Compile Data Set for Download or QSAR

Found 5773 hits Enz. Inhib. hit(s) with Target = 'TGF-beta receptor type I'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283064 (6-(1-(2,2-difluoroethyl)-4-(3-(2-hydroxypropan-2- ...) Show SMILES CC(C)(O)c1cccc(c1)-c1ncn(CC(F)F)c1-c1ccc2ncc(C#N)n2n1 Show InChI InChI=1S/C21H18F2N6O/c1-21(2,30)14-5-3-4-13(8-14)19-20(28(12-26-19)11-17(22)23)16-6-7-18-25-10-15(9-24)29(18)27-16/h3-8,10,12,17,30H,11H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.80	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283065 (6-(4-(3-cyano-4-fluorophenyl)-1-(2,2-difluoroethyl...) Show SMILES FC(F)Cn1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)c(c1)C#N Show InChI InChI=1S/C19H10F3N7/c20-14-2-1-11(5-12(14)6-23)18-19(28(10-26-18)9-16(21)22)15-3-4-17-25-8-13(7-24)29(17)27-15/h1-5,8,10,16H,9H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283066 (6-(1-(1-cyanocyclopropyl)-4-(4-fluorophenyl)-1H- i...) Show SMILES Fc1ccc(cc1)-c1ncn(c1-c1ccc2ncc(C#N)n2n1)C1(CC1)C#N Show InChI InChI=1S/C20H12FN7/c21-14-3-1-13(2-4-14)18-19(27(12-25-18)20(11-23)7-8-20)16-5-6-17-24-10-15(9-22)28(17)26-16/h1-6,10,12H,7-8H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283067 (6-(1-(2-cyanoethyl)-4-(4-fluorophenyl)-1H-imidazol...) Show SMILES Fc1ccc(cc1)-c1ncn(CCC#N)c1-c1ccc2ncc(C#N)n2n1 Show InChI InChI=1S/C19H12FN7/c20-14-4-2-13(3-5-14)18-19(26(12-24-18)9-1-8-21)16-6-7-17-23-11-15(10-22)27(17)25-16/h2-7,11-12H,1,9H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283068 (6-(4-(4-fluorophenyl)-1-((1r,3s,5R,7S)-3- hydroxya...) Show SMILES [H]C12C[C@H]3C[C@@](O)(C1)C[C@](C3)(C2)n1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)cc1 |r,TLB:4:3:11:5.7.8,4:5:11:10.2.3,THB:6:5:11:10.2.3| Show InChI InChI=1S/C26H23FN6O/c27-19-3-1-18(2-4-19)23-24(21-5-6-22-29-13-20(12-28)33(22)31-21)32(15-30-23)25-8-16-7-17(9-25)11-26(34,10-16)14-25/h1-6,13,15-17,34H,7-11,14H2/t16-,17?,25+,26-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283070 (6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-2-meth...) Show SMILES Cc1nc(c(-c2ccc3nccn3c2)n1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C19H15F3N4/c1-12-24-18(13-2-5-15(20)6-3-13)19(26(12)11-16(21)22)14-4-7-17-23-8-9-25(17)10-14/h2-10,16H,11H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	172	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283071 (6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-2-meth...) Show SMILES Cc1nc(c(-c2ccc3ncc(C(N)=O)n3c2)n1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C20H16F3N5O/c1-11-26-18(12-2-5-14(21)6-3-12)19(27(11)10-16(22)23)13-4-7-17-25-8-15(20(24)29)28(17)9-13/h2-9,16H,10H2,1H3,(H2,24,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.4	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283072 (5-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-2-meth...) Show SMILES Cc1nc(c(-c2ccc3[nH]ncc3c2)n1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C19H15F3N4/c1-11-24-18(12-2-5-15(20)6-3-12)19(26(11)10-17(21)22)13-4-7-16-14(8-13)9-23-25-16/h2-9,17H,10H2,1H3,(H,23,25)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29.6	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283074 (N-((6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H...) Show SMILES