,26)/t12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050719 (CHEMBL3317970) Show SMILES Fc1cnc(nc1NC1CCCCC1)-c1c[nH]c2ncc(Cl)cc12 Show InChI InChI=1S/C17H17ClFN5/c18-10-6-12-13(8-21-15(12)20-7-10)16-22-9-14(19)17(24-16)23-11-4-2-1-3-5-11/h6-9,11H,1-5H2,(H,20,21)(H,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050714 (CHEMBL3317988) Show SMILES Fc1cnc2[nH]cc(-c3ncc(F)c(N[C@H]4CCC[C@H](C4)NC(=O)N4CCOCC4)n3)c2c1 |r| Show InChI InChI=1S/C22H25F2N7O2/c23-13-8-16-17(11-26-19(16)25-10-13)20-27-12-18(24)21(30-20)28-14-2-1-3-15(9-14)29-22(32)31-4-6-33-7-5-31/h8,10-12,14-15H,1-7,9H2,(H,25,26)(H,29,32)(H,27,28,30)/t14-,15+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050715 (CHEMBL3317989) Show SMILES Fc1cnc2[nH]cc(-c3ncc(F)c(N[C@H]4CCC[C@H](C4)NC(=O)NC4CCOCC4)n3)c2c1 |r| Show InChI InChI=1S/C23H27F2N7O2/c24-13-8-17-18(11-27-20(17)26-10-13)21-28-12-19(25)22(32-21)29-15-2-1-3-16(9-15)31-23(33)30-14-4-6-34-7-5-14/h8,10-12,14-16H,1-7,9H2,(H,26,27)(H,28,29,32)(H2,30,31,33)/t15-,16+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050699 (CHEMBL3317984) Show SMILES CC(O)C(=O)N[C@@H]1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C20H22ClFN6O2/c1-10(29)20(30)27-13-4-2-3-12(6-13)26-19-16(22)9-25-18(28-19)15-8-24-17-14(15)5-11(21)7-23-17/h5,7-10,12-13,29H,2-4,6H2,1H3,(H,23,24)(H,27,30)(H,25,26,28)/t10?,12-,13+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050754 (CHEMBL3317976) Show SMILES OC[C@H](O)CN1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C19H22ClFN6O2/c20-11-4-14-15(6-23-17(14)22-5-11)18-24-7-16(21)19(26-18)25-12-2-1-3-27(8-12)9-13(29)10-28/h4-7,12-13,28-29H,1-3,8-10H2,(H,22,23)(H,24,25,26)/t12-,13+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050701 (CHEMBL3317986) Show SMILES CN(C)C(=O)N[C@@H]1CCC[C@@H](C1)Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 |r| Show InChI InChI=1S/C20H23F2N7O/c1-29(2)20(30)27-13-5-3-4-12(7-13)26-19-16(22)10-25-18(28-19)15-9-24-17-14(15)6-11(21)8-23-17/h6,8-10,12-13H,3-5,7H2,1-2H3,(H,23,24)(H,27,30)(H,25,26,28)/t12-,13+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050713 (CHEMBL3317987) Show SMILES Fc1cnc(nc1N[C@H]1CCC[C@H](C1)NC(=O)N1CCOCC1)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI InChI=1S/C22H25ClFN7O2/c23-13-8-16-17(11-26-19(16)25-10-13)20-27-12-18(24)21(30-20)28-14-2-1-3-15(9-14)29-22(32)31-4-6-33-7-5-31/h8,10-12,14-15H,1-7,9H2,(H,25,26)(H,29,32)(H,27,28,30)/t14-,15+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50586988 (CHEMBL5087029) Show SMILES OC(=O)CSc1cc(O)c2C(=O)c3ccccc3C(=O)c2c1O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to CM5 immobilized N-terminal His/Sumo tagged Influenza A virus (A/WSN/1933(H1N1)) PB2 CBD (318 to 486 residues) expressed in Escher...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116515 BindingDB Entry DOI: 10.7270/Q2JQ14XZ
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050720 (CHEMBL3317972) Show SMILES Fc1cnc(nc1NC1CCCC1)-c1c[nH]c2ncc(Cl)cc12 Show InChI InChI=1S/C16H15ClFN5/c17-9-5-11-12(7-20-14(11)19-6-9)15-21-8-13(18)16(23-15)22-10-3-1-2-4-10/h5-8,10H,1-4H2,(H,19,20)(H,21,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50586991 (CHEMBL5094914) Show SMILES O=C(N1CCc2[nH]c3ccccc3c2C1)c1cc(=O)[nH]c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to CM5 immobilized N-terminal His/Sumo tagged Influenza A virus (A/WSN/1933(H1N1)) PB2 CBD (318 to 486 residues) expressed in Escher...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116515 BindingDB Entry DOI: 10.7270/Q2JQ14XZ
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50586987 (CHEMBL5079585) Show SMILES O[C@@H](COc1ccc2C(=O)c3ccccc3C(=O)c2c1)Cn1cnc2ccccc12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to CM5 immobilized N-terminal His/Sumo tagged Influenza A virus (A/WSN/1933(H1N1)) PB2 CBD (318 to 486 residues) expressed in Escher...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116515 BindingDB Entry DOI: 10.7270/Q2JQ14XZ
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50521201 (CHEMBL4472996) Show SMILES Oc1cc(O)c2c(c1)oc(=O)c1ccccc21 Show InChI InChI=1S/C13H8O4/c14-7-5-10(15)12-8-3-1-2-4-9(8)13(16)17-11(12)6-7/h1-6,14-15H	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Binding affinity to Influenza A virus RNA polymerase PB2 by SPR assay				J Nat Prod 81: 2722-2730 (2018) Article DOI: 10.1021/acs.jnatprod.8b00656 BindingDB Entry DOI: 10.7270/Q2BG2SCR
