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Compile Data Set for Download or QSAR

Found 1726 hits Enz. Inhib. hit(s) with Target = 'Flap endonuclease 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283677
PNG
(5-[3-Fluoro-2'-(pyrimidin-2-yloxy)-4'- (trifluorom...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(cc1Oc1ncccn1)C(F)(F)F
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0n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283516
PNG
(4'-(3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazin-7- yl)...)
Show SMILES C[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2NCCOc2c1 |r|
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0n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283230
PNG
(4'-(5-Aminopyrazin-2-yl)-3'-fluoro-N-(3- hydroxy-2...)
Show SMILES CC(C)(CO)CNS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
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0n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283245
PNG
(4'-(5-aminopyrazin-2-yl)-3'-fluoro-N-((1S,2S)- 1-h...)
Show SMILES C[C@@H]([C@@H](O)c1ccccc1)N(C)S(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 |r|
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0n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283248
PNG
((trans)-4'-(5-Aminopyrazin-2-yl)-3'-fluoro-N-[2- (...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@H]1CCCC[C@@H]1CO |r|
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283262
PNG
((S)-(1-{[4'-(5-Aminopyrazin-2-yl)-3'- fluorobiphen...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1[C@H](CO)Cc2ccccc12 |r|
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283287
PNG
(4'-(5-aminopyrazin-2-yl)-3'-fluoro-N-((1S,2R)- 2-h...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@@H]1[C@H](O)Cc2ccccc12 |r|
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0n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283288
PNG
(4'-(5-aminopyrazin-2-yl)-3'-fluoro-N-((1R,2S)- 2-h...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@H]1[C@@H](O)Cc2ccccc12 |r|
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0n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283303
PNG
(5-{3-Fluoro-2'-[(4-pyrazin-2-ylpiperazin-1- yl)sul...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CCN(CC1)c1cnccn1
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283304
PNG
(5-{3-Fluoro-2'-[(4-pyrimidin-2-ylpiperazin-1- yl)s...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CCN(CC1)c1ncccn1
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283306
PNG
(4'-(5-Aminopyrazin-2-yl)-3'-fluoro-N-[1- (hydroxym...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)NC1(CO)CCCC1
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283335
PNG
(4'-(5-Aminopyrazxin-2-yl)-3'-fluoro-N-methyl-4- (t...)
Show SMILES CNS(=O)(=O)c1cc(ccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283337
PNG
(4'-(5-aminopyrazin-2-yl)-3'-fluoro-N-(2- hydroxyet...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(cc1S(=O)(=O)NCCO)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283502
PNG
(3'-Fluoro-4'-(5H-pyrrolo[2,3-b]pyrazin-2-yl)N-- N-...)
Show SMILES CC(NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2n1)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283508
PNG
(2-{2'-[(1,1-Dioxidothiomorpholin-4-yl)sulfonyl]- 3...)
Show SMILES Fc1cc(ccc1-c1cnc2[nH]ccc2n1)-c1ccccc1S(=O)(=O)N1CCS(=O)(=O)CC1
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM283229
PNG
(4'-(5-Aminopyrazin-2-yl)-3'-fluoro-N-(3- hydroxy-1...)
Show SMILES CC(C)(CCO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM337621
PNG
(5-{2-Fluoro-4-[2-tetrahydro-2H- pyran-4-ylsulfonyl...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(nc1S(=O)(=O)C1CCOCC1)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM167060
PNG
(US9073876, 146 | US9732093, Compound 146)
Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2cc(N)nc(Cc3ccccc3)n2)c1F
Show InChI InChI=1S/C25H23FN6O/c26-24-18(19-13-30-21(28)14-29-19)10-9-17(16-7-4-8-16)25(24)33-23-12-20(27)31-22(32-23)11-15-5-2-1-3-6-15/h1-3,5-6,9-10,12-14,16H,4,7-8,11H2,(H2,28,30)(H2,27,31,32)
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JANSSEN PHARMACEUTICA NV

US Patent




US Patent US9732093 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9MCX
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM167060
PNG
(US9073876, 146 | US9732093, Compound 146)
Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2cc(N)nc(Cc3ccccc3)n2)c1F
Show InChI InChI=1S/C25H23FN6O/c26-24-18(19-13-30-21(28)14-29-19)10-9-17(16-7-4-8-16)25(24)33-23-12-20(27)31-22(32-23)11-15-5-2-1-3-6-15/h1-3,5-6,9-10,12-14,16H,4,7-8,11H2,(H2,28,30)(H2,27,31,32)
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JANSSEN PHARMACEUTICA NV

