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Found 103 hits Enz. Inhib. hit(s) with Target = 'G protein-activated inward rectifier potassium channel 4'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347063
PNG
(US10202390, Example 18)
Show SMILES CCCn1cc(nn1)-c1cnc(cc1NC1CC1)-c1cnc2cc(cnn12)C#N
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US Patent




US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347074
PNG
(US10202390, Example 29)
Show SMILES CC(C)(O)CCc1cc(n[nH]1)-c1cnc(cc1NC1CCOCC1)-c1cnn2cc(cnc12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347061
PNG
(3-(4-(isopropylamino)-5-(1-(tetrahydro-2H-pyran-4-...)
Show SMILES CC(C)Nc1cc(ncc1-c1cn(nn1)C1CCOCC1)-c1cnc2cc(cnn12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347062
PNG
(US10202390, Example 17)
Show SMILES CC(C)Nc1cc(ncc1-c1cn(nn1)C1CN(C1)C(C)=O)-c1cnc2cc(cnn12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347064
PNG
(US10202390, Example 19)
Show SMILES CCCn1cc(nn1)-c1cnc(cc1NC1CC1)-c1cnc2cc(Cl)cnn12
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347058
PNG
(US10202390, Example 13)
Show SMILES CC(C)Nc1cc(ncc1-n1cc(CCC(C)(C)O)nn1)-c1cnn2cc(Cl)cnc12
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347072
PNG
(3-(5-(1-(3-hydroxy-3-methylbutyl)-1H-pyrazol-4-yl)...)
Show SMILES CC(C)Nc1cc(ncc1-c1cnn(CCC(C)(C)O)c1)-c1cnc2cc(cnn12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347067
PNG
(US10202390, Example 22)
Show SMILES CC(C)Nc1cc(ncc1-n1cc(CCC(C)(C)O)nn1)-c1cnc2cc(cnn12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347070
PNG
(US10202390, Example 25)
Show SMILES CC(C)(O)CCc1cn(nn1)-c1cnc(cc1N[C@H]1CC[C@H](F)C1)-c1cnn2cc(cnc12)C#N |r|
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347073
PNG
(US10202390, Example 28)
Show SMILES CC(C)Nc1cc(ncc1-c1cc([nH]n1)C1CCOCC1)-c1cnc2cc(cnn12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347060
PNG
(3-(4-(isopropylamino)-5-(4-propyl-1H-1,2,3-triazol...)
Show SMILES CCCc1cn(nn1)-c1cnc(cc1NC(C)C)-c1cnc2cc(cnn12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347056
PNG
(2-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-N-isopro...)
Show SMILES CCCc1cn(nn1)-c1cnc(cc1NC(C)C)-c1cnn2cc(Cl)cnc12
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347059
PNG
(US10202390, Example 14)
Show SMILES CC(C)(O)CCc1cn(nn1)-c1cnc(cc1NC1COC1)-c1cnn2cc(Cl)cnc12
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347068
PNG
(US10202390, Example 23)
Show SMILES CC(C)(O)CCc1cn(nn1)-c1cnc(cc1NC1CCOCC1)-c1cnn2cc(Cl)cnc12
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347057
PNG
(US10202390, Example 12)
Show SMILES CCCc1cn(nn1)-c1cnc(cc1NC(C)C)-c1cnn2cc(cnc12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347071
PNG
(US10202390, Example 26)
Show SMILES CC(C)(O)CCc1cn(nn1)-c1cnc(cc1NC1COC1)-c1cnn2cc(cnc12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347065
PNG
(US10202390, Example 20)
Show SMILES CCCn1cc(nn1)-c1cnc(cc1NC(C)C)-c1cnc2cc(Cl)cnn12
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347048
PNG
(US10202390, Example 3)
Show SMILES CC(C)Nc1cc(ncc1-c1cnn(c1)C1CCOCC1)-c1cnc2cc(cnn12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347066
PNG
(US10202390, Example 21)
Show SMILES COC(=O)N1CCC(n2cc(nn2)-c2cnc(cc2NC2CC2)-c2cnc3cc(Cl)cnn23)[C@](C)(O)C1 |r|
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347069
PNG
(US10202390, Example 24)
Show SMILES CC(C)(O)CCc1cn(nn1)-c1cnc(cc1NC1CC(F)(F)C1)-c1cnn2cc(cnc12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347051
PNG
(US10202390, Example 6)
Show SMILES CCCn1cc(cn1)-c1cnc(cc1NC(C)C)-c1cnc2cc(cnn12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347055
PNG
(US10202390, Example 10)
Show SMILES CCCn1cc(cn1)-c1cnc(cc1Nc1cnn(CC(F)F)c1)-c1cnc2cc(cnn12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347054
PNG
(US10202390, Example 9)
Show SMILES CCCn1cc(cn1)-c1cnc(cc1Nc1cnn(CC(F)F)c1)-c1cnc2cc(Cl)cnn12
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347052
PNG
(US10202390, Example 7 | US10202390, Example 8)
