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Compile Data Set for Download or QSAR

Found 312 hits Enz. Inhib. hit(s) with Target = 'Dual specificity protein kinase CLK2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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>8.75E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CLK2


Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317482
PNG
(4-(4-((1s,4s)-4-hydroxy-4- methylcyclohexyloxy)-5-...)
Show SMILES CNC(=O)c1ccc(cc1)-c1c[nH]c2nc(Nc3ccc(cc3OC)C(=O)NC3CN(C)C3)nc(OC3CC[C@@](C)(O)CC3)c12 |r,wU:39.43,wD:39.42,(6.47,11.4,;6.08,9.92,;4.59,9.52,;3.5,10.61,;4.19,8.03,;5.28,6.94,;4.88,5.45,;3.39,5.06,;2.3,6.15,;2.7,7.63,;2.99,3.57,;3.9,2.32,;2.99,1.08,;1.53,1.55,;.19,.78,;-1.14,1.55,;-2.47,.78,;-2.47,-.76,;-1.14,-1.53,;-1.14,-3.07,;-2.47,-3.84,;-3.81,-3.07,;-3.81,-1.53,;-5.14,-.76,;-6.47,-1.53,;-2.47,-5.38,;-1.14,-6.15,;-3.81,-6.15,;-3.81,-7.69,;-4.9,-8.78,;-3.81,-9.86,;-3.81,-11.4,;-2.72,-8.78,;-1.14,3.09,;.19,3.86,;.19,5.4,;-1.14,6.17,;-2.47,5.4,;-3.81,6.17,;-3.81,7.71,;-3.81,9.25,;-5.14,6.94,;-2.47,8.48,;-1.14,7.71,;1.53,3.09,)|
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n/an/a 1.43n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317465
PNG
(4-(4-(cyclopentyloxy)-5-(4- (methylcarbamoyl)pheny...)
Show SMILES CNC(=O)c1ccc(cc1)-c1c[nH]c2nc(Nc3ccc(cc3OC)C(=O)NC)nc(OC3CCCC3)c12
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n/an/a 1.91n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317483
PNG
(3-chloro-N-methyl-4-(5-(4- (methylcarbamoyl)phenyl...)
Show SMILES CNC(=O)c1ccc(cc1)-c1c[nH]c2nc(Nc3ccc(cc3Cl)C(=O)NC)nc(OC3CCOCC3)c12
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n/an/a 2.10n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317471
PNG
((S)-3-chloro-N-methyl-4-(5-(2- methylbenzo[d]oxazo...)
Show SMILES CNC(=O)c1ccc(Nc2nc(O[C@H]3CCOC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)c(Cl)c1 |r|
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n/an/a 2.27n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317469
PNG
(3-methoxy-4-(4-methoxy-5-(6- methoxypyridin-3-yl)-...)
Show SMILES CNC(=O)c1ccc(Nc2nc(OC)c3c(c[nH]c3n2)-c2ccc(OC)nc2)c(OC)c1
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n/an/a 2.29n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317475
PNG
(3-cyano-N-methyl-4-(5-(2- methylbenzo[d]oxazol-6-y...)
Show SMILES CNC(=O)c1ccc(Nc2nc(OC3CCOCC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)c(c1)C#N
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n/an/a 2.32n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317485
PNG
(3-chloro-N-methyl-4-(5-(1- methyl-1H-pyrazol-4-yl)...)
Show SMILES CNC(=O)c1ccc(Nc2nc(OC3CCOCC3)c3c(c[nH]c3n2)-c2cnn(C)c2)c(Cl)c1
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n/an/a 3.29n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317468
PNG
(4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6...)
Show SMILES COc1cc(ccc1Nc1nc(OC2CCCC2)c2c(c[nH]c2n1)-c1ccc2nc(C)oc2c1)C(=O)NCCO
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n/an/a 3.38n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317467
PNG
(3-methoxy-N-methyl-4-(5-(2- methylbenzo[d]oxazol-6...)
Show SMILES CNC(=O)c1ccc(Nc2nc(NC3CCOCC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)c(OC)c1
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n/an/a 3.5n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317460
PNG
(4-(5-(4-hydroxyphenyl)-4- (tetrahydro-2H-pyran-4-y...)
Show SMILES CNC(=O)c1ccc(Nc2nc(OC3CCOCC3)c3c(c[nH]c3n2)-c2ccc(O)cc2)c(OC)c1
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n/an/a 4.33n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317466
PNG
(4-(4-methoxy-5-(pyridin-4-yl)- 7H-pyrrolo[2,3-d]py...)
Show SMILES COc1nc(Nc2ccc(cc2C)C(=O)N(C)C)nc2[nH]cc(-c3ccncc3)c12
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n/an/a 4.56n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
CHEMBL4064608
PNG
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n/an/a 5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL




