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Compile Data Set for Download or QSAR

Found 49 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase; ERK1/ERK2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM28123
PNG
(3-cyanoquinoline, 8 | 4-({3-chloro-4-[(1-methyl-1H...)
Show SMILES COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(cnc2cc1OCCCN1CCOCC1)C#N
Show InChI InChI=1S/C28H29ClN6O3S/c1-34-8-6-31-28(34)39-26-5-4-20(14-22(26)29)33-27-19(17-30)18-32-23-16-25(24(36-2)15-21(23)27)38-11-3-7-35-9-12-37-13-10-35/h4-6,8,14-16,18H,3,7,9-13H2,1-2H3,(H,32,33)
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n/an/a 0.0100n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of MEK1 phosphorylation in LoVo cells


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50396073
PNG
(CHEMBL1235110)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)c1
Show InChI InChI=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8-3-2-7-14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22,23,24)/t14-,15+/m0/s1
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n/an/a 16n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assay


Bioorg Med Chem Lett 21: 6188-94 (2011)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50419256
PNG
(CHEMBL1835065 | US9579320, Example 302)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)c1
Show InChI InChI=1S/C17H22N6O2/c1-10-3-2-4-11(7-10)21-16-12(15(19)24)8-20-17(23-16)22-14-5-6-25-9-13(14)18/h2-4,7-8,13-14H,5-6,9,18H2,1H3,(H2,19,24)(H2,20,21,22,23)/t13-,14+/m0/s1
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n/an/a 20n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assay


Bioorg Med Chem Lett 21: 6188-94 (2011)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50419265
PNG
(CHEMBL1835069)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CC(F)(F)CC[C@@H]3N)ncc2C(N)=O)c1
Show InChI InChI=1S/C18H22F2N6O/c1-10-3-2-4-11(7-10)24-16-12(15(22)27)9-23-17(26-16)25-14-8-18(19,20)6-5-13(14)21/h2-4,7,9,13-14H,5-6,8,21H2,1H3,(H2,22,27)(H2,23,24,25,26)/t13-,14+/m0/s1
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n/an/a 63n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assay


Bioorg Med Chem Lett 21: 6188-94 (2011)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50419247
PNG
(CHEMBL1835071 | US8470835, 1)
Show SMILES Cc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)cc1
Show InChI InChI=1S/C17H22N6O2/c1-10-2-4-11(5-3-10)21-16-12(15(19)24)8-20-17(23-16)22-14-6-7-25-9-13(14)18/h2-5,8,13-14H,6-7,9,18H2,1H3,(H2,19,24)(H2,20,21,22,23)/t13-,14+/m0/s1
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n/an/a 79n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assay


Bioorg Med Chem Lett 21: 6188-94 (2011)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50419258
PNG
(CHEMBL1835070)
Show SMILES Cc1ccc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)ncc2C(N)=O)cc1
Show InChI InChI=1S/C18H24N6O/c1-11-6-8-12(9-7-11)22-17-13(16(20)25)10-21-18(24-17)23-15-5-3-2-4-14(15)19/h6-10,14-15H,2-5,19H2,1H3,(H2,20,25)(H2,21,22,23,24)/t14-,15+/m0/s1
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n/an/a 79n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assay


Bioorg Med Chem Lett 21: 6188-94 (2011)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50419260
PNG
(CHEMBL1834758)
Show SMILES Cc1cccc(Nc2nc(N[C@H]3CCCNC3)ncc2C(N)=O)c1
Show InChI InChI=1S/C17H22N6O/c1-11-4-2-5-12(8-11)21-16-14(15(18)24)10-20-17(23-16)22-13-6-3-7-19-9-13/h2,4-5,8,10,13,19H,3,6-7,9H2,1H3,(H2,18,24)(H2,20,21,22,23)/t13-/m0/s1
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n/an/a 126n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assay