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50050758 (CHEMBL3317979) Show SMILES N[C@@H]1CCCC[C@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(Cl)cc12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to influenza A virus (A/Puerto Rico/8/1934(H1N1)) PB2 by competition binding fluorescence polarization (FP) assay				J Med Chem 57: 6668-78 (2014) Article DOI: 10.1021/jm5007275 BindingDB Entry DOI: 10.7270/Q2R21316
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50586989 (CHEMBL5075807) Show SMILES Clc1ccc(CNc2ccc3[nH]c(=O)[nH]c3c2)cc1Cl Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to CM5 immobilized N-terminal His/Sumo tagged Influenza A virus (A/WSN/1933(H1N1)) PB2 CBD (318 to 486 residues) expressed in Escher...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116515 BindingDB Entry DOI: 10.7270/Q2JQ14XZ
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507221 (CHEMBL4542293) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1N1CCOc2cnc(nc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(51.16,-2.19,;52.49,-2.95,;53.82,-2.17,;52.51,-4.49,;53.85,-5.25,;53.86,-6.79,;52.53,-7.57,;51.2,-6.81,;51.96,-5.52,;53.08,-6.43,;51.19,-5.27,;49.88,-4.51,;49.39,-3.04,;47.87,-2.74,;46.85,-3.9,;47.35,-5.36,;46.33,-6.51,;46.81,-7.97,;48.32,-8.28,;49.35,-7.13,;48.87,-5.67,;48.8,-9.73,;47.9,-10.98,;48.81,-12.23,;50.27,-11.74,;51.61,-12.51,;52.94,-11.74,;52.93,-10.19,;54.27,-9.42,;51.6,-9.43,;50.27,-10.21,)| Show InChI InChI=1S/C22H22FN5O3/c23-13-7-14-15(9-25-19(14)24-8-13)20-26-10-16-21(27-20)28(5-6-31-16)18-12-3-1-11(2-4-12)17(18)22(29)30/h7-12,17-18H,1-6H2,(H,24,25)(H,29,30)/t11?,12?,17-,18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507222 (CHEMBL4459959) Show SMILES Cn1cc(F)c2c(N[C@H]3C4CCC(CC4)[C@@H]3C(O)=O)nc(nc12)-c1c[nH]c2ncc(F)cc12 |r,wU:15.17,wD:8.7,(19.15,-35.75,;20.47,-34.99,;20.63,-33.46,;22.14,-33.14,;22.76,-31.74,;22.91,-34.47,;24.41,-34.78,;25.72,-34,;27.05,-34.75,;27.06,-36.31,;28.39,-37.06,;29.73,-36.29,;29.72,-34.74,;28.94,-35.92,;27.82,-35.01,;28.37,-33.97,;28.36,-32.43,;27.02,-31.67,;29.69,-31.65,;24.88,-36.23,;23.86,-37.37,;22.36,-37.07,;21.88,-35.62,;24.35,-38.82,;23.45,-40.08,;24.36,-41.33,;25.82,-40.84,;27.16,-41.61,;28.5,-40.84,;28.49,-39.29,;29.83,-38.51,;27.16,-38.52,;25.82,-39.3,)| Show InChI InChI=1S/C23H22F2N6O2/c1-31-9-15(25)17-21(28-18-11-4-2-10(3-5-11)16(18)23(32)33)29-20(30-22(17)31)14-8-27-19-13(14)6-12(24)7-26-19/h6-11,16,18H,2-5H2,1H3,(H,26,27)(H,32,33)(H,28,29,30)/t10?,11?,16-,18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	9.60	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair
Polymerase basic protein 2 (Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)	BDBM50507223 (CHEMBL4470294) Show SMILES OC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(nc2SCCc12)-c1c[nH]c2ncc(F)cc12 |r,wU:3.2,wD:10.12,(54.38,-44.92,;55.71,-45.68,;57.05,-44.9,;55.72,-47.22,;57.07,-47.99,;57.08,-49.54,;55.75,-50.32,;54.41,-49.56,;55.18,-48.26,;56.29,-49.17,;54.41,-48.01,;53.08,-47.26,;51.76,-48.03,;52.24,-49.48,;51.22,-50.62,;49.72,-50.32,;49.23,-48.87,;47.83,-48.24,;47.99,-46.71,;49.49,-46.39,;50.26,-47.72,;51.7,-52.07,;50.8,-53.33,;51.71,-54.58,;53.18,-54.09,;54.52,-54.86,;55.85,-54.09,;55.85,-52.54,;57.18,-51.76,;54.51,-51.77,;53.17,-52.55,)| Show InChI InChI=1S/C22H22FN5O2S/c23-12-7-14-15(9-25-18(14)24-8-12)20-27-19(13-5-6-31-21(13)28-20)26-17-11-3-1-10(2-4-11)16(17)22(29)30/h7-11,16-17H,1-6H2,(H,24,25)(H,29,30)(H,26,27,28)/t10?,11?,16-,17-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.80	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of PB2 in Influenza A virus (A/Weiss/1943(H1N1)) infected in MDCK cells assessed as reduction in virus induced cell death after 5 days by ...				Eur J Med Chem 162: 249-265 (2019) Article DOI: 10.1016/j.ejmech.2018.11.015 BindingDB Entry DOI: 10.7270/Q2PG1W2P
					More data for this Ligand-Target Pair

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