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Compile Data Set for Download or QSAR

Found 3619 hits Enz. Inhib. hit(s) with Target = 'Sodium/glucose cotransporter 1 (SGLT1)'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 35.6n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...

J Med Chem 51: 1145-9 (2008)


Article DOI: 10.1021/jm701272q
BindingDB Entry DOI: 10.7270/Q2PN93X4
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM20877
PNG
(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3occc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H26O9/c1-12-8-16(27)20(15(26)4-2-13-3-5-17-14(10-13)6-7-31-17)18(9-12)32-24-23(30)22(29)21(28)19(11-25)33-24/h3,5-10,19,21-25,27-30H,2,4,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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n/an/an/an/a 6.60n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...

J Med Chem 51: 1145-9 (2008)


Article DOI: 10.1021/jm701272q
BindingDB Entry DOI: 10.7270/Q2PN93X4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM20878
PNG
((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Show SMILES COc1ccc(Cc2ccccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H24O7/c1-25-14-8-6-12(7-9-14)10-13-4-2-3-5-15(13)26-20-19(24)18(23)17(22)16(11-21)27-20/h2-9,16-24H,10-11H2,1H3/t16-,17-,18+,19-,20-/m1/s1
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n/an/an/an/a 9.20n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...

J Med Chem 51: 1145-9 (2008)


Article DOI: 10.1021/jm701272q
BindingDB Entry DOI: 10.7270/Q2PN93X4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM20879
PNG
(C-aryl glucoside, 5 | CHEMBL429911 | N-ethyl-2,6-d...)
Show SMILES CCNC(=O)c1c(O)c(Cc2ccc(OC)cc2)cc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1O
Show InChI InChI=1S/C23H29NO9/c1-3-24-23(31)16-17(26)12(8-11-4-6-13(32-2)7-5-11)9-14(18(16)27)22-21(30)20(29)19(28)15(10-25)33-22/h4-7,9,15,19-22,25-30H,3,8,10H2,1-2H3,(H,24,31)/t15-,19-,20+,21-,22+/m1/s1
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n/an/an/an/a 1.30E+3n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...

J Med Chem 51: 1145-9 (2008)


Article DOI: 10.1021/jm701272q
BindingDB Entry DOI: 10.7270/Q2PN93X4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a 1.39E+3n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...

J Med Chem 51: 1145-9 (2008)


Article DOI: 10.1021/jm701272q
BindingDB Entry DOI: 10.7270/Q2PN93X4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20875
PNG
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1
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n/an/an/an/a 330n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...

J Med Chem 51: 1145-9 (2008)


Article DOI: 10.1021/jm701272q
BindingDB Entry DOI: 10.7270/Q2PN93X4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20877
PNG
(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Show SMILES Cc1cc(O)c(C(=O)CCc2ccc3occc3c2)c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1
Show InChI InChI=1S/C24H26O9/c1-12-8-16(27)20(15(26)4-2-13-3-5-17-14(10-13)6-7-31-17)18(9-12)32-24-23(30)22(29)21(28)19(11-25)33-24/h3,5-10,19,21-25,27-30H,2,4,11H2,1H3/t19-,21-,22+,23-,24-/m1/s1
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n/an/an/an/a 211n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...

J Med Chem 51: 1145-9 (2008)


Article DOI: 10.1021/jm701272q
BindingDB Entry DOI: 10.7270/Q2PN93X4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20878
PNG
((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Show SMILES COc1ccc(Cc2ccccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C20H24O7/c1-25-14-8-6-12(7-9-14)10-13-4-2-3-5-15(13)26-20-19(24)18(23)17(22)16(11-21)27-20/h2-9,16-24H,10-11H2,1H3/t16-,17-,18+,19-,20-/m1/s1
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n/an/an/an/a>8.00E+3n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...