Bioorg Med Chem Lett 21: 6188-94 (2011)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50419259
PNG
(CHEMBL1835072)
Show SMILES COc1ccc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)ncc2C(N)=O)cc1
Show InChI InChI=1S/C17H22N6O3/c1-25-11-4-2-10(3-5-11)21-16-12(15(19)24)8-20-17(23-16)22-14-6-7-26-9-13(14)18/h2-5,8,13-14H,6-7,9,18H2,1H3,(H2,19,24)(H2,20,21,22,23)/t13-,14+/m0/s1
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n/an/a 126n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assay


Bioorg Med Chem Lett 21: 6188-94 (2011)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50419250
PNG
(CHEMBL1834757)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCCNC3)ncc2C(N)=O)c1
Show InChI InChI=1S/C17H22N6O/c1-11-4-2-5-12(8-11)21-16-14(15(18)24)10-20-17(23-16)22-13-6-3-7-19-9-13/h2,4-5,8,10,13,19H,3,6-7,9H2,1H3,(H2,18,24)(H2,20,21,22,23)/t13-/m1/s1
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n/an/a 158n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assay


Bioorg Med Chem Lett 21: 6188-94 (2011)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50419253
PNG
(CHEMBL1835061)
Show SMILES Cc1cccc(Nc2nc(NC[C@@H]3CCCN3)ncc2C(N)=O)c1
Show InChI InChI=1S/C17H22N6O/c1-11-4-2-5-12(8-11)22-16-14(15(18)24)10-21-17(23-16)20-9-13-6-3-7-19-13/h2,4-5,8,10,13,19H,3,6-7,9H2,1H3,(H2,18,24)(H2,20,21,22,23)/t13-/m0/s1
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n/an/a 200n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assay


Bioorg Med Chem Lett 21: 6188-94 (2011)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50419255
PNG
(CHEMBL1835064)
Show SMILES Cc1cccc(Nc2nc(N[C@H]3CCCC[C@H]3N)ncc2C(N)=O)c1
Show InChI InChI=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8-3-2-7-14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22,23,24)/t14-,15+/m1/s1
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n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assay


Bioorg Med Chem Lett 21: 6188-94 (2011)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50419262
PNG
(CHEMBL1835068)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3CCC(F)(F)C[C@@H]3N)ncc2C(N)=O)c1
Show InChI InChI=1S/C18H22F2N6O/c1-10-3-2-4-11(7-10)24-16-12(15(22)27)9-23-17(26-16)25-14-5-6-18(19,20)8-13(14)21/h2-4,7,9,13-14H,5-6,8,21H2,1H3,(H2,22,27)(H2,23,24,25,26)/t13-,14+/m0/s1
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n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assay


Bioorg Med Chem Lett 21: 6188-94 (2011)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50095232
PNG
(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)
Show SMILES COc1cc2c(Nc3ccc(Oc4ccccc4)cc3)c(cnc2cc1OCCCN1CCOCC1)C#N
Show InChI InChI=1S/C30H30N4O4/c1-35-28-18-26-27(19-29(28)37-15-5-12-34-13-16-36-17-14-34)32-21-22(20-31)30(26)33-23-8-10-25(11-9-23)38-24-6-3-2-4-7-24/h2-4,6-11,18-19,21H,5,12-17H2,1H3,(H,32,33)
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n/an/a 380n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL




Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237225
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 1.27E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50419251
PNG
(CHEMBL1835058)
Show SMILES Cc1cccc(Nc2nc(N[C@H]3CCNC3)ncc2C(N)=O)c1
Show InChI InChI=1S/C16H20N6O/c1-10-3-2-4-11(7-10)20-15-13(14(17)23)9-19-16(22-15)21-12-5-6-18-8-12/h2-4,7,9,12,18H,5-6,8H2,1H3,(H2,17,23)(H2,19,20,21,22)/t12-/m0/s1
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n/an/a 1.59E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assay


