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Found 37 hits Enz. Inhib. hit(s) with Target = 'C-RAF (Y340D Y341D)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322528
PNG
(5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a 0.400n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322529
PNG
(5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a 0.5n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322521
PNG
(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a 0.600n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322521
PNG
(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a 0.800n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322521
PNG
(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a 1n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM238347
PNG
(US9388165, 3)
Show SMILES Cc1ccc(cc1NC(=O)c1cccc2c(N)nccc12)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-15(23(33)31-17-5-2-4-16(13-17)25(26,27)28)12-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.80n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322530
PNG
(5-[3-[5-(2-chlorophenyl)-1H-imidazol-2-yl]chroman-...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322542
PNG
(5-[[(3R)-3-(4-phenyl-1H-imidazol-2-yl)-2,3-dihydro...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322541
PNG
(5-[[(3S)-3-(4-phenyl-1H-imidazol-2-yl)-2,3-dihydro...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322540
PNG
(5-[3-(5-phenyl-1H-pyrazol-3-yl)chroman-6-yl]oxy-3,...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322538
PNG
(5-[[3-(4-phenyl-1H-imidazol-2-yl)-2H-chromen-6-yl]...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322537
PNG
(5-[3-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-imid...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322536
PNG
(5-[3-[5-(1,3-benzodioxol-5-yl)-1H-imidazol-2-yl]ch...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322535
PNG
(5-[3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]chroman-...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322533
PNG
(5-[3-[5-(3-pyridyl)-1H-imidazol-2-yl]chroman-6-yl]...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322532
PNG
(5-[3-[4-(benzofuran-3-yl)-1H-imidazol-2-yl]chroman...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322531
PNG
(5-[3-[5-(3-chlorophenyl)-1H-imidazol-2-yl]chroman-...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322529
PNG
(5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322518
PNG
(5-[3-(1H-benzimidazol-2-yl)chroman-6-yl]oxy-3,4-di...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322521
PNG
(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322521
PNG
(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322521
PNG
(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322525
PNG
(5-[3[4-(4-pyridyl)-1H-imidazol-2-yl]chroman-6-yl]o...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322527
PNG
(5-[3-(4-tert-butyl-1H-imidazol-2-yl)chroman-6-yl]o...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322528
PNG
(5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a<4n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM238345
PNG
(US9388165, 1)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H19F3N4O2/c1-14-8-9-17(31-23(33)15-4-2-5-16(12-15)25(26,27)28)13-21(14)32-24(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,31,33)(H,32,34)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.10n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM238349
PNG
(US9388165, 6)
Show SMILES CCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(NC(=O)c4cccc5c(NC(C)(C)C)nccc45)c3)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C36H41F3N6O2/c1-6-44-16-18-45(19-17-44)22-25-12-13-26(21-30(25)36(37,38)39)41-33(46)24-11-10-23(2)31(20-24)42-34(47)29-9-7-8-28-27(29)14-15-40-32(28)43-35(3,4)5/h7-15,20-21H,6,16-19,22H2,1-5H3,(H,40,43)(H,41,46)(H,42,47)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.40n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM238348
PNG
(US9388165, 4)
Show SMILES Cc1ccc(cc1NC(=O)c1cccc2c(N)nccc12)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H18ClF3N4O2/c1-13-5-6-14(23(34)32-15-7-8-20(26)19(12-15)25(27,28)29)11-21(13)33-24(35)18-4-2-3-17-16(18)9-10-31-22(17)30/h2-12H,1H3,(H2,30,31)(H,32,34)(H,33,35)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 10.7n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM238346
PNG
(US9388165, 2)
Show SMILES Cc1ccc(cc1NC(=O)c1cccc2c(NC(C)(C)C)nccc12)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C29H27F3N4O2/c1-17-11-12-18(26(37)34-20-8-5-7-19(16-20)29(30,31)32)15-24(17)35-27(38)23-10-6-9-22-21(23)13-14-33-25(22)36-28(2,3)4/h5-16H,1-4H3,(H,33,36)(H,34,37)(H,35,38)
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PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM238350
PNG
(US9388165, 8)
Show SMILES Cc1ccc(cc1NC(=O)c1cccc2c(NC(C)(C)C)nccc12)C(=O)Nc1ccccc1
Show InChI InChI=1S/C28H28N4O2/c1-18-13-14-19(26(33)30-20-9-6-5-7-10-20)17-24(18)31-27(34)23-12-8-11-22-21(23)15-16-29-25(22)32-28(2,3)4/h5-17H,1-4H3,(H,29,32)(H,30,33)(H,31,34)
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PC cid
PC sid
UniChem
US Patent
n/an/a 20.5n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322519
PNG
(5-[3-(7-chloro-1H-benzimidazol-2-yl]chroman-6-yl]o...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a 52n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322534
PNG
(5-[3-[5-(4-methylsulfonylphenyl)-1H-imidazol-2-yl]...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a 52n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322547
PNG
(2-Methyl-4-[3-(5-phenyl-1H-imidazol-2-yl)chroman-6...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a 52n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM322539
PNG
(5-[3-(3-phenyl-1,2,4-oxadiazol-5-yl)chroman-6-yl]o...)
GoogleScholar
AffyNet 
UniChem
Article
n/an/a 52n/an/an/an/an/an/a



Universita degli Studi





J Med Chem 43: 3677-87 (2000)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM238351
PNG
(US9388165, 11)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(NC(=O)c3cccc4c(N)nccc34)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H23F3N6O2/c1-16-6-7-18(10-25(16)37-28(40)24-5-3-4-23-22(24)8-9-34-26(23)33)27(39)36-20-11-19(29(30,31)32)12-21(13-20)38-14-17(2)35-15-38/h3-15H,1-2H3,(H2,33,34)(H,36,39)(H,37,40)
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PC cid
PC sid
UniChem
US Patent
n/an/a 94.8n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM238352
PNG
(US9388165, 14)
Show SMILES Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1NC(=O)c1cccc2c(N)nccc12
Show InChI InChI=1S/C25H20F3N5O2/c1-14-8-9-17(32-24(35)31-16-5-2-4-15(12-16)25(26,27)28)13-21(14)33-23(34)20-7-3-6-19-18(20)10-11-30-22(19)29/h2-13H,1H3,(H2,29,30)(H,33,34)(H2,31,32,35)
GoogleScholar
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PC cid
PC sid
UniChem
US Patent
n/an/a 108n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM50396483
PNG
(PLX-4032 | RG 7204 | Ro 5185426 | US9388165, Refer...)
Show SMILES CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
Show InChI InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)
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PC cid
PC sid
PDB
UniChem
US Patent
n/an/a 128n/an/an/an/an/an/a



HANMI PHARM. CO., LTD.

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...


Citation and Details
More data for this
Ligand-Target Pair