J Med Chem 51: 1145-9 (2008)


Article DOI: 10.1021/jm701272q
BindingDB Entry DOI: 10.7270/Q2PN93X4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM20879
PNG
(C-aryl glucoside, 5 | CHEMBL429911 | N-ethyl-2,6-d...)
Show SMILES CCNC(=O)c1c(O)c(Cc2ccc(OC)cc2)cc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1O
Show InChI InChI=1S/C23H29NO9/c1-3-24-23(31)16-17(26)12(8-11-4-6-13(32-2)7-5-11)9-14(18(16)27)22-21(30)20(29)19(28)15(10-25)33-22/h4-7,9,15,19-22,25-30H,3,8,10H2,1-2H3,(H,24,31)/t15-,19-,20+,21-,22+/m1/s1
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n/an/an/an/a>8.00E+3n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...

J Med Chem 51: 1145-9 (2008)


Article DOI: 10.1021/jm701272q
BindingDB Entry DOI: 10.7270/Q2PN93X4
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM20880
PNG
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
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n/an/an/an/a 1.10n/an/a7.222



Bristol-Myers Squibb Company



Assay Description
Inhibitors were assayed for the ability to inhibit [14C]AMG uptake in a protein-free buffer over a 2 h incubation period. The response curve was fitt...

J Med Chem 51: 1145-9 (2008)


