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Compile Data Set for Download or QSAR

Found 703 hits Enz. Inhib. hit(s) with Target = 'AP2-associated protein kinase 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311218
PNG
((S)-1-(2-cyclopropyl-4-(quinolin-4-yl)phenoxy)-2,4...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C1CC1)-c1ccnc2ccccc12 |r|
PDB

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n/an/a 0.0700n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd., Jaipur, India.

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.


ACS Med Chem Lett 8: 595-597 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00208
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311218
PNG
((S)-1-(2-cyclopropyl-4-(quinolin-4-yl)phenoxy)-2,4...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C1CC1)-c1ccnc2ccccc12 |r|
PDB

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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311290
PNG
((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cc(c(OC[C@@](C)(N)CC(C)C)cn1)C(F)(F)F |r|
PDB

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US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311339
PNG
((S)-methyl (6-((2-amino-2,4-dimethylpentyl)oxy)-5-...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(OC[C@@](C)(N)CC(C)C)c(c1)C(F)F |r|
PDB

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US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311347
PNG
((S)-1-((3-(difluoromethyl)-5-(quinolin-4-yl)pyridi...)
Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)F)-c1ccnc2ccccc12 |r|
PDB

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n/an/a 0.230n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd., Jaipur, India.

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.


ACS Med Chem Lett 8: 595-597 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00208
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311347
PNG
((S)-1-((3-(difluoromethyl)-5-(quinolin-4-yl)pyridi...)
Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)F)-c1ccnc2ccccc12 |r|
PDB

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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311289
PNG
((S)-2,4-dimethyl-1-((6-(quinolin-4-yl)-4-(trifluor...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)(F)F)-c1ccnc2ccccc12 |r|
PDB

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US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311338
PNG
((S)-1-((3-(difluoromethyl)-5-(7-fluoroquinolin-4-y...)
Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)F)-c1ccnc2cc(F)ccc12 |r|
PDB

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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311155
PNG
((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-cyanop...)
Show SMILES CC(C)C[C@H](N)COc1ccc(cc1C#N)-c1ccnc(NC(C)=O)c1 |r|
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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311265
PNG
((S)-1-((4-(difluoromethyl)-6-(quinolin-4-yl)pyridi...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)F)-c1ccnc2ccccc12 |r|
PDB

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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311340
PNG
((S)-1-((5-(7-chloroquinolin-4-yl)-3-(difluoromethy...)
Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)F)-c1ccnc2cc(Cl)ccc12 |r|
PDB

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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311229
PNG
((S)-1-(4-(1,6-naphthyridin-4-yl)-2-(trifluoromethy...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)(F)F)-c1ccnc2ccncc12 |r|
PDB

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US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311189
PNG
((S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1ccc(OC[C@@](C)(N)CC(C)C)c(c1)C1CC1 |r|
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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311189
PNG
((S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1ccc(OC[C@@](C)(N)CC(C)C)c(c1)C1CC1 |r|
PDB

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n/an/a 0.320n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd., Jaipur, India.

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.


ACS Med Chem Lett 8: 595-597 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00208
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311176
PNG
((S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1ccc(OC[C@@](C)(N)CC(C)C)c(c1)C(F)(F)F |r|
PDB

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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311292
PNG
((S)-1-((4-(difluoromethyl)-5′-fluoro-2′...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)F)-c1cc(C)ncc1F |r|
PDB

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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311170
PNG
((S)-N-(4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-(t...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)(F)F)-c1ccnc(NC(C)=O)c1 |r|
PDB

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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311378
PNG
((S)-1-((4-chloro-6-(6-fluoroquinolin-4-yl)pyridin-...)
Show SMILES CC(C)C[C@@](C)(COc1cnc(cc1Cl)-c1ccnc2ccc(F)cc12)NC(=O)OC(C)(C)C |r|
PDB

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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311363
PNG
((S)-methyl (6-((2-amino-2,4-dimethylpentyl)oxy)-5-...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(OC[C@@](C)(N)CC(C)C)c(c1)C(F)(F)F |r|
PDB

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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311206
PNG
((S)-1-(2-(difluoromethyl)-4-(2-methylpyridin-4-yl)...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)F)-c1ccnc(C)c1 |r|
PDB

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n/an/a 0.380n/an/an/an/an/an/a



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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311382
PNG
((S)-1-((4-chloro-6-(6-chloroquinolin-4-yl)pyridin-...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1Cl)-c1ccnc2ccc(Cl)cc12 |r|
PDB

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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311375
PNG
((S)-1-((6-(7-fluoroquinolin-4-yl)-4-methylpyridin-...)
Show SMILES CC(C)C[C@@](C)(COc1cnc(cc1C)-c1ccnc2cc(F)ccc12)NC(=O)OC(C)(C)C |r|
PDB

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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM321130
PNG
((S)-8-((2-amino-2,4-dimethylpentyl)oxy)-7-chloro-6...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc-2c(COc3cnc(N)cc-23)c1Cl |r|
PDB

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n/an/a 0.410n/an/an/an/an/an/a



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US Patent US10174044 (2019)


Article DOI: 10.1016/j.bmcl.2009.03.077
BindingDB Entry DOI: 10.7270/Q2222WVN
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM50243381
PNG
(CHEMBL4062388)
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n/an/a 0.420n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd., Jaipur, India.

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.