Bioorg Med Chem Lett 21: 6188-94 (2011)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM26198
PNG
(4-tert-butyl-15-fluoro-3,5,10-triazatetracyclo[11....)
Show SMILES CC(C)(C)c1nc2c([nH]1)c1ccc(F)cc1c1c2cc[nH]c1=O
Show InChI InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
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n/an/a 1.78E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of p56 Lck tyrosine kinase


Citation and Details
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50419254
PNG
(CHEMBL1835063)
Show SMILES N[C@H]1CCCN(C1)c1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C17H19F3N6O/c18-17(19,20)10-3-1-5-12(7-10)24-15-13(14(22)27)8-23-16(25-15)26-6-2-4-11(21)9-26/h1,3,5,7-8,11H,2,4,6,9,21H2,(H2,22,27)(H,23,24,25)/t11-/m0/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assay


Bioorg Med Chem Lett 21: 6188-94 (2011)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237214
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O3/c1-27-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(26)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a 2.14E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237223
PNG
(1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2)ccc1O
Show InChI InChI=1S/C21H19FN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 3.12E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237222
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-1-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(cc1)N(Cc1ccc(O)c(OC)c1)C(=S)Nc1ccccc1
Show InChI InChI=1S/C22H22N2O3S/c1-26-19-11-9-18(10-12-19)24(22(28)23-17-6-4-3-5-7-17)15-16-8-13-20(25)21(14-16)27-2/h3-14,25H,15H2,1-2H3,(H,23,28)
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n/an/a 3.21E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237224
PNG
(1-(4-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Cl)cc2)ccc1O
Show InChI InChI=1S/C21H19ClN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 3.28E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237220
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-1, 3-diphenylthioure...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccccc2)ccc1O
Show InChI InChI=1S/C21H20N2O2S/c1-25-20-14-16(12-13-19(20)24)15-23(18-10-6-3-7-11-18)21(26)22-17-8-4-2-5-9-17/h2-14,24H,15H2,1H3,(H,22,26)
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n/an/a 3.35E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237213
PNG
(1-(4-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(Cl)cc2)ccc1O
Show InChI InChI=1S/C21H19ClN2O3/c1-27-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(26)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a 4.07E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237230
PNG
(1-(2, 4-Dichlorophenyl)-1-(4-hydroxy-3-methoxybenz...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Cl)cc2Cl)ccc1O
Show InChI InChI=1S/C21H18Cl2N2O2S/c1-27-20-11-14(7-10-19(20)26)13-25(18-9-8-15(22)12-17(18)23)21(28)24-16-5-3-2-4-6-16/h2-12,26H,13H2,1H3,(H,24,28)
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n/an/a 4.13E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237212
PNG
(1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(F)cc2)ccc1O
Show InChI InChI=1S/C21H19FN2O3/c1-27-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(26)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a 4.19E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237219
PNG
(1-(2, 4-Dichlorophenyl)-1-(4-hydroxy-3-methoxybenz...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(Cl)cc2Cl)ccc1O
Show InChI InChI=1S/C21H18Cl2N2O3/c1-28-20-11-14(7-10-19(20)26)13-25(18-9-8-15(22)12-17(18)23)21(27)24-16-5-3-2-4-6-16/h2-12,26H,13H2,1H3,(H,24,27)