Article DOI: 10.1021/jm701272q
BindingDB Entry DOI: 10.7270/Q2PN93X4
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176427
PNG
(US9688710, 26 N-(2-methyl-1-(4-methylpiperazin-1-y...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(C)(C)C(=O)N3CCNCC3)cc2)c1 |r|
Show InChI InChI=1S/C33H47N3O6S/c1-21-9-14-24(30-28(39)27(38)29(40)31(42-30)43-4)20-25(21)19-23-12-10-22(11-13-23)7-5-6-8-26(37)35-33(2,3)32(41)36-17-15-34-16-18-36/h9-14,20,27-31,34,38-40H,5-8,15-19H2,1-4H3,(H,35,37)/t27-,28-,29+,30+,31-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176427
PNG
(US9688710, 26 N-(2-methyl-1-(4-methylpiperazin-1-y...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(C)(C)C(=O)N3CCNCC3)cc2)c1 |r|
Show InChI InChI=1S/C33H47N3O6S/c1-21-9-14-24(30-28(39)27(38)29(40)31(42-30)43-4)20-25(21)19-23-12-10-22(11-13-23)7-5-6-8-26(37)35-33(2,3)32(41)36-17-15-34-16-18-36/h9-14,20,27-31,34,38-40H,5-8,15-19H2,1-4H3,(H,35,37)/t27-,28-,29+,30+,31-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176428
PNG
(US9688710, 27 N-(1-hydroxy-2-methylpropan-2-yl)-5-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(C)(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C29H41NO6S/c1-18-9-14-21(27-25(34)24(33)26(35)28(36-27)37-4)16-22(18)15-20-12-10-19(11-13-20)7-5-6-8-23(32)30-29(2,3)17-31/h9-14,16,24-28,31,33-35H,5-8,15,17H2,1-4H3,(H,30,32)/t24-,25-,26+,27+,28-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176428
PNG
(US9688710, 27 N-(1-hydroxy-2-methylpropan-2-yl)-5-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCC(=O)NC(C)(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C29H41NO6S/c1-18-9-14-21(27-25(34)24(33)26(35)28(36-27)37-4)16-22(18)15-20-12-10-19(11-13-20)7-5-6-8-23(32)30-29(2,3)17-31/h9-14,16,24-28,31,33-35H,5-8,15,17H2,1-4H3,(H,30,32)/t24-,25-,26+,27+,28-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176403
PNG
(US9688710, 2 4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C23H27ClO7S/c1-32-23-21(29)19(27)20(28)22(31-23)14-6-9-17(24)15(12-14)11-13-4-7-16(8-5-13)30-10-2-3-18(25)26/h4-9,12,19-23,27-29H,2-3,10-11H2,1H3,(H,25,26)/t19-,20-,21+,22+,23-/m1/s1
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n/an/a>1.00E+3n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176403
PNG
(US9688710, 2 4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C23H27ClO7S/c1-32-23-21(29)19(27)20(28)22(31-23)14-6-9-17(24)15(12-14)11-13-4-7-16(8-5-13)30-10-2-3-18(25)26/h4-9,12,19-23,27-29H,2-3,10-11H2,1H3,(H,25,26)/t19-,20-,21+,22+,23-/m1/s1
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n/an/a 50n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176430
PNG
(US9688710, 29 (2S,3R,4R,5S,6R)-2-(3-(4-chlorobenzy...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(Cl)cc2)c1 |r|
Show InChI InChI=1S/C20H23ClO4S/c1-11-3-6-13(10-14(11)9-12-4-7-15(21)8-5-12)19-17(23)16(22)18(24)20(25-19)26-2/h3-8,10,16-20,22-24H,9H2,1-2H3/t16-,17-,18+,19+,20-/m1/s1
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n/an/a 50n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176430
PNG
(US9688710, 29 (2S,3R,4R,5S,6R)-2-(3-(4-chlorobenzy...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(Cl)cc2)c1 |r|
Show InChI InChI=1S/C20H23ClO4S/c1-11-3-6-13(10-14(11)9-12-4-7-15(21)8-5-12)19-17(23)16(22)18(24)20(25-19)26-2/h3-8,10,16-20,22-24H,9H2,1-2H3/t16-,17-,18+,19+,20-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176456
PNG
(US9688710, 55 N-(1,3-dihydroxypropan-2-yl)-4-(4-(2...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C27H37NO8S/c1-16-5-8-18(26-24(33)23(32)25(34)27(36-26)37-2)13-19(16)12-17-6-9-21(10-7-17)35-11-3-4-22(31)28-20(14-29)15-30/h5-10,13,20,23-27,29-30,32-34H,3-4,11-12,14-15H2,1-2H3,(H,28,31)/t23-,24-,25+,26+,27-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176456
PNG
(US9688710, 55 N-(1,3-dihydroxypropan-2-yl)-4-(4-(2...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)NC(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C27H37NO8S/c1-16-5-8-18(26-24(33)23(32)25(34)27(36-26)37-2)13-19(16)12-17-6-9-21(10-7-17)35-11-3-4-22(31)28-20(14-29)15-30/h5-10,13,20,23-27,29-30,32-34H,3-4,11-12,14-15H2,1-2H3,(H,28,31)/t23-,24-,25+,26+,27-/m1/s1
PDB

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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176457
PNG
(US9688710, 56 N-((R)-1-amino-1-oxopropan-2-yl)-4-(...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)N[C@H](C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C27H36N2O7S/c1-15-6-9-18(25-23(32)22(31)24(33)27(36-25)37-3)14-19(15)13-17-7-10-20(11-8-17)35-12-4-5-21(30)29-16(2)26(28)34/h6-11,14,16,22-25,27,31-33H,4-5,12-13H2,1-3H3,(H2,28,34)(H,29,30)/t16-,22-,23-,24+,25+,27-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176457
PNG
(US9688710, 56 N-((R)-1-amino-1-oxopropan-2-yl)-4-(...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)N[C@H](C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C27H36N2O7S/c1-15-6-9-18(25-23(32)22(31)24(33)27(36-25)37-3)14-19(15)13-17-7-10-20(11-8-17)35-12-4-5-21(30)29-16(2)26(28)34/h6-11,14,16,22-25,27,31-33H,4-5,12-13H2,1-3H3,(H2,28,34)(H,29,30)/t16-,22-,23-,24+,25+,27-/m1/s1
PDB