ACS Med Chem Lett 8: 595-597 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00208
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311159
PNG
((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-methyl...)
Show SMILES CC(C)C[C@@H](COc1ccc(Br)cc1C)NC(=O)OC(C)(C)C |r|
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Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311287
PNG
((S)-1-((2′-chloro-4-(difluoromethyl)-5′...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)F)-c1cc(Cl)ncc1F |r|
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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311232
PNG
((S)-1-(4-(7-chloroquinolin-4-yl)-2-(trifluoromethy...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)(F)F)-c1ccnc2cc(Cl)ccc12 |r|
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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311374
PNG
((S)-1-((6-(7-chloroquinolin-4-yl)-4-methylpyridin-...)
Show SMILES CC(C)C[C@@](C)(COc1cnc(cc1C)-c1ccnc2cc(Cl)ccc12)NC(=O)OC(C)(C)C |r|
PDB

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Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311158
PNG
((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-(trifl...)
Show SMILES CC(C)C[C@H](N)COc1ccc(cc1OC(F)(F)F)-c1ccnc(NC(C)=O)c1 |r|
PDB

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Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311222
PNG
((S)-1-((3-chloro-5-(quinolin-4-yl)pyridin-2-yl)oxy...)
Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1Cl)-c1ccnc2ccccc12 |r|
PDB

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US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311332
PNG
((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-fluoro...)
Show SMILES CC(C)C[C@@](C)(COc1ncc(cc1Cl)-c1ccnc2cc(F)cc(F)c12)NC(=O)OC(C)(C)C |r|
PDB

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Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311157
PNG
((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-(trifl...)
Show SMILES CC(C)C[C@H](N)COc1ccc(cc1C(F)(F)F)-c1ccnc(NC(C)=O)c1 |r|
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n/an/a 0.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311217
PNG
((S)-1-(4-(6-fluoroquinolin-4-yl)-2-(trifluoromethy...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)(F)F)-c1ccnc2ccc(F)cc12 |r|
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n/an/a 0.510n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311193
PNG
((S)-1-(2-(difluoromethyl)-4-(2-(difluoromethyl)pyr...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)F)-c1ccnc(c1)C(F)F |r|
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n/an/a 0.510n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311266
PNG
((S)-1-((4-(difluoromethyl)-2′-methyl-[2,4...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)F)-c1ccnc(C)c1 |r|
PDB

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n/an/a 0.510n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd., Jaipur, India.

Curated by ChEMBL


Assay Description
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.


ACS Med Chem Lett 8: 595-597 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00208
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311266
PNG
((S)-1-((4-(difluoromethyl)-2′-methyl-[2,4...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)F)-c1ccnc(C)c1 |r|
PDB

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n/an/a 0.510n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311264
PNG
((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cc(C(F)F)c(OC[C@@](C)(N)CC(C)C)cn1 |r|
PDB

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n/an/a 0.510n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311216
PNG
((S)-1-(4-(5,7-difluoroquinolin-4-yl)-2-(trifluorom...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)(F)F)-c1ccnc2cc(F)cc(F)c12 |r|
PDB

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n/an/a 0.530n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311160
PNG
((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-chloro...)
Show SMILES CC(C)C[C@@H](COc1ccc(Br)cc1Cl)NC(=O)OC(C)(C)C |r|
PDB

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n/an/a 0.530n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311215
PNG
((S)-1-(4-(7-fluoroquinolin-4-yl)-2-(trifluoromethy...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)(F)F)-c1ccnc2cc(F)ccc12 |r|
PDB

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n/an/a 0.550n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311291
PNG
((S)-1-((2′-chloro-4-(difluoromethyl)-[2,4...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)F)-c1ccnc(Cl)c1 |r|
PDB

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n/an/a 0.560n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311360
PNG
((S)-1-(4-(6-chloroquinolin-4-yl)-2-(trifluoromethy...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)(F)F)-c1ccnc2ccc(Cl)cc12 |r|
PDB

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n/an/a 0.560n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311362
PNG
((S)-2,4-dimethyl-1-((5-(quinolin-4-yl)-3-(trifluor...)
Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)(F)F)-c1ccnc2ccccc12 |r|
PDB

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n/an/a 0.590n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM321107
PNG
((S)-ethyl (8-((2-amino-2,4-dimethylpentyl)oxy)-6H-...)
Show SMILES CCOC(=O)Nc1cc-2c(OCc3cc(OC[C@@](C)(N)CC(C)C)ccc-23)cn1 |r|
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n/an/a 0.620n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10174044 (2019)


Article DOI: 10.1016/j.bmcl.2009.03.077
BindingDB Entry DOI: 10.7270/Q2222WVN
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311250
PNG
((S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)...)
Show SMILES COC(=O)Nc1cc(c(F)cn1)-c1ccc(OC[C@@](C)(N)CC(C)C)c(c1)C#N |r|
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n/an/a 0.620n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311180
PNG
((S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1ccc(OC[C@@](C)(N)CC(C)C)c(c1)C(F)F |r|
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n/an/a 0.630n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311199
PNG
((S)-2,4-dimethyl-1-(4-(pyridin-4-yl)-2-(trifluorom...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)(F)F)-c1ccncc1 |r|
PDB

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n/an/a 0.640n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311344
PNG
((S)-1-((3-(difluoromethyl)-5-(5,7-difluoroquinolin...)
Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)F)-c1ccnc2cc(F)cc(F)c12 |r|
PDB

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n/an/a 0.640n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311210
PNG
((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1ccc(OC[C@@](C)(N)CC(C)C)c(Cl)n1 |r|
PDB

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n/an/a 0.650n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311178
PNG
((S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1ccc(OC[C@@](C)(N)CC(C)C)c(c1)C#N |r|
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Bristol-Myers Squibb Company

US Patent




US Patent US10155760 (2018)


Article DOI: 10.1021/jm070311l
BindingDB Entry DOI: 10.7270/Q2F191S4
More data for this
Ligand-Target Pair
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