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Compile Data Set for Download or QSAR

Found 114 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50333221
PNG
(6-(pyridin-4-yl)benzo[d]thiazol-2-amine | CHEMBL16...)
Show SMILES Nc1nc2ccc(cc2s1)-c1ccncc1
Show InChI InChI=1S/C12H9N3S/c13-12-15-10-2-1-9(7-11(10)16-12)8-3-5-14-6-4-8/h1-7H,(H2,13,15)
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n/an/a 2.51E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107268
PNG
(CHEMBL3600693)
Show SMILES CS(=O)(=O)c1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C13H11N3O2S2/c1-20(17,18)12-5-3-9(7-15-12)8-2-4-10-11(6-8)19-13(14)16-10/h2-7H,1H3,(H2,14,16)
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n/an/a 1.00E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50106970
PNG
(CHEMBL3600767)
Show SMILES Nc1nc2ccc(cc2s1)-c1cc[nH]c(=O)c1
Show InChI InChI=1S/C12H9N3OS/c13-12-15-9-2-1-7(5-10(9)17-12)8-3-4-14-11(16)6-8/h1-6H,(H2,13,15)(H,14,16)
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n/an/a 1.58E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50333219
PNG
(6-(6-methoxypyridin-3-yl)benzo[d]thiazol-2-amine |...)
Show SMILES COc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C13H11N3OS/c1-17-12-5-3-9(7-15-12)8-2-4-10-11(6-8)18-13(14)16-10/h2-7H,1H3,(H2,14,16)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107255
PNG
(CHEMBL3600783)
Show SMILES C[C@H](Nc1nc2ccc(cc2s1)-c1ccn(CC2CC2)c(=O)c1)C1CCOCC1 |r|
Show InChI InChI=1/C23H27N3O2S/c1-15(17-7-10-28-11-8-17)24-23-25-20-5-4-18(12-21(20)29-23)19-6-9-26(22(27)13-19)14-16-2-3-16/h4-6,9,12-13,15-17H,2-3,7-8,10-11,14H2,1H3,(H,24,25)/t15-/s2
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107015
PNG
(CHEMBL3600772)
Show SMILES CCCn1cc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C13H14N4S/c1-2-5-17-8-10(7-15-17)9-3-4-11-12(6-9)18-13(14)16-11/h3-4,6-8H,2,5H2,1H3,(H2,14,16)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107264
PNG
(CHEMBL3600688)
Show SMILES CCNc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C14H14N4S/c1-2-16-13-6-4-10(8-17-13)9-3-5-11-12(7-9)19-14(15)18-11/h3-8H,2H2,1H3,(H2,15,18)(H,16,17)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50106927
PNG
(CHEMBL3600702)
Show SMILES Nc1nc2ccc(cc2s1)-c1ncccn1
Show InChI InChI=1S/C11H8N4S/c12-11-15-8-3-2-7(6-9(8)16-11)10-13-4-1-5-14-10/h1-6H,(H2,12,15)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107276
PNG
(CHEMBL3600696)
Show SMILES CNC(=O)c1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C14H12N4OS/c1-16-13(19)11-5-3-9(7-17-11)8-2-4-10-12(6-8)20-14(15)18-10/h2-7H,1H3,(H2,15,18)(H,16,19)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50106926
PNG
(CHEMBL3600701)
Show SMILES Nc1nc2ccc(cc2s1)-c1cccnc1
Show InChI InChI=1S/C12H9N3S/c13-12-15-10-4-3-8(6-11(10)16-12)9-2-1-5-14-7-9/h1-7H,(H2,13,15)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107272
PNG
(CHEMBL3600698)
Show SMILES CC(C)Oc1cncc(c1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C15H15N3OS/c1-9(2)19-12-5-11(7-17-8-12)10-3-4-13-14(6-10)20-15(16)18-13/h3-9H,1-2H3,(H2,16,18)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50106969
PNG
(CHEMBL3600766)
Show SMILES Nc1nc2ccc(cc2s1)-c1ccc(=O)[nH]c1
Show InChI InChI=1S/C12H9N3OS/c13-12-15-9-3-1-7(5-10(9)17-12)8-2-4-11(16)14-6-8/h1-6H,(H2,13,15)(H,14,16)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107016
PNG
(CHEMBL3600773)
Show SMILES CC(C)n1cc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C13H14N4S/c1-8(2)17-7-10(6-15-17)9-3-4-11-12(5-9)18-13(14)16-11/h3-8H,1-2H3,(H2,14,16)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107011
PNG
(CHEMBL3600768)
Show SMILES Cn1ccc(n1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C11H10N4S/c1-15-5-4-8(14-15)7-2-3-9-10(6-7)16-11(12)13-9/h2-6H,1H3,(H2,12,13)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107243
PNG
(CHEMBL3600779)
Show SMILES Nc1nc2ccc(cc2s1)-c1ccn(CC2CC2)c(=O)c1
Show InChI InChI=1S/C16H15N3OS/c17-16-18-13-4-3-11(7-14(13)21-16)12-5-6-19(15(20)8-12)9-10-1-2-10/h3-8,10H,1-2,9H2,(H2,17,18)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107277
PNG
(CHEMBL97245)
Show SMILES Nc1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C13H10N2S/c14-13-15-11-7-6-10(8-12(11)16-13)9-4-2-1-3-5-9/h1-8H,(H2,14,15)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107274
PNG
(CHEMBL3600700)