US Patent




US Patent US9732093 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9MCX
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM169403
PNG
(US9079866, 808 | US9745328, Compound 808 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1cccnc1S(=O)(=O)C1CCCCC1
Show InChI InChI=1S/C21H21FN4O2S/c22-18-11-14(8-9-17(18)19-12-26-20(23)13-25-19)16-7-4-10-24-21(16)29(27,28)15-5-2-1-3-6-15/h4,7-13,15H,1-3,5-6H2,(H2,23,26)
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM337627
PNG
(5-(4-{2-[(1,1-Dioxidotetrahydra-2H- thiopyran-4-yl...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(nc1S(=O)(=O)C1CCS(=O)(=O)CC1)C(F)(F)F
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM167191
PNG
(US9073876, 272 | US9732093, Compound 272)
Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nc(N)c3ccccc3n2)c1F
Show InChI InChI=1S/C22H19FN6O/c23-19-14(17-10-27-18(24)11-26-17)9-8-13(12-4-3-5-12)20(19)30-22-28-16-7-2-1-6-15(16)21(25)29-22/h1-2,6-12H,3-5H2,(H2,24,27)(H2,25,28,29)
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JANSSEN PHARMACEUTICA NV

US Patent




US Patent US9732093 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9MCX
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM167191
PNG
(US9073876, 272 | US9732093, Compound 272)
Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nc(N)c3ccccc3n2)c1F
Show InChI InChI=1S/C22H19FN6O/c23-19-14(17-10-27-18(24)11-26-17)9-8-13(12-4-3-5-12)20(19)30-22-28-16-7-2-1-6-15(16)21(25)29-22/h1-2,6-12H,3-5H2,(H2,24,27)(H2,25,28,29)
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JANSSEN PHARMACEUTICA NV

US Patent




US Patent US9732093 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9MCX
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM169201
PNG
(US9079866, 602 | US9745328, Compound 602 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
Show InChI InChI=1S/C26H18F2N6/c27-21-9-15(5-7-19(21)23-11-33-25(29)13-31-23)17-3-1-2-4-18(17)16-6-8-20(22(28)10-16)24-12-34-26(30)14-32-24/h1-14H,(H2,29,33)(H2,30,34)
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0.600n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM169405
PNG
(US9079866, 810 | US9745328, Compound 810 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1cccnc1S(=O)(=O)C1CCCC1
Show InChI InChI=1S/C20H19FN4O2S/c21-17-10-13(7-8-16(17)18-11-25-19(22)12-24-18)15-6-3-9-23-20(15)28(26,27)14-4-1-2-5-14/h3,6-12,14H,1-2,4-5H2,(H2,22,25)
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0.600n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM169421
PNG
(US9079866, 826 | US9745328, Compound 826 | US98848...)
Show SMILES CC(C)S(=O)(=O)c1ncccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C21H18FN3O2S/c1-13(2)28(26,27)21-18(4-3-8-24-21)14-5-6-17(19(22)11-14)16-10-15-7-9-23-20(15)25-12-16/h3-13H,1-2H3,(H,23,25)
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0.700n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM337603
PNG
(4-{[4'-(5-Aminopyrazin-2-yl)-3'- fluorobiphenyl-2-...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1Oc1ccc(cc1)C(O)=O
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0.700n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM169270
PNG
(US9079866, 675 | US9745328, Compound 675 | US98848...)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1cnc(c(F)c1)-c1cnc(N)nc1
Show InChI InChI=1S/C19H20FN5O2S/c1-19(2,3)25-28(26,27)16-7-5-4-6-14(16)12-8-15(20)17(22-9-12)13-10-23-18(21)24-11-13/h4-11,25H,1-3H3,(H2,21,23,24)
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM167005
PNG
(US9073876, 91 | US9732093, Compound 91)
Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nccc(n2)-c2cccs2)c1F
Show InChI InChI=1S/C22H18FN5OS/c23-20-15(17-11-27-19(24)12-26-17)7-6-14(13-3-1-4-13)21(20)29-22-25-9-8-16(28-22)18-5-2-10-30-18/h2,5-13H,1,3-4H2,(H2,24,27)
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JANSSEN PHARMACEUTICA NV

US Patent




US Patent US9732093 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9MCX
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM167188
PNG
(US9073876, 269 | US9732093, Compound 269)
Show SMILES CNc1nc(C)cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1
Show InChI InChI=1S/C20H21FN6O/c1-11-8-17(27-20(23-2)26-11)28-19-13(12-4-3-5-12)6-7-14(18(19)21)15-9-25-16(22)10-24-15/h6-10,12H,3-5H2,1-2H3,(H2,22,25)(H,23,26,27)
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JANSSEN PHARMACEUTICA NV

