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Compile Data Set for Download or QSAR

Found 53 hits Enz. Inhib. hit(s) with Target = 'Leucine aminopeptidase (LAP)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50024594
PNG
((R)-1-Ammonium-3-methyl-butane-1-phosphonic acid a...)
Show SMILES CC(C)C[C@H]([NH3+])P(O)([O-])=O
Show InChI InChI=1S/C5H14NO3P/c1-4(2)3-5(6)10(7,8)9/h4-5H,3,6H2,1-2H3,(H2,7,8,9)/t5-/m1/s1
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0.230n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50316049
PNG
(1-amino-3-phenylpropylphosphonic acid | CHEMBL1090...)
Show SMILES NC(CCc1ccccc1)P(O)(O)=O
Show InChI InChI=1S/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)
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4.60n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025048
PNG
(CHEMBL3355099)
Show SMILES N[C@@H](CCc1ccccc1)P(O)(O)=O |r|
Show InChI InChI=1/C9H14NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h1-5,9H,6-7,10H2,(H2,11,12,13)/t9-/s2
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5n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50078125
PNG
((1-Amino-3-phenyl-propyl)-phosphinic acid | CHEMBL...)
Show SMILES OP(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C9H12NO2P/c10-9(13(11)12)7-6-8-4-2-1-3-5-8/h1-5,10-12H,6-7H2
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7.70n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025043
PNG
(CHEMBL3355104)
Show SMILES NC(CCc1ccc(CO)cc1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C20H26NO5P/c21-19(11-10-15-6-8-17(13-22)9-7-15)27(25,26)14-18(20(23)24)12-16-4-2-1-3-5-16/h1-9,18-19,22H,10-14,21H2,(H,23,24)(H,25,26)
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20n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025041
PNG
(CHEMBL3355106)
Show SMILES NC(CCc1ccncc1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C18H23N2O4P/c19-17(7-6-14-8-10-20-11-9-14)25(23,24)13-16(18(21)22)12-15-4-2-1-3-5-15/h1-5,8-11,16-17H,6-7,12-13,19H2,(H,21,22)(H,23,24)
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39n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025042
PNG
(CHEMBL3355105)
Show SMILES NC(CCc1cccnc1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C18H23N2O4P/c19-17(9-8-15-7-4-10-20-12-15)25(23,24)13-16(18(21)22)11-14-5-2-1-3-6-14/h1-7,10,12,16-17H,8-9,11,13,19H2,(H,21,22)(H,23,24)
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50n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50129684
PNG
(3-[(1-amino-3-phenyl-propyl)-hydroxy-phosphinoyl]-...)
Show SMILES OC(=O)C(Cc1ccccc1)CP(O)(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C19H24NO4P/c20-18(12-11-15-7-3-1-4-8-15)25(23,24)14-17(19(21)22)13-16-9-5-2-6-10-16/h1-10,17,20,23-25H,11-14H2,(H,21,22)
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66n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50129681
PNG
(3-[(1-Amino-3-phenyl-propyl)-hydroxy-phosphinoyl]-...)
Show SMILES OC(=O)C(Cc1ccc(O)cc1)CP(O)(O)C(=N)CCc1ccccc1
Show InChI InChI=1S/C19H24NO5P/c20-18(11-8-14-4-2-1-3-5-14)26(24,25)13-16(19(22)23)12-15-6-9-17(21)10-7-15/h1-7,9-10,16,20-21,24-26H,8,11-13H2,(H,22,23)
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67n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025070
PNG
(CHEMBL3355110)
Show SMILES NCc1ccc(CC(CP(O)(=O)C(N)CCc2cccnc2)C(O)=O)cc1
Show InChI InChI=1/C19H26N3O4P/c20-11-15-5-3-14(4-6-15)10-17(19(23)24)13-27(25,26)18(21)8-7-16-2-1-9-22-12-16/h1-6,9,12,17-18H,7-8,10-11,13,20-21H2,(H,23,24)(H,25,26)