FC(F)CNCc1cnc2ccc(cn12)-c1c(ncn1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C21H18F5N5/c22-15-4-1-13(2-5-15)20-21(30(12-29-20)11-18(25)26)14-3-6-19-28-8-16(31(19)10-14)7-27-9-17(23)24/h1-6,8,10,12,17-18,27H,7,9,11H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	121	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283075 (N-((6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H...) Show SMILES FC(F)Cn1cnc(c1-c1ccc2ncc(CNC3CC(F)(F)C3)n2c1)-c1ccc(F)cc1 Show InChI InChI=1S/C23H20F5N5/c24-16-4-1-14(2-5-16)21-22(32(13-31-21)12-19(25)26)15-3-6-20-30-10-18(33(20)11-15)9-29-17-7-23(27,28)8-17/h1-6,10-11,13,17,19,29H,7-9,12H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	988	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283076 (6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...) Show SMILES FC(F)Cn1cnc(c1-c1ccc2ncc(C(F)F)n2c1)-c1ccc(F)cc1 Show InChI InChI=1S/C19H13F5N4/c20-13-4-1-11(2-5-13)17-18(27(10-26-17)9-15(21)22)12-3-6-16-25-7-14(19(23)24)28(16)8-12/h1-8,10,15,19H,9H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20.9	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283077 (1-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H-...) Show SMILES CC(C)(O)c1cnc2ccc(cn12)-c1c(ncn1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C21H19F3N4O/c1-21(2,29)16-9-25-18-8-5-14(10-28(16)18)20-19(13-3-6-15(22)7-4-13)26-12-27(20)11-17(23)24/h3-10,12,17,29H,11H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	184	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283079 (N-cyclopropyl-6-(1-(2,2-difluoroethyl)-4-(4- fluor...) Show SMILES FC(F)Cn1cnc(c1-c1ccc2ncc(C(=O)NC3CC3)n2c1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H18F3N5O/c23-15-4-1-13(2-5-15)20-21(29(12-27-20)11-18(24)25)14-3-8-19-26-9-17(30(19)10-14)22(31)28-16-6-7-16/h1-5,8-10,12,16,18H,6-7,11H2,(H,28,31)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283080 (N-(2-amino-2-oxoethyl)-6-(1-(2,2-difluoroethyl)-4-...) Show SMILES NC(=O)CNC(=O)c1cnc2ccc(cn12)-c1c(ncn1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C21H17F3N6O2/c22-14-4-1-12(2-5-14)19-20(29(11-28-19)10-16(23)24)13-3-6-18-26-7-15(30(18)9-13)21(32)27-8-17(25)31/h1-7,9,11,16H,8,10H2,(H2,25,31)(H,27,32)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283081 (6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...) Show SMILES FC(F)Cn1cnc(c1-c1ccc2nncn2c1)-c1ccc(F)cc1 Show InChI InChI=1S/C17H12F3N5/c18-13-4-1-11(2-5-13)16-17(25(9-21-16)8-14(19)20)12-3-6-15-23-22-10-24(15)7-12/h1-7,9-10,14H,8H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	522	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283082 (7-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...) Show SMILES FC(F)Cn1cnc(c1-c1ccn2ncnc2c1)-c1ccc(F)cc1 Show InChI InChI=1S/C17H12F3N5/c18-13-3-1-11(2-4-13)16-17(24(10-22-16)8-14(19)20)12-5-6-25-15(7-12)21-9-23-25/h1-7,9-10,14H,8H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.9	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283083 (6-(2-(4-fluorophenyl)-6,7-dihydro-5H-pyrrolo[1,2- ...) Show SMILES NC(=O)c1cnc2ccc(cn12)-c1c(nc2CCCn12)-c1ccc(F)cc1 Show InChI InChI=1S/C20H16FN5O/c21-14-6-3-12(4-7-14)18-19(25-9-1-2-17(25)24-18)13-5-8-16-23-10-15(20(22)27)26(16)11-13/h3-8,10-11H,1-2,9H2,(H2,22,27)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283085 (US10287295, Example 284' | US11352360, Example 284...) Show SMILES COC(=O)Nc1cnc2ccc(cn12)-c1c(ncn1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C20H16F3N5O2/c1-30-20(29)26-17-8-24-16-7-4-13(9-28(16)17)19-18(12-2-5-14(21)6-3-12)25-11-27(19)10-15(22)23/h2-9,11,15H,10H2,1H3,(H,26,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	426	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283087 (3-cyclopropyl-6-(1-(2,2-difluoroethyl)-4-(4- fluor...) Show SMILES FC(F)Cn1cnc(c1-c1ccc2ncc(C3CC3)n2c1)-c1ccc(F)cc1 Show InChI InChI=1S/C21H17F3N4/c22-16-6-3-14(4-7-16)20-21(27(12-26-20)11-18(23)24)15-5-8-19-25-9-17(13-1-2-13)28(19)10-15/h3-10,12-13,18H,1-2,11H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	38.8	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283088 (6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...) Show SMILES FC(F)Cn1cnc(c1-c1ccc2ncc(F)n2c1)-c1ccc(F)cc1 Show InChI InChI=1S/C18H12F4N4/c19-13-4-1-11(2-5-13)17-18(25(10-24-17)9-14(20)21)12-3-6-16-23-7-15(22)26(16)8-12/h1-8,10,14H,9H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	56.7	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283089 (4-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H-...) Show SMILES FC(F)Cn1cnc(c1-c1ccc2ncc(N3CCOCC3)n2c1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H20F3N5O/c23-17-4-1-15(2-5-17)21-22(29(14-27-21)13-18(24)25)16-3-6-19-26-11-20(30(19)12-16)28-7-9-31-10-8-28/h1-6,11-12,14,18H,7-10,13H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	376	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283090 (6-(2-(4-fluorophenyl)-5,6,7,8-tetrahydroimidazo[1,...) Show SMILES NC(=O)c1cnc2ccc(cn12)-c1c(nc2CNCCn12)-c1ccc(F)cc1 Show InChI InChI=1S/C20H17FN6O/c21-14-4-1-12(2-5-14)18-19(26-8-7-23-10-17(26)25-18)13-3-6-16-24-9-15(20(22)28)27(16)11-13/h1-6,9,11,23H,7-8,10H2,(H2,22,28)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21.6	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283091 (US10287295, Example 291' | US11352360, Example 291...) Show SMILES COC(=O)N1CCn2c(C1)nc(c2-c1ccc2ncc(C(N)=O)n2c1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H19FN6O3/c1-32-22(31)27-8-9-28-18(12-27)26-19(13-2-5-15(23)6-3-13)20(28)14-4-7-17-25-10-16(21(24)30)29(17)11-14/h2-7,10-11H,8-9,12H2,1H3,(H2,24,30)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30.5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283092 (6-(7-acetyl-2-(4-fluorophenyl)-5,6,7,8- tetrahydro...) Show SMILES CC(=O)N1CCn2c(C1)nc(c2-c1ccc2ncc(C(N)=O)n2c1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H19FN6O2/c1-13(30)27-8-9-28-19(12-27)26-20(14-2-5-16(23)6-3-14)21(28)15-4-7-18-25-10-17(22(24)31)29(18)11-15/h2-7,10-11H,8-9,12H2,1H3,(H2,24,31)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40.8	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283093 (6-(2-(4-fluorophenyl)-7-methyl-5,6,7,8- tetrahydro...) Show SMILES CN1CCn2c(C1)nc(c2-c1ccc2ncc(C(N)=O)n2c1)-c1ccc(F)cc1 Show InChI InChI=1S/C21H19FN6O/c1-26-8-9-27-18(12-26)25-19(13-2-5-15(22)6-3-13)20(27)14-4-7-17-24-10-16(21(23)29)28(17)11-14/h2-7,10-11H,8-9,12H2,1H3,(H2,23,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43.3	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283094 (6-(7-(2,2-difluoroethyl)-2-(4-fluorophenyl)-5,6,7,...) Show