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Compile Data Set for Download or QSAR

Found 124 hits Enz. Inhib. hit(s) with Target = 'Eukaryotic elongation factor 2 kinase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50329427
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H13N5O/c16-14(21)10-8-12(11-6-7-18-15(17)20-11)19-13(10)9-4-2-1-3-5-9/h1-8,19H,(H2,16,21)(H2,17,18,20)
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n/an/a>1n/an/an/an/an/an/a



Nerviano Medical Sciences Srl

Curated by ChEMBL


Assay Description
Inhibition of EEF2K


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50442760
PNG
(CHEMBL2443044)
Show SMILES CN1CCC(CC1)NC(=O)c1cc(on1)-c1c(O)cc(O)cc1Oc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C22H22N4O7/c1-25-8-6-13(7-9-25)23-22(29)17-12-20(33-24-17)21-18(28)10-15(27)11-19(21)32-16-4-2-14(3-5-16)26(30)31/h2-5,10-13,27-28H,6-9H2,1H3,(H,23,29)
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of eEF2K (unknown origin)


Bioorg Med Chem 21: 7047-63 (2013)


Article DOI: 10.1016/j.bmc.2013.09.018
BindingDB Entry DOI: 10.7270/Q2V989HZ
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50442759
PNG
(CHEMBL2443138)
Show SMILES CN(C)c1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(C)CC2)cc1
Show InChI InChI=1S/C24H28N4O5/c1-27(2)16-4-6-18(7-5-16)32-21-13-17(29)12-20(30)23(21)22-14-19(26-33-22)24(31)25-15-8-10-28(3)11-9-15/h4-7,12-15,29-30H,8-11H2,1-3H3,(H,25,31)
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of eEF2K (unknown origin)


Bioorg Med Chem 21: 7047-63 (2013)


Article DOI: 10.1016/j.bmc.2013.09.018
BindingDB Entry DOI: 10.7270/Q2V989HZ
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50442757
PNG
(CHEMBL2443026)
Show SMILES CN(C)c1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(CC2)C2CCC3(CC2)OCCO3)cc1
Show InChI InChI=1S/C31H38N4O7/c1-34(2)21-3-5-24(6-4-21)41-27-18-23(36)17-26(37)29(27)28-19-25(33-42-28)30(38)32-20-9-13-35(14-10-20)22-7-11-31(12-8-22)39-15-16-40-31/h3-6,17-20,22,36-37H,7-16H2,1-2H3,(H,32,38)
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of eEF2K (unknown origin)


Bioorg Med Chem 21: 7047-63 (2013)


Article DOI: 10.1016/j.bmc.2013.09.018
BindingDB Entry DOI: 10.7270/Q2V989HZ
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50442758
PNG
(CHEMBL2443139)
Show SMILES CC(C)Nc1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(C)CC2)cc1
Show InChI InChI=1S/C25H30N4O5/c1-15(2)26-16-4-6-19(7-5-16)33-22-13-18(30)12-21(31)24(22)23-14-20(28-34-23)25(32)27-17-8-10-29(3)11-9-17/h4-7,12-15,17,26,30-31H,8-11H2,1-3H3,(H,27,32)
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Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of eEF2K (unknown origin)


Bioorg Med Chem 21: 7047-63 (2013)


Article DOI: 10.1016/j.bmc.2013.09.018
BindingDB Entry DOI: 10.7270/Q2V989HZ
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314444
PNG
(2-(4-chlorophenyl)-10-thia-5,7,12-triazatetracyclo...)
Show SMILES Nc1ncnc2c1sc1nc3CCCCCCCc3c(-c3ccc(Cl)cc3)c21
Show InChI InChI=1S/C22H21ClN4S/c23-14-10-8-13(9-11-14)17-15-6-4-2-1-3-5-7-16(15)27-22-18(17)19-20(28-22)21(24)26-12-25-19/h8-12H,1-7H2,(H2,24,25,26)
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n/an/a 110n/an/an/an/an/an/a



Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314436
PNG
(3-amino-4-(furan-2-yl)-6,7,8,9,10,11-hexahydro-5H-...)
Show SMILES NC(=O)c1sc2nc3CCCCCCCc3c(-c3ccco3)c2c1N
Show InChI InChI=1S/C19H21N3O2S/c20-16-15-14(13-9-6-10-24-13)11-7-4-2-1-3-5-8-12(11)22-19(15)25-17(16)18(21)23/h6,9-10H,1-5,7-8,20H2,(H2,21,23)
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n/an/a 170n/an/an/an/an/an/a



Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314406
PNG
(8-(morpholin-4-yl)-11-thia-9,14,16-triazatetracycl...)
Show SMILES Nc1ncnc2c1sc1nc(N3CCOCC3)c3CCCCc3c21
Show InChI InChI=1S/C17H19N5OS/c18-15-14-13(19-9-20-15)12-10-3-1-2-4-11(10)16(21-17(12)24-14)22-5-7-23-8-6-22/h9H,1-8H2,(H2,18,19,20)
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Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314427
PNG
(3-amino-4-(5-chlorofuran-2-yl)-5,6,7,8,9,10-hexahy...)
Show SMILES NC(=O)c1sc2nc3CCCCCCc3c(-c3ccc(Cl)o3)c2c1N
Show InChI InChI=1S/C18H18ClN3O2S/c19-12-8-7-11(24-12)13-9-5-3-1-2-4-6-10(9)22-18-14(13)15(20)16(25-18)17(21)23/h7-8H,1-6,20H2,(H2,21,23)
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Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053584
PNG
(CHEMBL1977874)
Show SMILES CCn1c(=O)n(C2CC2)c2nc(N)c(cc2c1=O)C(N)=O
Show InChI InChI=1S/C13H15N5O3/c1-2-17-12(20)8-5-7(10(15)19)9(14)16-11(8)18(13(17)21)6-3-4-6/h5-6H,2-4H2,1H3,(H2,14,16)(H2,15,19)
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n/an/a 280n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
ATP competitive inhibition of human eEF-2K using 5 uM ATP


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293963
PNG
(US10106552, Compound 38)
Show SMILES CC1(C)CCCc2c1nc1sc(C(N)=O)c(N)c1c2-c1cncs1
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Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314428
PNG
(3-amino-4-(5-(trifluoromethyl)furan-2-yl)-5,6,7,8,...)
Show SMILES NC(=O)c1sc2nc3CCCCCCc3c(-c3ccc(o3)C(F)(F)F)c2c1N
Show InChI InChI=1S/C19H18F3N3O2S/c20-19(21,22)12-8-7-11(27-12)13-9-5-3-1-2-4-6-10(9)25-18-14(13)15(23)16(28-18)17(24)26/h7-8H,1-6,23H2,(H2,24,26)
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Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314419
PNG
((E)-3-amino-4-(2-(furan-2-yl)vinyl)-5,6,7,8,9,10-h...)
Show SMILES NC(=O)c1sc2nc3CCCCCCc3c(\C=C\c3ccco3)c2c1N
Show InChI InChI=1S/C20H21N3O2S/c21-17-16-14(10-9-12-6-5-11-25-12)13-7-3-1-2-4-8-15(13)23-20(16)26-18(17)19(22)24/h5-6,9-11H,1-4,7-8,21H2,(H2,22,24)/b10-9+
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Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314429
PNG
(3-amino-4-(benzofuran-2-yl)-5,6,7,8,9,10-hexahydro...)
Show SMILES NC(=O)c1sc2nc3CCCCCCc3c(-c3cc4ccccc4o3)c2c1N
Show InChI InChI=1S/C22H21N3O2S/c23-19-18-17(16-11-12-7-5-6-10-15(12)27-16)13-8-3-1-2-4-9-14(13)25-22(18)28-20(19)21(24)26/h5-7,10-11H,1-4,8-9,23H2,(H2,24,26)
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Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314442
PNG
(2-(furan-2-yl)-10-thia-5,7,12-triazatetracyclo[11....)
Show SMILES Nc1ncnc2c1sc1nc3CCCCCCCc3c(-c3ccco3)c21
Show InChI InChI=1S/C20H20N4OS/c21-19-18-17(22-11-23-19)16-15(14-9-6-10-25-14)12-7-4-2-1-3-5-8-13(12)24-20(16)26-18/h6,9-11H,1-5,7-8H2,(H2,21,22,23)
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Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293965
PNG
(US10106552, Compound 40)
Show SMILES Cc1ncsc1-c1c2CCC(C)(C)c2nc2sc(C(N)=O)c(N)c12 |(-3.73,1.78,;-2.4,2.55,;-1.92,4.01,;-.38,4.01,;.09,2.55,;-1.15,1.64,;-1.15,.1,;-2.49,-.67,;-3.95,-.19,;-4.86,-1.44,;-3.95,-2.68,;-4.72,-4.01,;-3.18,-4.01,;-2.49,-2.21,;-1.15,-2.98,;.18,-2.21,;1.64,-2.68,;2.55,-1.44,;4.09,-1.44,;4.86,-.1,;4.86,-2.77,;1.64,-.19,;2.41,1.14,;.18,-.67,)|
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Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293961
PNG
(US10106552, Compound 36)
Show SMILES CC1CC(C)(C)Cc2nc3sc(C(N)=O)c(N)c3c(-c3cncs3)c12
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Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293960
PNG
(US10106552, Compound 35)
Show SMILES CC1(C)CCc2c(C1)nc1sc(C(N)=O)c(N)c1c2-c1cncs1
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Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293953
PNG
(US10106552, Compound 28)
Show SMILES CC1(C)CCc2c1nc1sc(C(N)=O)c(N)c1c2-c1cncs1
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Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053584
PNG
(CHEMBL1977874)
Show SMILES CCn1c(=O)n(C2CC2)c2nc(N)c(cc2c1=O)C(N)=O
Show InChI InChI=1S/C13H15N5O3/c1-2-17-12(20)8-5-7(10(15)19)9(14)16-11(8)18(13(17)21)6-3-4-6/h5-6H,2-4H2,1H3,(H2,14,16)(H2,15,19)
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n/an/a 420n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50375667
PNG
(CHEMBL437612 | TX-1918)
Show SMILES [#6]-c1cc(\[#6]=[#6]-2\[#6](=O)-[#6]=[#6]-[#6]-2=O)cc(-[#6])c1-[#8] |c:8|
Show InChI InChI=1S/C14H12O3/c1-8-5-10(6-9(2)14(8)17)7-11-12(15)3-4-13(11)16/h3-7,17H,1-2H3
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n/an/a 440n/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of eEF2 kinase