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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176458
PNG
(US9688710, 57 (S)-2-(4-(4-(2-methyl-5-((2S,3R,4R,5...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)N[C@@H](CC(N)=O)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C28H37N3O8S/c1-15-5-8-17(26-24(35)23(34)25(36)28(39-26)40-2)13-18(15)12-16-6-9-19(10-7-16)38-11-3-4-22(33)31-20(27(30)37)14-21(29)32/h5-10,13,20,23-26,28,34-36H,3-4,11-12,14H2,1-2H3,(H2,29,32)(H2,30,37)(H,31,33)/t20-,23+,24+,25-,26-,28+/m0/s1
PDB

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n/an/a 50n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176458
PNG
(US9688710, 57 (S)-2-(4-(4-(2-methyl-5-((2S,3R,4R,5...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCCCC(=O)N[C@@H](CC(N)=O)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C28H37N3O8S/c1-15-5-8-17(26-24(35)23(34)25(36)28(39-26)40-2)13-18(15)12-16-6-9-19(10-7-16)38-11-3-4-22(33)31-20(27(30)37)14-21(29)32/h5-10,13,20,23-26,28,34-36H,3-4,11-12,14H2,1-2H3,(H2,29,32)(H2,30,37)(H,31,33)/t20-,23+,24+,25-,26-,28+/m0/s1
PDB

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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176459
PNG
(US9688710, 58 2-methyl-2-(3-(5-(4-(2-methyl-5-((2S...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCNC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C30H43N3O6S/c1-18-9-14-21(26-24(35)23(34)25(36)27(39-26)40-4)17-22(18)16-20-12-10-19(11-13-20)8-6-5-7-15-32-29(38)33-30(2,3)28(31)37/h9-14,17,23-27,34-36H,5-8,15-16H2,1-4H3,(H2,31,37)(H2,32,33,38)/t23-,24-,25+,26+,27-/m1/s1
PDB

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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176459
PNG
(US9688710, 58 2-methyl-2-(3-(5-(4-(2-methyl-5-((2S...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCNC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C30H43N3O6S/c1-18-9-14-21(26-24(35)23(34)25(36)27(39-26)40-4)17-22(18)16-20-12-10-19(11-13-20)8-6-5-7-15-32-29(38)33-30(2,3)28(31)37/h9-14,17,23-27,34-36H,5-8,15-16H2,1-4H3,(H2,31,37)(H2,32,33,38)/t23-,24-,25+,26+,27-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176460
PNG
(US9688710, 59 1-(1-hydroxy-2-methylpropan-2-yl)-3-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCNC(=O)NC(C)(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C30H44N2O6S/c1-19-9-14-22(27-25(35)24(34)26(36)28(38-27)39-4)17-23(19)16-21-12-10-20(11-13-21)8-6-5-7-15-31-29(37)32-30(2,3)18-33/h9-14,17,24-28,33-36H,5-8,15-16,18H2,1-4H3,(H2,31,32,37)/t24-,25-,26+,27+,28-/m1/s1
PDB

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n/an/a 50n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176460
PNG
(US9688710, 59 1-(1-hydroxy-2-methylpropan-2-yl)-3-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCNC(=O)NC(C)(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C30H44N2O6S/c1-19-9-14-22(27-25(35)24(34)26(36)28(38-27)39-4)17-23(19)16-21-12-10-20(11-13-21)8-6-5-7-15-31-29(37)32-30(2,3)18-33/h9-14,17,24-28,33-36H,5-8,15-16,18H2,1-4H3,(H2,31,32,37)/t24-,25-,26+,27+,28-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176461
PNG
(US9688710, 60 N-(1-hydroxy-2-methylpropan-2-yl)-7-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCCC(=O)NC(C)(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C31H45NO6S/c1-20-11-16-23(29-27(36)26(35)28(37)30(38-29)39-4)18-24(20)17-22-14-12-21(13-15-22)9-7-5-6-8-10-25(34)32-31(2,3)19-33/h11-16,18,26-30,33,35-37H,5-10,17,19H2,1-4H3,(H,32,34)/t26-,27-,28+,29+,30-/m1/s1
PDB

