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Compile Data Set for Download or QSAR

Found 116 hits Enz. Inhib. hit(s) with Target = 'Arginase-2, mitochondrial'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50350311
PNG
(CHEMBL1812661)
Show SMILES [NH3+][C@@H](CCCCB(O)O)C([O-])=O
Show InChI InChI=1S/C6H14BNO4/c8-5(6(9)10)3-1-2-4-7(11)12/h5,11-12H,1-4,8H2,(H,9,10)/t5-/m0/s1
PDB
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8.5n/an/an/an/an/an/an/an/a



Drexel University

Curated by ChEMBL


Assay Description
Binding affinity to human arginase 2


J Med Chem 54: 5432-43 (2011)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50439247
PNG
(CHEMBL2418831)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C20H29BCl2N2O4/c22-17-6-3-13(9-18(17)23)12-25-15-4-5-16(25)11-14(10-15)20(24,19(26)27)7-1-2-8-21(28)29/h3,6,9,14-16,28-29H,1-2,4-5,7-8,10-12,24H2,(H,26,27)
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n/an/a 23n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50439246
PNG
(CHEMBL2418830)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C20H30BClN2O4/c22-16-5-3-14(4-6-16)13-24-17-7-8-18(24)12-15(11-17)20(23,19(25)26)9-1-2-10-21(27)28/h3-6,15,17-18,27-28H,1-2,7-13,23H2,(H,25,26)
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n/an/a 30n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50439245
PNG
(CHEMBL2418991)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccc(F)c(F)c1)C(O)=O
Show InChI InChI=1S/C20H29BF2N2O4/c22-17-6-3-13(9-18(17)23)12-25-15-4-5-16(25)11-14(10-15)20(24,19(26)27)7-1-2-8-21(28)29/h3,6,9,14-16,28-29H,1-2,4-5,7-8,10-12,24H2,(H,26,27)
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n/an/a 33n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50439244
PNG
(CHEMBL2418829)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C20H31BN2O4/c22-20(19(24)25,10-4-5-11-21(26)27)16-12-17-8-9-18(13-16)23(17)14-15-6-2-1-3-7-15/h1-3,6-7,16-18,26-27H,4-5,8-14,22H2,(H,24,25)
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n/an/a 47n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50439243
PNG
(CHEMBL2418998)
Show SMILES NC(CCCCB(O)O)(C1CCN(CCCc2ccc(Cl)cc2Cl)CC1)C(O)=O
Show InChI InChI=1S/C20H31BCl2N2O4/c22-17-6-5-15(18(23)14-17)4-3-11-25-12-7-16(8-13-25)20(24,19(26)27)9-1-2-10-21(28)29/h5-6,14,16,28-29H,1-4,7-13,24H2,(H,26,27)
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n/an/a 50n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50427899
PNG
(CHEMBL2326090)
Show SMILES CN[C@](CCCCB(O)O)(CCN1CCCCC1)C(O)=O
Show InChI InChI=1S/C14H29BN2O4/c1-16-14(13(18)19,7-3-4-9-15(20)21)8-12-17-10-5-2-6-11-17/h16,20-21H,2-12H2,1H3,(H,18,19)/t14-/m1/s1
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n/an/a 67n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50439241
PNG
(CHEMBL2418999)
Show SMILES NC(CCCCB(O)O)(C1CCN(CCCc2ccc(cc2)C(F)(F)F)CC1)C(O)=O
Show InChI InChI=1S/C21H32BF3N2O4/c23-21(24,25)18-7-5-16(6-8-18)4-3-13-27-14-9-17(10-15-27)20(26,19(28)29)11-1-2-12-22(30)31/h5-8,17,30-31H,1-4,9-15,26H2,(H,28,29)
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n/an/a 70n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50439242
PNG
(CHEMBL2418828)
Show SMILES NC(CCCCB(O)O)(C1CC2CCC(C1)N2)C(O)=O
Show InChI InChI=1S/C13H25BN2O4/c15-13(12(17)18,5-1-2-6-14(19)20)9-7-10-3-4-11(8-9)16-10/h9-11,16,19-20H,1-8,15H2,(H,17,18)
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n/an/a 85n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50427903
PNG
(CHEMBL2326087)
