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Compile Data Set for Download or QSAR

Found 176 hits Enz. Inhib. hit(s) with Target = 'Intermediate conductance calcium-activated potassium channel protein 4'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50371391
PNG
(SENICAPOC)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
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n/an/a 6n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Kca 3.1 (unknown origin)


J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4/Voltage-gated potassium channel beta subunit Mink/Voltage-gated potassium channel subunit Kv7.1


(Homo sapiens (Human))
BDBM50099566
PNG
((2-fluorophenyl)-(4-fluorophenyl)phenylacetamide |...)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccccc1F
Show InChI InChI=1S/C20H15F2NO/c21-16-12-10-15(11-13-16)20(19(23)24,14-6-2-1-3-7-14)17-8-4-5-9-18(17)22/h1-13H,(H2,23,24)
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n/an/a 9n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Selectivity for gardos channel; (Gardos channel vs 2000 nM for the cardiac IKs channel).)


J Med Chem 44: 1627-53 (2001)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50099566
PNG
((2-fluorophenyl)-(4-fluorophenyl)phenylacetamide |...)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccccc1F
Show InChI InChI=1S/C20H15F2NO/c21-16-12-10-15(11-13-16)20(19(23)24,14-6-2-1-3-7-14)17-8-4-5-9-18(17)22/h1-13H,(H2,23,24)
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n/an/a 9n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50371390
PNG
(CHEMBL272039)
Show SMILES NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccccc1F
Show InChI InChI=1S/C20H14F3NO/c21-15-9-5-13(6-10-15)20(19(24)25,14-7-11-16(22)12-8-14)17-3-1-2-4-18(17)23/h1-12H,(H2,24,25)
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n/an/a 10n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50371391
PNG
(SENICAPOC)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
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n/an/a 12n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50371385
PNG
(CHEMBL260736)
Show SMILES NC(=O)C(c1cccc(F)c1)(c1cccc(F)c1)c1cccc(F)c1
Show InChI InChI=1S/C20H14F3NO/c21-16-7-1-4-13(10-16)20(19(24)25,14-5-2-8-17(22)11-14)15-6-3-9-18(23)12-15/h1-12H,(H2,24,25)
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n/an/a 13n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50371389
PNG
(CHEMBL272040)
Show SMILES NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C20H15F2NO/c21-17-12-11-16(13-18(17)22)20(19(23)24,14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13H,(H2,23,24)
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n/an/a 14n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50371388
PNG
(CHEMBL270704)
Show SMILES NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H14F3NO/c21-16-7-1-13(2-8-16)20(19(24)25,14-3-9-17(22)10-4-14)15-5-11-18(23)12-6-15/h1-12H,(H2,24,25)
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n/an/a 14n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM314248
PNG
(US9611232, Example 13)
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n/an/a 15n/an/an/an/an/an/a



Merck Frosst Canada & Co.





Bioorg Med Chem Lett 15: 3886-90 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.116
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM314285
PNG
(US9611232, Example 17)
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n/an/a 15n/an/an/an/an/an/a



Merck Frosst Canada & Co.