Show SMILES Nc1nc2ccc(cc2s1)-c1ccccn1
Show InChI InChI=1S/C12H9N3S/c13-12-15-10-5-4-8(7-11(10)16-12)9-3-1-2-6-14-9/h1-7H,(H2,13,15)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107256
PNG
(CHEMBL3600784)
Show SMILES O=c1cc(ccn1CC1CC1)-c1ccc2nc(NCC3CCS(=O)(=O)CC3)sc2c1
Show InChI InChI=1S/C22H25N3O3S2/c26-21-12-18(5-8-25(21)14-16-1-2-16)17-3-4-19-20(11-17)29-22(24-19)23-13-15-6-9-30(27,28)10-7-15/h3-5,8,11-12,15-16H,1-2,6-7,9-10,13-14H2,(H,23,24)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50106928
PNG
(CHEMBL3600765)
Show SMILES Nc1nc2ccc(cc2s1)-c1cnccn1
Show InChI InChI=1S/C11H8N4S/c12-11-15-8-2-1-7(5-10(8)16-11)9-6-13-3-4-14-9/h1-6H,(H2,12,15)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107258
PNG
(CHEMBL3600683)
Show SMILES CCOc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C14H13N3OS/c1-2-18-13-6-4-10(8-16-13)9-3-5-11-12(7-9)19-14(15)17-11/h3-8H,2H2,1H3,(H2,15,17)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107012
PNG
(CHEMBL3600769)
Show SMILES Cn1nccc1-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C11H10N4S/c1-15-9(4-5-13-15)7-2-3-8-10(6-7)16-11(12)14-8/h2-6H,1H3,(H2,12,14)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107013
PNG
(CHEMBL3600770)
Show SMILES Cn1cc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C11H10N4S/c1-15-6-8(5-13-15)7-2-3-9-10(4-7)16-11(12)14-9/h2-6H,1H3,(H2,12,14)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107014
PNG
(CHEMBL3600771)
Show SMILES CCn1cc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C12H12N4S/c1-2-16-7-9(6-14-16)8-3-4-10-11(5-8)17-12(13)15-10/h3-7H,2H2,1H3,(H2,13,15)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107254
PNG
(CHEMBL3600782)
Show SMILES C[C@@H](Nc1nc2ccc(cc2s1)-c1ccn(CC2CC2)c(=O)c1)C1CCOCC1 |r|
Show InChI InChI=1/C23H27N3O2S/c1-15(17-7-10-28-11-8-17)24-23-25-20-5-4-18(12-21(20)29-23)19-6-9-26(22(27)13-19)14-16-2-3-16/h4-6,9,12-13,15-17H,2-3,7-8,10-11,14H2,1H3,(H,24,25)/t15-/s2
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107091
PNG
(CHEMBL3600774)
Show SMILES Nc1nc2ccc(cc2s1)-c1cnn(c1)C1CC1
Show InChI InChI=1S/C13H12N4S/c14-13-16-11-4-1-8(5-12(11)18-13)9-6-15-17(7-9)10-2-3-10/h1,4-7,10H,2-3H2,(H2,14,16)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107238
PNG
(CHEMBL3600776)
Show SMILES Nc1nc2ccc(cc2s1)-c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C17H14N4S/c18-17-20-15-7-6-13(8-16(15)22-17)14-9-19-21(11-14)10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H2,18,20)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107241
PNG
(CHEMBL3600777)
Show SMILES Cn1ccc(cc1=O)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C13H11N3OS/c1-16-5-4-9(7-12(16)17)8-2-3-10-11(6-8)18-13(14)15-10/h2-7H,1H3,(H2,14,15)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107242
PNG
(CHEMBL3600778)
Show SMILES CCn1ccc(cc1=O)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C14H13N3OS/c1-2-17-6-5-10(8-13(17)18)9-3-4-11-12(7-9)19-14(15)16-11/h3-8H,2H2,1H3,(H2,15,16)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107244
PNG
(CHEMBL3600780)
Show SMILES COCCOn1ccc(cc1=O)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C15H15N3O3S/c1-20-6-7-21-18-5-4-11(9-14(18)19)10-2-3-12-13(8-10)22-15(16)17-12/h2-5,8-9H,6-7H2,1H3,(H2,16,17)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107248
PNG
(CHEMBL3600781)
Show SMILES O=c1cc(ccn1CC1CC1)-c1ccc2nc(NCC3CCOCC3)sc2c1
Show InChI InChI=1S/C22H25N3O2S/c26-21-12-18(5-8-25(21)14-16-1-2-16)17-3-4-19-20(11-17)28-22(24-19)23-13-15-6-9-27-10-7-15/h3-5,8,11-12,15-16H,1-2,6-7,9-10,13-14H2,(H,23,24)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107263
PNG
(CHEMBL3600687)
Show SMILES CC(C)Oc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C15H15N3OS/c1-9(2)19-14-6-4-11(8-17-14)10-3-5-12-13(7-10)20-15(16)18-12/h3-9H,1-2H3,(H2,16,18)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107262
PNG
(CHEMBL3600686)
Show SMILES CNCc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C14H14N4S/c1-16-8-11-4-2-10(7-17-11)9-3-5-12-13(6-9)19-14(15)18-12/h2-7,16H,8H2,1H3,(H2,15,18)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107273
PNG
(CHEMBL3600699)
Show SMILES CS(=O)(=O)c1cncc(c1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C13H11N3O2S2/c1-20(17,18)10-4-9(6-15-7-10)8-2-3-11-12(5-8)19-13(14)16-11/h2-7H,1H3,(H2,14,16)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107271
PNG