Show SMILES CC(C)NCC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C11H25BN2O4/c1-9(2)14-8-6-11(13,10(15)16)5-3-4-7-12(17)18/h9,14,17-18H,3-8,13H2,1-2H3,(H,15,16)/t11-/m1/s1
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n/an/a 190n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50439240
PNG
(CHEMBL2418993)
Show SMILES CC(C)CCN1CCC(CC1)C(N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C16H33BN2O4/c1-13(2)5-10-19-11-6-14(7-12-19)16(18,15(20)21)8-3-4-9-17(22)23/h13-14,22-23H,3-12,18H2,1-2H3,(H,20,21)
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n/an/a 230n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50439239
PNG
(CHEMBL2418994)
Show SMILES NC(CCCCB(O)O)(C1CCN(Cc2ccccc2)CC1)C(O)=O
Show InChI InChI=1S/C18H29BN2O4/c20-18(17(22)23,10-4-5-11-19(24)25)16-8-12-21(13-9-16)14-15-6-2-1-3-7-15/h1-3,6-7,16,24-25H,4-5,8-14,20H2,(H,22,23)
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n/an/a 230n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50439238
PNG
(CHEMBL2418995)
Show SMILES NC(CCCCB(O)O)(C1CCN(Cc2ccc(Cl)cc2)CC1)C(O)=O
Show InChI InChI=1S/C18H28BClN2O4/c20-16-5-3-14(4-6-16)13-22-11-7-15(8-12-22)18(21,17(23)24)9-1-2-10-19(25)26/h3-6,15,25-26H,1-2,7-13,21H2,(H,23,24)
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n/an/a 240n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290405
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(2-(3,4- dich...)
Show SMILES N[C@]1(CN(CCNCc2ccc(Cl)c(Cl)c2)C[C@@H]1CCCB(O)O)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290404
PNG
((3R,4S)-3-amino-1-(2-(benzylamino)ethyl)-4-(3- bor...)
Show SMILES N[C@]1(CN(CCNCc2ccccc2)C[C@@H]1CCCB(O)O)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290403
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(((S)-1,2,3,4...)
Show SMILES N[C@]1(CN(C[C@@H]2Cc3ccccc3CN2)C[C@@H]1CCCB(O)O)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290391
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1,3'-bipyrrolid...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C1CCNC1)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290388
PNG
((3R,4S)-3-amino-1-(2-aminoethyl)-4-(3-boronopropyl...)
Show SMILES NCCN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290385
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(piperidin-2-...)
Show SMILES N[C@]1(CN(CC2CCCCN2)C[C@@H]1CCCB(O)O)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290380
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(3-(4- carbox...)
Show SMILES N[C@]1(CN(CCCc2ccccc2)C[C@@H]1CCCB(O)O)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290378
PNG
((3R,4S)-3-amino-1-(2-aminocyclopentyl)-4-(3- boron...)
Show SMILES NC1CCCC1N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290430
PNG
((1S,2S,4R)-1-amino-4-(2-aminoethyl)-2-(3- boronopr...)
Show SMILES NCC[C@H]1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290402
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(2-(pyrrolidi...)
Show SMILES N[C@]1(CN(CCN2CCCC2)C[C@@H]1CCCB(O)O)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290368
PNG
((2S,3S)-3-amino-2-(3-boronopropyl)tetrahydrofuran-...)
Show SMILES N[C@]1(CCO[C@H]1CCCB(O)O)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290428
PNG
((1S,2S,4R)-1-amino-4-(aminomethyl)-2-(3- boronopro...)
Show SMILES NC[C@@H]1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290427
PNG
((1S,2S,4S)-1-amino-2-(3-boronopropyl)-4- (dimethyl...)
Show SMILES CN(C)[C@H]1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290426
PNG
((1S,2S,4S)-1-amino-4-(benzylamino)-2-(3- boronopro...)
Show SMILES N[C@]1(C[C@H](C[C@@H]1CCCB(O)O)NCc1ccccc1)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