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74n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025099
PNG
(CHEMBL3355111)
Show SMILES NCc1cccc(CC(CP(O)(=O)C(N)CCc2ccncc2)C(O)=O)c1
Show InChI InChI=1/C19H26N3O4P/c20-12-16-3-1-2-15(10-16)11-17(19(23)24)13-27(25,26)18(21)5-4-14-6-8-22-9-7-14/h1-3,6-10,17-18H,4-5,11-13,20-21H2,(H,23,24)(H,25,26)
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108n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025066
PNG
(CHEMBL3355109)
Show SMILES NCc1ccc(CC(CP(O)(=O)C(N)CCc2ccccc2)C(O)=O)cc1
Show InChI InChI=1/C20H27N2O4P/c21-13-17-8-6-16(7-9-17)12-18(20(23)24)14-27(25,26)19(22)11-10-15-4-2-1-3-5-15/h1-9,18-19H,10-14,21-22H2,(H,23,24)(H,25,26)
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138n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025044
PNG
(CHEMBL3355103)
Show SMILES NC(CCc1ccc(O)cc1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C19H24NO5P/c20-18(11-8-14-6-9-17(21)10-7-14)26(24,25)13-16(19(22)23)12-15-4-2-1-3-5-15/h1-7,9-10,16,18,21H,8,11-13,20H2,(H,22,23)(H,24,25)
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157n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025050
PNG
(CHEMBL3355108)
Show SMILES NCc1cccc(CC(CP(O)(=O)C(N)CCc2ccccc2)C(O)=O)c1
Show InChI InChI=1/C20H27N2O4P/c21-13-17-8-4-7-16(11-17)12-18(20(23)24)14-27(25,26)19(22)10-9-15-5-2-1-3-6-15/h1-8,11,18-19H,9-10,12-14,21-22H2,(H,23,24)(H,25,26)
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195n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50337147
PNG
((RS)-1-amino-3-cyclohexylpropylphosphonic acid | C...)
Show SMILES NC(CCC1CCCCC1)P(O)(O)=O
Show InChI InChI=1S/C9H20NO3P/c10-9(14(11,12)13)7-6-8-4-2-1-3-5-8/h8-9H,1-7,10H2,(H2,11,12,13)
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210n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025047
PNG
(CHEMBL3355100)
Show SMILES Cc1cc(C)cc(CCC(N)P(O)(=O)CC(Cc2ccccc2)C(O)=O)c1
Show InChI InChI=1/C21H28NO4P/c1-15-10-16(2)12-18(11-15)8-9-20(22)27(25,26)14-19(21(23)24)13-17-6-4-3-5-7-17/h3-7,10-12,19-20H,8-9,13-14,22H2,1-2H3,(H,23,24)(H,25,26)
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213n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025046
PNG
(CHEMBL3355101)
Show SMILES NC(CCc1ccc(cc1)[N+]([O-])=O)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C19H23N2O6P/c20-18(11-8-14-6-9-17(10-7-14)21(24)25)28(26,27)13-16(19(22)23)12-15-4-2-1-3-5-15/h1-7,9-10,16,18H,8,11-13,20H2,(H,22,23)(H,26,27)
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215n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50024597
PNG
((S)-1-Ammonium-3-methyl-butane-1-phosphonic acid a...)
Show SMILES CC(C)C[C@@H]([NH3+])P(O)([O-])=O
Show InChI InChI=1S/C5H14NO3P/c1-4(2)3-5(6)10(7,8)9/h4-5H,3,6H2,1-2H3,(H2,7,8,9)/t5-/m0/s1
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220n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025045
PNG
(CHEMBL3355102)
Show SMILES NC(CCc1cccc(O)c1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C19H24NO5P/c20-18(10-9-15-7-4-8-17(21)12-15)26(24,25)13-16(19(22)23)11-14-5-2-1-3-6-14/h1-8,12,16,18,21H,9-11,13,20H2,(H,22,23)(H,24,25)
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593n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50025049
PNG
(CHEMBL3355107)
Show SMILES Cc1cc(C)cc(CC(CP(O)(=O)C(N)CCc2ccccc2)C(O)=O)c1
Show InChI InChI=1/C21H28NO4P/c1-15-10-16(2)12-18(11-15)13-19(21(23)24)14-27(25,26)20(22)9-8-17-6-4-3-5-7-17/h3-7,10-12,19-20H,8-9,13-14,22H2,1-2H3,(H,23,24)(H,25,26)
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1.03E+3n/an/an/an/an/an/an/an/a



