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Compile Data Set for Download or QSAR

Found 104 hits Enz. Inhib. hit(s) with Target = 'Beta-catenin'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-catenin


(Homo sapiens (Human))
BDBM213761
PNG
(US9284299, 12 | US9738628, Compound 12)
Show SMILES On1nnc2cc(CCc3nn[nH]n3)ccc12
Show InChI InChI=1S/C9H9N7O/c17-16-8-3-1-6(5-7(8)10-15-16)2-4-9-11-13-14-12-9/h1,3,5,17H,2,4H2,(H,11,12,13,14)
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UniChem
Article
US Patent
3.14E+3n/an/an/an/an/an/an/an/a



University of Utah Research Foundation

US Patent




US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213761
PNG
(US9284299, 12 | US9738628, Compound 12)
Show SMILES On1nnc2cc(CCc3nn[nH]n3)ccc12
Show InChI InChI=1S/C9H9N7O/c17-16-8-3-1-6(5-7(8)10-15-16)2-4-9-11-13-14-12-9/h1,3,5,17H,2,4H2,(H,11,12,13,14)
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UniChem
US Patent
3.14E+3 -31.4n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin/Tcf4


(Homo sapiens (Human))
BDBM213761
PNG
(US9284299, 12 | US9738628, Compound 12)
Show SMILES On1nnc2cc(CCc3nn[nH]n3)ccc12
Show InChI InChI=1S/C9H9N7O/c17-16-8-3-1-6(5-7(8)10-15-16)2-4-9-11-13-14-12-9/h1,3,5,17H,2,4H2,(H,11,12,13,14)
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UniChem
US Patent
3.14E+3 -31.4n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM335730
PNG
(US9738628, Compound 17)
Show SMILES On1nnc2cc(NCc3nn[nH]n3)ccc12
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UniChem
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US Patent
3.38E+3n/an/an/an/an/an/an/an/a



University of Utah Research Foundation

US Patent




US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213766
PNG
(US9284299, 17)
Show SMILES On1ncc2cc(NCc3nn[nH]n3)ccc12
Show InChI InChI=1S/C9H9N7O/c17-16-8-2-1-7(3-6(8)4-11-16)10-5-9-12-14-15-13-9/h1-4,10,17H,5H2,(H,12,13,14,15)
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US Patent
3.38E+3 -31.2n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM32102
PNG
(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Show SMILES Cn1ncnc2c1nc(=O)n(C)c2=O
Show InChI InChI=1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3
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3.65E+3 -31.0n/an/an/an/an/a7.425



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin/Tcf4


(Homo sapiens (Human))
BDBM32102
PNG
(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Show SMILES Cn1ncnc2c1nc(=O)n(C)c2=O
Show InChI InChI=1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3
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3.65E+3 -31.0n/an/an/an/an/a7.425



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM32102
PNG
(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Show SMILES Cn1ncnc2c1nc(=O)n(C)c2=O
Show InChI InChI=1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3
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3.65E+3n/an/an/an/an/an/an/an/a



University of Utah Research Foundation

US Patent




US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213761
PNG
(US9284299, 12 | US9738628, Compound 12)
Show SMILES On1nnc2cc(CCc3nn[nH]n3)ccc12
Show InChI InChI=1S/C9H9N7O/c17-16-8-3-1-6(5-7(8)10-15-16)2-4-9-11-13-14-12-9/h1,3,5,17H,2,4H2,(H,11,12,13,14)
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US Patent
3.83E+3 -30.9n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin/Tcf4


(Homo sapiens (Human))
BDBM213761
PNG
(US9284299, 12 | US9738628, Compound 12)
Show SMILES On1nnc2cc(CCc3nn[nH]n3)ccc12
Show InChI InChI=1S/C9H9N7O/c17-16-8-3-1-6(5-7(8)10-15-16)2-4-9-11-13-14-12-9/h1,3,5,17H,2,4H2,(H,11,12,13,14)
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UniChem
US Patent
3.83E+3 -30.9n/an/an/an/an/a7.425