US Patent




US Patent US9732093 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9MCX
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM167188
PNG
(US9073876, 269 | US9732093, Compound 269)
Show SMILES CNc1nc(C)cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1
Show InChI InChI=1S/C20H21FN6O/c1-11-8-17(27-20(23-2)26-11)28-19-13(12-4-3-5-12)6-7-14(18(19)21)15-9-25-16(22)10-24-15/h6-10,12H,3-5H2,1-2H3,(H2,22,25)(H,23,26,27)
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JANSSEN PHARMACEUTICA NV

US Patent




US Patent US9732093 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9MCX
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM169155
PNG
(US9079866, 556 | US9745328, Compound 556 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(cc1Oc1nccc(N)n1)C(F)(F)F
Show InChI InChI=1S/C21H14F4N6O/c22-15-7-11(1-3-14(15)16-9-30-19(27)10-29-16)13-4-2-12(21(23,24)25)8-17(13)32-20-28-6-5-18(26)31-20/h1-10H,(H2,27,30)(H2,26,28,31)
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM168719
PNG
(US9079866, 100 | US9745328, Compound 100 | US98848...)
Show SMILES CC(C)(CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
Show InChI InChI=1S/C20H21FN4O3S/c1-20(2,12-26)25-29(27,28)18-6-4-3-5-14(18)13-7-8-15(16(21)9-13)17-10-24-19(22)11-23-17/h3-11,25-26H,12H2,1-2H3,(H2,22,24)
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM169465
PNG
(US9079866, 109 | US9745328, Compound 109 | US98848...)
Show SMILES CC(C)[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 |r|
Show InChI InChI=1/C21H23FN4O3S/c1-13(2)19(12-27)26-30(28,29)20-6-4-3-5-15(20)14-7-8-16(17(22)9-14)18-10-25-21(23)11-24-18/h3-11,13,19,26-27H,12H2,1-2H3,(H2,23,25)/t19-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM168670
PNG
(US9079866, 47 | US9745328, Compound 47 | US9884878...)
Show SMILES CCN(CC)S(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
Show InChI InChI=1S/C20H21FN4O2S/c1-3-25(4-2)28(26,27)19-8-6-5-7-15(19)14-9-10-16(17(21)11-14)18-12-24-20(22)13-23-18/h5-13H,3-4H2,1-2H3,(H2,22,24)
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM168673
PNG
(US9079866, 50 | US9745328, Compound 50 | US9884878...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CCCC(F)(F)C1
Show InChI InChI=1S/C21H19F3N4O2S/c22-17-10-14(6-7-16(17)18-11-27-20(25)12-26-18)15-4-1-2-5-19(15)31(29,30)28-9-3-8-21(23,24)13-28/h1-2,4-7,10-12H,3,8-9,13H2,(H2,25,27)
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM168678
PNG
(US9079866, 55 | US9745328, Compound 55 | US9884878...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CCC(O)(CC1)C(F)(F)F
Show InChI InChI=1S/C22H20F4N4O3S/c23-17-11-14(5-6-16(17)18-12-29-20(27)13-28-18)15-3-1-2-4-19(15)34(32,33)30-9-7-21(31,8-10-30)22(24,25)26/h1-6,11-13,31H,7-10H2,(H2,27,29)
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM169054
PNG
(US9079866, 455 | US9745328, Compound 455 | US98848...)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]cc(CO)c2c1
Show InChI InChI=1S/C24H24FN3O3S/c1-24(2,3)28-32(30,31)22-7-5-4-6-19(22)15-8-9-18(21(25)11-15)16-10-20-17(14-29)13-27-23(20)26-12-16/h4-13,28-29H,14H2,1-3H3,(H,26,27)
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM169122
PNG
(US9079866, 523 | US9745328, Compound 523 | US98848...)
Show SMILES Nc1nccc(Oc2ccccc2-c2ccc(c(F)c2)-c2cnc3[nH]ccc3c2)n1
Show InChI InChI=1S/C23H16FN5O/c24-19-12-14(5-6-17(19)16-11-15-7-9-26-22(15)28-13-16)18-3-1-2-4-20(18)30-21-8-10-27-23(25)29-21/h1-13H,(H,26,28)(H2,25,27,29)
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM169123
PNG
(US9079866, 524 | US9745328, Compound 524 | US98848...)
Show SMILES Nc1ccnc(Oc2ccccc2-c2ccc(c(F)c2)-c2cnc3[nH]ccc3c2)n1
Show InChI InChI=1S/C23H16FN5O/c24-19-12-14(5-6-17(19)16-11-15-7-9-26-22(15)28-13-16)18-3-1-2-4-20(18)30-23-27-10-8-21(25)29-23/h1-13H,(H,26,28)(H2,25,27,29)
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM169134
PNG
(US9079866, 535 | US9745328, Compound 535 | US98848...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1Oc1cc(N)ncn1
Show InChI InChI=1S/C20H15FN6O/c21-15-7-12(5-6-14(15)16-9-25-19(23)10-24-16)13-3-1-2-4-17(13)28-20-8-18(22)26-11-27-20/h1-11H,(H2,23,25)(H2,22,26,27)
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM168640
PNG
(US9079866, 13 | US9745328, Compound 13)
Show SMILES CC(C)(NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)C(F)(F)F
Show InChI InChI=1S/C20H18F4N4O2S/c1-19(2,20(22,23)24)28-31(29,30)17-6-4-3-5-13(17)12-7-8-14(15(21)9-12)16-10-27-18(25)11-26-16/h3-11,28H,1-2H3,(H2,25,27)
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM60470
PNG
(BDBM168646 | US9079866, 127 | US9745328, Compound ...)
Show SMILES C[C@@H](NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)C(F)(F)F |r|
Show InChI InChI=1/C19H16F4N4O2S/c1-11(19(21,22)23)27-30(28,29)17-5-3-2-4-13(17)12-6-7-14(15(20)8-12)16-9-26-18(24)10-25-16/h2-11,27H,1H3,(H2,24,26)/t11-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM168648
PNG
(US9079866, 22 | US9079866, 23 | US9745328, Compoun...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@@H]1CCc2ccccc12 |r|
Show InChI InChI=1/C25H21FN4O2S/c26-21-13-17(9-11-20(21)23-14-29-25(27)15-28-23)19-7-3-4-8-24(19)33(31,32)30-22-12-10-16-5-1-2-6-18(16)22/h1-9,11,13-15,22,30H,10,12H2,(H2,27,29)/t22-/s2
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM168649
PNG
(US9079866, 26 | US9745328, Compound 26 | US9884878...)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C22H17FN4O2S/c23-19-12-15(10-11-18(19)20-13-26-22(24)14-25-20)17-8-4-5-9-21(17)30(28,29)27-16-6-2-1-3-7-16/h1-14,27H,(H2,24,26)
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM167001
PNG
(US9073876, 87 | US9732093, Compound 87)
Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nccc(n2)-c2ccccc2)c1F
Show InChI InChI=1S/C24H20FN5O/c25-22-18(20-13-29-21(26)14-28-20)10-9-17(15-7-4-8-15)23(22)31-24-27-12-11-19(30-24)16-5-2-1-3-6-16/h1-3,5-6,9-15H,4,7-8H2,(H2,26,29)
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JANSSEN PHARMACEUTICA NV

