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Found 141 hits Enz. Inhib. hit(s) with Target = 'Histone lysine demethylase PHF8'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276044
PNG
(2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...)
Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


Article DOI: 10.1016/j.bmcl.2005.11.052
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276067
PNG
(2-[1-[(3-chloro-2-fluorophenyl)methyl]imidazol-4-y...)
Show SMILES Fc1c(Cl)cccc1Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276050
PNG
(2-[1-(3,4-dihydro-2H-chromen-4-ylmethyl)imidazol-4...)
Show SMILES C(C1CCOc2ccccc12)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276044
PNG
(2-[1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]-4-(1H...)
Show SMILES Clc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276067
PNG
(2-[1-[(3-chloro-2-fluorophenyl)methyl]imidazol-4-y...)
Show SMILES Fc1c(Cl)cccc1Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


Article DOI: 10.1016/j.bmcl.2005.11.052
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276050
PNG
(2-[1-(3,4-dihydro-2H-chromen-4-ylmethyl)imidazol-4...)
Show SMILES C(C1CCOc2ccccc12)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


Article DOI: 10.1016/j.bmcl.2005.11.052
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50155508
PNG
(CHEMBL3780833)
Show SMILES C[C@@H](N1CCC[C@@H](CNCc2cc(ccn2)C(O)=O)C1=O)c1ccccc1 |r|
Show InChI InChI=1/C21H25N3O3/c1-15(16-6-3-2-4-7-16)24-11-5-8-18(20(24)25)13-22-14-19-12-17(21(26)27)9-10-23-19/h2-4,6-7,9-10,12,15,18,22H,5,8,11,13-14H2,1H3,(H,26,27)/t15-,18+/s2
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Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 preincubated for 10 mins followed by substrate addition by AlphaLISA assay


ACS Med Chem Lett 7: 128-30 (2016)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50155507
PNG
(CHEMBL3780904)
Show SMILES C[C@@H](N1CC[C@@H](CNCc2cc(ccn2)C(O)=O)C1=O)c1ccccc1 |r|
Show InChI InChI=1/C20H23N3O3/c1-14(15-5-3-2-4-6-15)23-10-8-17(19(23)24)12-21-13-18-11-16(20(25)26)7-9-22-18/h2-7,9,11,14,17,21H,8,10,12-13H2,1H3,(H,25,26)/t14-,17+/s2
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Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 preincubated for 10 mins followed by substrate addition by AlphaLISA assay


ACS Med Chem Lett 7: 128-30 (2016)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50155505
PNG
(CHEMBL3781414)
Show SMILES CCN1CCC(CNCc2cc(ccn2)C(O)=O)C1=O
Show InChI InChI=1/C14H19N3O3/c1-2-17-6-4-11(13(17)18)8-15-9-12-7-10(14(19)20)3-5-16-12/h3,5,7,11,15H,2,4,6,8-9H2,1H3,(H,19,20)
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Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 preincubated for 10 mins followed by substrate addition by AlphaLISA assay


ACS Med Chem Lett 7: 128-30 (2016)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50155450
PNG
(CHEMBL3779953)
Show SMILES Cc1cn2CCN(Cc3cc(ccn3)C(O)=O)CCc2n1
Show InChI InChI=1S/C15H18N4O2/c1-11-9-19-7-6-18(5-3-14(19)17-11)10-13-8-12(15(20)21)2-4-16-13/h2,4,8-9H,3,5-7,10H2,1H3,(H,20,21)
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Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 preincubated for 10 mins followed by substrate addition by AlphaLISA assay


ACS Med Chem Lett 7: 128-30 (2016)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50155449
PNG
(CHEMBL3780958)
Show SMILES COc1ccc(cc1)[C@@H](C)N1CCC[C@@H](CNCc2cc(ccn2)C(O)=O)C1=O |r|
Show InChI InChI=1/C22H27N3O4/c1-15(16-5-7-20(29-2)8-6-16)25-11-3-4-18(21(25)26)13-23-14-19-12-17(22(27)28)9-10-24-19/h5-10,12,15,18,23H,3-4,11,13-14H2,1-2H3,(H,27,28)/t15-,18+/s2
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Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 preincubated for 10 mins followed by substrate addition by AlphaLISA assay


ACS Med Chem Lett 7: 128-30 (2016)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50155509
PNG
(CHEMBL3780689)
Show SMILES C[C@@H](N1CCC[C@H](CNCc2cc(ccn2)C(O)=O)C1=O)c1ccccc1 |r|
Show InChI InChI=1/C21H25N3O3/c1-15(16-6-3-2-4-7-16)24-11-5-8-18(20(24)25)13-22-14-19-12-17(21(26)27)9-10-23-19/h2-4,6-7,9-10,12,15,18,22H,5,8,11,13-14H2,1H3,(H,26,27)/t15-,18-/s2
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Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 preincubated for 10 mins followed by substrate addition by AlphaLISA assay


