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Compile Data Set for Download or QSAR

Found 127 hits Enz. Inhib. hit(s) with Target = 'Histamine receptor H3'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442630
PNG
(CHEMBL2441638)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)C2CCCCC2)c(C)c1
Show InChI InChI=1S/C23H35N3O/c1-17-15-20(25-14-12-21(16-25)26-13-6-7-18(26)2)10-11-22(17)24-23(27)19-8-4-3-5-9-19/h10-11,15,18-19,21H,3-9,12-14,16H2,1-2H3,(H,24,27)/t18-,21-/m0/s1
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0.390n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443217
PNG
(CHEMBL3087669)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2c(C)noc2C)c(C)c1
Show InChI InChI=1S/C22H30N4O2/c1-14-12-18(25-11-9-19(13-25)26-10-5-6-15(26)2)7-8-20(14)23-22(27)21-16(3)24-28-17(21)4/h7-8,12,15,19H,5-6,9-11,13H2,1-4H3,(H,23,27)/t15-,19-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442628
PNG
(CHEMBL2441640)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)C2CCCC2)c(C)c1
Show InChI InChI=1S/C22H33N3O/c1-16-14-19(9-10-21(16)23-22(26)18-7-3-4-8-18)24-13-11-20(15-24)25-12-5-6-17(25)2/h9-10,14,17-18,20H,3-8,11-13,15H2,1-2H3,(H,23,26)/t17-,20-/m0/s1
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Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442627
PNG
(CHEMBL2441641)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)C2C(C)(C)C2(C)C)c(C)c1
Show InChI InChI=1S/C24H37N3O/c1-16-14-18(26-13-11-19(15-26)27-12-7-8-17(27)2)9-10-20(16)25-22(28)21-23(3,4)24(21,5)6/h9-10,14,17,19,21H,7-8,11-13,15H2,1-6H3,(H,25,28)/t17-,19-/m0/s1
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0.550n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442629
PNG
(CHEMBL2441639)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)C2CC3CCC2C3)c(C)c1
Show InChI InChI=1S/C24H35N3O/c1-16-12-20(26-11-9-21(15-26)27-10-3-4-17(27)2)7-8-23(16)25-24(28)22-14-18-5-6-19(22)13-18/h7-8,12,17-19,21-22H,3-6,9-11,13-15H2,1-2H3,(H,25,28)/t17-,18?,19?,21-,22?/m0/s1
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0.550n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442626
PNG
(CHEMBL2441642)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)CC2CCCC2)c(C)c1
Show InChI InChI=1S/C23H35N3O/c1-17-14-20(25-13-11-21(16-25)26-12-5-6-18(26)2)9-10-22(17)24-23(27)15-19-7-3-4-8-19/h9-10,14,18-19,21H,3-8,11-13,15-16H2,1-2H3,(H,24,27)/t18-,21-/m0/s1
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0.850n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442632
PNG
(CHEMBL2441636)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)C2CCOCC2)c(C)c1
Show InChI InChI=1S/C22H33N3O2/c1-16-14-19(24-11-7-20(15-24)25-10-3-4-17(25)2)5-6-21(16)23-22(26)18-8-12-27-13-9-18/h5-6,14,17-18,20H,3-4,7-13,15H2,1-2H3,(H,23,26)/t17-,20-/m0/s1
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0.970n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443216
PNG
(CHEMBL3087667)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2cc(C)no2)c(C)c1
Show InChI InChI=1S/C21H28N4O2/c1-14-11-17(24-10-8-18(13-24)25-9-4-5-16(25)3)6-7-19(14)22-21(26)20-12-15(2)23-27-20/h6-7,11-12,16,18H,4-5,8-10,13H2,1-3H3,(H,22,26)/t16-,18-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443227
PNG
(CHEMBL3087356)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2cccc(C)n2)c(C)c1
Show InChI InChI=1S/C23H30N4O/c1-16-14-19(26-13-11-20(15-26)27-12-5-7-18(27)3)9-10-21(16)25-23(28)22-8-4-6-17(2)24-22/h4,6,8-10,14,18,20H,5,7,11-13,15H2,1-3H3,(H,25,28)/t18-,20-/m0/s1
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1.40n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443226
PNG
(CHEMBL3087357)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2ccoc2)c(C)c1
Show InChI InChI=1S/C21H27N3O2/c1-15-12-18(5-6-20(15)22-21(25)17-8-11-26-14-17)23-10-7-19(13-23)24-9-3-4-16(24)2/h5-6,8,11-12,14,16,19H,3-4,7,9-10,13H2,1-2H3,(H,22,25)/t16-,19-/m0/s1
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1.80n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50434389
PNG
(CHEMBL2387288)
Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)NCc2cccs2)cc1
Show InChI InChI=1S/C21H28N4OS/c1-16-4-2-11-25(16)19-10-12-24(15-19)18-8-6-17(7-9-18)23-21(26)22-14-20-5-3-13-27-20/h3,5-9,13,16,19H,2,4,10-12,14-15H2,1H3,(H2,22,23,26)
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1.90n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from cloned rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation coun...