University of Athens

Curated by ChEMBL


Assay Description
Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation


J Med Chem 57: 8140-51 (2014)


Article DOI: 10.1021/jm501071f
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM234297
PNG
(Met-ψ[P(O)(OH)CH2]-Ala (5))
Show SMILES CSCCC(N)P(O)(=O)CC(C)C(O)=O
Show InChI InChI=1/C8H18NO4PS/c1-6(8(10)11)5-14(12,13)7(9)3-4-15-2/h6-7H,3-5,9H2,1-2H3,(H,10,11)(H,12,13)
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3.64E+3 -31.0n/an/an/an/an/a8.425



Academy of Sciences of the Czech Republic



Assay Description
LAP was assayed in 75 mM triethanolamine hydrochloride buffer (pH = 8.4, containing 5 mM MgCl2) at 25C. The substrate (L-leucine-p-nitroanilide) was...


J Enzyme Inhib Med Chem 26: 155-61 (2011)


Article DOI: 10.3109/14756366.2010.482047
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170875
PNG
(CHEMBL3805288)
Show SMILES NC(CNCc1ccc(N)cc1)P(O)(O)=O
Show InChI InChI=1/C9H16N3O3P/c10-8-3-1-7(2-4-8)5-12-6-9(11)16(13,14)15/h1-4,9,12H,5-6,10-11H2,(H2,13,14,15)
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7.02E+3n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170881
PNG
(CHEMBL3805028)
Show SMILES CC(C)CNCC(N)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C16H27N2O4P/c1-12(2)9-18-10-15(17)23(21,22)11-14(16(19)20)8-13-6-4-3-5-7-13/h3-7,12,14-15,18H,8-11,17H2,1-2H3,(H,19,20)(H,21,22)
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1.52E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170878
PNG
(CHEMBL3806197)
Show SMILES COc1ccc(CCNCC(N)P(O)(O)=O)cc1
Show InChI InChI=1/C11H19N2O4P/c1-17-10-4-2-9(3-5-10)6-7-13-8-11(12)18(14,15)16/h2-5,11,13H,6-8,12H2,1H3,(H2,14,15,16)
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1.95E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170897
PNG
(CHEMBL3805573)
Show SMILES NC(CNC1CCCCCC1)P(O)(O)=O
Show InChI InChI=1/C9H21N2O3P/c10-9(15(12,13)14)7-11-8-5-3-1-2-4-6-8/h8-9,11H,1-7,10H2,(H2,12,13,14)
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2.08E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170880
PNG
(CHEMBL3806187)
Show SMILES CCCNCC(N)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C15H25N2O4P/c1-2-8-17-10-14(16)22(20,21)11-13(15(18)19)9-12-6-4-3-5-7-12/h3-7,13-14,17H,2,8-11,16H2,1H3,(H,18,19)(H,20,21)
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2.10E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170884
PNG
(CHEMBL3805495)
Show SMILES COc1ccc(CCNCC(N)P(O)(=O)CC(Cc2ccccc2)C(O)=O)cc1
Show InChI InChI=1/C21H29N2O5P/c1-28-19-9-7-16(8-10-19)11-12-23-14-20(22)29(26,27)15-18(21(24)25)13-17-5-3-2-4-6-17/h2-10,18,20,23H,11-15,22H2,1H3,(H,24,25)(H,26,27)
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2.11E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM234295
PNG
(Met-PH (2))
Show SMILES CSCCC(N)P(O)=O
Show InChI InChI=1/C4H12NO2PS/c1-9-3-2-4(5)8(6)7/h4,8H,2-3,5H2,1H3,(H,6,7)
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2.20E+4 -26.6n/an/an/an/an/a8.425



