Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor [696-1022,L858R] (Homo sapiens (Human)) | BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 1.70 | n/a | n/a | n/a | 7.4 | 22 |
Harvard Medical School | Assay Description The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro... | Cancer Cell 11: 217-27 (2007) Article DOI: 10.1016/j.ccr.2006.12.017 BindingDB Entry DOI: 10.7270/Q2JQ0ZBW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [696-1022,L858R] (Homo sapiens (Human)) | BDBM5447 (CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 2.60 | n/a | n/a | n/a | 7.4 | 22 |
Harvard Medical School | Assay Description The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro... | Cancer Cell 11: 217-27 (2007) Article DOI: 10.1016/j.ccr.2006.12.017 BindingDB Entry DOI: 10.7270/Q2JQ0ZBW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [696-1022,L858R] (Homo sapiens (Human)) | BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | 7.4 | 22 |
Harvard Medical School | Assay Description The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro... | Proc Natl Acad Sci U S A 105: 2070-5 (2008) Article DOI: 10.1073/pnas.0709662105 BindingDB Entry DOI: 10.7270/Q2DZ06MJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [696-1022,L858R] (Homo sapiens (Human)) | BDBM5447 (CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | 7.4 | 22 |
Harvard Medical School | Assay Description The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro... | Proc Natl Acad Sci U S A 105: 2070-5 (2008) Article DOI: 10.1073/pnas.0709662105 BindingDB Entry DOI: 10.7270/Q2DZ06MJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [671-1210,L858R] (Homo sapiens (Human)) | BDBM27965 (3-{2-[(2-methoxyphenyl)methyl]-1H-1,3-benzodiazol-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [671-1210,L858R] (Homo sapiens (Human)) | BDBM27966 (1-{4-[4-(4-amino-3-{2-[(2-methoxyphenyl)methyl]-1H...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [671-1210,L858R] (Homo sapiens (Human)) | BDBM27964 (3-(2-(2-methoxybenzyl)-1H-benzo[d]imidazol-5-yl)-1...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [671-1210,L858R] (Homo sapiens (Human)) | BDBM27963 (3-(2-(2-chlorobenzyl)-1H-benzo[d]imidazol-5-yl)-1-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 65 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [671-1210,L858R] (Homo sapiens (Human)) | BDBM27962 (1-((1r,4r)-4-morpholinocyclohexyl)-3-(2-(thiophen-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 361 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [671-1210,L858R] (Homo sapiens (Human)) | BDBM27961 (3-(2-benzyl-1H-1,3-benzodiazol-6-yl)-1-[4-(morphol...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [671-1210,L858R] (Homo sapiens (Human)) | BDBM27967 (ethyl 4-[4-(4-amino-3-{2-[(2-methoxyphenyl)methyl]...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [671-1210,L858R] (Homo sapiens (Human)) | BDBM27970 (1-{4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohex...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [671-1210,L858R] (Homo sapiens (Human)) | BDBM27969 (3-{2-[(2-methoxyphenyl)methyl]-1H-1,3-benzodiazol-...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [671-1210,L858R] (Homo sapiens (Human)) | BDBM27968 (4-[4-(4-amino-3-{2-[(2-methoxyphenyl)methyl]-1H-1,...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Abbott Laboratories | Assay Description Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of ... | Bioorg Med Chem Lett 19: 1718-21 (2009) Article DOI: 10.1016/j.bmcl.2009.01.086 BindingDB Entry DOI: 10.7270/Q2CJ8BTG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [696-1022,L858R] (Homo sapiens (Human)) | BDBM435711 (US10570155, Compound 1II | US11332479, Compound 1I...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.95 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SQ93MQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [696-1022,L858R] (Homo sapiens (Human)) | BDBM435718 (US10570155, Compound 2II | US11332479, Compound 2I...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SQ93MQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [696-1022,L858R] (Homo sapiens (Human)) | BDBM554457 (US11332479, Compound 31II) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.83 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SQ93MQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [696-1022,L858R] (Homo sapiens (Human)) | BDBM50289149 (GW305074X | GW5074 | US10570155, GW5074 | US113324...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.58 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SQ93MQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [696-1022,L858R] (Homo sapiens (Human)) | BDBM554465 (US11332479, Compound 52III) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.41 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SQ93MQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [696-1022,L858R] (Homo sapiens (Human)) | BDBM554458 (US11332479, Compound 37III) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SQ93MQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [696-1022,L858R] (Homo sapiens (Human)) | BDBM50396483 (PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SQ93MQ | |||||||||||
More data for this Ligand-Target Pair |