Bioorg Med Chem Lett 23: 3416-20 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443225
PNG
(CHEMBL3087671)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NS(=O)(=O)c2ccc(F)c(F)c2)c(C)n1
Show InChI InChI=1S/C21H26F2N4O2S/c1-14-4-3-10-27(14)16-9-11-26(13-16)21-8-7-20(15(2)24-21)25-30(28,29)17-5-6-18(22)19(23)12-17/h5-8,12,14,16,25H,3-4,9-11,13H2,1-2H3/t14-,16-/m0/s1
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2.5n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50437067
PNG
(CHEMBL2403550)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2cc(F)ccc2C)c(C)c1
Show InChI InChI=1S/C24H30FN3O/c1-16-6-7-19(25)14-22(16)24(29)26-23-9-8-20(13-17(23)2)27-12-10-21(15-27)28-11-4-5-18(28)3/h6-9,13-14,18,21H,4-5,10-12,15H2,1-3H3,(H,26,29)/t18-,21-/m0/s1
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Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cell membranes after 1 hr by scin...


Bioorg Med Chem Lett 23: 4044-7 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50437067
PNG
(CHEMBL2403550)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2cc(F)ccc2C)c(C)c1
Show InChI InChI=1S/C24H30FN3O/c1-16-6-7-19(25)14-22(16)24(29)26-23-9-8-20(13-17(23)2)27-12-10-21(15-27)28-11-4-5-18(28)3/h6-9,13-14,18,21H,4-5,10-12,15H2,1-3H3,(H,26,29)/t18-,21-/m0/s1
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Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443224
PNG
(CHEMBL3087670)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2ccccc2)c(C)n1
Show InChI InChI=1S/C22H28N4O/c1-16-7-6-13-26(16)19-12-14-25(15-19)21-11-10-20(17(2)23-21)24-22(27)18-8-4-3-5-9-18/h3-5,8-11,16,19H,6-7,12-15H2,1-2H3,(H,24,27)/t16-,19-/m0/s1
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3n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442640
PNG
(CHEMBL2441653)
Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)CC2CCCC2)cc1
Show InChI InChI=1S/C22H33N3O/c1-17-5-4-13-25(17)21-12-14-24(16-21)20-10-8-19(9-11-20)23-22(26)15-18-6-2-3-7-18/h8-11,17-18,21H,2-7,12-16H2,1H3,(H,23,26)
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Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50434405
PNG
(CHEMBL2387306)
Show SMILES Clc1cc(Cl)cc(NC(=O)Nc2ccc(OCCCN3CCCCC3)cc2)c1
Show InChI InChI=1S/C21H25Cl2N3O2/c22-16-13-17(23)15-19(14-16)25-21(27)24-18-5-7-20(8-6-18)28-12-4-11-26-9-2-1-3-10-26/h5-8,13-15H,1-4,9-12H2,(H2,24,25,27)
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Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from cloned rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation coun...