SMILES NC(=O)c1cnc2ccc(cn12)-c1c(nc2CN(CC(F)F)CCn12)-c1ccc(F)cc1 Show InChI InChI=1S/C22H19F3N6O/c23-15-4-1-13(2-5-15)20-21(30-8-7-29(11-17(24)25)12-19(30)28-20)14-3-6-18-27-9-16(22(26)32)31(18)10-14/h1-6,9-10,17H,7-8,11-12H2,(H2,26,32)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.2	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283095 (N-(4-(4-fluorophenyl)-5-(imidazo[1,2-a]pyridin-6-y...) Show SMILES CC(=O)Nc1nc(c([nH]1)-c1ccc2nccn2c1)-c1ccc(F)cc1 Show InChI InChI=1S/C18H14FN5O/c1-11(25)21-18-22-16(12-2-5-14(19)6-3-12)17(23-18)13-4-7-15-20-8-9-24(15)10-13/h2-10H,1H3,(H2,21,22,23,25)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283096 (1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-5- (imida...) Show SMILES Nc1nc(c(-c2ccc3nccn3c2)n1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C18H14F3N5/c19-13-4-1-11(2-5-13)16-17(26(10-14(20)21)18(22)24-16)12-3-6-15-23-7-8-25(15)9-12/h1-9,14H,10H2,(H2,22,24)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	109	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283097 (N-(5-(3-cyanoimidazo[1,2-a]pyridin-6-yl)-1-(2,2- d...) Show SMILES CC(=O)Nc1nc(c(-c2ccc3ncc(C#N)n3c2)n1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C21H15F3N6O/c1-12(31)27-21-28-19(13-2-5-15(22)6-3-13)20(30(21)11-17(23)24)14-4-7-18-26-9-16(8-25)29(18)10-14/h2-7,9-10,17H,11H2,1H3,(H,27,28,31)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	542	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283098 (6-(2-amino-1-(2,2-difluoroethyl)-4-(4-fluorophenyl...) Show SMILES Nc1nc(c(-c2ccc3ncc(C#N)n3c2)n1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C19H13F3N6/c20-13-4-1-11(2-5-13)17-18(28(10-15(21)22)19(24)26-17)12-3-6-16-25-8-14(7-23)27(16)9-12/h1-6,8-9,15H,10H2,(H2,24,26)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	44.8	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283099 (6-(1-(azetidin-3-yl)-4-(4-fluorophenyl)-1H-imidazo...) Show SMILES Fc1ccc(cc1)-c1ncn(C2CNC2)c1-c1ccc2ncc(C#N)n2n1 Show InChI InChI=1S/C19H14FN7/c20-13-3-1-12(2-4-13)18-19(26(11-24-18)15-8-22-9-15)16-5-6-17-23-10-14(7-21)27(17)25-16/h1-6,10-11,15,22H,8-9H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	86.2	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283100 (US10287295, Example 195A' | US11352360, Example 19...) Show SMILES CC(C)(C)OC(=O)N1CC(C1)n1cnc(c1-c1ccc2ncc(C(N)=O)n2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C24H24FN7O3/c1-24(2,3)35-23(34)30-11-16(12-30)31-13-28-20(14-4-6-15(25)7-5-14)21(31)17-8-9-19-27-10-18(22(26)33)32(19)29-17/h4-10,13,16H,11-12H2,1-3H3,(H2,26,33)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	244	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282873 (6-(4-(4-fluorophenyl)-1-(oxetan-3-yl)-1H-imidazol-...) Show SMILES Fc1ccc(cc1)-c1ncn(C2COC2)c1-c1ccc2ncc(C#N)n2c1 Show InChI InChI=1S/C20H14FN5O/c21-15-4-1-13(2-5-15)19-20(26(12-24-19)17-10-27-11-17)14-3-6-18-23-8-16(7-22)25(18)9-14/h1-6,8-9,12,17H,10-11H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	568	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283069 (6-(4-(4-fluorophenyl)-1-neopentyl-1H-imidazol-5- y...) Show SMILES CC(C)(C)Cn1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C21H19FN6/c1-21(2,3)12-27-13-25-19(14-4-6-15(22)7-5-14)20(27)17-8-9-18-24-11-16(10-23)28(18)26-17/h4-9,11,13H,12H2,1-3H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	