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM32102
PNG
(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Show SMILES Cn1ncnc2c1nc(=O)n(C)c2=O
Show InChI InChI=1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3
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5.82E+3 -29.9n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM32102
PNG
(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Show SMILES Cn1ncnc2c1nc(=O)n(C)c2=O
Show InChI InChI=1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3
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5.82E+3n/an/an/an/an/an/an/an/a



University of Utah Research Foundation

US Patent




US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin/Tcf4


(Homo sapiens (Human))
BDBM32102
PNG
(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Show SMILES Cn1ncnc2c1nc(=O)n(C)c2=O
Show InChI InChI=1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3
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5.82E+3 -29.9n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin/Tcf4


(Homo sapiens (Human))
BDBM50094484
PNG
(CHEBI:3556 | CHEMBL2323033 | US9284299, CGP049090 ...)
Show SMILES COc1c(C[C@H](C)O)c2c3c(C[C@H](C)O)c(OC)c(=O)c4c(O)cc5OCOc6cc(O)c(c2c6c5c34)c1=O |r|
Show InChI InChI=1S/C27H29NO3/c29-26(27(30,23-12-6-2-7-13-23)24-14-8-3-9-15-24)31-25-17-20-28(21-18-25)19-16-22-10-4-1-5-11-22/h1-15,25,30H,16-21H2
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5.87E+3 -29.9n/an/an/an/an/a7.425



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213763
PNG
(US9284299, 14)
Show SMILES On1ncc2cc(CCc3noc(=S)[nH]3)ccc12
Show InChI InChI=1S/C11H10N4O2S/c16-15-9-3-1-7(5-8(9)6-12-15)2-4-10-13-11(18)17-14-10/h1,3,5-6,16H,2,4H2,(H,13,14,18)
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US Patent
7.24E+3 -29.3n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213756
PNG
(US9284299, 7 | US9738628, Compound 14)
Show SMILES On1nnc2cc(CCc3noc(=S)[nH]3)ccc12
Show InChI InChI=1S/C10H9N5O2S/c16-15-8-3-1-6(5-7(8)12-14-15)2-4-9-11-10(18)17-13-9/h1,3,5,16H,2,4H2,(H,11,13,18)
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7.24E+3n/an/an/an/an/an/an/an/a



University of Utah Research Foundation

US Patent




US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213761
PNG
(US9284299, 12 | US9738628, Compound 12)
Show SMILES On1nnc2cc(CCc3nn[nH]n3)ccc12
Show InChI InChI=1S/C9H9N7O/c17-16-8-3-1-6(5-7(8)10-15-16)2-4-9-11-13-14-12-9/h1,3,5,17H,2,4H2,(H,11,12,13,14)
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US Patent
7.60E+3 -29.2n/an/an/an/an/a7.425



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213761
PNG
(US9284299, 12 | US9738628, Compound 12)
Show SMILES On1nnc2cc(CCc3nn[nH]n3)ccc12
Show InChI InChI=1S/C9H9N7O/c17-16-8-3-1-6(5-7(8)10-15-16)2-4-9-11-13-14-12-9/h1,3,5,17H,2,4H2,(H,11,12,13,14)
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US Patent
7.60E+3n/an/an/an/an/an/an/an/a



University of Utah Research Foundation

US Patent




US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin/APC-R3


(Homo sapiens (Human))
BDBM50094484
PNG
(CHEBI:3556 | CHEMBL2323033 | US9284299, CGP049090 ...)
Show SMILES COc1c(C[C@H](C)O)c2c3c(C[C@H](C)O)c(OC)c(=O)c4c(O)cc5OCOc6cc(O)c(c2c6c5c34)c1=O |r|
Show InChI InChI=1S/C27H29NO3/c29-26(27(30,23-12-6-2-7-13-23)24-14-8-3-9-15-24)31-25-17-20-28(21-18-25)19-16-22-10-4-1-5-11-22/h1-15,25,30H,16-21H2
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US Patent
8.31E+3 -29.0n/an/an/an/an/a7.425