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n/an/a 5.22E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237221
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-3-phenyl-1-p-tolylth...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(C)cc2)ccc1O
Show InChI InChI=1S/C22H22N2O2S/c1-16-8-11-19(12-9-16)24(22(27)23-18-6-4-3-5-7-18)15-17-10-13-20(25)21(14-17)26-2/h3-14,25H,15H2,1-2H3,(H,23,27)
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n/an/a 5.47E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237211
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-1-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(cc1)N(Cc1ccc(O)c(OC)c1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c1-27-19-11-9-18(10-12-19)24(22(26)23-17-6-4-3-5-7-17)15-16-8-13-20(25)21(14-16)28-2/h3-14,25H,15H2,1-2H3,(H,23,26)
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n/an/a 5.76E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237210
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-3-phenyl-1-p-tolylur...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(C)cc2)ccc1O
Show InChI InChI=1S/C22H22N2O3/c1-16-8-11-19(12-9-16)24(22(26)23-18-6-4-3-5-7-18)15-17-10-13-20(25)21(14-17)27-2/h3-14,25H,15H2,1-2H3,(H,23,26)
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n/an/a 6.12E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237228
PNG
(1-(2-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccccc2Br)ccc1O
Show InChI InChI=1S/C21H19BrN2O2S/c1-26-20-13-15(11-12-19(20)25)14-24(18-10-6-5-9-17(18)22)21(27)23-16-7-3-2-4-8-16/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 6.14E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237218
PNG
(1-(2, 4-Difluorophenyl)-1-(4-hydroxy-3-methoxybenz...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(F)cc2F)ccc1O
Show InChI InChI=1S/C21H18F2N2O3/c1-28-20-11-14(7-10-19(20)26)13-25(18-9-8-15(22)12-17(18)23)21(27)24-16-5-3-2-4-6-16/h2-12,26H,13H2,1H3,(H,24,27)
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n/an/a 6.47E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237209
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-1, 3-diphenylurea (1...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccccc2)ccc1O
Show InChI InChI=1S/C21H20N2O3/c1-26-20-14-16(12-13-19(20)24)15-23(18-10-6-3-7-11-18)21(25)22-17-8-4-2-5-9-17/h2-14,24H,15H2,1H3,(H,22,25)
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n/an/a 6.77E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237229
PNG
(1-(2, 4-Difluorophenyl)-1-(4-hydroxy-3-methoxybenz...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2F)ccc1O
Show InChI InChI=1S/C21H18F2N2O2S/c1-27-20-11-14(7-10-19(20)26)13-25(18-9-8-15(22)12-17(18)23)21(28)24-16-5-3-2-4-6-16/h2-12,26H,13H2,1H3,(H,24,28)
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n/an/a 6.92E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237227
PNG
(1-(2-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccccc2Cl)ccc1O
Show InChI InChI=1S/C21H19ClN2O2S/c1-26-20-13-15(11-12-19(20)25)14-24(18-10-6-5-9-17(18)22)21(27)23-16-7-3-2-4-8-16/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 6.99E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM3428
PNG
(1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyri...)
Show SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C18H18Cl2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
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n/an/a 7.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against platelet-derived growth factor receptor