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Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290423
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((5,7-dichlor...)
Show SMILES N[C@]1(CN(CC2Cc3c(Cl)cc(Cl)cc3CN2)C[C@@H]1CCCB(O)O)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



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Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290421
PNG
((3R,4S)-3-amino-1-(2-amino-3-phenylpropyl)-4-(3- b...)
Show SMILES NC(CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O)Cc1ccccc1 |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290420
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(7-chloro-1,2...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)C1Cc2ccc(Cl)cc2CN1)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



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Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290419
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((7-(trifluor...)
Show SMILES N[C@]1(CN(CC2Cc3ccc(cc3CN2)C(F)(F)F)C[C@@H]1CCCB(O)O)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



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Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290416
PNG
((3R,4S)-3-amino-1-(2-(biphenyl-4-ylamino)ethyl)-4-...)
Show SMILES N[C@]1(CN(CCNc2ccc(cc2)-c2ccccc2)C[C@@H]1CCCB(O)O)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



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Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290415
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((6-chloro-1,...)
Show SMILES N[C@]1(CN(CC2Cc3cc(Cl)ccc3CN2)C[C@@H]1CCCB(O)O)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290413
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((7-chloro-1,...)
Show SMILES N[C@]1(CN(CC2Cc3ccc(Cl)cc3CN2)C[C@@H]1CCCB(O)O)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290408
PNG
((3R,4S)-3-amino-1-(2-aminocyclohexyl)-4-(3- borono...)
Show SMILES NC1CCCCC1N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r|
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n/an/a<250n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50427905
PNG
(CHEMBL2326085)
Show SMILES CCN(CC)CC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C12H27BN2O4/c1-3-15(4-2)10-8-12(14,11(16)17)7-5-6-9-13(18)19/h18-19H,3-10,14H2,1-2H3,(H,16,17)/t12-/m1/s1
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n/an/a 270n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50439237
PNG
(CHEMBL2418996)
Show SMILES NC(CCCCB(O)O)(C1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)C(O)=O
Show InChI InChI=1S/C18H27BCl2N2O4/c20-15-4-3-13(11-16(15)21)12-23-9-5-14(6-10-23)18(22,17(24)25)7-1-2-8-19(26)27/h3-4,11,14,26-27H,1-2,5-10,12,22H2,(H,24,25)
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n/an/a 290n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50427911
PNG
(CHEMBL2326095)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCCC1)C(O)=O
Show InChI InChI=1S/C12H25BN2O4/c14-12(11(16)17,5-1-2-7-13(18)19)6-10-15-8-3-4-9-15/h18-19H,1-10,14H2,(H,16,17)/t12-/m1/s1
PDB
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Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50427904
PNG
(CHEMBL2326086)
Show SMILES CCCN(C)CC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C12H27BN2O4/c1-3-9-15(2)10-7-12(14,11(16)17)6-4-5-8-13(18)19/h18-19H,3-10,14H2,1-2H3,(H,16,17)/t12-/m1/s1
PDB
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n/an/a 320n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50439236
PNG
(CHEMBL2418997)
Show SMILES NC(CCCCB(O)O)(C1CCN(CCc2ccc(Cl)cc2Cl)CC1)C(O)=O
Show InChI InChI=1S/C19H29BCl2N2O4/c21-16-4-3-14(17(22)13-16)5-10-24-11-6-15(7-12-24)19(23,18(25)26)8-1-2-9-20(27)28/h3-4,13,15,27-28H,1-2,5-12,23H2,(H,25,26)
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n/an/a 330n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50427909
PNG
(CHEMBL2326097)
Show SMILES COC[C@@H]1CCCN1CC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H29BN2O5/c1-22-11-12-5-4-9-17(12)10-7-14(16,13(18)19)6-2-3-8-15(20)21/h12,20-21H,2-11,16H2,1H3,(H,18,19)/t12-,14+/m0/s1
PDB
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n/an/a 340n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50427906
PNG
(CHEMBL2326084)
Show SMILES CCN(CCO)CC[C@](N)(CCCCB(O)O)C(O)=O
Show InChI InChI=1S/C12H27BN2O5/c1-2-15(9-10-16)8-6-12(14,11(17)18)5-3-4-7-13(19)20/h16,19-20H,2-10,14H2,1H3,(H,17,18)/t12-/m1/s1
PDB
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n/an/a 390n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50427913
PNG
(CHEMBL2326093)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCC(O)CC1)C(O)=O
Show InChI InChI=1S/C13H27BN2O5/c15-13(12(18)19,5-1-2-7-14(20)21)6-10-16-8-3-11(17)4-9-16/h11,17,20-21H,1-10,15H2,(H,18,19)/t13-/m1/s1
PDB
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n/an/a 420n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50427900
PNG
((R)-2-amino-6-borono-2-[2-(piperidin-1-yl)ethyl]he...)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCCCC1)C(O)=O
Show InChI InChI=1S/C13H27BN2O4/c15-13(12(17)18,6-2-3-8-14(19)20)7-11-16-9-4-1-5-10-16/h19-20H,1-11,15H2,(H,17,18)/t13-/m1/s1
PDB
MMDB