ACS Med Chem Lett 7: 128-30 (2016)

More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50395083
PNG
(CHEMBL2164246)
Show SMILES NNC(=O)CCC(O)=O
Show InChI InChI=1S/C4H8N2O3/c5-6-3(7)1-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9)
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University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assay


J Med Chem 55: 6639-43 (2012)


Article DOI: 10.1021/jm300677j
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM50395076
PNG
(CHEMBL2164243)
Show SMILES CN(C)NC(=O)CCC(O)=O
Show InChI InChI=1S/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2,1-2H3,(H,7,9)(H,10,11)
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University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of human PHF8 expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assay


J Med Chem 55: 6639-43 (2012)


Article DOI: 10.1021/jm300677j
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276039
PNG
(2-(1-methylimidazol-4-yl)-4-(1H-triazol-4-yl)pyrid...)
Show SMILES Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276040
PNG
(2-[1-[(2-chlorophenyl)methyl]imidazol-4-yl]-4-(1H-...)
Show SMILES Clc1ccccc1Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276041
PNG
(2-[5-(4-fluorophenyl)-1-methylimidazol-4-yl]-4-(1H...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1)-c1cc(ccn1)-c1c[nH]nn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276043
PNG
(2-[1-(1-phenylethyl)imidazol-4-yl]-4-(1H-triazol-4...)
Show SMILES CC(c1ccccc1)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276045
PNG
(2-[1-[2-(2-methoxyphenyl)ethyl]imidazol-4-yl]-4-(1...)
Show SMILES COc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276046
PNG
(2-[1-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)imid...)
Show SMILES C(C1CCCc2ccccc12)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276047
PNG
(2-[1-[2-(2-ethoxyphenyl)ethyl]imidazol-4-yl]-4-(1H...)
Show SMILES CCOc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276048
PNG
(4-(1H-triazol-4-yl)-2-[1-[2-[2-(2,2,2-trifluoroeth...)
Show SMILES FC(F)(F)COc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276049
PNG
(2-[1-[2-[2-(cyclopropylmethoxy)phenyl]ethyl]imidaz...)
Show SMILES C(Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1)c1ccccc1OCC1CC1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276053
PNG
(4-[2-[1-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)i...)
Show SMILES N#Cc1[nH]nnc1-c1ccnc(c1)-c1cn(CC2CCCc3ccccc23)cn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276054
PNG
(4-[2-[1-(2-naphthalen-1-ylethyl)imidazol-4-yl]pyri...)
Show SMILES N#Cc1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2cccc3ccccc23)cn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276057
PNG
(2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]-4-...)
Show SMILES Clc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2nn[nH]c2I)c1Cl
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276058
PNG
(2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]-4-...)
Show SMILES Fc1[nH]nnc1-c1ccnc(c1)-c1cn(Cc2cccc(Cl)c2Cl)cn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276059
PNG
(2-[1-[(2,3-dichlorophenyl)methyl]imidazol-4-yl]-4-...)
Show SMILES Clc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1Cl
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276060
PNG
(2-[1-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]i...)
Show SMILES FC(F)(F)c1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1Cl
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276061
PNG
(2-[1-(2-naphthalen-1-ylethyl)imidazol-4-yl]-4-(1H-...)
Show SMILES C(Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1)c1cccc2ccccc12
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276062
PNG
(2-[5-(4-fluoro-3-methoxyphenyl)-1-methylimidazol-4...)
Show SMILES COc1cc(ccc1F)-c1c(ncn1C)-c1cc(ccn1)-c1c[nH]nn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276066
PNG
(2-[1-[(2-fluoro-3-methylphenyl)methyl]imidazol-4-y...)
Show SMILES Cc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1F
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276068
PNG
(2-[1-[(2-fluoro-3-methoxyphenyl)methyl]imidazol-4-...)
Show SMILES COc1cccc(Cn2cnc(c2)-c2cc(ccn2)-c2c[nH]nn2)c1F
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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276069
PNG
(4-(1H-triazol-4-yl)-2-[1-[2-[2-(trifluoromethyl)ph...)
Show SMILES FC(F)(F)c1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
PDB