99.2	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283073 (1-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H-...) Show SMILES CC(O)c1cnc2ccc(cn12)-c1c(ncn1CC(F)F)-c1ccc(F)cc1 |w:1.1| Show InChI InChI=1S/C20H17F3N4O/c1-12(28)16-8-24-18-7-4-14(9-27(16)18)20-19(13-2-5-15(21)6-3-13)25-11-26(20)10-17(22)23/h2-9,11-12,17,28H,10H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	137	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282897 (6-(4-(3-Chlorpohenyl)-2-methyl-1H-imidazol-5-yl)- ...) Show SMILES Cc1nc(c([nH]1)-c1ccc2cn[nH]c2c1)-c1cccc(Cl)c1 Show InChI InChI=1S/C17H13ClN4/c1-10-20-16(11-3-2-4-14(18)7-11)17(21-10)12-5-6-13-9-19-22-15(13)8-12/h2-9H,1H3,(H,19,22)(H,20,21)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282901 (6-(1-(3,3-difluorocyclobutyl)-4-(4-fluorophenyl)-1...) Show SMILES NC(=O)c1cnc2ccc(nn12)-c1c(ncn1C1CC(F)(F)C1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H15F3N6O/c21-12-3-1-11(2-4-12)17-18(28(10-26-17)13-7-20(22,23)8-13)14-5-6-16-25-9-15(19(24)30)29(16)27-14/h1-6,9-10,13H,7-8H2,(H2,24,30)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.10	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282794 (6-(1-(3,3-difluorocyclobutyl)-4-(4-fluorophenyl)-1...) Show SMILES Fc1ccc(cc1)-c1ncn(C2CC(F)(F)C2)c1-c1ccc2ncc(C#N)n2n1 Show InChI InChI=1S/C20H13F3N6/c21-13-3-1-12(2-4-13)18-19(28(11-26-18)14-7-20(22,23)8-14)16-5-6-17-25-10-15(9-24)29(17)27-16/h1-6,10-11,14H,7-8H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.2	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282799 (6-(1-(4,4-difluorocyclohexyl)-4-(4-fluorophenyl)-1...) Show SMILES Fc1ccc(cc1)-c1ncn(C2CCC(F)(F)CC2)c1-c1ccc2ncc(C#N)n2n1 Show InChI InChI=1S/C22H17F3N6/c23-15-3-1-14(2-4-15)20-21(18-5-6-19-27-12-17(11-26)31(19)29-18)30(13-28-20)16-7-9-22(24,25)10-8-16/h1-6,12-13,16H,7-10H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.9	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282817 (6-(4-(4-fluorophenyl)-1-isopropyl-1H-imidazol-5- y...) Show SMILES CC(C)n1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)cc1 Show InChI InChI=1S/C19H15FN6/c1-12(2)25-11-23-18(13-3-5-14(20)6-4-13)19(25)16-7-8-17-22-10-15(9-21)26(17)24-16/h3-8,10-12H,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282821 ((R)-6-(4-(4-fluorophenyl)-1-(4,4,4-trifluoro-1- hy...) Show SMILES OC[C@@H](CC(F)(F)F)n1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C20H14F4N6O/c21-13-3-1-12(2-4-13)18-19(29(11-27-18)14(10-31)7-20(22,23)24)16-5-6-17-26-9-15(8-25)30(17)28-16/h1-6,9,11,14,31H,7,10H2/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282832 (6-(4-(3-chloro-4-fluorophenyl)-1-((cis)-3- hydroxy...) Show SMILES O[C@H]1C[C@H](C1)n1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)c(Cl)c1 |r,wU:3.5,1.0,(-2.83,-5.84,;-1.74,-4.75,;-1.74,-3.21,;-.2,-3.21,;-.2,-4.75,;.88,-2.12,;2.35,-2.6,;3.25,-1.35,;2.35,-.11,;.88,-.58,;-.45,.19,;-.45,1.73,;-1.78,2.5,;-3.12,1.73,;-4.58,2.2,;-5.49,.96,;-4.58,-.29,;-5.06,-1.75,;-5.53,-3.22,;-3.12,.19,;-1.78,-.58,;2.75,1.38,;1.66,2.47,;2.06,3.96,;3.54,4.35,;3.94,5.84,;4.63,3.27,;6.12,3.66,;4.24,1.78,)| Show InChI InChI=1S/C20H14ClFN6O/c21-15-5-11(1-2-16(15)22)19-20(27(10-25-19)12-6-14(29)7-12)17-3-4-18-24-9-13(8-23)28(18)26-17/h1-5,9-10,12,14,29H,6-7H2/t12-,14+	