Bioorg Med Chem Lett 15: 3886-90 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.116
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50371395
PNG
(CHEMBL273092)
Show SMILES NC(=O)C(c1ccc(F)cc1)(c1ccccc1F)c1ccccc1F
Show InChI InChI=1S/C20H14F3NO/c21-14-11-9-13(10-12-14)20(19(24)25,15-5-1-3-7-17(15)22)16-6-2-4-8-18(16)23/h1-12H,(H2,24,25)
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n/an/a 15n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50371384
PNG
(CHEMBL270071)
Show SMILES NC(=O)C(c1ccccc1)(c1ccccc1)c1ccccc1F
Show InChI InChI=1S/C20H16FNO/c21-18-14-8-7-13-17(18)20(19(22)23,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H,(H2,22,23)
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n/an/a 15n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50371382
PNG
(CHEMBL408700)
Show SMILES NC(=O)C(c1ccc(F)cc1)(c1cccc(F)c1)c1cccc(F)c1
Show InChI InChI=1S/C20H14F3NO/c21-16-9-7-13(8-10-16)20(19(24)25,14-3-1-5-17(22)11-14)15-4-2-6-18(23)12-15/h1-12H,(H2,24,25)
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n/an/a 15n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM205030
PNG
(US9556132, 7 | process for preparing 2-(2-{2-[1-(2...)
Show SMILES Fc1ccccc1-n1nnnc1-c1ccccc1-c1ccccc1OCC#N
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n/an/a 16n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM205069
PNG
(US9556132, 33 | process for preparing 5-{2-[2-(flu...)
Show SMILES FCc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
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n/an/a 17n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50371386
PNG
(CHEMBL260953)
Show SMILES NC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1cccc(F)c1
Show InChI InChI=1S/C20H14F3NO/c21-16-8-4-13(5-9-16)20(19(24)25,14-6-10-17(22)11-7-14)15-2-1-3-18(23)12-15/h1-12H,(H2,24,25)
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n/an/a 17n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50279107
PNG
(1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole | C...)
Show SMILES Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1cccn1
Show InChI InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
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n/an/a 20n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay


Bioorg Med Chem Lett 19: 2299-304 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.077
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50279107
PNG
(1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole | C...)
Show SMILES Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1cccn1
Show InChI InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
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n/an/a 20n/an/an/an/an/an/a



4SC AG

Curated by ChEMBL


Assay Description
Inhibition of IK1 (unknown origin)


Bioorg Med Chem Lett 19: 2299-304 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.077
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50371377
PNG
(CHEMBL406683)
Show SMILES NC(c1ccccc1)(c1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C19H16ClN/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H,21H2
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n/an/a 20n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM314217
PNG
(US9611232, Example 11)
PDB

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n/an/a 22n/an/an/an/an/an/a



Merck Frosst Canada & Co.





Bioorg Med Chem Lett 15: 3886-90 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.116
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50371387
PNG
(CHEMBL261606)
Show SMILES NC(=O)C(c1ccccc1)(c1ccccc1F)c1ccccc1F
Show InChI InChI=1S/C20H15F2NO/c21-17-12-6-4-10-15(17)20(19(23)24,14-8-2-1-3-9-14)16-11-5-7-13-18(16)22/h1-13H,(H2,23,24)
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n/an/a 30n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50371383
PNG
(CHEMBL261828)
Show SMILES NC(=O)C(c1ccccc1)(c1cccc(F)c1)c1cccc(F)c1
Show InChI InChI=1S/C20H15F2NO/c21-17-10-4-8-15(12-17)20(19(23)24,14-6-2-1-3-7-14)16-9-5-11-18(22)13-16/h1-13H,(H2,23,24)
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n/an/a 30n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM205019
PNG
(US9556132, 4 | process for preparing 1-(2-fluoroph...)
Show SMILES COCCOc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
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n/an/a 30n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50371396
PNG
(CHEMBL270913)
Show SMILES NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc(F)cc1F
Show InChI InChI=1S/C20H15F2NO/c21-16-11-12-17(18(22)13-16)20(19(23)24,14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-13H,(H2,23,24)
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n/an/a 34n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM205016
PNG
(US9556132, 3 | process for preparing 5-[2-(2-ethox...)
Show SMILES CCOc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
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n/an/a 37n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM200905
PNG
(US9533999, i-39)
Show SMILES Fc1ccc(CN2c3sccc3S(=O)(=O)CC2=O)cc1OC(F)(F)F
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n/an/a 39n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50019902
PNG
(CHEMBL3287207)
Show SMILES CC(N1c2sccc2S(=O)(=O)CC1=O)c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C15H11F4NO4S2/c1-8(9-2-3-10(16)11(6-9)24-15(17,18)19)20-13(21)7-26(22,23)12-4-5-25-14(12)20/h2-6,8H,7H2,1H3
PDB

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n/an/a 39n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50371394
PNG
(CHEMBL258604)
Show SMILES NC(=O)C(c1ccccc1)(c1ccccc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H16FNO/c21-18-13-11-17(12-14-18)20(19(22)23,15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-14H,(H2,22,23)
PDB