Show SMILES CC(C)Nc1cc(ncc1-c1cnn(CC(F)(F)F)c1)-c1cnc2cc(cnn12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347052
PNG
(US10202390, Example 7 | US10202390, Example 8)
Show SMILES CC(C)Nc1cc(ncc1-c1cnn(CC(F)(F)F)c1)-c1cnc2cc(cnn12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347047
PNG
(2-(7-chloroimidazo[1,2-b]pyridazin-3-yl)-N-isoprop...)
Show SMILES CC(C)Nc1cc(ncc1-c1cnn(c1)C1CCOCC1)-c1cnc2cc(Cl)cnn12
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347050
PNG
(US10202390, Example 5)
Show SMILES CC(C)Nc1cc(ncc1-c1cnn(CC(C)(C)O)c1)-c1cnc2cc(cnn12)C#N
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US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437954
PNG
(CHEMBL2409269)
Show SMILES Fc1cccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)c1
Show InChI InChI=1S/C20H19FN4O/c21-15-5-4-6-16(12-15)22-20(26)23-19-13-17(11-14-9-10-14)24-25(19)18-7-2-1-3-8-18/h1-8,12-14H,9-11H2,(H2,22,23,26)
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Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437955
PNG
(CHEMBL2409135)
Show SMILES Cc1cccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)c1
Show InChI InChI=1S/C21H22N4O/c1-15-6-5-7-17(12-15)22-21(26)23-20-14-18(13-16-10-11-16)24-25(20)19-8-3-2-4-9-19/h2-9,12,14,16H,10-11,13H2,1H3,(H2,22,23,26)
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Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437953
PNG
(CHEMBL2409098)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)c1
Show InChI InChI=1S/C21H19F3N4O/c22-21(23,24)15-5-4-6-16(12-15)25-20(29)26-19-13-17(11-14-9-10-14)27-28(19)18-7-2-1-3-8-18/h1-8,12-14H,9-11H2,(H2,25,26,29)
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Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437990
PNG
(CHEMBL2409099)
Show SMILES Fc1ccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)cc1
Show InChI InChI=1S/C20H19FN4O/c21-15-8-10-16(11-9-15)22-20(26)23-19-13-17(12-14-6-7-14)24-25(19)18-4-2-1-3-5-18/h1-5,8-11,13-14H,6-7,12H2,(H2,22,23,26)
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Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437989
PNG
(CHEMBL2409100)
Show SMILES Fc1ccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)cc1Cl
Show InChI InChI=1S/C20H18ClFN4O/c21-17-11-14(8-9-18(17)22)23-20(27)24-19-12-15(10-13-6-7-13)25-26(19)16-4-2-1-3-5-16/h1-5,8-9,11-13H,6-7,10H2,(H2,23,24,27)
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n/an/a 310n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437988
PNG
(CHEMBL2409101)
Show SMILES Clc1cccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)c1
Show InChI InChI=1S/C20H19ClN4O/c21-15-5-4-6-16(12-15)22-20(26)23-19-13-17(11-14-9-10-14)24-25(19)18-7-2-1-3-8-18/h1-8,12-14H,9-11H2,(H2,22,23,26)
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n/an/a 340n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347049
PNG
(US10202390, Example 4)
Show SMILES CC(C)Nc1cc(ncc1-c1cnn(CC(C)(C)O)c1)-c1cnc2cc(Cl)cnn12
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n/an/a 396n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437987
PNG
(CHEMBL2409102)
Show SMILES Clc1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)c1
Show InChI InChI=1S/C20H19ClN4O/c21-15-8-5-9-16(12-15)22-20(26)23-19-13-18(14-6-4-7-14)24-25(19)17-10-2-1-3-11-17/h1-3,5,8-14H,4,6-7H2,(H2,22,23,26)
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n/an/a 480n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437952
PNG
(CHEMBL2409118)
Show SMILES Fc1ccc(NC(=O)Nc2cc(CC3CC3)nn2-c2ccccc2)cc1F
Show InChI InChI=1S/C20H18F2N4O/c21-17-9-8-14(11-18(17)22)23-20(27)24-19-12-15(10-13-6-7-13)25-26(19)16-4-2-1-3-5-16/h1-5,8-9,11-13H,6-7,10H2,(H2,23,24,27)
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n/an/a 560n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM347046
PNG
(3-(5-(4-(2-hydroxypropan-2-yl)-1H-pyrazol-1-yl)-4-...)
Show SMILES CC(C)Nc1cc(ncc1-n1cc(cn1)C(C)(C)O)-c1cnn2cc(cnc12)C#N
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n/an/a 578n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent