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n/an/a 50n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176461
PNG
(US9688710, 60 N-(1-hydroxy-2-methylpropan-2-yl)-7-...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCCC(=O)NC(C)(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C31H45NO6S/c1-20-11-16-23(29-27(36)26(35)28(37)30(38-29)39-4)18-24(20)17-22-14-12-21(13-15-22)9-7-5-6-8-10-25(34)32-31(2,3)19-33/h11-16,18,26-30,33,35-37H,5-10,17,19H2,1-4H3,(H,32,34)/t26-,27-,28+,29+,30-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176462
PNG
(US9688710, 61 N-(1,3-dihydroxy-2-(hydroxymethyl)pr...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCCC(=O)NC(CO)(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C31H45NO8S/c1-20-9-14-23(29-27(38)26(37)28(39)30(40-29)41-2)16-24(20)15-22-12-10-21(11-13-22)7-5-3-4-6-8-25(36)32-31(17-33,18-34)19-35/h9-14,16,26-30,33-35,37-39H,3-8,15,17-19H2,1-2H3,(H,32,36)/t26-,27-,28+,29+,30-/m1/s1
PDB

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Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176462
PNG
(US9688710, 61 N-(1,3-dihydroxy-2-(hydroxymethyl)pr...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCCCCC(=O)NC(CO)(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C31H45NO8S/c1-20-9-14-23(29-27(38)26(37)28(39)30(40-29)41-2)16-24(20)15-22-12-10-21(11-13-22)7-5-3-4-6-8-25(36)32-31(17-33,18-34)19-35/h9-14,16,26-30,33-35,37-39H,3-8,15,17-19H2,1-2H3,(H,32,36)/t26-,27-,28+,29+,30-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176402
PNG
(US9688710, 1 (E)-3-(4-(2-methyl-5-((2S,3R,4R,5S,6R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\C(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C28H36N2O5S/c1-18-4-10-21(27-25(33)24(32)26(34)28(35-27)36-3)17-22(18)16-20-7-5-19(6-8-20)9-11-23(31)30-14-12-29(2)13-15-30/h4-11,17,24-28,32-34H,12-16H2,1-3H3/b11-9+/t24-,25-,26+,27+,28-/m1/s1
PDB

