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Compile Data Set for Download or QSAR

Found 249 hits Enz. Inhib. hit(s) with Target = 'Histone acetyltransferase KAT2A/KAT2B'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234923
PNG
(CHEMBL4069412)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br |r|
PDB

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PDB
PubMed
1.30n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL




J Med Chem 60: 695-709 (2017)


BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234923
PNG
(CHEMBL4069412)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br |r|
PDB
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1.30n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL




J Med Chem 60: 695-709 (2017)


BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234923
PNG
(CHEMBL4069412)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br |r|
PDB

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1.40n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL




J Med Chem 60: 695-709 (2017)


BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234923
PNG
(CHEMBL4069412)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br |r|
PDB
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1.40n/an/an/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL




J Med Chem 60: 695-709 (2017)


BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens (Human))
BDBM50443232
PNG
(CHEMBL3086883)
Show SMILES Cc1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc2ccccn2)c(N)cc1O |w:4.3|
Show InChI InChI=1S/C18H17N5O3S/c1-12-10-16(15(19)11-17(12)24)22-21-13-5-7-14(8-6-13)27(25,26)23-18-4-2-3-9-20-18/h2-11,24H,19H2,1H3,(H,20,23)
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5.52E+3n/an/an/an/an/an/an/an/a



Icahn School of Medicine at Mount Sinai

Curated by ChEMBL


Assay Description
Displacement of fluorescein-labeled MS239 from recombinant human PCAF after 1 hr by fluorescence anisotropy assay


J Med Chem 56: 9251-64 (2013)


Article DOI: 10.1021/jm401334s
BindingDB Entry DOI: 10.7270/Q2ZW1NCF
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234932
PNG
(CHEMBL4103402 | US10239861, Example 20)
Show SMILES CC(C)C[C@H]1C[C@H](CN(C)C1)Nc1cnn(C)c(=O)c1Cl |r|
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n/an/a 12.7n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234932
PNG
(CHEMBL4103402 | US10239861, Example 20)
Show SMILES CC(C)C[C@H]1C[C@H](CN(C)C1)Nc1cnn(C)c(=O)c1Cl |r|
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n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL




J Med Chem 60: 695-709 (2017)


BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM311486
PNG
(CHEM-US-00192 | US10155764, Example 65B)
Show SMILES C[C@@H](Nc1nn(C)c(=O)c2cccnc12)[C@H](N(C)C)c1ccccc1 |r|
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n/an/a 19n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL




J Med Chem 60: 695-709 (2017)


BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371542
PNG
(4-chloro-5-(((3R,5S)-1,5-dimethylpiperidin-3-yl)am...)
PDB
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n/an/a 21.5n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371577
PNG
((S)-4-chloro-2-methyl-5-((1-methylazepan-3-yl)amin...)
PDB
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n/an/a 32.9n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371546
PNG
(US10239861, Example 26)
PDB
MMDB

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n/an/a 34.8n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371541
PNG
((racemic)-4-chloro-5-(((3RS,5SR)-1,5-dimethylpiper...)
PDB
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n/an/a 36.5n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234923
PNG
(CHEMBL4069412)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br |r|
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n/an/a 40n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL




J Med Chem 60: 695-709 (2017)


BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371549
PNG
(US10239861, Example 29)
PDB
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n/an/a 48.5n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234932
PNG
(CHEMBL4103402 | US10239861, Example 20)
Show SMILES CC(C)C[C@H]1C[C@H](CN(C)C1)Nc1cnn(C)c(=O)c1Cl |r|
PDB
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n/an/a 49.6n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371533
PNG
(4-bromo-2-methyl-5-((1-methylazepan-3-yl)amino)pyr...)
PDB
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n/an/a 51n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234945
PNG
(CHEMBL4061142 | US10239861, Example 59)
Show SMILES CN1CCC[C@@H](C1)Nc1cnn(C)c(=O)c1Cl |r|
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n/an/a 51.2n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371545
PNG
(4-chloro-5-((1,6-dimethylpiperidin-3-yl)amino)-2-m...)
PDB
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n/an/a 60n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234923
PNG
(CHEMBL4069412)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br |r|
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n/an/a 60n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL




J Med Chem 60: 695-709 (2017)


BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371521
PNG
(4-chloro-2-methyl-5-((1-methylazepan-3-yl)amino)py...)
PDB
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n/an/a 62n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234923
PNG
(CHEMBL4069412)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br |r|
PDB
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n/an/a 63n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL




J Med Chem 60: 695-709 (2017)


BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234931
PNG
(CHEMBL4088595)
Show SMILES C[C@H](Nc1nn(C)c(=O)n(C)c1=O)[C@@H](N(C)C)c1ccc(cc1)S(=O)(=O)c1ccccc1 |r|
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n/an/a 70n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL




J Med Chem 60: 695-709 (2017)


BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234939
PNG
(CHEMBL4084253)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Cl |r|
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n/an/a 79n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL




J Med Chem 60: 695-709 (2017)


BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234943
PNG
(CHEMBL4099456 | US10239861, Example 3)
Show SMILES CN1CCCC(C1)Nc1cnn(C)c(=O)c1Cl
PDB
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n/an/a 85n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371527
PNG
((R)-5-((1-benzylpiperidin-3-yl)amino)-4-chloro-2-m...)
PDB
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n/an/a 85.6n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371564
PNG
(4-chloro-5-[[1-[[3-(difluoromethoxy)phenyl]methyl]...)
PDB
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n/an/a 94.9n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371559
PNG
((R)-4-chloro-2-methyl-5-((2,3,4,5-tetrahydro-1H-be...)
PDB
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n/an/a 102n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371576
PNG
(4-chloro-5-[[1-[(4-fluorophenyl)methyl]-3-piperidy...)
PDB
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n/an/a 139n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371547
PNG
(US10239861, Example 27)
PDB
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n/an/a 144n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371552
PNG
(4-chloro-5-((1-isopropylpiperidin-3-yl)amino)-2-me...)
PDB
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n/an/a 147n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371560
PNG
(4-chloro-2-methyl-5-((1-methylazocan-3-yl)amino)py...)
PDB
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n/an/a 155n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371554
PNG
(US10239861, Example 34 | racemic-5-((1-benzylpiper...)
PDB
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n/an/a 155n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371521
PNG
(4-chloro-2-methyl-5-((1-methylazepan-3-yl)amino)py...)
PDB
MMDB

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n/an/a 165n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371544
PNG
(4-chloro-2-methyl-5-((1-methyl-5-phenylpiperidin-3...)
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n/an/a 167n/an/an/an/an/an/a



GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371578
PNG
((R)-4-chloro-2-methyl-5-((1-methylazepan-3-yl)amin...)
PDB
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GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371548
PNG
(US10239861, Example 28)
PDB
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GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371569
PNG
(4-chloro-5-[[1-(1H-imidazol-4-ylmethyl)-3-piperidy...)
PDB
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GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371524
PNG
((racemic)-4-chloro-2-methyl-5-((1-methylazepan-4-y...)
PDB
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GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371561
PNG
(Racemic-4-chloro-2-methyl-5-[[1-(3-phenylpropyl)-3...)
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GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234944
PNG
(CHEMBL4072538 | US10239861, Example 60)
Show SMILES CN1CCC[C@H](C1)Nc1cnn(C)c(=O)c1Cl |r|
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GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371566
PNG
(4-chloro-5-((1-(3,5-dichlorobenzyl)piperidin-3-yl)...)
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GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234926
PNG
(CHEMBL4101945)
Show SMILES CN1CCc2c(C1)cccc2Nc1cnn(C)c(=O)c1Cl
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GlaxoSmithKline

Curated by ChEMBL




J Med Chem 60: 695-709 (2017)


BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase PCAF


(Homo sapiens (Human))
BDBM50151650
PNG
(CHEMBL3775229)
Show SMILES CNC(=O)C(C)NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(CCC(N)=O)NC(=O)C(NC(=O)C(C)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(NC(=O)CNC(=O)CNC(=O)NC(CCCCNC(=O)CSCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n1cnc2c(N)ncnc12)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(O)=O)C(C)O)C(C)O)C(C)O
Show InChI InChI=1/C116H205N42O45P3S/c1-56(2)46-72(102(181)145-66(27-20-39-132-112(122)123)94(173)141-59(6)93(172)155-84(62(9)161)106(185)149-71(32-34-78(120)164)99(178)144-65(25-15-18-37-118)101(180)156-85(63(10)162)107(186)148-67(28-21-40-133-113(124)125)95(174)140-58(5)92(171)128-13)150-103(182)74(50-159)152-105(184)83(61(8)160)154-81(167)49-135-80(166)48-136-115(191)153-69(96(175)142-60(7)109(188)157-44-23-30-75(157)104(183)147-68(29-22-41-134-114(126)127)98(177)143-64(24-14-17-36-117)97(176)146-70(31-33-77(119)163)100(179)151-73(111(189)190)47-57(3)4)26-16-19-38-129-82(168)52-207-45-43-130-79(165)35-42-131-108(187)89(170)116(11,12)53-200-206(197,198)203-205(195,196)199-51-76-88(202-204(192,193)194)87(169)110(201-76)158-55-139-86-90(121)137-54-138-91(86)158/h54-76,83-85,87-89,110,159-162,169-170H,14-53,117-118H2,1-13H3,(H2,119,163)(H2,120,164)(H,128,171)(H,129,168)(H,130,165)(H,131,187)(H,135,166)(H,140,174)(H,141,173)(H,142,175)(H,143,177)(H,144,178)(H,145,181)(H,146,176)(H,147,183)(H,148,186)(H,149,185)(H,150,182)(H,151,179)(H,152,184)(H,154,167)(H,155,172)(H,156,180)(H,189,190)(H,195,196)(H,197,198)(H2,121,137,138)(H4,122,123,132)(H4,124,125,133)(H4,126,127,134)(H2,136,153,191)(H2,192,193,194)
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University of Freiburg

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human FLAG-tagged PCAF expressed in baculovirus expression system using histone substrate incubated for 10 mins...


J Med Chem 59: 1249-70 (2016)


BindingDB Entry DOI: 10.7270/Q2DV1MRN
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371563
PNG
(4-chloro-5-[[1-[(4-dimethylaminophenyl)methyl]-3-p...)
PDB
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GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371537
PNG
((E)-2-(but-2-en-1-yl)-4-chloro-5-((1-methylazepan-...)
PDB
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GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371550
PNG
(4-chloro-5-((1-(2-methoxyethyl)piperidin-3-yl)amin...)
PDB
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GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM50234926
PNG
(CHEMBL4101945)
Show SMILES CN1CCc2c(C1)cccc2Nc1cnn(C)c(=O)c1Cl
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n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL




J Med Chem 60: 695-709 (2017)


BindingDB Entry DOI: 10.7270/Q2W09863
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A


(Homo sapiens (Human))
BDBM50028142
PNG
(CHEMBL2177300)
Show SMILES C[C@H]1C[C@@H](Nc2ccc(Cl)cc2)c2cc(ccc2N1C(C)=O)-c1ccc(cc1)C(O)=O |r|
Show InChI InChI=1/C25H23ClN2O3/c1-15-13-23(27-21-10-8-20(26)9-11-21)22-14-19(7-12-24(22)28(15)16(2)29)17-3-5-18(6-4-17)25(30)31/h3-12,14-15,23,27H,13H2,1-2H3,(H,30,31)/t15-,23+/s2
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of human GCN5 by BROMOscan assay


J Med Chem 57: 8111-31 (2014)


Article DOI: 10.1021/jm5010539
BindingDB Entry DOI: 10.7270/Q23R0VGR
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371528
PNG
((S)-5-((1-benzylpiperidin-3-yl)amino)-4-chloro-2-m...)
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GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
Histone acetyltransferase KAT2A/KAT2B


(Homo sapiens (Human))
BDBM371571
PNG
(4-chloro-2-methyl-5-[[1-[(1-methylpyrazol-4-yl)met...)
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GLSynthesis Inc.





J Med Chem 48: 3919-29 (2005)


Article DOI: 10.1021/jm049059x
More data for this
Ligand-Target Pair
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