US Patent US10202390 (2019)


Article DOI: 10.1021/jm061107l
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437984
PNG
(CHEMBL2409105)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)cc1Cl
Show InChI InChI=1S/C20H18ClFN4O/c21-16-11-14(9-10-17(16)22)23-20(27)24-19-12-18(13-5-4-6-13)25-26(19)15-7-2-1-3-8-15/h1-3,7-13H,4-6H2,(H2,23,24,27)
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n/an/a 610n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437986
PNG
(CHEMBL2409103)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)c1
Show InChI InChI=1S/C21H19F3N4O/c22-21(23,24)15-8-5-9-16(12-15)25-20(29)26-19-13-18(14-6-4-7-14)27-28(19)17-10-2-1-3-11-17/h1-3,5,8-14H,4,6-7H2,(H2,25,26,29)
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n/an/a 690n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437985
PNG
(CHEMBL2409104)
Show SMILES Brc1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)c1
Show InChI InChI=1S/C20H19BrN4O/c21-15-8-5-9-16(12-15)22-20(26)23-19-13-18(14-6-4-7-14)24-25(19)17-10-2-1-3-11-17/h1-3,5,8-14H,4,6-7H2,(H2,22,23,26)
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n/an/a 720n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437958
PNG
(CHEMBL2409124)
Show SMILES CC(C)c1cc(NC(=O)Nc2cccc(F)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C19H19FN4O/c1-13(2)17-12-18(24(23-17)16-9-4-3-5-10-16)22-19(25)21-15-8-6-7-14(20)11-15/h3-13H,1-2H3,(H2,21,22,25)
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n/an/a 780n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437957
PNG
(CHEMBL2409125)
Show SMILES CC(C)c1cc(NC(=O)Nc2cccc(C)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H22N4O/c1-14(2)18-13-19(24(23-18)17-10-5-4-6-11-17)22-20(25)21-16-9-7-8-15(3)12-16/h4-14H,1-3H3,(H2,21,22,25)
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n/an/a 850n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437959
PNG
(CHEMBL2409123)
Show SMILES CC(C)c1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H19F3N4O/c1-13(2)17-12-18(27(26-17)16-9-4-3-5-10-16)25-19(28)24-15-8-6-7-14(11-15)20(21,22)23/h3-13H,1-2H3,(H2,24,25,28)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437966
PNG
(CHEMBL2409114)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C19H18F2N4O/c1-12(2)17-11-18(25(24-17)14-6-4-3-5-7-14)23-19(26)22-13-8-9-15(20)16(21)10-13/h3-12H,1-2H3,(H2,22,23,26)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437956
PNG
(CHEMBL2409126)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(C)cc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C20H22N4O/c1-14(2)18-13-19(24(23-18)17-7-5-4-6-8-17)22-20(25)21-16-11-9-15(3)10-12-16/h4-14H,1-3H3,(H2,21,22,25)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50202477
PNG
(CHEMBL3955249)
Show SMILES [H][C@]12[C@@H](OC(=O)c3ccccc3)[C@@H](C)C[C@]1(OC(C)=O)[C@@H](OC(C)=O)[C@]1(C)OC[C@@]3([C@@H]2OC(C)=O)C(=O)C=C[C@@H]([C@@]13[H])C(C)(C)OC(C)=O |r,c:40|
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n/an/a 2.50E+3n/an/an/an/an/an/a