Bioorg Med Chem Lett 23: 3416-20 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50434382
PNG
(CHEMBL2387309)
Show SMILES Fc1ccc(NC(=O)Nc2ccc(OCCCN3CCCCC3)cc2)c(F)c1
Show InChI InChI=1S/C21H25F2N3O2/c22-16-5-10-20(19(23)15-16)25-21(27)24-17-6-8-18(9-7-17)28-14-4-13-26-11-2-1-3-12-26/h5-10,15H,1-4,11-14H2,(H2,24,25,27)
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Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from cloned rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation coun...


Bioorg Med Chem Lett 23: 3416-20 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443223
PNG
(CHEMBL3087358)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2ccco2)c(C)c1
Show InChI InChI=1S/C21H27N3O2/c1-15-13-17(7-8-19(15)22-21(25)20-6-4-12-26-20)23-11-9-18(14-23)24-10-3-5-16(24)2/h4,6-8,12-13,16,18H,3,5,9-11,14H2,1-2H3,(H,22,25)/t16-,18-/m0/s1
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Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442631
PNG
(CHEMBL2441637)
Show SMILES C[C@H]1CCCN1[C@@H]1CCN(C1)c1ccc(NC(=O)C2CCOCC2)c(C)c1
Show InChI InChI=1S/C22H33N3O2/c1-16-14-19(24-11-7-20(15-24)25-10-3-4-17(25)2)5-6-21(16)23-22(26)18-8-12-27-13-9-18/h5-6,14,17-18,20H,3-4,7-13,15H2,1-2H3,(H,23,26)/t17-,20+/m0/s1
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Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50434401
PNG
(CHEMBL2387314)
Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)NC2CCCCC2)cc1
Show InChI InChI=1S/C22H34N4O/c1-17-6-5-14-26(17)21-13-15-25(16-21)20-11-9-19(10-12-20)24-22(27)23-18-7-3-2-4-8-18/h9-12,17-18,21H,2-8,13-16H2,1H3,(H2,23,24,27)
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Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from cloned rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation coun...


Bioorg Med Chem Lett 23: 3416-20 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443222
PNG
(CHEMBL3087673)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2cccc3ccccc23)c(C)n1
Show InChI InChI=1S/C26H30N4O/c1-18-7-6-15-30(18)21-14-16-29(17-21)25-13-12-24(19(2)27-25)28-26(31)23-11-5-9-20-8-3-4-10-22(20)23/h3-5,8-13,18,21H,6-7,14-17H2,1-2H3,(H,28,31)/t18-,21-/m0/s1
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4.20n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200837
PNG
(2-[2-((2s,3's)-2-methyl-[1,3']bipyrrolidin...)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ncc(cn1)N1CCC2(CCOCC2)C1=O
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4.21n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50262939
PNG
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Show SMILES Cc1nc2cccc(c2c(=O)n1-c1ccc(OCCCN2CCCC2)cc1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N3O2/c1-16-27-20-7-4-6-19(23(24,25)26)21(20)22(30)29(16)17-8-10-18(11-9-17)31-15-5-14-28-12-2-3-13-28/h4,6-11H,2-3,5,12-15H2,1H3
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4.30n/an/an/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in HEK293T cells


J Med Chem 51: 4780-9 (2008)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443221
PNG
(CHEMBL3087668)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2coc(C)n2)c(C)c1
Show InChI InChI=1S/C21H28N4O2/c1-14-11-17(24-10-8-18(12-24)25-9-4-5-15(25)2)6-7-19(14)23-21(26)20-13-27-16(3)22-20/h6-7,11,13,15,18H,4-5,8-10,12H2,1-3H3,(H,23,26)/t15-,18-/m0/s1
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4.60n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50434400
PNG
(CHEMBL2387315)
Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)NC2CCCCC2)c(C)c1
Show InChI InChI=1S/C23H36N4O/c1-17-15-20(26-14-12-21(16-26)27-13-6-7-18(27)2)10-11-22(17)25-23(28)24-19-8-4-3-5-9-19/h10-11,15,18-19,21H,3-9,12-14,16H2,1-2H3,(H2,24,25,28)
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4.60n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from cloned rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation coun...