J Med Chem 60: 10071-10091 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01290
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50237672
PNG
(CHEMBL4089159)
Show SMILES COC(=O)C1=C(Nc2ccccc2Cl)O\C(=C/c2c[nH]c3ncccc23)C1=O |c:4|
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n/an/a 5.30n/an/an/an/an/an/a



Carna Biosciences, Inc.

Curated by ChEMBL




Eur J Med Chem 130: 406-418 (2017)


Article DOI: 10.1016/j.ejmech.2017.02.030
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317481
PNG
(4-(4-cyclobutoxy-5-(2- methylbenzo[d]oxazol-6-yl)-...)
Show SMILES COc1cc(ccc1Nc1nc(OC2CCC2)c2c(c[nH]c2n1)-c1ccc2nc(C)oc2c1)C(=O)NC1COC1
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n/an/a 5.92n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235022
PNG
(CHEMBL4078898)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12 |r|
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n/an/a 6n/an/an/an/an/an/a



SRI International

Curated by ChEMBL




Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235020
PNG
(CHEMBL4094492)
Show SMILES CC(C)n1cnc2c(Nc3cc(Cl)cc(NC(C)=O)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12 |r|
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n/an/a 7n/an/an/an/an/an/a



SRI International

Curated by ChEMBL




Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317462
PNG
(4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6...)
Show SMILES CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)c(OC)c1
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n/an/a 8.17n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317476
PNG
(N-methyl-4-(5-(2- methylbenzo[d]oxazol-6-yl)-4- (t...)
Show SMILES CNC(=O)c1ccc(Nc2nc(OC3CCOCC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)c(c1)C(F)(F)F
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n/an/a 9.41n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317477
PNG
(4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6...)
Show SMILES CNC(=O)c1cc(OC)c(Nc2nc(OC3CCCC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)cc1F
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n/an/a 10.4n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235035
PNG
(CHEMBL4066861)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12 |r|
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n/an/a 11n/an/an/an/an/an/a



SRI International

Curated by ChEMBL




Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317484
PNG
(3-chloro-4-(4-(cyclopentyloxy)-5- (2-methylbenzo[d...)
Show SMILES CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)c(Cl)c1
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n/an/a 12.5n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235020
PNG
(CHEMBL4094492)
Show SMILES CC(C)n1cnc2c(Nc3cc(Cl)cc(NC(C)=O)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12 |r|
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n/an/a 13n/an/an/an/an/an/a



SRI International

Curated by ChEMBL




Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235036
PNG
(CHEMBL4082309)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCC[C@@H]3N)nc12 |r|
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n/an/a 14n/an/an/an/an/an/a



SRI International

Curated by ChEMBL




Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235024
PNG
(CHEMBL4088144)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CCCC[C@@H]3N)nc12 |r|
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n/an/a 16n/an/an/an/an/an/a



SRI International

Curated by ChEMBL




Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235022
PNG
(CHEMBL4078898)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc12 |r|
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n/an/a 16n/an/an/an/an/an/a