Bioorg Med Chem Lett 7: 2415-2420 (1997)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237226
PNG
(1-(2-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccccc2F)ccc1O
Show InChI InChI=1S/C21H19FN2O2S/c1-26-20-13-15(11-12-19(20)25)14-24(18-10-6-5-9-17(18)22)21(27)23-16-7-3-2-4-8-16/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 7.22E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237215
PNG
(1-(2-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccccc2F)ccc1O
Show InChI InChI=1S/C21H19FN2O3/c1-27-20-13-15(11-12-19(20)25)14-24(18-10-6-5-9-17(18)22)21(26)23-16-7-3-2-4-8-16/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a 9.15E+3n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50290834
PNG
(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)
Show SMILES COc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C19H19NO5/c1-21-16-6-5-12(9-17(16)22-2)25-15-7-8-20-14-11-19(24-4)18(23-3)10-13(14)15/h5-11H,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor (PDGF-R) from NIH 3T3 cells


Bioorg Med Chem Lett 7: 2935-2940 (1997)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237216
PNG
(1-(2-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccccc2Cl)ccc1O
Show InChI InChI=1S/C21H19ClN2O3/c1-27-20-13-15(11-12-19(20)25)14-24(18-10-6-5-9-17(18)22)21(26)23-16-7-3-2-4-8-16/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a 1.01E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237217
PNG
(1-(2-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccccc2Br)ccc1O
Show InChI InChI=1S/C21H19BrN2O3/c1-27-20-13-15(11-12-19(20)25)14-24(18-10-6-5-9-17(18)22)21(26)23-16-7-3-2-4-8-16/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a 1.02E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50419257
PNG
(CHEMBL1835067)
Show SMILES Cc1cccc(Nc2nc(N[C@@H]3COC[C@@H]3N)ncc2C(N)=O)c1
Show InChI InChI=1S/C16H20N6O2/c1-9-3-2-4-10(5-9)20-15-11(14(18)23)6-19-16(22-15)21-13-8-24-7-12(13)17/h2-6,12-13H,7-8,17H2,1H3,(H2,18,23)(H2,19,20,21,22)/t12-,13+/m0/s1
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n/an/a 1.26E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assay


Bioorg Med Chem Lett 21: 6188-94 (2011)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237225
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a 2.27E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237223
PNG
(1-(4-Fluorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(F)cc2)ccc1O
Show InChI InChI=1S/C21H19FN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237224
PNG
(1-(4-Chlorophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3...)
Show SMILES COc1cc(CN(C(=S)Nc2ccccc2)c2ccc(Cl)cc2)ccc1O
Show InChI InChI=1S/C21H19ClN2O2S/c1-26-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(27)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,27)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237214
PNG
(1-(4-Bromophenyl)-1-(4-hydroxy-3-methoxybenzyl)-3-...)
Show SMILES COc1cc(CN(C(=O)Nc2ccccc2)c2ccc(Br)cc2)ccc1O
Show InChI InChI=1S/C21H19BrN2O3/c1-27-20-13-15(7-12-19(20)25)14-24(18-10-8-16(22)9-11-18)21(26)23-17-5-3-2-4-6-17/h2-13,25H,14H2,1H3,(H,23,26)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM237222
PNG
(1-(4-Hydroxy-3-methoxybenzyl)-1-(4-methoxyphenyl)-...)
Show SMILES COc1ccc(cc1)N(Cc1ccc(O)c(OC)c1)C(=S)Nc1ccccc1
Show InChI InChI=1S/C22H22N2O3S/c1-26-19-11-9-18(10-12-19)24(22(28)23-17-6-4-3-5-7-17)15-16-8-13-20(25)21(14-16)27-2/h3-14,25H,15H2,1-2H3,(H,23,28)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Nanjing University



Assay Description
Detection of the effect of compounds on p-MEK1/2, t-ERK1/2, pERK1/2, p-Rsk1 and p-Elk-1 activity in B16-F10 cells was performed using ELISA kits (Inv...


J Enzyme Inhib Med Chem 27: 708-14 (2012)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM50126732
PNG
(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Show SMILES CCN(CC)CC=Cc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc2c1C
Show InChI InChI=1S/C25H27Cl2N5O/c1-5-32(6-2)14-8-11-19-15(3)16-12-13-20-23(21(16)24(33)28-19)31(4)25(29-20)30-22-17(26)9-7-10-18(22)27/h7-13H,5-6,14H2,1-4H3,(H,28,33)(H,29,30)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Mitogen-activated protein kinase


J Med Chem 46: 1337-49 (2003)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM3443
PNG
(1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyr...)
Show SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against platelet-derived growth factor receptor


Bioorg Med Chem Lett 7: 2415-2420 (1997)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase; ERK1/ERK2


(Homo sapiens (Human))
BDBM3441
PNG
(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Show SMILES Cc1cc(C)c(C)c(c1C)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C
Show InChI InChI=1S/C22H28N6O/c1-11-8-12(2)14(4)17(13(11)3)16-9-15-10-24-20(23)26-18(15)25-19(16)27-21(29)28-22(5,6)7/h8-10H,1-7H3,(H4,23,24,25,26,27,28,29)
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n/an/a>5.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL




Bioorg Med Chem Lett 7: 2415-2420 (1997)

More data for this
Ligand-Target Pair