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin/E-cadherin


(Homo sapiens (Human))
BDBM50094484
PNG
(CHEBI:3556 | CHEMBL2323033 | US9284299, CGP049090 ...)
Show SMILES COc1c(C[C@H](C)O)c2c3c(C[C@H](C)O)c(OC)c(=O)c4c(O)cc5OCOc6cc(O)c(c2c6c5c34)c1=O |r|
Show InChI InChI=1S/C27H29NO3/c29-26(27(30,23-12-6-2-7-13-23)24-14-8-3-9-15-24)31-25-17-20-28(21-18-25)19-16-22-10-4-1-5-11-22/h1-15,25,30H,16-21H2
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1.17E+4 -28.2n/an/an/an/an/a7.425



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin/E-cadherin


(Homo sapiens (Human))
BDBM213748
PNG
(US9284299, PKF115-584 | US9738628, Compound PKF115...)
Show SMILES COc1cc(O)c2c3c1c1c(OC)cc(O)c4c1c(c(C[C@@H](C)OC(=O)c1ccccc1)c(OC)c4=O)c3c(C[C@@H](C)OC(=O)Oc1ccc(O)cc1)c(OC)c2=O |r|
Show InChI InChI=1/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45-47H,16-17H2,1-6H3/t20-,21-/s2
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1.30E+4 -27.9n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin/E-cadherin


(Homo sapiens (Human))
BDBM32102
PNG
(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Show SMILES Cn1ncnc2c1nc(=O)n(C)c2=O
Show InChI InChI=1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3
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1.33E+4 -27.8n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213764
PNG
(US9284299, 15)
Show SMILES On1ncc2cc(COC[N]3=NNN=C3)ccc12 |c:13,t:10|
Show InChI InChI=1S/C10H11N6O2/c17-16-10-2-1-8(3-9(10)4-12-16)5-18-7-15-6-11-13-14-15/h1-4,6,17H,5,7H2,(H,11,13,14)
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1.36E+4 -27.8n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213753
PNG
(US9284299, 4 | US9738628, Compound 15)
Show SMILES On1nnc2cc(COCc3nn[nH]n3)ccc12
Show InChI InChI=1S/C9H9N7O2/c17-16-8-2-1-6(3-7(8)10-15-16)4-18-5-9-11-13-14-12-9/h1-3,17H,4-5H2,(H,11,12,13,14)
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1.36E+4n/an/an/an/an/an/an/an/a



University of Utah Research Foundation

US Patent




US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin/E-cadherin


(Homo sapiens (Human))
BDBM50094484
PNG
(CHEBI:3556 | CHEMBL2323033 | US9284299, CGP049090 ...)
Show SMILES COc1c(C[C@H](C)O)c2c3c(C[C@H](C)O)c(OC)c(=O)c4c(O)cc5OCOc6cc(O)c(c2c6c5c34)c1=O |r|
Show InChI InChI=1S/C27H29NO3/c29-26(27(30,23-12-6-2-7-13-23)24-14-8-3-9-15-24)31-25-17-20-28(21-18-25)19-16-22-10-4-1-5-11-22/h1-15,25,30H,16-21H2
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1.44E+4 -27.6n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213767
PNG
(US9284299, 18 | US9738628, Compound 18)
Show SMILES Cc1noc(C)c1C(=O)N(Cc1nn[nH]n1)c1ccc2n(O)ncc2c1
Show InChI InChI=1S/C15H14N8O3/c1-8-14(9(2)26-19-8)15(24)22(7-13-17-20-21-18-13)11-3-4-12-10(5-11)6-16-23(12)25/h3-6,25H,7H2,1-2H3,(H,17,18,20,21)
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1.66E+4n/an/an/an/an/an/an/an/a



University of Utah Research Foundation

US Patent




US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213767
PNG
(US9284299, 18 | US9738628, Compound 18)
Show SMILES Cc1noc(C)c1C(=O)N(Cc1nn[nH]n1)c1ccc2n(O)ncc2c1
Show InChI InChI=1S/C15H14N8O3/c1-8-14(9(2)26-19-8)15(24)22(7-13-17-20-21-18-13)11-3-4-12-10(5-11)6-16-23(12)25/h3-6,25H,7H2,1-2H3,(H,17,18,20,21)
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1.66E+4 -27.3n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213748
PNG
(US9284299, PKF115-584 | US9738628, Compound PKF115...)
Show SMILES COc1cc(O)c2c3c1c1c(OC)cc(O)c4c1c(c(C[C@@H](C)OC(=O)c1ccccc1)c(OC)c4=O)c3c(C[C@@H](C)OC(=O)Oc1ccc(O)cc1)c(OC)c2=O |r|
Show InChI InChI=1/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45-47H,16-17H2,1-6H3/t20-,21-/s2
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1.78E+4 -27.1n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin/Tcf4