Bioorg Med Chem Lett 23: 3416-20 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443220
PNG
(CHEMBL3087359)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)c2cc(C)n[nH]2)c(C)c1
Show InChI InChI=1S/C21H29N5O/c1-14-11-17(25-10-8-18(13-25)26-9-4-5-16(26)3)6-7-19(14)22-21(27)20-12-15(2)23-24-20/h6-7,11-12,16,18H,4-5,8-10,13H2,1-3H3,(H,22,27)(H,23,24)/t16-,18-/m0/s1
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4.70n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50443219
PNG
(CHEMBL3087672)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)Cc2ccccc2)c(C)n1
Show InChI InChI=1S/C23H30N4O/c1-17-7-6-13-27(17)20-12-14-26(16-20)22-11-10-21(18(2)24-22)25-23(28)15-19-8-4-3-5-9-19/h3-5,8-11,17,20H,6-7,12-16H2,1-2H3,(H,25,28)/t17-,20-/m0/s1
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4.90n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation...


Bioorg Med Chem Lett 23: 6269-73 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50434392
PNG
(CHEMBL2387285)
Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)N2CCCCC2)cc1
Show InChI InChI=1S/C21H32N4O/c1-17-6-5-14-25(17)20-11-15-24(16-20)19-9-7-18(8-10-19)22-21(26)23-12-3-2-4-13-23/h7-10,17,20H,2-6,11-16H2,1H3,(H,22,26)
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6n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from cloned rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation coun...


Bioorg Med Chem Lett 23: 3416-20 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247467
PNG
(US9453023, 26)
Show SMILES C[C@H]1CCCN1C1CC[C@@H](C1)c1ccc(NC(=O)c2c(C)noc2C)cc1
Show InChI InChI=1/C22H29N3O2/c1-14-5-4-12-25(14)20-11-8-18(13-20)17-6-9-19(10-7-17)23-22(26)21-15(2)24-27-16(21)3/h6-7,9-10,14,18,20H,4-5,8,11-13H2,1-3H3,(H,23,26)/t14-,18-,20?/s2
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6.01n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247449
PNG
(US9453023, 8)
Show SMILES CC1CCCN1C1CC[C@@H](C1)c1ccc(cc1)N1CCCC2(CCNCC2)C1=O
Show InChI InChI=1/C25H37N3O/c1-19-4-2-16-27(19)23-10-7-21(18-23)20-5-8-22(9-6-20)28-17-3-11-25(24(28)29)12-14-26-15-13-25/h5-6,8-9,19,21,23,26H,2-4,7,10-18H2,1H3/t19?,21-,23?/s2
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6.07n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247453
PNG
(US9453023, 12)
Show SMILES C[C@H]1CCCN1[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCC2(CCOCC2)C1=O
Show InChI InChI=1/C25H36N2O2/c1-19-3-2-15-26(19)22-8-4-20(5-9-22)21-6-10-23(11-7-21)27-16-12-25(24(27)28)13-17-29-18-14-25/h6-7,10-11,19-20,22H,2-5,8-9,12-18H2,1H3/t19-,20-,22-/s2
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6.10n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50193199
PNG
((S)-1-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)-3...)
Show SMILES FC(F)(F)c1ccc(\C=C\C(=O)N2CCC[C@H]2CN2CCCC2)cc1
Show InChI InChI=1S/C19H23F3N2O/c20-19(21,22)16-8-5-15(6-9-16)7-10-18(25)24-13-3-4-17(24)14-23-11-1-2-12-23/h5-10,17H,1-4,11-14H2/b10-7+/t17-/m0/s1
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6.30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to rhesus monkey histamine H3 receptor