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n/an/a 40n/an/an/an/an/an/a



Icagen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Gardos channel in human RBC assessed as inhibition of ionomycin-stimulated [86Rb] efflux


J Med Chem 51: 976-82 (2008)


Article DOI: 10.1021/jm070663s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50019905
PNG
(CHEMBL3287210 | US9533999, ii-4)
Show SMILES CC(N1C(=O)CSc2cccnc12)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N2OS/c1-10(11-4-2-5-12(8-11)16(17,18)19)21-14(22)9-23-13-6-3-7-20-15(13)21/h2-8,10H,9H2,1H3
PDB

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n/an/a 41n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50019905
PNG
(CHEMBL3287210 | US9533999, ii-4)
Show SMILES CC(N1C(=O)CSc2cccnc12)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N2OS/c1-10(11-4-2-5-12(8-11)16(17,18)19)21-14(22)9-23-13-6-3-7-20-15(13)21/h2-8,10H,9H2,1H3
PDB

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n/an/a 41n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM314284
PNG
(US9611232, Example 15)
PDB

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n/an/a 42n/an/an/an/an/an/a



Merck Frosst Canada & Co.





Bioorg Med Chem Lett 15: 3886-90 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.116
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM314215
PNG
(US9611232, Example 7)
PDB

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n/an/a 45n/an/an/an/an/an/a



Merck Frosst Canada & Co.





Bioorg Med Chem Lett 15: 3886-90 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.116
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM200937
PNG
(US9533999, ii-5)
Show SMILES FC(F)(F)c1cc(CN2C(=O)CSc3cccnc23)ccc1Cl
PDB

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n/an/a 46n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM200946
PNG
(US9533999, ii-8)
Show SMILES FC(F)(F)S(=O)(=O)c1cc(CN2C(=O)CSc3cccnc23)ccc1Cl
PDB

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n/an/a 47n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50019903
PNG
(CHEMBL3287208 | US9533999, i-40)
Show SMILES Fc1ccc(CN2c3ccsc3S(=O)(=O)CC2=O)cc1OC(F)(F)F
Show InChI InChI=1S/C14H9F4NO4S2/c15-9-2-1-8(5-11(9)23-14(16,17)18)6-19-10-3-4-24-13(10)25(21,22)7-12(19)20/h1-5H,6-7H2
PDB

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n/an/a 48n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50019903
PNG
(CHEMBL3287208 | US9533999, i-40)
Show SMILES Fc1ccc(CN2c3ccsc3S(=O)(=O)CC2=O)cc1OC(F)(F)F
Show InChI InChI=1S/C14H9F4NO4S2/c15-9-2-1-8(5-11(9)23-14(16,17)18)6-19-10-3-4-24-13(10)25(21,22)7-12(19)20/h1-5H,6-7H2
PDB

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n/an/a 48n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50019900
PNG
(CHEMBL3287205 | US9533999, i-5)
Show SMILES Fc1ccc(CN2C(=O)CS(=O)(=O)c3cccnc23)cc1OC(F)(F)F
Show InChI InChI=1S/C15H10F4N2O4S/c16-10-4-3-9(6-11(10)25-15(17,18)19)7-21-13(22)8-26(23,24)12-2-1-5-20-14(12)21/h1-6H,7-8H2
PDB

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n/an/a 49n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50019900
PNG
(CHEMBL3287205 | US9533999, i-5)
Show SMILES Fc1ccc(CN2C(=O)CS(=O)(=O)c3cccnc23)cc1OC(F)(F)F
Show InChI InChI=1S/C15H10F4N2O4S/c16-10-4-3-9(6-11(10)25-15(17,18)19)7-21-13(22)8-26(23,24)12-2-1-5-20-14(12)21/h1-6H,7-8H2
PDB