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n/an/a 550n/an/an/an/an/a25



Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276070
PNG
(2-[1-[2-(2-chlorophenyl)-2-methylpropyl]imidazol-4...)
Show SMILES CC(C)(Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1)c1ccccc1Cl
PDB

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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276072
PNG
(4-(1H-triazol-4-yl)-2-[1-[2-[2-(trifluoromethoxy)p...)
Show SMILES FC(F)(F)Oc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
PDB

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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276073
PNG
(4-(5-fluoro-1H-triazol-4-yl)-2-[1-(2-naphthalen-1-...)
Show SMILES Fc1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2cccc3ccccc23)cn1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276082
PNG
(1-benzyl-4-{1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl}...)
Show SMILES C(c1ccccc1)n1cnc(c1)-c1cc2[nH]nnc2cn1
PDB

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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
histone lysine demethylase PHF8 isoform 2


(Homo sapiens (Human))
BDBM276093
PNG
(2-(5-bromo-1-(2-chlorobenzyl)-1H-imidazol-4-yl)-4-...)
Show SMILES Clc1ccccc1Cn1cnc(c1Br)-c1cc(ccn1)-c1cn[nH]n1
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Celgene Quanticel Research, Inc.

US Patent




US Patent US10071984 (2018)


Article DOI: 10.1021/jm960689b
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276039
PNG
(2-(1-methylimidazol-4-yl)-4-(1H-triazol-4-yl)pyrid...)
Show SMILES Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
PDB

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Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


Article DOI: 10.1016/j.bmcl.2005.11.052
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276040
PNG
(2-[1-[(2-chlorophenyl)methyl]imidazol-4-yl]-4-(1H-...)
Show SMILES Clc1ccccc1Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
PDB

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Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


Article DOI: 10.1016/j.bmcl.2005.11.052
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276041
PNG
(2-[5-(4-fluorophenyl)-1-methylimidazol-4-yl]-4-(1H...)
Show SMILES Cn1cnc(c1-c1ccc(F)cc1)-c1cc(ccn1)-c1c[nH]nn1
PDB

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Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


Article DOI: 10.1016/j.bmcl.2005.11.052
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276043
PNG
(2-[1-(1-phenylethyl)imidazol-4-yl]-4-(1H-triazol-4...)
Show SMILES CC(c1ccccc1)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
PDB

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Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


Article DOI: 10.1016/j.bmcl.2005.11.052
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276045
PNG
(2-[1-[2-(2-methoxyphenyl)ethyl]imidazol-4-yl]-4-(1...)
Show SMILES COc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
PDB

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Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


Article DOI: 10.1016/j.bmcl.2005.11.052
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276046
PNG
(2-[1-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)imid...)
Show SMILES C(C1CCCc2ccccc12)n1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
PDB

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Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


Article DOI: 10.1016/j.bmcl.2005.11.052
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276047
PNG
(2-[1-[2-(2-ethoxyphenyl)ethyl]imidazol-4-yl]-4-(1H...)
Show SMILES CCOc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
PDB

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Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


Article DOI: 10.1016/j.bmcl.2005.11.052
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276048
PNG
(4-(1H-triazol-4-yl)-2-[1-[2-[2-(2,2,2-trifluoroeth...)
Show SMILES FC(F)(F)COc1ccccc1CCn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1
PDB

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Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


Article DOI: 10.1016/j.bmcl.2005.11.052
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM276049
PNG
(2-[1-[2-[2-(cyclopropylmethoxy)phenyl]ethyl]imidaz...)
Show SMILES C(Cn1cnc(c1)-c1cc(ccn1)-c1c[nH]nn1)c1ccccc1OCC1CC1
PDB

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Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


Article DOI: 10.1016/j.bmcl.2005.11.052
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM319596
PNG
(4-[2-[1-(1,2,3,4-tetrahydronaphthalen- 1-ylmethyl)...)
Show SMILES [C-]#[N+]c1[nH]nnc1-c1ccnc(c1)-c1cn(CC2CCCc3ccccc23)cn1
PDB

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Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


Article DOI: 10.1016/j.bmcl.2005.11.052
More data for this
Ligand-Target Pair
Histone lysine demethylase PHF8


(Homo sapiens (Human))
BDBM319597
PNG
(4-[2-[1-(2-naphthalen-1-ylethyl)imidazol- 4-yl]pyr...)
Show SMILES [C-]#[N+]c1[nH]nnc1-c1ccnc(c1)-c1cn(CCc2cccc3ccccc23)cn1
PDB

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Celgene Quanticel Research, Inc.

US Patent




US Patent US10174003 (2019)


Article DOI: 10.1016/j.bmcl.2005.11.052
More data for this
Ligand-Target Pair
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