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n/an/a 509n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50427907
PNG
(CHEMBL2326099)
Show SMILES N[C@](CCCCB(O)O)(CCN1Cc2ccccc2C1)C(O)=O
Show InChI InChI=1S/C16H25BN2O4/c18-16(15(20)21,7-3-4-9-17(22)23)8-10-19-11-13-5-1-2-6-14(13)12-19/h1-2,5-6,22-23H,3-4,7-12,18H2,(H,20,21)/t16-/m1/s1
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Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50427910
PNG
(CHEMBL2326096)
Show SMILES N[C@](CCCCB(O)O)(CCN1CC[C@@H](CO)C1)C(O)=O
Show InChI InChI=1S/C13H27BN2O5/c15-13(12(18)19,4-1-2-6-14(20)21)5-8-16-7-3-11(9-16)10-17/h11,17,20-21H,1-10,15H2,(H,18,19)/t11-,13-/m1/s1
PDB
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Institutes for Pharmaceutical Discovery , LLC

Curated by ChEMBL


Assay Description
Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea ...


J Med Chem 56: 2568-80 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50427911
PNG
(CHEMBL2326095)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCCC1)C(O)=O
Show InChI InChI=1S/C12H25BN2O4/c14-12(11(16)17,5-1-2-7-13(18)19)6-10-15-8-3-4-9-15/h18-19H,1-10,14H2,(H,16,17)/t12-/m1/s1
PDB
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n/an/a 620n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human Arg2 by colorimetric assay


Bioorg Med Chem Lett 23: 2027-30 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM50427911
PNG
(CHEMBL2326095)
Show SMILES N[C@](CCCCB(O)O)(CCN1CCCC1)C(O)=O
Show InChI InChI=1S/C12H25BN2O4/c14-12(11(16)17,5-1-2-7-13(18)19)6-10-15-8-3-4-9-15/h18-19H,1-10,14H2,(H,16,17)/t12-/m1/s1
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n/an/a 620n/an/an/an/an/an/a



Institutes for Pharmaceutical Discovery

Curated by ChEMBL


Assay Description
Inhibition of human arginase-2 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assay


Bioorg Med Chem Lett 23: 4837-41 (2013)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290389
PNG
(5-((3R,4S)-3-amino-4-(3-boronopropyl)-3-carboxypyr...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)c1cccnc1)C(O)=O |r|
PDB
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n/an/a 625n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
Arginase-2, mitochondrial


(Homo sapiens (Human))
BDBM290425
PNG
((1S,2S,4S)-1,4-diamino-2-(3-boronopropyl)cyclopent...)
Show SMILES CC(OO)[C@]1(N)C[C@@H](N)C[C@@H]1CCCB(O)O |r|
PDB
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n/an/a 625n/an/an/an/a7.425



Bristol-Myers Squibb Company





Bioorg Med Chem Lett 14: 343-6 (2004)

More data for this
Ligand-Target Pair
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