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Found 105 hits Enz. Inhib. hit(s) with Target = '6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM200906
PNG
(US9233946, 5)
Show SMILES CC(C)c1ccc2sc(c(C)c2c1)S(=O)(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C19H19NO4S2/c1-11(2)13-7-8-17-16(10-13)12(3)19(25-17)26(23,24)20-15-6-4-5-14(9-15)18(21)22/h4-11,20H,1-3H3,(H,21,22)
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n/an/a 60n/an/an/an/an/an/a



KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM200908
PNG
(US9233946, 7)
Show SMILES CC(C)c1ccc2sc(c(C)c2c1)S(=O)(=O)Nc1ncc(s1)C(O)=O
Show InChI InChI=1S/C16H16N2O4S3/c1-8(2)10-4-5-12-11(6-10)9(3)15(23-12)25(21,22)18-16-17-7-13(24-16)14(19)20/h4-8H,1-3H3,(H,17,18)(H,19,20)
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n/an/a 100n/an/an/an/an/an/a



KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM200939
PNG
(US9233946, 38)
Show SMILES Cc1c(sc2ccc(Cl)cc12)S(=O)(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C16H12ClNO4S2/c1-9-13-8-11(17)5-6-14(13)23-16(9)24(21,22)18-12-4-2-3-10(7-12)15(19)20/h2-8,18H,1H3,(H,19,20)
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n/an/a 130n/an/an/an/an/an/a



KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM200941
PNG
(US9233946, 40)
Show SMILES Cc1ccc2sc(cc2c1)S(=O)(=O)Nc1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C16H13N5O2S2/c1-10-5-6-14-12(7-10)9-15(24-14)25(22,23)19-13-4-2-3-11(8-13)16-17-20-21-18-16/h2-9,19H,1H3,(H,17,18,20,21)
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n/an/a 140n/an/an/an/an/an/a



KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM200944
PNG
(US9233946, 43)
Show SMILES Cc1c(sc2ccc(F)cc12)S(=O)(=O)Nc1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C16H12FN5O2S2/c1-9-13-8-11(17)5-6-14(13)25-16(9)26(23,24)20-12-4-2-3-10(7-12)15-18-21-22-19-15/h2-8,20H,1H3,(H,18,19,21,22)
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n/an/a 170n/an/an/an/an/an/a



KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM201035
PNG
(US9233946, 134)
Show SMILES Cc1c(sc2ccc(Cl)cc12)S(=O)(=O)Nc1cccc(C(O)=O)c1O
Show InChI InChI=1S/C16H12ClNO5S2/c1-8-11-7-9(17)5-6-13(11)24-16(8)25(22,23)18-12-4-2-3-10(14(12)19)15(20)21/h2-7,18-19H,1H3,(H,20,21)
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n/an/a 180n/an/an/an/an/an/a



KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM200945
PNG
(US9233946, 44)
Show SMILES Cc1c(sc2c(Cl)cccc12)S(=O)(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C16H12ClNO4S2/c1-9-12-6-3-7-13(17)14(12)23-16(9)24(21,22)18-11-5-2-4-10(8-11)15(19)20/h2-8,18H,1H3,(H,19,20)
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n/an/a 200n/an/an/an/an/an/a



KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267057
PNG
(2-Hydroxyethyl 4-{[(5'-fluoro-2'-hydroxybiphenyl-3...)
Show SMILES OCCOC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2cc(F)ccc2O)cc1O
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n/an/a 200n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267062
PNG
(Butyl 4-{[(4,5-dichloro-2-thienyl)sulfonyl]amino}-...)
Show SMILES CCCCOC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)cc1O
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n/an/a 200n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM200917
PNG
(US9233946, 16)
Show SMILES O=S(=O)(Nc1cccc(c1)-c1nnn[nH]1)c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C19H15N5O2S/c25-27(26,18-11-5-8-15(13-18)14-6-2-1-3-7-14)22-17-10-4-9-16(12-17)19-20-23-24-21-19/h1-13,22H,(H,20,21,23,24)
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n/an/a 390n/an/an/an/an/an/a



KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM200922
PNG
(US9233946, 21)
Show SMILES CSc1nccc(n1)-c1ccc(s1)S(=O)(=O)Nc1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C16H13N7O2S3/c1-26-16-17-8-7-12(18-16)13-5-6-14(27-13)28(24,25)21-11-4-2-3-10(9-11)15-19-22-23-20-15/h2-9,21H,1H3,(H,19,20,22,23)
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n/an/a 420n/an/an/an/an/an/a



KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM200943
PNG
(US9233946, 42)
Show SMILES COc1cccc2c(C)c(sc12)S(=O)(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H15NO5S2/c1-10-13-7-4-8-14(23-2)15(13)24-17(10)25(21,22)18-12-6-3-5-11(9-12)16(19)20/h3-9,18H,1-2H3,(H,19,20)
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n/an/a 420n/an/an/an/an/an/a



KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM200928
PNG
(US9233946, 27)
Show SMILES Cc1ccc(cc1)-c1ccc(s1)S(=O)(=O)Nc1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C18H15N5O2S2/c1-12-5-7-13(8-6-12)16-9-10-17(26-16)27(24,25)21-15-4-2-3-14(11-15)18-19-22-23-20-18/h2-11,21H,1H3,(H,19,20,22,23)
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n/an/a 480n/an/an/an/an/an/a



KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM200919
PNG
(US9233946, 18)
Show SMILES FC(F)(F)c1cc(Cl)c(c(Cl)c1)S(=O)(=O)Nc1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C14H8Cl2F3N5O2S/c15-10-5-8(14(17,18)19)6-11(16)12(10)27(25,26)22-9-3-1-2-7(4-9)13-20-23-24-21-13/h1-6,22H,(H,20,21,23,24)
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KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267074
PNG
(3-Morpholin-4-ylpropyl 4-({[5-chloro-4-(5-fluoro-2...)
Show SMILES CC1CN(CCCOC(=O)c2ccc(NS(=O)(=O)c3cc(c(Cl)s3)-c3cc(F)ccc3O)cc2O)CCO1
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n/an/a 600n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM201002
PNG
(US9233946, 101)
Show SMILES Fc1ccc(-c2ccc(s2)S(=O)(=O)Nc2cccc(c2)-c2nnn[nH]2)c(F)c1
Show InChI InChI=1S/C17H11F2N5O2S2/c18-11-4-5-13(14(19)9-11)15-6-7-16(27-15)28(25,26)22-12-3-1-2-10(8-12)17-20-23-24-21-17/h1-9,22H,(H,20,21,23,24)
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n/an/a 600n/an/an/an/an/an/a



KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267054
PNG
(2-(1H-Pyrrol-1-yl)ethyl 4-{[(4,5-dichlorothiophen-...)
Show SMILES Oc1cc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)ccc1C(=O)OCCn1cccc1
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n/an/a 600n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM201003
PNG
(US9233946, 102)
Show SMILES Fc1ccc(cc1Cl)-c1ccc(s1)S(=O)(=O)Nc1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C17H11ClFN5O2S2/c18-13-9-10(4-5-14(13)19)15-6-7-16(27-15)28(25,26)22-12-3-1-2-11(8-12)17-20-23-24-21-17/h1-9,22H,(H,20,21,23,24)
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n/an/a 660n/an/an/an/an/an/a



KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM200925
PNG
(US9233946, 24)
Show SMILES COc1ccccc1-c1ccc(s1)S(=O)(=O)Nc1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C18H15N5O3S2/c1-26-15-8-3-2-7-14(15)16-9-10-17(27-16)28(24,25)21-13-6-4-5-12(11-13)18-19-22-23-20-18/h2-11,21H,1H3,(H,19,20,22,23)
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KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267055
PNG
(2-Methoxyethyl 4-({[3-(2,3-dihydro-1-benzofuran-5-...)
Show SMILES COCCOC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2ccc3OCCc3c2)cc1O
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n/an/a 700n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM200927
PNG
(US9233946, 26)
Show SMILES Clc1ccccc1-c1ccc(s1)S(=O)(=O)Nc1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C17H12ClN5O2S2/c18-14-7-2-1-6-13(14)15-8-9-16(26-15)27(24,25)21-12-5-3-4-11(10-12)17-19-22-23-20-17/h1-10,21H,(H,19,20,22,23)
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n/an/a 750n/an/an/an/an/an/a



KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267082
PNG
(3-[(5-Methylisoxazol-3-yl)amino]propyl 4-{[(5'-flu...)
Show SMILES Cc1cc(NCCCOC(=O)c2ccc(NS(=O)(=O)c3cccc(c3)-c3cc(F)ccc3O)cc2O)no1
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n/an/a 800n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267065
PNG
(2-Methoxy-1-methylethyl 4-{[(4,5-dichlorothiophen-...)
Show SMILES COCC(C)OC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)cc1O
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n/an/a 800n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267064
PNG
(Benzyl 4-{[(4,5-dichloro-2-thienyl)sulfonyl]amino}...)
Show SMILES Oc1cc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)ccc1C(=O)OCc1ccccc1
PDB

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n/an/a 800n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267031
PNG
(4-{[(5-Chloro-4-phenyl-2-thienyl)sulfonyl]amino}-2...)
Show SMILES OC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccccc2)cc1O
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n/an/a 800n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267031
PNG
(4-{[(5-Chloro-4-phenyl-2-thienyl)sulfonyl]amino}-2...)
Show SMILES OC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccccc2)cc1O
PDB

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n/an/a 900n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267066
PNG
(2-Methoxyethyl 4-({[5-chloro-4-(2,3-dihydro-1-benz...)
Show SMILES COCCOC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccc3OCCc3c2)cc1O
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n/an/a 900n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267068
PNG
(General Procedure 9 | US9718809, 82)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2ccccc2O)cc1O
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n/an/a 1.08E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267035
PNG
(2-Methoxyethyl 4-({[5-chloro-4-(2-hydroxyphenyl)-2...)
Show SMILES COCCOC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccccc2O)cc1O
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n/an/a 1.20E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267063
PNG
(1-Methyl-3-morpholin-4-ylpropyl 4-{[(4,5-dichlorot...)
Show SMILES CC(CCN1CCOCC1)OC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)cc1O
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n/an/a 1.20E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267061
PNG
(2-Methoxy-1-(methoxymethyl)ethyl 4-{[(3,5-dichloro...)
Show SMILES COCC(COC)OC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)cc1O
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n/an/a 1.40E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267030
PNG
(Methyl 2-hydroxy-4-({[(2'-hydroxybiphenyl-4-yl)met...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)Cc2ccc(cc2)-c2ccccc2O)cc1O
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n/an/a 1.40E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267076
PNG
(2-Hydroxyethyl 4-{[(5-chloro-4-phenyl-2-thienyl)su...)
Show SMILES OCCOC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2ccccc2)cc1O
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n/an/a 1.40E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267039
PNG
(Methyl 2-hydroxy-4-({[3-(piperidin-1-yl)phenyl]sul...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)N2CCCCC2)cc1O
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n/an/a 1.50E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267033
PNG
(Methyl 2-(acetyloxy)-4-{[(4,5-dichlorothiophen-2-y...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)c(Cl)s2)cc1OC(C)=O
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n/an/a 1.50E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267071
PNG
(Methyl 4-[(biphenyl-3-ylsulfonyl)amino]-2-hydroxyb...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2ccccc2)cc1O
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n/an/a 1.60E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267025
PNG
(4-{[(4-Bromo-2,5-dichlorothiophen-3-yl)sulfonyl]am...)
Show SMILES OC(=O)c1ccc(NS(=O)(=O)c2c(Cl)sc(Cl)c2Br)cc1O
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n/an/a 1.70E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267077
PNG
(Methyl 4-({[3-(5-acetyl-2-thienyl)phenyl]sulfonyl}...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2ccc(s2)C(C)=O)cc1O
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n/an/a 1.70E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267024
PNG
(Methyl 4-({[3-(2,3-dihydro-1-benzofuran-5-yl)-5-(t...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(cc(c2)C(F)(F)F)-c2ccc3OCCc3c2)cc1O
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n/an/a 1.70E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267070
PNG
(1-Benzylpyrrolidin-3-yl 2-hydroxy-4-{[(2,4,5-trich...)
Show SMILES Oc1cc(NS(=O)(=O)c2c(Cl)sc(Cl)c2Cl)ccc1C(=O)OC1CCN(Cc2ccccc2)C1
PDB