SRI International

Curated by ChEMBL




Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235019
PNG
(CHEMBL4067013)
Show SMILES CC(C)n1cnc2c(Nc3cc(Cl)cc(NC(C)=O)c3)nc(N[C@H]3CCCC[C@H]3N)nc12 |r|
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n/an/a 17n/an/an/an/an/an/a



SRI International

Curated by ChEMBL




Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Mus musculus)
BDBM50239782
PNG
(CHEMBL4082113)
Show SMILES COc1ccc2sc(cc2c1)C(=O)N(C)Cc1cccc(F)c1
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n/an/a 19n/an/an/an/an/an/a



Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo , Cairo 11835, Egypt.

Curated by ChEMBL




J Med Chem 60: 5377-5391 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01915
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50435433
PNG
(CHEMBL1898197)
Show SMILES Clc1ccc(CNc2nccc(n2)-c2ccc3OCOc3c2)cc1Cl
Show InChI InChI=1S/C18H13Cl2N3O2/c19-13-3-1-11(7-14(13)20)9-22-18-21-6-5-15(23-18)12-2-4-16-17(8-12)25-10-24-16/h1-8H,9-10H2,(H,21,22,23)
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n/an/a 20n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of CLK2 (unknown origin)


Bioorg Med Chem Lett 23: 3654-61 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.096
BindingDB Entry DOI: 10.7270/Q2M90B2B
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50435449
PNG
(CHEMBL2392364)
Show SMILES Clc1cc(Cl)cc(CNc2nccc(n2)-c2ccc3OCOc3c2)c1
Show InChI InChI=1S/C18H13Cl2N3O2/c19-13-5-11(6-14(20)8-13)9-22-18-21-4-3-15(23-18)12-1-2-16-17(7-12)25-10-24-16/h1-8H,9-10H2,(H,21,22,23)
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n/an/a 23n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of CLK2 (unknown origin)


Bioorg Med Chem Lett 23: 3654-61 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.096
BindingDB Entry DOI: 10.7270/Q2M90B2B
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235021
PNG
(CHEMBL4104657)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCC[C@H]3N)nc12 |r|
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n/an/a 26n/an/an/an/an/an/a



SRI International

Curated by ChEMBL




Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235031
PNG
(CHEMBL4064123)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCNC3)nc12 |r|
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n/an/a 26n/an/an/an/an/an/a



SRI International

Curated by ChEMBL




Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235023
PNG
(CHEMBL4073318)
Show SMILES CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CCCC[C@H]3N)nc12 |r|
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n/an/a 26n/an/an/an/an/an/a



SRI International

Curated by ChEMBL




Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317458
PNG
(4-(4-(cyclopentylamino)-5-(4- hydroxyphenyl)-7H-py...)
Show SMILES CNC(=O)c1ccc(Nc2nc(NC3CCCC3)c3c(c[nH]c3n2)-c2ccc(O)cc2)c(OC)c1
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n/an/a 26n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235037
PNG
(CHEMBL4102101)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCNC3)nc12 |r|
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n/an/a 28n/an/an/an/an/an/a



SRI International

Curated by ChEMBL




Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317470
PNG
(3-chloro-N-methyl-4-(5-(2- methylbenzo[d]oxazol-6-...)
Show SMILES CNC(=O)c1ccc(Nc2nc(OC3CCOCC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)c(Cl)c1
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n/an/a 29.1n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50435469
PNG
(CHEMBL1899256)
Show SMILES Brc1ccc(CNc2nccc(n2)-c2ccc3OCOc3c2)cc1Br
Show InChI InChI=1S/C18H13Br2N3O2/c19-13-3-1-11(7-14(13)20)9-22-18-21-6-5-15(23-18)12-2-4-16-17(8-12)25-10-24-16/h1-8H,9-10H2,(H,21,22,23)
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n/an/a 30n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of CLK2 (unknown origin)


Bioorg Med Chem Lett 23: 3654-61 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.096
BindingDB Entry DOI: 10.7270/Q2M90B2B
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50238867
PNG
(CHEMBL4083249)
Show SMILES C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
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n/an/a 31n/an/an/an/an/an/a



State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy , Chengdu 610041, P.R. China.