Rytmion Ltd.

Curated by ChEMBL


Assay Description
Inhibition of GTPgammaS-induced activation of GIRK1/4 (unknown origin) expressed in HEK293 cells assessed as decrease in channel current after 2 mins...


J Nat Prod 79: 1990-2004 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00260
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437964
PNG
(CHEMBL2409116)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCCC2)cc1F
Show InChI InChI=1S/C21H20F2N4O/c22-17-11-10-15(12-18(17)23)24-21(28)25-20-13-19(14-6-4-5-7-14)26-27(20)16-8-2-1-3-9-16/h1-3,8-14H,4-7H2,(H2,24,25,28)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50202479
PNG
(CHEBI:69714 | EUPHORBIAPROLIFERIN C | Euphorbiapro...)
Show SMILES [H][C@]12[C@@H](OC(=O)C(C)C)[C@@H](C)C[C@]1(OC(C)=O)[C@@H](OC(C)=O)[C@]1(C)OC[C@@]3([C@@H]2OC(C)=O)C(=O)C=C[C@@H]([C@@]13[H])C(C)(C)OC(C)=O |r,c:36|
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n/an/a 4.70E+3n/an/an/an/an/an/a



Rytmion Ltd.

Curated by ChEMBL


Assay Description
Inhibition of GTPgammaS-induced activation of GIRK1/4 (unknown origin) expressed in HEK293 cells assessed as decrease in channel current after 2 mins...


J Nat Prod 79: 1990-2004 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00260
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50202481
PNG
(CHEMBL3901192)
Show SMILES [H][C@@]12C[C@](C)(OC(C)=O)[C@]1([H])[C@@]1([H])[C@@]3(C)OC[C@@]1([C@H](OC(C)=O)[C@@]1([H])[C@@H](OC(=O)c4cccnc4)[C@@H](C)C[C@]1(OC(C)=O)[C@H]3OC(C)=O)C(=O)[C@@H]2OC(=O)C(C)CC |r|
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n/an/a 4.90E+3n/an/an/an/an/an/a



Rytmion Ltd.

Curated by ChEMBL


Assay Description
Inhibition of GTPgammaS-induced activation of GIRK1/4 (unknown origin) expressed in HEK293 cells assessed as decrease in channel current after 2 mins...


J Nat Prod 79: 1990-2004 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00260
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50202478
PNG
(CHEMBL3899370)
Show SMILES [H][C@]12[C@@H](OC(=O)CC)[C@@H](C)C[C@]1(OC(C)=O)[C@@H](OC(C)=O)[C@]1(C)OC[C@@]3([C@@H]2OC(C)=O)C(=O)C=C[C@@H]([C@@]13[H])C(C)(C)OC(C)=O |r,c:35|
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n/an/a 6.70E+3n/an/an/an/an/an/a



Rytmion Ltd.

Curated by ChEMBL


Assay Description
Inhibition of GTPgammaS-induced activation of GIRK1/4 (unknown origin) expressed in HEK293 cells assessed as decrease in channel current after 2 mins...


J Nat Prod 79: 1990-2004 (2016)


Article DOI: 10.1021/acs.jnatprod.6b00260
More data for this
Ligand-Target Pair
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