BindingDB PrimarySearch

Found 4 hits Enz. Inhib. hit(s) with Target = 'C-terminal-binding protein 1 (CtBP1)'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
C-terminal-binding protein 1 (Homo sapiens (Human))	BDBM154570 (2-Hydroxyimino-3-phenylpropanoic acid (HIPP)) Show SMILES ON=C(Cc1ccccc1)C(O)=O \|w:1.0\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	370	n/a	n/a	n/a	7.5	n/a
University of Massachusetts Medical School					Assay Description Purified CtBP2 was dialyzed overnight against 500 mL of 50 mM glycylglycine at pH 8.5, 300 mM NaCl, 1 mM EDTA, and 2 mM TCEP, with or without 1.5 mM ...				ACS Chem Biol 10: 1118-27 (2015) Article DOI: 10.1021/cb500820b BindingDB Entry DOI: 10.7270/Q2416VTK
University of Massachusetts Medical School					More data for this Ligand-Target Pair				3D Structure (crystal)
C-terminal-binding protein 1 (Homo sapiens (Human))	BDBM154571 (4-Methylthio 2-oxobutyric acid (MTOB)) Show SMILES CSCCC(=O)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase DrugBank KEGG PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	1.26E+6	n/a	n/a	n/a	7.5	n/a
University of Massachusetts Medical School					Assay Description Purified CtBP2 was dialyzed overnight against 500 mL of 50 mM glycylglycine at pH 8.5, 300 mM NaCl, 1 mM EDTA, and 2 mM TCEP, with or without 1.5 mM ...				ACS Chem Biol 10: 1118-27 (2015) Article DOI: 10.1021/cb500820b BindingDB Entry DOI: 10.7270/Q2416VTK
University of Massachusetts Medical School					More data for this Ligand-Target Pair				3D Structure (crystal)
C-terminal-binding protein 1 (Homo sapiens (Human))	BDBM154570 (2-Hydroxyimino-3-phenylpropanoic acid (HIPP)) Show SMILES ON=C(Cc1ccccc1)C(O)=O \|w:1.0\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	2.77E+3	n/a	n/a	n/a	8.5	n/a
University of Massachusetts Medical School					Assay Description Purified CtBP2 was dialyzed overnight against 500 mL of 50 mM glycylglycine at pH 8.5, 300 mM NaCl, 1 mM EDTA, and 2 mM TCEP, with or without 1.5 mM ...				ACS Chem Biol 10: 1118-27 (2015) Article DOI: 10.1021/cb500820b BindingDB Entry DOI: 10.7270/Q2416VTK
University of Massachusetts Medical School					More data for this Ligand-Target Pair				3D Structure (crystal)
C-terminal-binding protein 1 (Homo sapiens (Human))	BDBM213227 (Nicotinamide adenine dinucleotide (NAD)) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a
Oregon Health and Science University					Assay Description Equilibrium dialysis was performed using purified recombinant CtBP proteins (10 μM) in binding buffer (25 mM Tris-Cl, 100 mM NaCl, 1 mM EDTA, 5%...				J Biol Chem 288: 27836-48 (2013) Article DOI: 10.1074/jbc.M113.493569 BindingDB Entry DOI: 10.7270/Q2V40T2K
Oregon Health and Science University					More data for this Ligand-Target Pair