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282836 (6-(4-(3-chloro-4-fluorophenyl)-1-(3-methyloxetan-3...) Show SMILES CC1(COC1)n1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C20H14ClFN6O/c1-20(9-29-10-20)27-11-25-18(12-2-3-15(22)14(21)6-12)19(27)16-4-5-17-24-8-13(7-23)28(17)26-16/h2-6,8,11H,9-10H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM282999 (US10287295, Example 201' | US11352360, Example 201...) Show SMILES CC(C)OC(=O)NCc1cnc2ccc(nn12)-c1c(ncn1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C22H21F3N6O2/c1-13(2)33-22(32)27-10-16-9-26-19-8-7-17(29-31(16)19)21-20(14-3-5-15(23)6-4-14)28-12-30(21)11-18(24)25/h3-9,12-13,18H,10-11H2,1-2H3,(H,27,32)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283000 (N-((6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H...) Show SMILES CC(C)(C)C(=O)NCc1cnc2ccc(nn12)-c1c(ncn1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C23H23F3N6O/c1-23(2,3)22(33)28-11-16-10-27-19-9-8-17(30-32(16)19)21-20(14-4-6-15(24)7-5-14)29-13-31(21)12-18(25)26/h4-10,13,18H,11-12H2,1-3H3,(H,28,33)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43.8	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283001 (6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...) Show SMILES ONC(=N)c1cnc2ccc(nn12)-c1c(ncn1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C18H14F3N7O/c19-11-3-1-10(2-4-11)16-17(27(9-24-16)8-14(20)21)12-5-6-15-23-7-13(18(22)26-29)28(15)25-12/h1-7,9,14,29H,8H2,(H2,22,26)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283002 (2-(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H-...) Show SMILES CC(C)(O)c1cnc2ccc(nn12)-c1c(ncn1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C20H18F3N5O/c1-20(2,29)15-9-24-17-8-7-14(26-28(15)17)19-18(12-3-5-13(21)6-4-12)25-11-27(19)10-16(22)23/h3-9,11,16,29H,10H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283003 (6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...) Show SMILES NNC(=O)c1cnc2ccc(nn12)-c1c(ncn1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C18H14F3N7O/c19-11-3-1-10(2-4-11)16-17(27(9-24-16)8-14(20)21)12-5-6-15-23-7-13(18(29)25-22)28(15)26-12/h1-7,9,14H,8,22H2,(H,25,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283004 (6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...) Show SMILES CNC(=O)c1cnc2ccc(nn12)-c1c(ncn1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C19H15F3N6O/c1-23-19(29)14-8-24-16-7-6-13(26-28(14)16)18-17(11-2-4-12(20)5-3-11)25-10-27(18)9-15(21)22/h2-8,10,15H,9H2,1H3,(H,23,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM283005 (6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...) Show SMILES CN(C)C(=O)c1cnc2ccc(nn12)-c1c(ncn1CC(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C20H17F3N6O/c1-27(2)20(30)15-9-24-17-8-7-14(26-29(15)17)19-18(12-3-5-13(21)6-4-12)25-11-28(19)10-16(22)23/h3-9,11,16H,10H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	25
Rigel Pharmaceuticals, Inc.; Bristol-Myers Squibb Company US Patent					Assay Description Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...				US Patent US9884868 (2018) BindingDB Entry DOI: 10.7270/Q20P122M
					More data for this Ligand-Target Pair

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