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n/an/a 1.80E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM200958
PNG
(US9233946, 57)
Show SMILES Fc1cc(Br)ccc1S(=O)(=O)Nc1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C13H9BrFN5O2S/c14-9-4-5-12(11(15)7-9)23(21,22)18-10-3-1-2-8(6-10)13-16-19-20-17-13/h1-7,18H,(H,16,17,19,20)
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US Patent
n/an/a 1.83E+3n/an/an/an/an/an/a



KANCERA AB

US Patent


Assay Description
Method B: The kinase activity of the bi-functional enzyme is readily quantified based on the production of ADP and F-2,6-P2 from ATP and F6P. The ADP...


Citation and Details
More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267080
PNG
(General Procedure 14 | US9718809, 230)
Show SMILES Oc1ccc(F)cc1-c1cccc(c1)S(=O)(=O)Nc1ccc(C(=O)OCCCNc2cccnc2)c(O)c1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267021
PNG
(Methyl 4-[(tert-butoxycarbonyl)amino]-2-hydroxyben...)
Show SMILES COC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1O
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n/an/a 1.90E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267026
PNG
(Methyl 4-({[5-(2,5-difluorophenyl)thiophen-2-yl]su...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2ccc(s2)-c2cc(F)ccc2F)cc1O
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n/an/a 2.00E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267049
PNG
(Methyl 4-({[5-chloro-4-(5-fluoro-2-hydroxyphenyl)-...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2cc(F)ccc2O)cc1O
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n/an/a 2.00E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267078
PNG
(2-Methoxy-1-(methoxymethyl)ethyl 4-({[5-chloro-4-(...)
Show SMILES COCC(COC)OC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2cccc(F)c2)cc1O
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n/an/a 2.00E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267038
PNG
(Methyl 4-({[5-(dimethylamino)naphthalen-1-yl]sulfo...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc3c(cccc23)N(C)C)cc1O
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n/an/a 2.10E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267029
PNG
(Methyl 4-{[(2,5-dichloro-3-thienyl)sulfonyl]amino}...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)sc2Cl)cc1O
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n/an/a 2.30E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267041
PNG
(Methyl 4-[({5-chloro-4-[3-(dimethylcarbamoyl)pheny...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cc(c(Cl)s2)-c2cccc(c2)C(=O)N(C)C)cc1O
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n/an/a 2.40E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)


(Homo sapiens (Human))
BDBM267079
PNG
(Methyl 2-hydroxy-4-({[4'-(trifluoromethoxy)bipheny...)
Show SMILES COC(=O)c1ccc(NS(=O)(=O)c2cccc(c2)-c2ccc(OC(F)(F)F)cc2)cc1O
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n/an/a 2.40E+3n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.





J Med Chem 41: 2960-71 (1998)

More data for this
Ligand-Target Pair
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