(Homo sapiens (Human))
BDBM213748
PNG
(US9284299, PKF115-584 | US9738628, Compound PKF115...)
Show SMILES COc1cc(O)c2c3c1c1c(OC)cc(O)c4c1c(c(C[C@@H](C)OC(=O)c1ccccc1)c(OC)c4=O)c3c(C[C@@H](C)OC(=O)Oc1ccc(O)cc1)c(OC)c2=O |r|
Show InChI InChI=1/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45-47H,16-17H2,1-6H3/t20-,21-/s2
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University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213748
PNG
(US9284299, PKF115-584 | US9738628, Compound PKF115...)
Show SMILES COc1cc(O)c2c3c1c1c(OC)cc(O)c4c1c(c(C[C@@H](C)OC(=O)c1ccccc1)c(OC)c4=O)c3c(C[C@@H](C)OC(=O)Oc1ccc(O)cc1)c(OC)c2=O |r|
Show InChI InChI=1/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45-47H,16-17H2,1-6H3/t20-,21-/s2
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University of Utah Research Foundation

US Patent




US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin/E-cadherin


(Homo sapiens (Human))
BDBM32102
PNG
(1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,...)
Show SMILES Cn1ncnc2c1nc(=O)n(C)c2=O
Show InChI InChI=1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3
PDB

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US Patent
1.99E+4 -26.8n/an/an/an/an/a7.425



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213752
PNG
(US9284299, 11 | US9284299, 3 | US9738628, Compound...)
Show SMILES On1nnc2cc(Cc3noc(=S)[nH]3)ccc12
Show InChI InChI=1S/C9H7N5O2S/c15-14-7-2-1-5(3-6(7)11-13-14)4-8-10-9(17)16-12-8/h1-3,15H,4H2,(H,10,12,17)
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2.24E+4 -26.5n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213752
PNG
(US9284299, 11 | US9284299, 3 | US9738628, Compound...)
Show SMILES On1nnc2cc(Cc3noc(=S)[nH]3)ccc12
Show InChI InChI=1S/C9H7N5O2S/c15-14-7-2-1-5(3-6(7)11-13-14)4-8-10-9(17)16-12-8/h1-3,15H,4H2,(H,10,12,17)
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US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213756
PNG
(US9284299, 7 | US9738628, Compound 14)
Show SMILES On1nnc2cc(CCc3noc(=S)[nH]3)ccc12
Show InChI InChI=1S/C10H9N5O2S/c16-15-8-3-1-6(5-7(8)12-14-15)2-4-9-11-10(18)17-13-9/h1,3,5,16H,2,4H2,(H,11,13,18)
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2.44E+4 -26.3n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213756
PNG
(US9284299, 7 | US9738628, Compound 14)
Show SMILES On1nnc2cc(CCc3noc(=S)[nH]3)ccc12
Show InChI InChI=1S/C10H9N5O2S/c16-15-8-3-1-6(5-7(8)12-14-15)2-4-9-11-10(18)17-13-9/h1,3,5,16H,2,4H2,(H,11,13,18)
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2.44E+4n/an/an/an/an/an/an/an/a



University of Utah Research Foundation

US Patent




US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM50436058
PNG
(CHEMBL254381 | PNU-74654 | US9738628, Compound PNU...)
Show SMILES Cc1ccc(\C=N\NC(=O)c2ccccc2Oc2ccccc2)o1
Show InChI InChI=1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+
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2.44E+4n/an/an/an/an/an/an/an/a



University of Utah Research Foundation

US Patent




US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM50392084
PNG
(CHEMBL2152586 | US9284299, PNU-74654)
Show SMILES NC(=O)c1ccccc1Oc1ccccc1
Show InChI InChI=1S/C13H11NO2/c14-13(15)11-8-4-5-9-12(11)16-10-6-2-1-3-7-10/h1-9H,(H2,14,15)
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2.44E+4 -26.3n/an/an/an/an/a7.425