Academy of Sciences of the Czech Republic



Assay Description
LAP was assayed in 75 mM triethanolamine hydrochloride buffer (pH = 8.4, containing 5 mM MgCl2) at 25C. The substrate (L-leucine-p-nitroanilide) was...


J Enzyme Inhib Med Chem 26: 155-61 (2011)


Article DOI: 10.3109/14756366.2010.482047
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM234294
PNG
(Met-P (1))
Show SMILES CSCCC(N)P(O)(O)=O
Show InChI InChI=1/C4H12NO3PS/c1-10-3-2-4(5)9(6,7)8/h4H,2-3,5H2,1H3,(H2,6,7,8)
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2.26E+4 -26.5n/an/an/an/an/a8.425



Academy of Sciences of the Czech Republic



Assay Description
LAP was assayed in 75 mM triethanolamine hydrochloride buffer (pH = 8.4, containing 5 mM MgCl2) at 25C. The substrate (L-leucine-p-nitroanilide) was...


J Enzyme Inhib Med Chem 26: 155-61 (2011)


Article DOI: 10.3109/14756366.2010.482047
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170883
PNG
(CHEMBL3805118)
Show SMILES NC(CNC1CCCCCC1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C19H31N2O4P/c20-18(13-21-17-10-6-1-2-7-11-17)26(24,25)14-16(19(22)23)12-15-8-4-3-5-9-15/h3-5,8-9,16-18,21H,1-2,6-7,10-14,20H2,(H,22,23)(H,24,25)
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2.38E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170876
PNG
(CHEMBL3805817)
Show SMILES COc1ccc(CNCC(N)P(O)(O)=O)cc1
Show InChI InChI=1/C10H17N2O4P/c1-16-9-4-2-8(3-5-9)6-12-7-10(11)17(13,14)15/h2-5,10,12H,6-7,11H2,1H3,(H2,13,14,15)
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2.62E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170877
PNG
(CHEMBL3804956)
Show SMILES NCc1ccc(CNCC(N)P(O)(O)=O)cc1
Show InChI InChI=1/C10H18N3O3P/c11-5-8-1-3-9(4-2-8)6-13-7-10(12)17(14,15)16/h1-4,10,13H,5-7,11-12H2,(H2,14,15,16)
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2.65E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170882
PNG
(CHEMBL3804856)
Show SMILES NC(CNC1CCCCC1)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C18H29N2O4P/c19-17(12-20-16-9-5-2-6-10-16)25(23,24)13-15(18(21)22)11-14-7-3-1-4-8-14/h1,3-4,7-8,15-17,20H,2,5-6,9-13,19H2,(H,21,22)(H,23,24)
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2.83E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170871
PNG
(CHEMBL3806230)
Show SMILES NC(CNCCN1CCNCC1)P(O)(O)=O
Show InChI InChI=1/C8H21N4O3P/c9-8(16(13,14)15)7-11-3-6-12-4-1-10-2-5-12/h8,10-11H,1-7,9H2,(H2,13,14,15)
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5.58E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50316030
PNG
(1-aminopentylphosphonic acid | CHEMBL1089899 | Nle...)
Show SMILES CCCCC(N)P(O)(O)=O
Show InChI InChI=1S/C5H14NO3P/c1-2-3-4-5(6)10(7,8)9/h5H,2-4,6H2,1H3,(H2,7,8,9)
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5.80E+4 -24.2n/an/an/an/an/a8.425



Academy of Sciences of the Czech Republic



Assay Description
LAP was assayed in 75 mM triethanolamine hydrochloride buffer (pH = 8.4, containing 5 mM MgCl2) at 25C. The substrate (L-leucine-p-nitroanilide) was...