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n/an/a 50n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176402
PNG
(US9688710, 1 (E)-3-(4-(2-methyl-5-((2S,3R,4R,5S,6R...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\C(=O)N3CCN(C)CC3)cc2)c1 |r|
Show InChI InChI=1S/C28H36N2O5S/c1-18-4-10-21(27-25(33)24(32)26(34)28(35-27)36-3)17-22(18)16-20-7-5-19(6-8-20)9-11-23(31)30-14-12-29(2)13-15-30/h4-11,17,24-28,32-34H,12-16H2,1-3H3/b11-9+/t24-,25-,26+,27+,28-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176403
PNG
(US9688710, 2 4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C23H27ClO7S/c1-32-23-21(29)19(27)20(28)22(31-23)14-6-9-17(24)15(12-14)11-13-4-7-16(8-5-13)30-10-2-3-18(25)26/h4-9,12,19-23,27-29H,2-3,10-11H2,1H3,(H,25,26)/t19-,20-,21+,22+,23-/m1/s1
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n/an/a 550n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176403
PNG
(US9688710, 2 4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C23H27ClO7S/c1-32-23-21(29)19(27)20(28)22(31-23)14-6-9-17(24)15(12-14)11-13-4-7-16(8-5-13)30-10-2-3-18(25)26/h4-9,12,19-23,27-29H,2-3,10-11H2,1H3,(H,25,26)/t19-,20-,21+,22+,23-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176404
PNG
(US9688710, 3 4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C23H28ClNO6S/c1-32-23-21(29)19(27)20(28)22(31-23)14-6-9-17(24)15(12-14)11-13-4-7-16(8-5-13)30-10-2-3-18(25)26/h4-9,12,19-23,27-29H,2-3,10-11H2,1H3,(H2,25,26)/t19-,20-,21+,22+,23-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176404
PNG
(US9688710, 3 4-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCCC(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C23H28ClNO6S/c1-32-23-21(29)19(27)20(28)22(31-23)14-6-9-17(24)15(12-14)11-13-4-7-16(8-5-13)30-10-2-3-18(25)26/h4-9,12,19-23,27-29H,2-3,10-11H2,1H3,(H2,25,26)/t19-,20-,21+,22+,23-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176405
PNG
(US9688710, 4 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCC(O)CO)cc2)c1 |r|
Show InChI InChI=1S/C23H30O7S/c1-13-3-6-15(22-20(27)19(26)21(28)23(30-22)31-2)10-16(13)9-14-4-7-18(8-5-14)29-12-17(25)11-24/h3-8,10,17,19-28H,9,11-12H2,1-2H3/t17?,19-,20-,21+,22+,23-/m1/s1
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n/an/a 50n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176405
PNG
(US9688710, 4 4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(OCC(O)CO)cc2)c1 |r|
Show InChI InChI=1S/C23H30O7S/c1-13-3-6-15(22-20(27)19(26)21(28)23(30-22)31-2)10-16(13)9-14-4-7-18(8-5-14)29-12-17(25)11-24/h3-8,10,17,19-28H,9,11-12H2,1-2H3/t17?,19-,20-,21+,22+,23-/m1/s1
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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176406
PNG
(US9688710, 5 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-...)
Show SMILES COCCOCCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C24H31ClO7S/c1-29-9-10-30-11-12-31-18-6-3-15(4-7-18)13-17-14-16(5-8-19(17)25)23-21(27)20(26)22(28)24(32-23)33-2/h3-8,14,20-24,26-28H,9-13H2,1-2H3/t20-,21-,22+,23+,24-/m1/s1
PDB

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n/an/a 50n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176406
PNG
(US9688710, 5 (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-...)
Show SMILES COCCOCCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Show InChI InChI=1S/C24H31ClO7S/c1-29-9-10-30-11-12-31-18-6-3-15(4-7-18)13-17-14-16(5-8-19(17)25)23-21(27)20(26)22(28)24(32-23)33-2/h3-8,14,20-24,26-28H,9-13H2,1-2H3/t20-,21-,22+,23+,24-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176407
PNG
(US9688710, 6 N-(1-hydroxy-2-methylpropan-2-yl)-4-(...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C28H39NO6S/c1-17-8-13-20(26-24(33)23(32)25(34)27(35-26)36-4)15-21(17)14-19-11-9-18(10-12-19)6-5-7-22(31)29-28(2,3)16-30/h8-13,15,23-27,30,32-34H,5-7,14,16H2,1-4H3,(H,29,31)/t23-,24-,25+,26+,27-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176407
PNG
(US9688710, 6 N-(1-hydroxy-2-methylpropan-2-yl)-4-(...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)CO)cc2)c1 |r|
Show InChI InChI=1S/C28H39NO6S/c1-17-8-13-20(26-24(33)23(32)25(34)27(35-26)36-4)15-21(17)14-19-11-9-18(10-12-19)6-5-7-22(31)29-28(2,3)16-30/h8-13,15,23-27,30,32-34H,5-7,14,16H2,1-4H3,(H,29,31)/t23-,24-,25+,26+,27-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176408
PNG
(US9688710, 7 (S,E)-2-amino-5-(4-(2-methyl-5-((2S,3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\CC(N)C(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C25H31NO6S/c1-14-6-11-17(23-21(28)20(27)22(29)25(32-23)33-2)13-18(14)12-16-9-7-15(8-10-16)4-3-5-19(26)24(30)31/h3-4,6-11,13,19-23,25,27-29H,5,12,26H2,1-2H3,(H,30,31)/b4-3+/t19?,20-,21-,22+,23+,25-/m1/s1
PDB