US Patent




US Patent US9732093 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9MCX
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM167005
PNG
(US9073876, 91 | US9732093, Compound 91)
Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nccc(n2)-c2cccs2)c1F
Show InChI InChI=1S/C22H18FN5OS/c23-20-15(17-11-27-19(24)12-26-17)7-6-14(13-3-1-4-13)21(20)29-22-25-9-8-16(28-22)18-5-2-10-30-18/h2,5-13H,1,3-4H2,(H2,24,27)
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JANSSEN PHARMACEUTICA NV

US Patent




US Patent US9732093 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9MCX
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM167014
PNG
(US9073876, 100 | US9732093, Compound 100)
Show SMILES COc1nc(N)cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1
Show InChI InChI=1S/C19H19FN6O2/c1-27-19-25-14(21)7-16(26-19)28-18-11(10-3-2-4-10)5-6-12(17(18)20)13-8-24-15(22)9-23-13/h5-10H,2-4H2,1H3,(H2,22,24)(H2,21,25,26)
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JANSSEN PHARMACEUTICA NV

US Patent




US Patent US9732093 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9MCX
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM169033
PNG
(US9079866, 434 | US9745328, Compound 434 | US98848...)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)c(n1)C#N
Show InChI InChI=1S/C21H20FN5O2S/c1-21(2,3)27-30(28,29)19-7-5-4-6-14(19)13-8-9-15(16(22)10-13)18-12-25-20(24)17(11-23)26-18/h4-10,12,27H,1-3H3,(H2,24,25)
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Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
Flap endonuclease 1


(Homo sapiens (Human))
BDBM169037
PNG
(US9079866, 438 | US9745328, Compound 438 | US98848...)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2nnc(N)s2)c(F)c1
Show InChI InChI=1S/C18H19FN4O2S2/c1-18(2,3)23-27(24,25)15-7-5-4-6-12(15)11-8-9-13(14(19)10-11)16-21-22-17(20)26-16/h4-10,23H,1-3H3,(H2,20,22)
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1n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent




US Patent US9745328 (2017)


BindingDB Entry DOI: 10.7270/Q2H13446
More data for this
Ligand-Target Pair
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