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213768
PNG
(US9284299, 19 | US9738628, Compound 19)
Show SMILES On1ncc2cc(ccc12)N(Cc1nn[nH]n1)C(=O)c1cc(F)cc(Br)c1
Show InChI InChI=1S/C16H11BrFN7O2/c17-11-3-9(4-12(18)6-11)16(26)24(8-15-20-22-23-21-15)13-1-2-14-10(5-13)7-19-25(14)27/h1-7,27H,8H2,(H,20,21,22,23)
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2.87E+4 -25.9n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213768
PNG
(US9284299, 19 | US9738628, Compound 19)
Show SMILES On1ncc2cc(ccc12)N(Cc1nn[nH]n1)C(=O)c1cc(F)cc(Br)c1
Show InChI InChI=1S/C16H11BrFN7O2/c17-11-3-9(4-12(18)6-11)16(26)24(8-15-20-22-23-21-15)13-1-2-14-10(5-13)7-19-25(14)27/h1-7,27H,8H2,(H,20,21,22,23)
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University of Utah Research Foundation

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US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213769
PNG
(US9284299, 20 | US9738628, Compound 20)
Show SMILES On1ncc2cc(ccc12)N(Cc1nn[nH]n1)C(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C16H12ClN7O2/c17-12-3-1-2-10(6-12)16(25)23(9-15-19-21-22-20-15)13-4-5-14-11(7-13)8-18-24(14)26/h1-8,26H,9H2,(H,19,20,21,22)
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3.31E+4 -25.6n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213769
PNG
(US9284299, 20 | US9738628, Compound 20)
Show SMILES On1ncc2cc(ccc12)N(Cc1nn[nH]n1)C(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C16H12ClN7O2/c17-12-3-1-2-10(6-12)16(25)23(9-15-19-21-22-20-15)13-4-5-14-11(7-13)8-18-24(14)26/h1-8,26H,9H2,(H,19,20,21,22)
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University of Utah Research Foundation

US Patent




US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM50094484
PNG
(CHEBI:3556 | CHEMBL2323033 | US9284299, CGP049090 ...)
Show SMILES COc1c(C[C@H](C)O)c2c3c(C[C@H](C)O)c(OC)c(=O)c4c(O)cc5OCOc6cc(O)c(c2c6c5c34)c1=O |r|
Show InChI InChI=1S/C27H29NO3/c29-26(27(30,23-12-6-2-7-13-23)24-14-8-3-9-15-24)31-25-17-20-28(21-18-25)19-16-22-10-4-1-5-11-22/h1-15,25,30H,16-21H2
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3.56E+4 -25.4n/an/an/an/an/an/a25



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin/Tcf4


(Homo sapiens (Human))
BDBM50094484
PNG
(CHEBI:3556 | CHEMBL2323033 | US9284299, CGP049090 ...)
Show SMILES COc1c(C[C@H](C)O)c2c3c(C[C@H](C)O)c(OC)c(=O)c4c(O)cc5OCOc6cc(O)c(c2c6c5c34)c1=O |r|
Show InChI InChI=1S/C27H29NO3/c29-26(27(30,23-12-6-2-7-13-23)24-14-8-3-9-15-24)31-25-17-20-28(21-18-25)19-16-22-10-4-1-5-11-22/h1-15,25,30H,16-21H2
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University of Utah Research Foundation

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Assay Description
Experiments were performed in 96-well Microfluor 2 black plates (Waltham, Mass.), and the samples were read by a Synergy 2 plate reader (Biotek, Wino...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM50094484
PNG
(CHEBI:3556 | CHEMBL2323033 | US9284299, CGP049090 ...)
Show SMILES COc1c(C[C@H](C)O)c2c3c(C[C@H](C)O)c(OC)c(=O)c4c(O)cc5OCOc6cc(O)c(c2c6c5c34)c1=O |r|
Show InChI InChI=1S/C27H29NO3/c29-26(27(30,23-12-6-2-7-13-23)24-14-8-3-9-15-24)31-25-17-20-28(21-18-25)19-16-22-10-4-1-5-11-22/h1-15,25,30H,16-21H2
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US Patent




