BindingDB PrimarySearch

Found 8 hits Enz. Inhib. hit(s) with Target = 'Nitric Oxide Synthase, brain Mutant (D597N)'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nitric oxide synthase, brain [D597N] (Rattus norvegicus (rat))	BDBM190667 (US10759791, Compound 14j \| nNOS inhibitor, 5) Show SMILES CNCCCc1cncc(CCc2cc(C)cc(N)n2)c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	46.7	-43.5	n/a	n/a	n/a	n/a	n/a	7.4	37
University of California , Irvine					Assay Description The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...				Biochemistry 55: 3702-7 (2016) Article DOI: 10.1021/acs.biochem.6b00261 BindingDB Entry DOI: 10.7270/Q2WW7GFX
University of California , Irvine					More data for this Ligand-Target Pair				3D Structure (crystal)
Nitric oxide synthase, brain [D597N] (Rattus norvegicus (rat))	BDBM190668 (US10759791, Compound 14k \| nNOS inhibitor, 6) Show SMILES CN(C)CCCc1cncc(CCc2cc(C)cc(N)n2)c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	97.5	-41.6	n/a	n/a	n/a	n/a	n/a	7.4	37
University of California , Irvine					Assay Description The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...				Biochemistry 55: 3702-7 (2016) Article DOI: 10.1021/acs.biochem.6b00261 BindingDB Entry DOI: 10.7270/Q2WW7GFX
University of California , Irvine					More data for this Ligand-Target Pair				3D Structure (crystal)
Nitric oxide synthase, brain [D597N] (Rattus norvegicus (rat))	BDBM152712 (4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...) Show SMILES CNCCN(C)c1cncc(CCc2cc(C)cc(N)n2)c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	139	-40.7	n/a	n/a	n/a	n/a	n/a	7.4	37
University of California , Irvine					Assay Description The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...				Biochemistry 55: 3702-7 (2016) Article DOI: 10.1021/acs.biochem.6b00261 BindingDB Entry DOI: 10.7270/Q2WW7GFX
University of California , Irvine					More data for this Ligand-Target Pair				3D Structure (crystal)
Nitric oxide synthase, brain [D597N] (Rattus norvegicus (rat))	BDBM190666 (US10759791, Compound 14h \| nNOS inhibitor, 4) Show SMILES CN1CCC(CC1)c1cncc(CCc2cc(C)cc(N)n2)c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	641	-36.8	n/a	n/a	n/a	n/a	n/a	7.4	37
University of California , Irvine					Assay Description The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...				Biochemistry 55: 3702-7 (2016) Article DOI: 10.1021/acs.biochem.6b00261 BindingDB Entry DOI: 10.7270/Q2WW7GFX
University of California , Irvine					More data for this Ligand-Target Pair				3D Structure (crystal)
Nitric oxide synthase, brain [D597N] (Rattus norvegicus (rat))	BDBM190665 (US10759791, Compound 14g \| nNOS inhibitor, 3) Show SMILES CN1CCN(CC1)c1cncc(CCc2cc(C)cc(N)n2)c1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	748	-36.4	n/a	n/a	n/a	n/a	n/a	7.4	37
University of California , Irvine					Assay Description The assay was performed at 37 °C in HEPES buffer (100 mM, with 10% glycerol, pH 7.4) in the presence of 10 uM L-arginine. Also included were 100 ...				Biochemistry 55: 3702-7 (2016) Article DOI: 10.1021/acs.biochem.6b00261 BindingDB Entry DOI: 10.7270/Q2WW7GFX
University of California , Irvine					More data for this Ligand-Target Pair				3D Structure (crystal)
Nitric oxide synthase, brain [D597N] (Rattus norvegicus (rat))	BDBM21961 ((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	2.10E+4	-27.1	n/a	n/a	n/a	n/a	n/a	7.5	30
University of California at Irvine					Assay Description Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...				Nat Struct Mol Biol 11: 54-9 (2004) Article DOI: 10.1038/nsmb704 BindingDB Entry DOI: 10.7270/Q27942ZS
University of California at Irvine					More data for this Ligand-Target Pair				3D Structure (crystal)
Nitric oxide synthase, brain [D597N] (Rattus norvegicus (rat))	BDBM21960 (3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	3.40E+4	-25.9	n/a	n/a	n/a	n/a	n/a	7.5	30
University of California at Irvine					Assay Description Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...				Nat Struct Mol Biol 11: 54-9 (2004) Article DOI: 10.1038/nsmb704 BindingDB Entry DOI: 10.7270/Q27942ZS
University of California at Irvine					More data for this Ligand-Target Pair				3D Structure (crystal)
Nitric oxide synthase, brain [D597N] (Rattus norvegicus (rat))	BDBM22030 ((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	6.70E+4	-24.2	n/a	n/a	n/a	n/a	n/a	7.5	30
University of California at Irvine					Assay Description Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...				Nat Struct Mol Biol 11: 54-9 (2004) Article DOI: 10.1038/nsmb704 BindingDB Entry DOI: 10.7270/Q27942ZS
University of California at Irvine					More data for this Ligand-Target Pair				3D Structure (crystal)