J Enzyme Inhib Med Chem 26: 155-61 (2011)


Article DOI: 10.3109/14756366.2010.482047
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170879
PNG
(CHEMBL3805472)
Show SMILES NCC(N)P(O)(=O)CC(Cc1ccccc1)C(O)=O
Show InChI InChI=1/C12H19N2O4P/c13-7-11(14)19(17,18)8-10(12(15)16)6-9-4-2-1-3-5-9/h1-5,10-11H,6-8,13-14H2,(H,15,16)(H,17,18)
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6.44E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170894
PNG
(CHEMBL3805338)
Show SMILES NC(CNCC1CCNCC1)P(O)(O)=O
Show InChI InChI=1/C8H20N3O3P/c9-8(15(12,13)14)6-11-5-7-1-3-10-4-2-7/h7-8,10-11H,1-6,9H2,(H2,12,13,14)
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6.84E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170895
PNG
(CHEMBL3805487)
Show SMILES NC(CNCC1CCCO1)P(O)(O)=O
Show InChI InChI=1/C7H17N2O4P/c8-7(14(10,11)12)5-9-4-6-2-1-3-13-6/h6-7,9H,1-5,8H2,(H2,10,11,12)
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6.91E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170873
PNG
(CHEMBL3805193)
Show SMILES CC(C)(C)c1ccc(CNCC(N)P(O)(O)=O)cc1
Show InChI InChI=1/C13H23N2O3P/c1-13(2,3)11-6-4-10(5-7-11)8-15-9-12(14)19(16,17)18/h4-7,12,15H,8-9,14H2,1-3H3,(H2,16,17,18)
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7.11E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170898
PNG
(CHEMBL3805964)
Show SMILES CN(C)CCNCC(N)P(O)(O)=O
Show InChI InChI=1/C6H18N3O3P/c1-9(2)4-3-8-5-6(7)13(10,11)12/h6,8H,3-5,7H2,1-2H3,(H2,10,11,12)
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7.26E+4n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM234296
PNG
(Nle-PH (4))
Show SMILES CCCCC(N)P(O)=O
Show InChI InChI=1/C5H14NO2P/c1-2-3-4-5(6)9(7)8/h5,9H,2-4,6H2,1H3,(H,7,8)
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7.39E+4 -23.6n/an/an/an/an/a8.425



Academy of Sciences of the Czech Republic



Assay Description
LAP was assayed in 75 mM triethanolamine hydrochloride buffer (pH = 8.4, containing 5 mM MgCl2) at 25C. The substrate (L-leucine-p-nitroanilide) was...


J Enzyme Inhib Med Chem 26: 155-61 (2011)


Article DOI: 10.3109/14756366.2010.482047
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170874
PNG
(CHEMBL3805544)
Show SMILES NC(CNCCc1ccccc1)P(O)(O)=O
Show InChI InChI=1/C10H17N2O3P/c11-10(16(13,14)15)8-12-7-6-9-4-2-1-3-5-9/h1-5,10,12H,6-8,11H2,(H2,13,14,15)
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1.08E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170900
PNG
(CHEMBL3806247)
Show SMILES CCCCCCNCC(N)P(O)(O)=O
Show InChI InChI=1/C8H21N2O3P/c1-2-3-4-5-6-10-7-8(9)14(11,12)13/h8,10H,2-7,9H2,1H3,(H2,11,12,13)
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1.19E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM234299
PNG
(Nle-ψ[P(O)(OH)O]-L-AlaOMe (7))
Show SMILES CCCCC(N)P(O)(=O)O[C@@H](C)C(=O)OC |r|
Show InChI InChI=1/C9H20NO5P/c1-4-5-6-8(10)16(12,13)15-7(2)9(11)14-3/h7-8H,4-6,10H2,1-3H3,(H,12,13)/t7-,8?/s2
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2.19E+5 -20.9n/an/an/an/an/a8.425