J Med Chem 54: 26-53 (2011)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247455
PNG
(US9453023, 14)
Show SMILES C[C@@H]1CCCN1[C@H]1CC[C@@H](CC1)c1ccc(N2CCC3(CCN(CC3)C(=O)OC(C)(C)C)C2=O)c(F)c1
Show InChI InChI=1/C30H44FN3O3/c1-21-6-5-16-33(21)24-10-7-22(8-11-24)23-9-12-26(25(31)20-23)34-19-15-30(27(34)35)13-17-32(18-14-30)28(36)37-29(2,3)4/h9,12,20-22,24H,5-8,10-11,13-19H2,1-4H3/t21-,22-,24-/s2
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6.61n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442631
PNG
(CHEMBL2441637)
Show SMILES C[C@H]1CCCN1[C@@H]1CCN(C1)c1ccc(NC(=O)C2CCOCC2)c(C)c1
Show InChI InChI=1S/C22H33N3O2/c1-16-14-19(24-11-7-20(15-24)25-10-3-4-17(25)2)5-6-21(16)23-22(26)18-8-12-27-13-9-18/h5-6,14,17-18,20H,3-4,7-13,15H2,1-2H3,(H,23,26)/t17-,20+/m0/s1
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6.80n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM247462
PNG
(US9453023, 21)
Show SMILES C[C@H]1CCCN1C1CCC(=CC1)c1ccc(NC(=O)OCc2ccccc2)c(F)c1
Show InChI InChI=1/C25H29FN2O2/c1-18-6-5-15-28(18)22-12-9-20(10-13-22)21-11-14-24(23(26)16-21)27-25(29)30-17-19-7-3-2-4-8-19/h2-4,7-9,11,14,16,18,22H,5-6,10,12-13,15,17H2,1H3,(H,27,29)/t18-,22?/s2
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6.88n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50434387
PNG
(CHEMBL2387290)
Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)NCc2cc(Cl)cc(Cl)c2)cc1
Show InChI InChI=1S/C23H28Cl2N4O/c1-16-3-2-9-29(16)22-8-10-28(15-22)21-6-4-20(5-7-21)27-23(30)26-14-17-11-18(24)13-19(25)12-17/h4-7,11-13,16,22H,2-3,8-10,14-15H2,1H3,(H2,26,27,30)
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7.10n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from cloned rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation coun...


Bioorg Med Chem Lett 23: 3416-20 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200827
PNG
(2-[2-methyl-6-((2s,3's)-2-methyl-[1,3']bip...)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCOCC3)C2=O)c(C)n1
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7.10n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442625
PNG
(CHEMBL2441643)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)C2CCCO2)c(C)c1
Show InChI InChI=1S/C21H31N3O2/c1-15-13-17(7-8-19(15)22-21(25)20-6-4-12-26-20)23-11-9-18(14-23)24-10-3-5-16(24)2/h7-8,13,16,18,20H,3-6,9-12,14H2,1-2H3,(H,22,25)/t16-,18-,20?/m0/s1
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7.30n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442624
PNG
(CHEMBL2441635)
Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)C2CCCO2)c(C)c1
Show InChI InChI=1S/C21H31N3O2/c1-15-13-17(7-8-19(15)22-21(25)20-6-4-12-26-20)23-11-9-18(14-23)24-10-3-5-16(24)2/h7-8,13,16,18,20H,3-6,9-12,14H2,1-2H3,(H,22,25)
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7.30n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50437068
PNG
(CHEMBL2403549)
Show SMILES C[C@H]1CCCN1[C@@H]1CCN(C1)c1ccc(NC(=O)c2cc(F)ccc2C)c(C)c1
Show InChI InChI=1S/C24H30FN3O/c1-16-6-7-19(25)14-22(16)24(29)26-23-9-8-20(13-17(23)2)27-12-10-21(15-27)28-11-4-5-18(28)3/h6-9,13-14,18,21H,4-5,10-12,15H2,1-3H3,(H,26,29)/t18-,21+/m0/s1
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7.30n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from recombinant rhesus monkey histamine H3 receptor transfected in CHO cell membranes after 1 hr by scin...


Bioorg Med Chem Lett 23: 4044-7 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM200831
PNG
(2-[2-methyl-6-((2s,3's)-2-methyl-[1,3']bip...)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(N2CCC3(CCNCC3)C2=O)c(C)n1
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7.57n/an/an/an/an/an/an/an/a



Sanofi

US Patent


Assay Description
Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50434388
PNG
(CHEMBL2387289)
Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)NCc2cccs2)cc1C
Show InChI InChI=1S/C22H30N4OS/c1-16-13-18(24-22(27)23-14-20-6-4-12-28-20)7-8-21(16)25-11-9-19(15-25)26-10-3-5-17(26)2/h4,6-8,12-13,17,19H,3,5,9-11,14-15H2,1-2H3,(H2,23,24,27)
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8.40n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from cloned rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation coun...