Curated by ChEMBL




J Med Chem 60: 6337-6352 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00665
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50235030
PNG
(CHEMBL4091876)
Show SMILES CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCNC3)nc12 |r|
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n/an/a 34n/an/an/an/an/an/a



SRI International

Curated by ChEMBL




Bioorg Med Chem Lett 27: 406-412 (2017)


Article DOI: 10.1016/j.bmcl.2016.12.056
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317456
PNG
(4-(4-(cyclopentyloxy)-5-(4- hydroxyphenyl)-7H-pyrr...)
Show SMILES CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(c[nH]c3n2)-c2ccc(O)cc2)c(c1)C(C)C
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n/an/a 34.9n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50435425
PNG
(CHEMBL1904905)
Show SMILES Clc1ccc(CNc2nccc(n2)-c2ccc3OCCOc3c2)cc1Cl
Show InChI InChI=1S/C19H15Cl2N3O2/c20-14-3-1-12(9-15(14)21)11-23-19-22-6-5-16(24-19)13-2-4-17-18(10-13)26-8-7-25-17/h1-6,9-10H,7-8,11H2,(H,22,23,24)
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n/an/a 39n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of CLK2 (unknown origin)


Bioorg Med Chem Lett 23: 3654-61 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.096
BindingDB Entry DOI: 10.7270/Q2M90B2B
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317472
PNG
(N,3-dimethyl-4-(5-(2- methylbenzo[d]oxazol-6-yl)-4...)
Show SMILES CNC(=O)c1ccc(Nc2nc(OC3CCOCC3)c3c(c[nH]c3n2)-c2ccc3nc(C)oc3c2)c(C)c1
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n/an/a 40.1n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50435436
PNG
(CHEMBL2392365)
Show SMILES Brc1cc(Br)cc(CNc2nccc(n2)-c2ccc3OCOc3c2)c1
Show InChI InChI=1S/C18H13Br2N3O2/c19-13-5-11(6-14(20)8-13)9-22-18-21-4-3-15(23-18)12-1-2-16-17(7-12)25-10-24-16/h1-8H,9-10H2,(H,21,22,23)
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n/an/a 41n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of CLK2 (unknown origin)


Bioorg Med Chem Lett 23: 3654-61 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.096
BindingDB Entry DOI: 10.7270/Q2M90B2B
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50208625
PNG
(CHEMBL3885431)
Show SMILES COc1cccc2c1[nH]c1c2c(cc2cnccc12)C#N
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n/an/a 44n/an/an/an/an/an/a



CNRS

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged human recombinant CLK2 expressed in Escherichia coli using RS peptide as substrate incubated for 30 mins in presence of [gam...


Eur J Med Chem 124: 920-934 (2016)


Article DOI: 10.1016/j.ejmech.2016.08.069
BindingDB Entry DOI: 10.7270/Q24X59S3
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50435441
PNG
(CHEMBL1868723)
Show SMILES FC(F)(F)c1cccc(Nc2nccc(n2)-c2ccc3OCOc3c2)c1
Show InChI InChI=1S/C18H12F3N3O2/c19-18(20,21)12-2-1-3-13(9-12)23-17-22-7-6-14(24-17)11-4-5-15-16(8-11)26-10-25-15/h1-9H,10H2,(H,22,23,24)
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n/an/a 52n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of CLK2 (unknown origin)