Academy of Sciences of the Czech Republic



Assay Description
LAP was assayed in 75 mM triethanolamine hydrochloride buffer (pH = 8.4, containing 5 mM MgCl2) at 25C. The substrate (L-leucine-p-nitroanilide) was...


J Enzyme Inhib Med Chem 26: 155-61 (2011)


Article DOI: 10.3109/14756366.2010.482047
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170896
PNG
(CHEMBL3805251)
Show SMILES NC(CNC1CCCCC1N)P(O)(O)=O
Show InChI InChI=1/C8H20N3O3P/c9-6-3-1-2-4-7(6)11-5-8(10)15(12,13)14/h6-8,11H,1-5,9-10H2,(H2,12,13,14)
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2.40E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM234298
PNG
(Nle-ψ[P(O)(OH)O]-L-Ala (6))
Show SMILES CCCCC(N)P(O)(=O)O[C@@H](C)C(O)=O |r|
Show InChI InChI=1/C8H18NO5P/c1-3-4-5-7(9)15(12,13)14-6(2)8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)(H,12,13)/t6-,7?/s2
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2.69E+5 -20.4n/an/an/an/an/a8.425



Academy of Sciences of the Czech Republic



Assay Description
LAP was assayed in 75 mM triethanolamine hydrochloride buffer (pH = 8.4, containing 5 mM MgCl2) at 25C. The substrate (L-leucine-p-nitroanilide) was...


J Enzyme Inhib Med Chem 26: 155-61 (2011)


Article DOI: 10.3109/14756366.2010.482047
More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170899
PNG
(CHEMBL3806100)
Show SMILES NCCNCC(N)P(O)(O)=O
Show InChI InChI=1/C4H14N3O3P/c5-1-2-7-3-4(6)11(8,9)10/h4,7H,1-3,5-6H2,(H2,8,9,10)
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2.89E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using Leu-AMC as substrate preincubated for 30 to 60 mins followed by substrate addition meas...


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170891
PNG
(CHEMBL3805986)
Show SMILES NC(CNCc1ccccc1)P(O)(O)=O
Show InChI InChI=1/C9H15N2O3P/c10-9(15(12,13)14)7-11-6-8-4-2-1-3-5-8/h1-5,9,11H,6-7,10H2,(H2,12,13,14)
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3.50E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using L-leucine p-nitro-anilide as substrate by spectrophotometric analysis


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170892
PNG
(CHEMBL3804861)
Show SMILES CC(NCC(N)P(O)(O)=O)c1ccccc1
Show InChI InChI=1/C10H17N2O3P/c1-8(9-5-3-2-4-6-9)12-7-10(11)16(13,14)15/h2-6,8,10,12H,7,11H2,1H3,(H2,13,14,15)
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6.00E+5n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using L-leucine p-nitro-anilide as substrate by spectrophotometric analysis


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
Leucine aminopeptidase (LAP)


(Sus scrofa (Pig))
BDBM50170893
PNG
(CHEMBL3804843)
Show SMILES NC(CN1CCCCC1)P(O)(O)=O
Show InChI InChI=1/C7H17N2O3P/c8-7(13(10,11)12)6-9-4-2-1-3-5-9/h7H,1-6,8H2,(H2,10,11,12)
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1.41E+6n/an/an/an/an/an/an/an/a



Wroclaw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of porcine kidney leucine aminopeptidase M17 using L-leucine p-nitro-anilide as substrate by spectrophotometric analysis


Eur J Med Chem 117: 187-96 (2016)

More data for this
Ligand-Target Pair
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