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Compile Data Set for Download or QSAR

Found 1673 hits Enz. Inhib. hit(s) with Target = 'Inhibitor of nuclear factor kappa-B kinase subunit beta'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312816
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(ccc23)-n2cnc(C)c2)C1=O |r|
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0.0500n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312809
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1ccc2c(nc(C(N)=O)n2c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312760
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CNc1nccc2n(nc(C(N)=O)c12)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312904
PNG
((5R)-1-[3-[2-[(3R)-3-hydroxy- 1-methyl-2-oxo-pyrro...)
Show SMILES C[C@@H]1Cc2c(C1)n(nc2C(N)=O)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312905
PNG
(5-amino-2-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-p...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)c(N)s2)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312906
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CNc1nc2n(nc(C(N)=O)c2s1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312724
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1ccc2n(nc(C(N)=O)c2c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312839
PNG
(4-(ethylamino)-1-[3-[2-[(3R)- 3-hydroxy-1-methyl-2...)
Show SMILES CCNc1nccc2n(nc(C(N)=O)c12)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312850
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1cc2n(nc(C(N)=O)c2cn1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312864
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1ccc2c(nn(-c3cccc(c3)C#C[C@]3(O)CCN(C)C3=O)c2n1)C(N)=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312885
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccc(C)nc23)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312899
PNG
(6-fluoro-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccc(F)cc23)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312776
PNG
(1-[4-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1ccc2n(nc(C(N)=O)c2c1)-c1cc(ccn1)C#C[C@]1(O)CCN(C)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312785
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1cnc2n(nc(C(N)=O)c2c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312787
PNG
(6-chloro-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cnc(Cl)cc23)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312788
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccccc23)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312796
PNG
(8-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3cccnc23)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312801
PNG
(7-cyano-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-p...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccc(cc23)C#N)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312805
PNG
(7-chloro-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccc(Cl)cc23)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312806
PNG
(1,7-bis[3-[2-[(3R)-3-hydroxy- 1-methyl-2-oxo-pyrro...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccc(cc23)-c2cccc(c2)C#C[C@]2(O)CCN(C)C2=O)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312808
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1ccn2c(nc(-c3cccc(c3)C#C[C@]3(O)CCN(C)C3=O)c2c1)C(N)=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312907
PNG
(2-[2-fluoro-5-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccc(F)c(c2)-c2nc(C(N)=O)c(C)s2)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312812
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)C2N=C(C(N)=O)c3cc(ccc23)-c2ccn(C)n2)C1=O |r,t:16|
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Genentech, Inc.

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US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312804
PNG
(6-chloro-1-[3-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3cc(Cl)ccc23)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312813
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(ccc23)-c2ccn(C)n2)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312711
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccccc23)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312823
PNG
(5-[1-(2-hydroxyethyl)pyrazol- 4-yl]-1-[3-[2-[(3R)-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(ccc23)-c2cnn(CCO)c2)C1=O |r|
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US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312822
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CNC(=O)c1ccc2n(nc(C(N)=O)c2c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O |r|
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Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312765
PNG
(5-fluoro-1-[4-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3cc(F)ccc23)C1=O |r|
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0.0800n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312764
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cccnc23)C1=O |r|
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0.0800n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312866
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccc(nc23)-c2cnn(C)c2)C1=O |r|
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0.0900n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312763
PNG
(1-[4-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3ccccc23)C1=O |r|
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0.0980n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312814
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cc(cnc23)-c2cnn(C)c2)C1=O |r|
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312903
PNG
((5S)-1-[3-[2-[(3R)-3-hydroxy- 1-methyl-2-oxo-pyrro...)
Show SMILES C[C@H]1Cc2c(C1)n(nc2C(N)=O)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O |r|
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312774
PNG
(6-fluoro-1-[4-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3ccc(F)cc23)C1=O |r|
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312891
PNG
(1-[3-[(3R)-3-hydroxy-3-(5- methyl-1,3,4-oxadiazol-...)
Show SMILES COc1ccn2c(nc(-c3cccc(c3)C#C[C@@](C)(O)c3nnc(C)o3)c2c1)C(N)=O |r|
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312896
PNG
(6-chloro-1-[2-fluoro-5-[2-[(3R)- 3-hydroxy-1-methy...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccc(F)c(c2)-c2nc(C(N)=O)n3cc(Cl)ccc23)C1=O |r|
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312888
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccc(cc23)C(N)=O)C1=O |r|
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0.100n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312887
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3CCCCc23)C1=O |r|
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0.110n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312840
PNG
(4-(cyclopropylamino)-1-[3- [2-[(3R)-3-hydroxy-1-me...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3c(NC4CC4)nccc23)C1=O |r|
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0.110n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312884
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3ccnnc23)C1=O |r|
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0.130n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312870
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COc1ncc2c(nn(-c3cccc(c3)C#C[C@]3(O)CCN(C)C3=O)c2n1)C(N)=O |r|
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0.130n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312807
PNG
(7-(cyclobutoxy)-1-[3-[2-[(3R)- 3-hydroxy-1-methyl-...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccc(OC4CCC4)cc23)C1=O |r|
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0.140n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312783
PNG
(6-fluoro-1-[4-[2-[(7R)-7-hy- droxy-5,6-dihydrocycl...)
Show SMILES NC(=O)c1nn(-c2cc(ccn2)C#C[C@]2(O)CCc3cccnc23)c2cc(F)ccc12 |r|
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0.140n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312802
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-c2nc(C(N)=O)n3ccc(cc23)C(F)(F)F)C1=O |r|
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0.150n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312777
PNG
(5-bromo-1-[4-[2-[(3R)-3-hy- droxy-1-methyl-2-oxo-p...)
Show SMILES CN1CC[C@@](O)(C#Cc2ccnc(c2)-n2nc(C(N)=O)c3cc(Br)ccc23)C1=O |r|
PDB

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0.150n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312824
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cncnc23)C1=O |r|
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0.190n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312893
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES COC1CN(C1)c1cnc2n(nc(C(N)=O)c2c1)-c1cccc(c1)C#C[C@]1(O)CCN(C)C1=O |r|
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0.190n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312848
PNG
(1-[3-[2-[(3R)-3-hydroxy-1- methyl-2-oxo-pyrrolidin...)
Show SMILES CN1CC[C@@](O)(C#Cc2cccc(c2)-n2nc(C(N)=O)c3cnc(cc23)N2CC[C@@H](O)C2)C1=O |r|
PDB

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0.190n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta


(Homo sapiens (Human))
BDBM312875
PNG
(US9605005, Example 165 | ethyl 3-carbamoyl-1-[4-[2...)
Show SMILES CCOC(=O)N1CCc2c(C1)c(nn2-c1cc(ccn1)C#C[C@]1(O)CCN(C)C1=O)C(N)=O |r|
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0.230n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent




US Patent US9605005 (2017)


BindingDB Entry DOI: 10.7270/Q2T43W61
More data for this
Ligand-Target Pair
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