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n/an/a 50n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176408
PNG
(US9688710, 7 (S,E)-2-amino-5-(4-(2-methyl-5-((2S,3...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(\C=C\CC(N)C(O)=O)cc2)c1 |r|
Show InChI InChI=1S/C25H31NO6S/c1-14-6-11-17(23-21(28)20(27)22(29)25(32-23)33-2)13-18(14)12-16-9-7-15(8-10-16)4-3-5-19(26)24(30)31/h3-4,6-11,13,19-23,25,27-29H,5,12,26H2,1-2H3,(H,30,31)/b4-3+/t19?,20-,21-,22+,23+,25-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176409
PNG
(US9688710, 8 N-(1,3-dihydroxy-2-(hydroxymethyl)pro...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(CO)(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C28H39NO8S/c1-17-6-11-20(26-24(35)23(34)25(36)27(37-26)38-2)13-21(17)12-19-9-7-18(8-10-19)4-3-5-22(33)29-28(14-30,15-31)16-32/h6-11,13,23-27,30-32,34-36H,3-5,12,14-16H2,1-2H3,(H,29,33)/t23-,24-,25+,26+,27-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176409
PNG
(US9688710, 8 N-(1,3-dihydroxy-2-(hydroxymethyl)pro...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(CO)(CO)CO)cc2)c1 |r|
Show InChI InChI=1S/C28H39NO8S/c1-17-6-11-20(26-24(35)23(34)25(36)27(37-26)38-2)13-21(17)12-19-9-7-18(8-10-19)4-3-5-22(33)29-28(14-30,15-31)16-32/h6-11,13,23-27,30-32,34-36H,3-5,12,14-16H2,1-2H3,(H,29,33)/t23-,24-,25+,26+,27-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1


(Homo sapiens (Human))		BDBM176410
PNG
(US9688710, 9 N-(1-amino-2-methyl-1-oxopropan-2-yl)...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C28H38N2O6S/c1-16-8-13-19(25-23(33)22(32)24(34)26(36-25)37-4)15-20(16)14-18-11-9-17(10-12-18)6-5-7-21(31)30-28(2,3)27(29)35/h8-13,15,22-26,32-34H,5-7,14H2,1-4H3,(H2,29,35)(H,30,31)/t22-,23-,24+,25+,26-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 1 (SGLT1; accession number NP_000334; GI: 4507031) was cloned into pIRESpuro2 vector for mammalian expressio...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM176410
PNG
(US9688710, 9 N-(1-amino-2-methyl-1-oxopropan-2-yl)...)
Show SMILES CS[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(C)c(Cc2ccc(CCCC(=O)NC(C)(C)C(N)=O)cc2)c1 |r|
Show InChI InChI=1S/C28H38N2O6S/c1-16-8-13-19(25-23(33)22(32)24(34)26(36-25)37-4)15-20(16)14-18-11-9-17(10-12-18)6-5-7-21(31)30-28(2,3)27(29)35/h8-13,15,22-26,32-34H,5-7,14H2,1-4H3,(H2,29,35)(H,30,31)/t22-,23-,24+,25+,26-/m1/s1
PDB

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n/an/a<10n/an/an/an/a7.3n/a



Lexicon Pharmaceuticals, Inc.

US Patent


Assay Description
Human sodium/glucose co-transporter type 2 (SGLT2; accession number P31639; GI:400337) was cloned into pIRESpuro2 vector for mammalian expression (co...

US Patent US9688710 (2017)


BindingDB Entry DOI: 10.7270/Q2154F7P
More data for this
Ligand-Target Pair
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