Proc Natl Acad Sci USA 104: 20523-8 (2007)

Checked by Author
Article DOI: 10.1073/pnas.0708800104
BindingDB Entry DOI: 10.7270/Q2DB82RH
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314420
PNG
(3-amino-4-(3-methylthiophen-2-yl)-5,6,7,8,9,10-hex...)
Show SMILES Cc1ccsc1-c1c2CCCCCCc2nc2sc(C(N)=O)c(N)c12 |(19.42,1.74,;17.96,2.21,;17.48,3.68,;15.94,3.68,;15.47,2.21,;16.72,1.31,;16.72,-.23,;15.39,-1,;14.31,.09,;12.76,.09,;11.67,-1,;11.67,-2.54,;12.77,-3.63,;14.31,-3.63,;15.39,-2.54,;16.72,-3.31,;18.05,-2.55,;19.53,-3.03,;20.44,-1.78,;21.98,-1.79,;22.76,-.45,;22.75,-3.12,;19.53,-.52,;20.01,.94,;18.05,-1,)|
Show InChI InChI=1S/C19H21N3OS2/c1-10-8-9-24-16(10)13-11-6-4-2-3-5-7-12(11)22-19-14(13)15(20)17(25-19)18(21)23/h8-9H,2-7,20H2,1H3,(H2,21,23)
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Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293966
PNG
(US10106552, Compound 41)
Show SMILES Cc1nc(C)c(s1)-c1c2CCC(C)(C)c2nc2sc(C(N)=O)c(N)c12 |(.39,4.68,;-.38,3.35,;-1.92,3.35,;-2.4,1.88,;-3.73,1.11,;-1.15,.98,;.09,1.88,;-1.15,-.56,;-2.49,-1.33,;-3.95,-.86,;-4.86,-2.1,;-3.95,-3.35,;-4.72,-4.68,;-3.18,-4.68,;-2.49,-2.87,;-1.15,-3.64,;.18,-2.87,;1.64,-3.35,;2.55,-2.1,;4.09,-2.1,;4.86,-.77,;4.86,-3.44,;1.64,-.86,;2.41,.48,;.18,-1.33,)|
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n/an/a 500n/an/an/an/an/an/a



Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314418
PNG
(3-amino-4-(furan-2-yl)-5,6,7,8,9,10-hexahydrocyclo...)
Show SMILES NC(=O)c1sc2nc3CCCCCCc3c(-c3ccco3)c2c1N
Show InChI InChI=1S/C18H19N3O2S/c19-15-14-13(12-8-5-9-23-12)10-6-3-1-2-4-7-11(10)21-18(14)24-16(15)17(20)22/h5,8-9H,1-4,6-7,19H2,(H2,20,22)
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Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314430
PNG
(3-amino-4-(5-ethylfuran-2-yl)-5,6,7,8,9,10-hexahyd...)
Show SMILES CCc1ccc(o1)-c1c2CCCCCCc2nc2sc(C(N)=O)c(N)c12
Show InChI InChI=1S/C20H23N3O2S/c1-2-11-9-10-14(25-11)15-12-7-5-3-4-6-8-13(12)23-20-16(15)17(21)18(26-20)19(22)24/h9-10H,2-8,21H2,1H3,(H2,22,24)
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Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293954
PNG
(US10106552, Compound 29)
Show SMILES Cn1cc(cn1)-c1c2CCC(C)(C)c2nc2sc(C(N)=O)c(N)c12
PDB

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n/an/a 700n/an/an/an/an/an/a



Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293950
PNG
(US10106552, Compound 25)
Show SMILES CC1(C)CCc2c1nc1sc(C(N)=O)c(N)c1c2-c1cc(Br)cs1
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n/an/a 800n/an/an/an/an/an/a



Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293959
PNG
(US10106552, Compound 34)
Show SMILES CC1(C)CCc2c1nc1sc(C(N)=O)c(N)c1c2-c1sccc1Br |(-4.72,-4.01,;-3.95,-2.68,;-3.18,-4.01,;-4.86,-1.44,;-3.95,-.19,;-2.49,-.67,;-2.49,-2.21,;-1.15,-2.98,;.18,-2.21,;1.64,-2.68,;2.55,-1.44,;4.09,-1.44,;4.86,-.1,;4.86,-2.77,;1.64,-.19,;2.41,1.14,;.18,-.67,;-1.15,.1,;-1.15,1.64,;.09,2.55,;-.38,4.01,;-1.92,4.01,;-2.4,2.55,;-3.73,1.78,)|
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n/an/a 800n/an/an/an/an/an/a



Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314431
PNG
(3-amino-4-(5-(hydroxymethyl)furan-2-yl)-5,6,7,8,9,...)
Show SMILES NC(=O)c1sc2nc3CCCCCCc3c(-c3ccc(CO)o3)c2c1N
Show InChI InChI=1S/C19H21N3O3S/c20-16-15-14(13-8-7-10(9-23)25-13)11-5-3-1-2-4-6-12(11)22-19(15)26-17(16)18(21)24/h7-8,23H,1-6,9,20H2,(H2,21,24)
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Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314415
PNG
(4-(3-amino-2-carbamoyl-5,6,7,8,9,10-hexahydrocyclo...)
Show SMILES NC(=O)c1sc2nc3CCCCCCc3c(-c3ccc(cc3)C(O)=O)c2c1N
Show InChI InChI=1S/C21H21N3O3S/c22-17-16-15(11-7-9-12(10-8-11)21(26)27)13-5-3-1-2-4-6-14(13)24-20(16)28-18(17)19(23)25/h7-10H,1-6,22H2,(H2,23,25)(H,26,27)
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n/an/a 860n/an/an/an/an/an/a



Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314409
PNG
(3-amino-4-isobutyl-5,6,7,8,9,10-hexahydrocycloocta...)
Show SMILES CC(C)Cc1c2CCCCCCc2nc2sc(C(N)=O)c(N)c12
Show InChI InChI=1S/C18H25N3OS/c1-10(2)9-12-11-7-5-3-4-6-8-13(11)21-18-14(12)15(19)16(23-18)17(20)22/h10H,3-9,19H2,1-2H3,(H2,20,22)
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n/an/a 860n/an/an/an/an/an/a



Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293962
PNG
(US10106552, Compound 37)
Show SMILES CC1(C)CCCc2c1nc1sc(C(N)=O)c(N)c1c2-c1cc(Br)co1
PDB

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n/an/a 900n/an/an/an/an/an/a



Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293968
PNG
(US10106552, Compound 43)
Show SMILES NC(=O)c1sc2nc3C4CCC(C4)c3c(-c3cncs3)c2c1N
PDB

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n/an/a 900n/an/an/an/an/an/a



Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293943
PNG
(US10106552, Compound 18)
Show SMILES CC1(C)CCc2c1nc1sc(C(N)=O)c(N)c1c2-c1ccsc1
PDB

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n/an/a 900n/an/an/an/an/an/a



Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053583
PNG
(CHEMBL3327225)
Show SMILES CCCn1c(=O)n(C2CC2)c2nc(N)c(cc2c1=O)C(N)=O
Show InChI InChI=1S/C14H17N5O3/c1-2-5-18-13(21)9-6-8(11(16)20)10(15)17-12(9)19(14(18)22)7-3-4-7/h6-7H,2-5H2,1H3,(H2,15,17)(H2,16,20)
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n/an/a 930n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314421
PNG
(3-amino-4-(pyridin-3-yl)-5,6,7,8,9,10-hexahydrocyc...)
Show SMILES NC(=O)c1sc2nc3CCCCCCc3c(-c3cccnc3)c2c1N
Show InChI InChI=1S/C19H20N4OS/c20-16-15-14(11-6-5-9-22-10-11)12-7-3-1-2-4-8-13(12)23-19(15)25-17(16)18(21)24/h5-6,9-10H,1-4,7-8,20H2,(H2,21,24)
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n/an/a 940n/an/an/an/an/an/a



Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314422
PNG
(3-amino-4-(1-methyl-1H-pyrrol-2-yl)-5,6,7,8,9,10-h...)
Show SMILES Cn1cccc1-c1c2CCCCCCc2nc2sc(C(N)=O)c(N)c12 |(14.66,-10.94,;16.12,-10.46,;16.59,-8.99,;18.13,-8.99,;18.61,-10.46,;17.37,-11.36,;17.38,-12.9,;16.05,-13.67,;14.96,-12.58,;13.42,-12.58,;12.33,-13.67,;12.33,-15.21,;13.42,-16.3,;14.96,-16.3,;16.04,-15.21,;17.37,-15.98,;18.7,-15.22,;20.18,-15.7,;21.1,-14.45,;22.64,-14.46,;23.41,-13.12,;23.4,-15.79,;20.19,-13.19,;20.67,-11.73,;18.71,-13.67,)|
Show InChI InChI=1S/C19H22N4OS/c1-23-10-6-9-13(23)14-11-7-4-2-3-5-8-12(11)22-19-15(14)16(20)17(25-19)18(21)24/h6,9-10H,2-5,7-8,20H2,1H3,(H2,21,24)
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n/an/a 990n/an/an/an/an/an/a



Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314412
PNG
(3-amino-4-(3,4-dichlorophenyl)-5,6,7,8,9,10-hexahy...)
Show SMILES NC(=O)c1sc2nc3CCCCCCc3c(-c3ccc(Cl)c(Cl)c3)c2c1N
Show InChI InChI=1S/C20H19Cl2N3OS/c21-12-8-7-10(9-13(12)22)15-11-5-3-1-2-4-6-14(11)25-20-16(15)17(23)18(27-20)19(24)26/h7-9H,1-6,23H2,(H2,24,26)
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n/an/a 990n/an/an/an/an/an/a



Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293951
PNG
(US10106552, Compound 26)
Show SMILES CCC(C)c1c2CCC(C)(C)c2nc2sc(C(N)=O)c(N)c12
PDB

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n/an/a 1.00E+3n/an/an/an/an/an/a



Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50053577
PNG
(CHEMBL3326370)
Show SMILES CCn1c2nc(N)c(cc2c(=O)n(CC)c1=O)C(N)=O
Show InChI InChI=1S/C12H15N5O3/c1-3-16-10-7(11(19)17(4-2)12(16)20)5-6(9(14)18)8(13)15-10/h5H,3-4H2,1-2H3,(H2,13,15)(H2,14,18)
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n/an/a 1.00E+3n/an/an/an/an/an/a



The University of Texas at Austin

Curated by ChEMBL


Assay Description
Inhibition of human recombinant eEF-2K expressed in bacteria pre-incubated for 30 mins before adding peptide substrate and [gamma32P]ATP by scintilla...