(CHEMBL3600697)
Show SMILES CN(C)C(=O)c1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C15H14N4OS/c1-19(2)14(20)12-6-4-10(8-17-12)9-3-5-11-13(7-9)21-15(16)18-11/h3-8H,1-2H3,(H2,16,18)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107270
PNG
(CHEMBL3600695)
Show SMILES COCCOc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C15H15N3O2S/c1-19-6-7-20-14-5-3-11(9-17-14)10-2-4-12-13(8-10)21-15(16)18-12/h2-5,8-9H,6-7H2,1H3,(H2,16,18)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107269
PNG
(CHEMBL3600694)
Show SMILES Nc1nc2ccc(cc2s1)-c1ccc(OCCO)nc1
Show InChI InChI=1S/C14H13N3O2S/c15-14-17-11-3-1-9(7-12(11)20-14)10-2-4-13(16-8-10)19-6-5-18/h1-4,7-8,18H,5-6H2,(H2,15,17)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107260
PNG
(CHEMBL3600684)
Show SMILES CCSc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C14H13N3S2/c1-2-18-13-6-4-10(8-16-13)9-3-5-11-12(7-9)19-14(15)17-11/h3-8H,2H2,1H3,(H2,15,17)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107267
PNG
(CHEMBL3600692)
Show SMILES Nc1nc2ccc(cc2s1)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C13H8F3N3S/c14-13(15,16)11-4-2-8(6-18-11)7-1-3-9-10(5-7)20-12(17)19-9/h1-6H,(H2,17,19)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107266
PNG
(CHEMBL3600691)
Show SMILES Cc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C13H11N3S/c1-8-2-3-10(7-15-8)9-4-5-11-12(6-9)17-13(14)16-11/h2-7H,1H3,(H2,14,16)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107275
PNG
(CHEMBL3600690)
Show SMILES Nc1nc2ccc(cc2s1)-c1ccc(CO)nc1
Show InChI InChI=1S/C13H11N3OS/c14-13-16-11-4-2-8(5-12(11)18-13)9-1-3-10(7-17)15-6-9/h1-6,17H,7H2,(H2,14,16)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107261
PNG
(CHEMBL3600685)
Show SMILES COCc1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C14H13N3OS/c1-18-8-11-4-2-10(7-16-11)9-3-5-12-13(6-9)19-14(15)17-12/h2-7H,8H2,1H3,(H2,15,17)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50107265
PNG
(CHEMBL3600689)
Show SMILES CCN(C)c1ccc(cn1)-c1ccc2nc(N)sc2c1
Show InChI InChI=1S/C15H16N4S/c1-3-19(2)14-7-5-11(9-17-14)10-4-6-12-13(8-10)20-15(16)18-12/h4-9H,3H2,1-2H3,(H2,16,18)
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AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay


Bioorg Med Chem Lett 25: 3189-93 (2015)


BindingDB Entry DOI: 10.7270/Q2KK9DKR
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50026612
PNG
(BIBF-1120 | NINTEDANIB | Nintedanib | Vargatef)
Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
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Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PIP5K1C kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50308060
PNG
(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Show SMILES C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PIP5K1C kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/an/a 2.70E+3n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PIP5K1C kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50326053
PNG
(CHEMBL608533 | PKC-412)
Show SMILES CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 |r|
Show InChI InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PIP5K1C kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM25045
PNG
(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PIP5K1C kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM50237710
PNG
(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PIP5K1C kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM31095
PNG
(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1
Show InChI InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1
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n/an/an/a>1.00E+4n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PIP5K1C kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma


(Homo sapiens (Human))
BDBM60665
PNG
(BDBM50249542 | US9145414, R406 | US9212178, R406)
Show SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC
Show InChI InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
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n/an/an/a 130n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PIP5K1C kinase domain


Nat Biotechnol 29: 1046-51 (2011)


Article DOI: 10.1038/nbt.1990
BindingDB Entry DOI: 10.7270/Q25D8S70
More data for this
Ligand-Target Pair
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