Bioorg Med Chem Lett 23: 3416-20 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442626
PNG
(CHEMBL2441642)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)CC2CCCC2)c(C)c1
Show InChI InChI=1S/C23H35N3O/c1-17-14-20(25-13-11-21(16-25)26-12-5-6-18(26)2)9-10-22(17)24-23(27)15-19-7-3-4-8-19/h9-10,14,18-19,21H,3-8,11-13,15-16H2,1-2H3,(H,24,27)/t18-,21-/m0/s1
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8.40n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442637
PNG
(CHEMBL2441658)
Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)C2CCCO2)cc1
Show InChI InChI=1S/C20H29N3O2/c1-15-4-2-11-23(15)18-10-12-22(14-18)17-8-6-16(7-9-17)21-20(24)19-5-3-13-25-19/h6-9,15,18-19H,2-5,10-14H2,1H3,(H,21,24)
UniProtKB/TrEMBL

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8.70n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442630
PNG
(CHEMBL2441638)
Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ccc(NC(=O)C2CCCCC2)c(C)c1
Show InChI InChI=1S/C23H35N3O/c1-17-15-20(25-14-12-21(16-25)26-13-6-7-18(26)2)10-11-22(17)24-23(27)19-8-4-3-5-9-19/h10-11,15,18-19,21H,3-9,12-14,16H2,1-2H3,(H,24,27)/t18-,21-/m0/s1
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9n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442645
PNG
(CHEMBL2441647)
Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)C2CC2)c(C)c1
Show InChI InChI=1S/C20H29N3O/c1-14-12-17(7-8-19(14)21-20(24)16-5-6-16)22-11-9-18(13-22)23-10-3-4-15(23)2/h7-8,12,15-16,18H,3-6,9-11,13H2,1-2H3,(H,21,24)
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9.60n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50442646
PNG
(CHEMBL2441646)
Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)C2CC2)cc1
Show InChI InChI=1S/C19H27N3O/c1-14-3-2-11-22(14)18-10-12-21(13-18)17-8-6-16(7-9-17)20-19(23)15-4-5-15/h6-9,14-15,18H,2-5,10-13H2,1H3,(H,20,23)
UniProtKB/TrEMBL

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9.70n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rhesus monkey histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 23: 6141-5 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50434393
PNG
(CHEMBL2387284)
Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)N2CCN(CC2)c2ccccc2)cc1
Show InChI InChI=1S/C26H35N5O/c1-21-6-5-14-31(21)25-13-15-30(20-25)24-11-9-22(10-12-24)27-26(32)29-18-16-28(17-19-29)23-7-3-2-4-8-23/h2-4,7-12,21,25H,5-6,13-20H2,1H3,(H,27,32)
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11n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from cloned rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation coun...


Bioorg Med Chem Lett 23: 3416-20 (2013)

More data for this
Ligand-Target Pair
Histamine receptor H3


(Macaca mulatta (Rhesus macaque))
BDBM50434397
PNG
(CHEMBL2387318)
Show SMILES CC1CCCN1C1CCN(C1)c1ccc(NC(=O)N2CCN(C)CC2)c(C)c1
Show InChI InChI=1S/C22H35N5O/c1-17-15-19(26-10-8-20(16-26)27-9-4-5-18(27)2)6-7-21(17)23-22(28)25-13-11-24(3)12-14-25/h6-7,15,18,20H,4-5,8-14,16H2,1-3H3,(H,23,28)
UniProtKB/TrEMBL

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11n/an/an/an/an/an/an/an/a



Sanofi US

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from cloned rhesus monkey histamine H3 receptor transfected in CHO cells after 1 hr by scintillation coun...


Bioorg Med Chem Lett 23: 3416-20 (2013)

More data for this
Ligand-Target Pair
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