US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM50094602
PNG
(CHEMBL3589010 | US9284299, iCRT14 | US9738628, Com...)
Show SMILES Cc1cc(\C=C2/SC(=O)N(C2=O)c2ccccc2)c(C)n1-c1cccnc1
Show InChI InChI=1S/C27H30N4/c1-18-19(2)31(20(3)21-12-6-4-7-13-21)27-24(18)26(28-23-16-10-11-17-23)29-25(30-27)22-14-8-5-9-15-22/h4-9,12-15,20,23H,10-11,16-17H2,1-3H3,(H,28,29,30)/t20-/m0/s1
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4.07E+4 -25.1n/an/an/an/an/a7.425



University of Utah Research Foundation

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Assay Description
Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM50094602
PNG
(CHEMBL3589010 | US9284299, iCRT14 | US9738628, Com...)
Show SMILES Cc1cc(\C=C2/SC(=O)N(C2=O)c2ccccc2)c(C)n1-c1cccnc1
Show InChI InChI=1S/C27H30N4/c1-18-19(2)31(20(3)21-12-6-4-7-13-21)27-24(18)26(28-23-16-10-11-17-23)29-25(30-27)22-14-8-5-9-15-22/h4-9,12-15,20,23H,10-11,16-17H2,1-3H3,(H,28,29,30)/t20-/m0/s1
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US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213752
PNG
(US9284299, 11 | US9284299, 3 | US9738628, Compound...)
Show SMILES On1nnc2cc(Cc3noc(=S)[nH]3)ccc12
Show InChI InChI=1S/C9H7N5O2S/c15-14-7-2-1-5(3-6(7)11-13-14)4-8-10-9(17)16-12-8/h1-3,15H,4H2,(H,10,12,17)
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4.20E+4 -25.0n/an/an/an/an/a7.425



University of Utah Research Foundation

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Assay Description
Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213752
PNG
(US9284299, 11 | US9284299, 3 | US9738628, Compound...)
Show SMILES On1nnc2cc(Cc3noc(=S)[nH]3)ccc12
Show InChI InChI=1S/C9H7N5O2S/c15-14-7-2-1-5(3-6(7)11-13-14)4-8-10-9(17)16-12-8/h1-3,15H,4H2,(H,10,12,17)
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4.20E+4n/an/an/an/an/an/an/an/a



University of Utah Research Foundation

US Patent




US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213749
PNG
(US9284299, iCRT5 | US9738628, Compound iCRT5)
Show SMILES COc1ccc(\C=C2/SC(=S)N(CCCC(O)=O)C2=O)cc1OC
Show InChI InChI=1S/C16H17NO5S2/c1-21-11-6-5-10(8-12(11)22-2)9-13-15(20)17(16(23)24-13)7-3-4-14(18)19/h5-6,8-9H,3-4,7H2,1-2H3,(H,18,19)/b13-9-
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UniChem
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US Patent
4.68E+4n/an/an/an/an/an/an/an/a



University of Utah Research Foundation

US Patent




US Patent US9738628 (2017)


Article DOI: 10.1021/jm030434f
More data for this
Ligand-Target Pair
Beta-catenin


(Homo sapiens (Human))
BDBM213749
PNG
(US9284299, iCRT5 | US9738628, Compound iCRT5)
Show SMILES COc1ccc(\C=C2/SC(=S)N(CCCC(O)=O)C2=O)cc1OC
Show InChI InChI=1S/C16H17NO5S2/c1-21-11-6-5-10(8-12(11)22-2)9-13-15(20)17(16(23)24-13)7-3-4-14(18)19/h5-6,8-9H,3-4,7H2,1-2H3,(H,18,19)/b13-9-
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4.68E+4 -24.7n/an/an/an/an/a7.425



University of Utah Research Foundation

US Patent


Assay Description
Experiments were performed in white opaque 384-well plates from PerkinElmer (Waltham, Mass.), and the samples were read on a Synergy 2 plate reader (...


US Patent US9284299 (2016)


BindingDB Entry DOI: 10.7270/Q2WW7GGC
More data for this
Ligand-Target Pair
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