Bioorg Med Chem Lett 23: 3654-61 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.096
BindingDB Entry DOI: 10.7270/Q2M90B2B
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM317455
PNG
(4-(4-(cyclopentyloxy)-5-(4- hydroxyphenyl)-7H-pyrr...)
Show SMILES CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(c[nH]c3n2)-c2ccc(O)cc2)c(OC)c1
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n/an/a 53.9n/an/an/an/an/an/a



Signal Pharmaceuticals, LLC

US Patent




US Patent US9623028 (2017)


Article DOI: 10.1021/jm0512600
BindingDB Entry DOI: 10.7270/Q2VQ34R8
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Mus musculus)
BDBM50097868
PNG
(CHEMBL3589661)
Show SMILES OC(=O)c1nc2ccccc2c2[nH]c3c(Br)cccc3c12
Show InChI InChI=1S/C16H9BrN2O2/c17-10-6-3-5-9-12-14(19-13(9)10)8-4-1-2-7-11(8)18-15(12)16(20)21/h1-7,19H,(H,20,21)
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n/an/a 55n/an/an/an/an/an/a



Technische Universit£t Braunschweig

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CLK2 expressed in Escherichia coli using RS peptide as substrate after 30 mins by scintillation counting analysis


J Med Chem 58: 3131-43 (2015)


Article DOI: 10.1021/jm501994d
BindingDB Entry DOI: 10.7270/Q2736SPK
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM50435426
PNG
(CHEMBL1877990)
Show SMILES C(Nc1nccc(n1)-c1ccc2OCOc2c1)c1cccnc1
Show InChI InChI=1S/C17H14N4O2/c1-2-12(9-18-6-1)10-20-17-19-7-5-14(21-17)13-3-4-15-16(8-13)23-11-22-15/h1-9H,10-11H2,(H,19,20,21)
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n/an/a 60n/an/an/an/an/an/a



University of Kansas Specialized Chemistry Center

Curated by ChEMBL


Assay Description
Inhibition of CLK2 (unknown origin)


Bioorg Med Chem Lett 23: 3654-61 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.096
BindingDB Entry DOI: 10.7270/Q2M90B2B
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Mus musculus)
BDBM50097867
PNG
(CHEMBL3589660)
Show SMILES OC(=O)c1nc2ccccc2c2[nH]c3c(Cl)cccc3c12
Show InChI InChI=1S/C16H9ClN2O2/c17-10-6-3-5-9-12-14(19-13(9)10)8-4-1-2-7-11(8)18-15(12)16(20)21/h1-7,19H,(H,20,21)
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n/an/a 61n/an/an/an/an/an/a



Technische Universit£t Braunschweig

Curated by ChEMBL


Assay Description
Inhibition of mouse recombinant CLK2 expressed in Escherichia coli using RS peptide as substrate after 30 mins by scintillation counting analysis


J Med Chem 58: 3131-43 (2015)


Article DOI: 10.1021/jm501994d
BindingDB Entry DOI: 10.7270/Q2736SPK
More data for this
Ligand-Target Pair
Dual specificity protein kinase CLK2


(Homo sapiens (Human))
BDBM181050
PNG
(3A5)
Show SMILES Cc1nc2ccc3sc(NC(=O)c4ccc5ncsc5c4)nc3c2s1
Show InChI InChI=1S/C17H10N4OS3/c1-8-19-11-4-5-12-14(15(11)24-8)20-17(25-12)21-16(22)9-2-3-10-13(6-9)23-7-18-10/h2-7H,1H3,(H,20,21,22)
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n/an/a 68n/an/an/an/an/an/a



University College London



Assay Description
For kinase inhibition assays, the final concentrations of the enzymes were 15, 14.5, 14.5, and 8.8 nM for CLK1, CLK2, CLK3, and Dyrk1A (Invitrogen, c...


Biochemistry 55: 608-17 (2016)


Article DOI: 10.1021/acs.biochem.5b01128
BindingDB Entry DOI: 10.7270/Q2N58K5J
More data for this
Ligand-Target Pair
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