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n/an/a 49n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50019904
PNG
(CHEMBL3287209 | US9533999, ii-1)
Show SMILES FC(F)(F)Oc1cccc(CN2C(=O)CSc3cccnc23)c1
Show InChI InChI=1S/C15H11F3N2O2S/c16-15(17,18)22-11-4-1-3-10(7-11)8-20-13(21)9-23-12-5-2-6-19-14(12)20/h1-7H,8-9H2
PDB

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n/an/a 52n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50019904
PNG
(CHEMBL3287209 | US9533999, ii-1)
Show SMILES FC(F)(F)Oc1cccc(CN2C(=O)CSc3cccnc23)c1
Show InChI InChI=1S/C15H11F3N2O2S/c16-15(17,18)22-11-4-1-3-10(7-11)8-20-13(21)9-23-12-5-2-6-19-14(12)20/h1-7H,8-9H2
PDB

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n/an/a 52n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM200942
PNG
(US9533999, ii-7)
Show SMILES FC(F)(F)Sc1cc(CN2C(=O)CSc3cccnc23)ccc1Cl
PDB

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n/an/a 52n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM205066
PNG
(US9556132, 30 | process for preparing (e)-n-[(2-{2...)
Show SMILES O\N=C/c1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
PDB

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n/an/a 57n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM314198
PNG
((S)-2-(5,5-bis(4-fluorophenyl)-2-oxo-4-phenyloxazo...)
PDB

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n/an/a 58n/an/an/an/an/an/a



Merck Frosst Canada & Co.





Bioorg Med Chem Lett 15: 3886-90 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.116
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM205065
PNG
(US9556132, 29 | process for preparing 1-(2-fluorop...)
Show SMILES COCc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1F
PDB

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n/an/a 58n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50019907
PNG
(CHEMBL3287212)
Show SMILES CC(N1c2scnc2SCC1=O)c1ccc(F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C14H10F4N2O2S2/c1-7(20-11(21)5-23-12-13(20)24-6-19-12)8-2-3-9(15)10(4-8)22-14(16,17)18/h2-4,6-7H,5H2,1H3
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n/an/a 60n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM200966
PNG
(US9533999, ii-17)
Show SMILES Fc1ccc(CN2c3scnc3SCC2=O)cc1OC(F)(F)F
PDB

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n/an/a 60n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...


US Patent US9533999 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM314321
PNG
(US9611232, Example 32)
PDB

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n/an/a 62n/an/an/an/an/an/a



Merck Frosst Canada & Co.





Bioorg Med Chem Lett 15: 3886-90 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.116
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM314288
PNG
(US9611232, Example 19)
PDB

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n/an/a 63n/an/an/an/an/an/a



Merck Frosst Canada & Co.





Bioorg Med Chem Lett 15: 3886-90 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.116
More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM205077
PNG
(US9556132, 56 | process for preparing 2-{5-[2-(2-m...)
Show SMILES COc1ccccc1-c1ccccc1-c1nnnn1-c1ccccc1C#N
PDB

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n/an/a 64n/an/an/an/a7.3n/a



Saniona A/S

US Patent


Assay Description
Human HEK293 cells over-expressing human IK are grown in culture medium (DMEM supplemented with 10% foetal bovine serum), in polystyrene culture flas...


US Patent US9556132 (2017)

More data for this
Ligand-Target Pair
Intermediate conductance calcium-activated potassium channel protein 4


(Homo sapiens (Human))
BDBM50019906
PNG
(CHEMBL3287211 | US9533999, ii-11)
Show SMILES OCc1ccc2SCC(=O)N(Cc3ccc(Cl)c(c3)C(F)(F)F)c2n1
Show InChI InChI=1S/C16H12ClF3N2O2S/c17-12-3-1-9(5-11(12)16(18,19)20)6-22-14(24)8-25-13-4-2-10(7-23)21-15(13)22/h1-5,23H,6-8H2
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n/an/a 66n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human KCa3.1 overexpressed in HEK293 cells assessed as thallium influx preincubated for 15 mins followed by thallium/ionomycin addition...


ACS Med Chem Lett 5: 460-1 (2014)


Article DOI: 10.1021/ml500090s
More data for this
Ligand-Target Pair
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