Bioorg Med Chem 22: 4910-6 (2014)


Article DOI: 10.1016/j.bmc.2014.06.050
BindingDB Entry DOI: 10.7270/Q2XD139S
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293935
PNG
(US10106552, Compound 10)
Show SMILES CC1(C)CCc2c(C1)nc1sc(C(N)=O)c(N)c1c2-c1ccco1
PDB

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Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293958
PNG
(US10106552, Compound 33)
Show SMILES CC1(C)CCc2nc3sc(C(N)=O)c(N)c3c(-c3cncs3)c2C1
PDB

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n/an/a 1.10E+3n/an/an/an/an/an/a



Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314408
PNG
(3-amino-4-methyl-5,6,7,8,9,10-hexahydrocycloocta[b...)
Show SMILES Cc1c2CCCCCCc2nc2sc(C(N)=O)c(N)c12
Show InChI InChI=1S/C15H19N3OS/c1-8-9-6-4-2-3-5-7-10(9)18-15-11(8)12(16)13(20-15)14(17)19/h2-7,16H2,1H3,(H2,17,19)
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Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314413
PNG
(3-amino-4-(4-chlorophenyl)-5,6,7,8,9,10-hexahydroc...)
Show SMILES NC(=O)c1sc2nc3CCCCCCc3c(-c3ccc(Cl)cc3)c2c1N
Show InChI InChI=1S/C20H20ClN3OS/c21-12-9-7-11(8-10-12)15-13-5-3-1-2-4-6-14(13)24-20-16(15)17(22)18(26-20)19(23)25/h7-10H,1-6,22H2,(H2,23,25)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314423
PNG
(3-amino-4-(furan-3-yl)-5,6,7,8,9,10-hexahydrocyclo...)
Show SMILES NC(=O)c1sc2nc3CCCCCCc3c(-c3ccoc3)c2c1N
Show InChI InChI=1S/C18H19N3O2S/c19-15-14-13(10-7-8-23-9-10)11-5-3-1-2-4-6-12(11)21-18(14)24-16(15)17(20)22/h7-9H,1-6,19H2,(H2,20,22)
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Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314432
PNG
(3-amino-4-(4,5-dimethylfuran-2-yl)-5,6,7,8,9,10-he...)
Show SMILES Cc1cc(oc1C)-c1c2CCCCCCc2nc2sc(C(N)=O)c(N)c12
Show InChI InChI=1S/C20H23N3O2S/c1-10-9-14(25-11(10)2)15-12-7-5-3-4-6-8-13(12)23-20-16(15)17(21)18(26-20)19(22)24/h9H,3-8,21H2,1-2H3,(H2,22,24)
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Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM50314435
PNG
(3-amino-4-(furan-2-yl)-6,7,8,9-tetrahydro-5H-cyclo...)
Show SMILES NC(=O)c1sc2nc3CCCCCc3c(-c3ccco3)c2c1N
Show InChI InChI=1S/C17H17N3O2S/c18-14-13-12(11-7-4-8-22-11)9-5-2-1-3-6-10(9)20-17(13)23-15(14)16(19)21/h4,7-8H,1-3,5-6,18H2,(H2,19,21)
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Myriad Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of GST tagged eEf2K expressed in Escherichia coli by fluorometric method


Bioorg Med Chem Lett 20: 2283-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.005
BindingDB Entry DOI: 10.7270/Q2F18ZVT
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293927
PNG
(US10106552, Compound 2)
Show SMILES CC1(C)CCc2nc3sc(C(N)=O)c(N)c3c(-c3ccc(Cl)o3)c2C1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293942
PNG
(US10106552, Compound 17)
Show SMILES CC1(C)CCc2c1nc1sc(C(N)=O)c(N)c1c2-c1ccoc1
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Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
Eukaryotic elongation factor 2 kinase


(Homo sapiens (Human))
BDBM293944
PNG
(US10106552, Compound 19)
Show SMILES CC1(C)CCc2c1nc1sc(C(N)=O)c(N)c1c2C1CC1
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Longevica Pharmaceuticals, Inc.

US Patent




US Patent US10106552 (2018)


Article DOI: 10.1021/jm040099a
BindingDB Entry DOI: 10.7270/Q25M67SV
More data for this
Ligand-Target Pair
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